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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
PLD1 5337 phospholipase D1, phosphatidylcholine-specific  3- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
20711340   2010Cell line : HCT116, HCA 7, Colo 741, RKO

Source : -

Sample Type : FVB mice

No. of Sample : -

Stage : -

Transfection, Reporter Gene Assay,Immunoprecipitation, Western Blotting,PLD activity assay,real time RT-PCR,Immunohistochemistry,Chromatin immunoprecipitation Up-regulation-Therapeutic interventions targeting PLD may confer a clinical benefit in Wnt/beta-catenin-driven malignancies.

25475140   2014Cell line : HT29,HCT116

Source : -

Sample Type : -

No. of Sample : -

Stage : -

Western blotting,Electron microscopyUp-regulation-Phosphatidylcholine-specific PLD1 and PLD2 are the classic mammalian isoforms of PLD and elevated expression.


Gene Details



NC_000003.11 (171318195..171528284, complement)

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Gene Type protein coding
Gene Family Pleckstrin homology (PH) domain containing
Description This gene encodes a phosphatidylcholine-specific phospholipase which catalyzes the hydrolysis of phosphatidylcholine in order to yield phosphatidic acid and choline. The enzyme may play a role in signal transduction and subcellular trafficking. Alternative splicing results in multiple transcript variants with both catalytic and regulatory properties. [provided by RefSeq, Sep 2011]  
Chromosome 3
Location 3q26
Start 171318195  
End 171528284  
Strand -  
Gene Sequence

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Length 210090  
OMIM ID 602382   
HGNC ID HGNC:9067   
Unigene ID Hs.382865   
Ensembl ID ENSG00000075651   
PharmGKB ID PA164742228   

mRNA Information


mRNA ID ?NM_002662.4
Exon join(1..96,72413..72603,72836..72963,74858..75003, 75525..75630,76986..77051,84419..84477,85707..85799, 96450..96602,100786..100935,101657..101740,110669..110750, 118053..118163,121619..121819,122911..123124, 132801..132929,133662..133780,135882..135995, 148325..148435,151194..151282,165472..165585, 167606..167655,189975..190109,198063..198216, 205079..205196,207193..210090)  
mRNA Sequence

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Length 5911  



CDS Information


   
Location 128..3238
CDS Sequence

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CCDS ID CCDS3216.1



Protein Information


      
Protein IDNP_002653.1
Protein Namephospholipase D1, phosphatidylcholine-specific
Molecular Wt. (Da)105856
Protein Sequence

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Length 1074  
Uniprot IDP52926
Ensembl Protein ID ENSP00000346658  



Post-translational Modification Information (Source : HPRD)


Residue Type site
TPhosphorylation147
SPhosphorylation2
SPhosphorylation561
SPhosphorylation629;-
SPhosphorylation45

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                   
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
58ACTA130NP_001091.1in vivo12388543   
60ACTB32NP_001092.1in vitro;in vivo11373276   
71ACTG117NP_001605.1in vitro;in vivo12388543   
375ARF154NP_001649.1in vitro;in vivo9688545   
382ARF62714NP_001654.1in vivo12379803   
387RHOA1323NP_001655.1in vitro;in vivo11   311   142   125   938   500   000   000   
391RHOG1537NP_001656.2in vitro12376551   
998CDC42309NP_001782.1in vitro;in vivo10747870   
5585PKN13019NP_998725.1in vitro;in vivo11259428   
5879RAC13627NP_061485.1in vivo11950936   
5898RALA1549NP_005393.2in vitro;in vivo9207251   
6622SNCA1227NP_000336.1in vitro;in vivo11821392   
6812STXBP14235NP_003156.1in vitro;in vivo14744865   


Pathway Information


                                                                                    
Pathway Name Pathway ID
cAMP signaling pathway hsa04024
Choline metabolism in cancer hsa05231
Endocytosis hsa04144
Ether lipid metabolism hsa00565
Fc gamma R-mediated phagocytosis hsa04666
Glutamatergic synapse hsa04724
Glycerophospholipid metabolism hsa00564
GnRH signaling pathway hsa04912
Metabolic pathways hsa01100
Pancreatic cancer hsa05212
Pathways in cancer hsa05200
Phospholipase D signaling pathway hsa04072
Ras signaling pathway hsa04014
Sphingolipid signaling pathway hsa04071


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd09844754-935  PLDc_vPLD1_2
cl15239754-935  PLDc_SF superfamily
cd09842352-502  PLDc_vPLD1_1
cl15239352-502  PLDc_SF superfamily
cd0729678-209  PX_PLD1
cl0256378-209  PX_domain superfamily
cd01254197-326  PH_PLD
cl17171197-326  PH-like superfamily
cd09141754-935  PLDc_vPLD1_2_yPLD_like_2
cd09845759-935  PLDc_vPLD2_2
cd09138352-497  PLDc_vPLD1_2_yPLD_like_1
cd09843352-497  PLDc_vPLD2_1
cd0689578-209  PX_PLD
cd09105754-933  PLDc_vPLD1_2_like_2
cd09104352-497  PLDc_vPLD1_2_like_1
cd0729778-209  PX_PLD2
cd09142759-928  PLDc_pPLD_like_2
cd09199759-929  PLDc_pPLDalpha_2
cd09200761-929  PLDc_pPLDbeta_2
pfam0078784-206  PX
cd09139362-494  PLDc_pPLD_like_1
cd09140356-493  PLDc_vPLD1_2_like_bac_1
smart0031287-207  PX
cd09143762-919  PLDc_vPLD1_2_like_bac_2
cd09198362-494  PLDc_pPLDbeta_1
cd09197362-494  PLDc_pPLDalpha_1
cd00138363-493  PLDc_SF
cd06093102-208  PX_domain
cd00138764-931  PLDc_SF
cd09154355-495  PLDc_SMU_988_like_1
smart00233222-328  PH
pfam00169222-327  PH
pfam00614459-486  PLDc
cl23414459-486  PLDc superfamily
smart00155892-918  PLDc
cd09128888-935  PLDc_unchar1_2
cd0689792-208  PX_SNARE
cd0687698-194  PX_MDM1p
cd09110356-480  PLDc_CLS_1
smart00155459-486  PLDc
cd09112894-937  PLDc_CLS_2
cd00821222-323  PH
pfam00614891-918  PLDc
cl23414891-918  PLDc superfamily
cd09162895-920  PLDc_CLS_unchar1_2
cd09159896-933  PLDc_ybhO_like_2
cd09113896-935  PLDc_ymdC_like_2
cd0687597-132  PX_IRAS
cd09126355-496  PLDc_C_DEXD_like
cd09127894-937  PLDc_unchar1_1
PLN0286682-1059  PLN02866
PLN02270362-986  PLN02270
PLN02352674-952  PLN02352
PLN03008640-929  PLN03008
COG1502665-937  Cls
pfam13091896-937  PLDc_2


Ontology Information


   
HPRD ID9014
Molecular ClassEnzyme: Phosphodiesterase
Molecular FunctionMHC class I receptor activity (GO:0030106); MHC class II receptor activity (GO:0045012)
Biological ProcessImmune response (GO:0006955)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
Q13393DB09031MiltefosineSmallMoleculeDrug
Q13393DB00122CholineSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO