Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PIN4 | 5303 | Protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) | X | EPVH; PAR14; PAR17 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20089989 | 2010 | Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : - | Biochemical isolation to nano-LC-MS/MS analysis | Unknown | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of the parvulin subfamily of the peptidyl-prolyl cis/trans isomerase protein family. The encoded protein catalyzes the isomerization of peptidylprolyl bonds, and may play a role in the cell cycle, chromatin remodeling, and/or ribosome biogenesis. The encoded protein may play an additional role in the mitochondria. [provided by RefSeq, Dec 2009] |
| Chromosome | X |
| Location | Xq13 |
| Start | 72181676 |
| End | 72263964 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 82289 |
| OMIM ID | 300252 |
| HGNC ID | HGNC:8992 |
| Unigene ID | Hs.655623 |
| Ensembl ID | ENSG00000102309 |
| PharmGKB ID | PA33324 |
mRNA Information
| mRNA ID | NM_001170747.1 |
|---|---|
| Exon | join(1..153,4786..4859,15110..15229,81032..82289) | mRNA Sequence | Download Select all |
| Length | 1605 |
CDS Information
| Location | join(36..153,4786..4859,15110..15229,81032..81121) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS55447.1 |
Protein Information
| Protein ID | NP_001164218.1 |
|---|---|
| Protein Name | Protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) |
| Molecular Wt. (Da) | 14048 |
| Protein Sequence | Download Select all |
| Length | 133 |
| Uniprot ID | Q14031 |
| Ensembl Protein ID | ENSP00000334733 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 44 |
| S | Phosphorylation | 44 |
| K | Acetylation | 57 |
| Y | Phosphorylation | 147 |
Enzyme Information
| EC | 5.2.1.8 |
|---|---|
| Name | peptidylprolyl isomerase PPIase cyclophilin [misleading, see comments] peptide bond isomerase peptidyl-prolyl cis-trans isomerase |
| Class | Isomerases; cis-trans-Isomerases; cis-trans Isomerases (only sub-subclass identified to date) |
| Sysname | peptidylproline cis-trans-isomerase |
| Substrate | peptidylproline (omega=180) |
| Product | peptidylproline (omega=0) |
| Reaction (IUBMB) |  |
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2091 | FBL | 617 | NP_001427.2 | in vitro | 11960984 |
| 6709 | SPTAN1 | 1684 | NP_001123910.1 | yeast 2-hybrid | 16169070 |
| 84164 | ASCC2 | 16515 | NP_115580.2 | yeast 2-hybrid | 16169070 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00639 | 42-129 | Rotamase |
| cl08278 | 42-129 | Rotamase_2 superfamily |
| pfam13616 | 32-131 | Rotamase_3 |
| PTZ00356 | 59-125 | PTZ00356 |
| PRK15441 | 42-131 | PRK15441 |
| pfam13145 | 54-131 | Rotamase_2 |
| PRK02998 | 38-131 | prsA |
| PRK03095 | 38-127 | prsA |
| PRK03002 | 38-131 | prsA |
| COG0760 | 36-131 | SurA |
| PRK00059 | 35-131 | prsA |
| PRK04405 | 38-125 | prsA |
| PRK10770 | 38-125 | PRK10770 |
| PRK10788 | 53-97 | PRK10788 |
| TIGR02933 | 48-128 | nifM_nitrog |
| PRK10770 | 55-127 | PRK10770 |
Ontology Information
| HPRD ID | 375 |
|---|---|
| Molecular Class | Enzyme: Isomerase |
| Molecular Function | Extracellular matrix structural constituent (GO:0005201) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
No matching records could be found.