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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PLAUR | 5329 | plasminogen activator, urokinase receptor | 19 | URKR, UPAR, CD87 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23136192 | 2013 | Cell line : SW480, SW620 Source : - Sample Type : Tumor and normal healthy tissue No. of Sample : 203 Stage : - | Immunohistochemistry,Western blotting ,Transient transfection of colon cancer cells. | Up-regulation | - | Promotion of colon tumorigenesis by FOXM1 directly and significantly correlated with activation of urokinase-type plasminogen activator receptor (PLAUR) expression and elevation of invasion and metastasis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | CD molecules |
| Description | This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq, Jul 2008] |
| Chromosome | 19 |
| Location | 19q13 |
| Start | 44150247 |
| End | 44174498 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 24252 |
| OMIM ID | 173391 |
| HGNC ID | HGNC:9053 |
| Unigene ID | Hs.466871 |
| Ensembl ID | ENSG00000011422 |
| PharmGKB ID | PA33383 |
mRNA Information
| mRNA ID | ?NM_001005376.2 |
|---|---|
| Exon | join(1..281,2656..2766,4888..5031,13707..13868, 14774..14908,17976..18122,23799..24252) | mRNA Sequence | Download Select all |
| Length | 1455 |
Protein Information
| Protein ID | NP_001005376.1 |
|---|---|
| Protein Name | plasminogen activator, urokinase receptor |
| Molecular Wt. (Da) | 119563 |
| Protein Sequence | Download Select all |
| Length | 335 |
| Uniprot ID | O95619 |
| Ensembl Protein ID | ENSP00000247843 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Proteolytic Cleavage | 108 |
| T | Proteolytic Cleavage | 108 |
| T | Proteolytic Cleavage | 108 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2534 | FYN | 655 | NP_002028.1 | in vitro;in vivo | 9417082 |
| 3055 | HCK | 796 | NP_002101.2 | in vitro | 11097855 |
| 3684 | ITGAM | 411 | NP_000623.2 | in vitro;in vivo | 10744708 |
| 3688 | ITGB1 | 628 | NP_391987.1 | in vivo | 10388537 |
| 3716 | JAK1 | 992 | NP_002218.2 | in vitro;in vivo | 9417082 |
| 4035 | LRP1 | 138 | NP_002323.2 | in vitro | 11359936 |
| 6835 | SURF2 | 15948 | NP_059973.3 | yeast 2-hybrid | 16169070 |
| 7297 | TYK2 | 1490 | NP_003322.3 | in vivo | 9974409 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Complement and coagulation cascades | hsa04610 |
| Proteoglycans in cancer | hsa05205 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00117 | 215-296 | LU |
| cl10471 | 215-296 | LU superfamily |
| cd00117 | 115-201 | LU |
| cl10471 | 115-201 | LU superfamily |
| cd00117 | 23-101 | LU |
| cl10471 | 23-101 | LU superfamily |
| smart00134 | 214-296 | LU |
| smart00134 | 115-202 | LU |
| pfam00021 | 216-294 | UPAR_LY6 |
| pfam00021 | 25-99 | UPAR_LY6 |
| smart00134 | 23-101 | LU |
Ontology Information
| HPRD ID | 3726 |
|---|---|
| Molecular Class | Cell surface receptor |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| Q03405 | DB00009 | Alteplase | BiotechDrug |
| Q03405 | DB00013 | Urokinase | BiotechDrug |
| Q03405 | DB00015 | Reteplase | BiotechDrug |
| Q03405 | DB00029 | Anistreplase | BiotechDrug |
| Q03405 | DB00031 | Tenecteplase | BiotechDrug |