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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PITX2 | 5308 | paired-like homeodomain 2 | 4 | IGDS, RS, Brx1, Otlx2, ARP1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21479692 | 2011 | Cell line : 5 Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 92 Stage : - | - | Up-regulation | - | PITX2 expression is significantly related to the biological behavior of CRC cells and appears to be correlated with clinical survival. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Homeoboxes / PRD class |
| Description | This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] |
| Chromosome | 4 |
| Location | 4q25 |
| Start | 111538579 |
| End | 111563279 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 24701 |
| OMIM ID | 601542 |
| HGNC ID | HGNC:9005 |
| Unigene ID | Hs.643588 |
| Ensembl ID | ENSG00000164093 |
| PharmGKB ID | PA33339 |
mRNA Information
| mRNA ID | ?NM_000325.5 |
|---|---|
| Exon | join(1..205,9116..9171,20755..20960,23436..24701) | mRNA Sequence | Download Select all |
| Length | 1736 |
Protein Information
| Protein ID | NP_000316.2 |
|---|---|
| Protein Name | paired-like homeodomain 2 |
| Molecular Wt. (Da) | 101053 |
| Protein Sequence | Download Select all |
| Length | 317 |
| Uniprot ID | P35658 |
| Ensembl Protein ID | ENSP00000352400 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 58;- |
| S | Phosphorylation | 60;- |
| S | Phosphorylation | 63;- |
| S | Phosphorylation | 64;- |
| T | Phosphorylation | 62;- |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1499 | CTNNB1 | 286 | NP_001895.1 | in vitro;in vivo | 1 246 417 915 728 250 |
| 3065 | HDAC1 | 3143 | NP_004955.2 | in vivo | 12464179 |
| 5626 | PROP1 | 3325 | NP_006252.3 | in vitro | 9685346 |
| 51176 | LEF1 | 1075 | NP_057353.1 | in vitro | 15728254 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| TGF-beta signaling pathway | hsa04350 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00086 | 86-144 | homeodomain |
| cl00084 | 86-144 | homeodomain superfamily |
| pfam00046 | 86-142 | Homeobox |
| smart00389 | 85-141 | HOX |
| pfam03826 | 274-292 | OAR |
| cl08404 | 274-292 | OAR superfamily |
| COG5576 | 40-142 | COG5576 |
Ontology Information
| HPRD ID | 5648 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Growth factor activity (GO:0008083) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.