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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20089989 | 2010 | Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : - | Biochemical isolation to nano-LC-MS/MS analysis | Unknown | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Armadillo repeat containing |
| Description | This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene product may regulate the signaling activity of beta-catenin. Two alternately spliced transcripts encoding two protein isoforms have been identified. A processed pseudogene with high similarity to this locus has been mapped to chromosome 12p13. [provided by RefSeq, Jul 2008] |
| Chromosome | 12 |
| Location | 12p11 |
| Start | 32790746 |
| End | 32896846 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 106101 |
| OMIM ID | 602861 |
| HGNC ID | HGNC:9024 |
| Unigene ID | Hs.164384 |
| Ensembl ID | ENSG00000057294 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001005242.2 |
|---|---|
| Exon | join(1..338,17815..17927,18304..19001,27785..27920, 45874..46081,55642..55819,72685..72802,74216..74380, 75318..75491,94291..94444,100549..100738,104116..104203, 104355..106101) | mRNA Sequence | Download Select all |
| Length | 4307 |
CDS Information
| Location | join(116..338,17815..17927,18304..19001,27785..27920, 45874..46081,55642..55819,72685..72802,74216..74380, 75318..75491,94291..94444,100549..100738,104116..104203, 104355..104423) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS31771.1 |
Protein Information
| Protein ID | NP_001005242.2 |
|---|---|
| Protein Name | Plakophilin 2 |
| Molecular Wt. (Da) | 92625 |
| Protein Sequence | Download Select all |
| Length | 837 |
| Uniprot ID | P12107 |
| Ensembl Protein ID | ENSP00000302551 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 169;- |
| S | Phosphorylation | 169;- |
| S | Phosphorylation | 132;- |
| S | Phosphorylation | 132;- |
| S | Phosphorylation | 135 |
| S | Phosphorylation | 135 |
| S | Phosphorylation | 151 |
| S | Phosphorylation | 154 |
| S | Phosphorylation | 155 |
| S | Phosphorylation | 151 |
| S | Phosphorylation | 154 |
| S | Phosphorylation | 155 |
| S | Phosphorylation | 197 |
| S | Phosphorylation | 197 |
| S | Phosphorylation | 329 |
| S | Phosphorylation | 329 |
| S | Phosphorylation | 251 |
| S | Phosphorylation | 251 |
| Y | Phosphorylation | 10 |
| Y | Phosphorylation | 10 |
| Y | Phosphorylation | 12 |
| Y | Phosphorylation | 12 |
| Y | Phosphorylation | 166 |
| Y | Phosphorylation | 166 |
| Y | Phosphorylation | 217 |
| Y | Phosphorylation | 217 |
| Y | Phosphorylation | 86 |
| Y | Phosphorylation | 86 |
| S | Phosphorylation | 293 |
| S | Phosphorylation | 293 |
| S | Phosphorylation | 294 |
| S | Phosphorylation | 294 |
| T | Phosphorylation | 80 |
| T | Phosphorylation | 80 |
| S | Phosphorylation | 44 |
| S | Phosphorylation | 44 |
| Y | Phosphorylation | 686 |
| S | Phosphorylation | 693 |
| Y | Phosphorylation | 642 |
| S | Phosphorylation | 649 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1499 | CTNNB1 | 286 | NP_001895.1 | in vivo;yeast 2-hybrid | 11790773 |
| 1823 | DSC1 | 511 | NP_077739.1 | yeast 2-hybrid | 11790773 |
| 1824 | DSC2 | 512 | NP_077740.1 | yeast 2-hybrid | 11790773 |
| 1828 | DSG1 | 515 | NP_001933.2 | in vivo;yeast 2-hybrid | 11790773 |
| 1829 | DSG2 | 516 | NP_001934.2 | in vivo;yeast 2-hybrid | 11790773 |
| 1832 | DSP | 513 | NP_004406.2 | in vivo;yeast 2-hybrid | 11790773 |
| 3728 | JUP | 1414 | NP_002221.1 | in vivo | 11790773 |
| 3852 | KRT5 | 1010 | NP_000415.2 | in vitro | 10852826 |
| 3875 | KRT18 | 1020 | NP_000215.1 | in vitro | 10852826 |
| 4093 | SMAD9 | 4484 | BAA21128.1 | yeast 2-hybrid | 15231748 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | hsa05412 |
Structure Information
| PDB ID | 1TEN |
|---|---|
| Resolution | 1.8 |
| Method | X-RAY DIFFRACTION |
| Chains | A |
| Molecule | TENASCIN |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00020 | 675-804 | ARM |
| cl22454 | 675-804 | ARM superfamily |
| cd00020 | 350-467 | ARM |
| cl22454 | 350-467 | ARM superfamily |
| cd00020 | 408-567 | ARM |
| cd00020 | 724-825 | ARM |
Ontology Information
| HPRD ID | 1863 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Protein threonine/tyrosine kinase activity (GO:0004712) |
| Biological Process | Cell communication (GO:0007154) |
Drug Information
No matching records could be found.