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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PLAU | 5328 | Plasminogen activator, urokinase | 10 | ATF; QPD; UPA; URK; u-PA; BDPLT5 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22930170 | 2012 | Cell line : KM 12C, KM 12SM, HT 29 Source : ATCC. Sample Type : - No. of Sample : - Stage : - | Microarray analysis,Real time RT-PCR and Flow cytometry | Up-regulation | - | Gene differentially expressed and analysed bye by Microarray. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009] |
| Chromosome | 10 |
| Location | 10q22.2 |
| Start | 73909182 |
| End | 73917501 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 8320 |
| OMIM ID | 191840 |
| HGNC ID | HGNC:9052 |
| Unigene ID | Hs.77274 |
| Ensembl ID | ENSG00000122861 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_011539866.1 |
|---|---|
| Exon | join(1..113,2344..2431,2860..2887,3034..3141,3743..3917, 4109..4200,4358..4577,4799..4947,5595..5735,6070..6218, 7208..8320) | mRNA Sequence | Download Select all |
| Length | 2680 |
CDS Information
| Location | join(2375..2431,2860..2887,3034..3141,3743..3917, 4109..4200,4358..4577,4799..4947,5595..5735,6070..6218, 7208..7384) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS7339.1 |
Protein Information
| Protein ID | NP_002649.1 |
|---|---|
| Protein Name | Plasminogen activator, urokinase |
| Molecular Wt. (Da) | 46368 |
| Protein Sequence | Download Select all |
| Length | 431 |
| Uniprot ID | P21964 |
| Ensembl Protein ID | ENSP00000354511 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| K | Proteolytic Cleavage | 178 |
| K | Proteolytic Cleavage | 178 |
Enzyme Information
| EC | 3.4.21.73 |
|---|---|
| Name | u-plasminogen activator urokinase urinary plasminogen activator cellular plasminogen activator urokinase-type plasminogen activator double-chain urokinase-type plasminogen activator two-chain urokinase-type plasminogen activator urokinase plasminogen activator uPA u-PA abbokinase urinary esterase A |
| Class | Hydrolases; Acting on peptide bonds (peptidases); Serine endopeptidases |
| Sysname | |
| Substrate | |
| Product | |
| Reaction (IUBMB) |  |
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3482 | IGF2R | 928 | NP_000867.2 | in vitro | 9566979 |
| 4811 | NID1 | 574 | NP_002499.2 | in vitro | 1499567 |
| 5054 | SERPINE1 | 1418 | NP_000593.1 | in vitro;in vivo | 216 184 625 448 763 000 000 |
| 5055 | SERPINB2 | 1420 | NP_002566.1 | in vitro;in vivo | 216 184 683 888 102 000 000 |
| 5269 | SERPINB6 | 1413 | NP_004559.4 | in vitro | 7548163 |
| 5327 | PLAT | 1419 | NP_000921.1 | in vitro | 7721771 |
| 5329 | PLAUR | 1421 | NP_002650.1 | in vitro;in vivo | 3 031 025 115 015 270 000 000 |
| 5340 | PLG | 1417 | NP_000292.1 | in vitro | 392 021 628 293 804 000 000 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Complement and coagulation cascades | hsa04610 |
| MicroRNAs in cancer | hsa05206 |
| NF-kappa B signaling pathway | hsa04064 |
| Proteoglycans in cancer | hsa05205 |
| Transcriptional misregulation in cancer | hsa05202 |
Structure Information
| PDB ID | 1C5W |
|---|---|
| Resolution | 1.94 |
| Method | X-RAY DIFFRACTION |
| Chains | A |
| Molecule | PROTEIN (UROKINASE-TYPE PLASMINOGEN ACTIVATOR) |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00190 | 179-422 | Tryp_SPc |
| cl21584 | 179-422 | Tryp_SPc superfamily |
| cd00108 | 67-152 | KR |
| cl00100 | 67-152 | KR superfamily |
| smart00130 | 69-153 | KR |
| pfam00051 | 70-151 | Kringle |
| smart00020 | 178-419 | Tryp_SPc |
| pfam00089 | 179-419 | Trypsin |
| COG5640 | 178-424 | COG5640 |
Ontology Information
| HPRD ID | 272 |
|---|---|
| Molecular Class | Serine protease |
| Molecular Function | Carboxypeptidase activity (GO:0004180) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P00749 | DB00013 | Urokinase | BiotechDrug |
| P00749 | DB00594 | Amiloride | SmallMoleculeDrug |