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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
PLD2 5338 phospholipase D2  17- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
25475140   2014Cell line : HT29, HCT116

Source : -

Sample Type : -

No. of Sample : -

Stage : -

Western blot analysis,Electron microscopy.Up-regulation-PLD2 might have a role in autophagy and that its inhibition might provide a new therapeutic basis for targeting autophagy.


Gene Details



NC_000017.10 (4710396..4726727)

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Gene Type protein coding
Gene Family -
Description The protein encoded by this gene catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline. The activity of the encoded enzyme is enhanced by phosphatidylinositol 4,5-bisphosphate and ADP-ribosylation factor-1. This protein localizes to the peripheral membrane and may be involved in cytoskeletal organization, cell cycle control, transcriptional regulation, and/or regulated secretion. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]  
Chromosome 17
Location 17p13.3
Start 4710396  
End 4726727  
Strand +  
Gene Sequence

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Length 16332  
OMIM ID 602384   
HGNC ID HGNC:9068   
Unigene ID Hs.104519   
Ensembl ID ENSG00000129219   
PharmGKB ID PA33397   

mRNA Information


mRNA ID ?NM_001243108.1
Exon join(1..125,672..781,884..1014,1174..1316,2000..2105, 2198..2263,2393..2451,2591..2683,2777..2929,3702..3851, 7318..7401,7533..7611,8376..8486,8664..8834,9520..9646, 9837..9955,10046..10159,10902..11006,11197..11285, 11394..11507,11674..11723,11984..12118,12329..12482, 14693..14807,15540..16332)  
mRNA Sequence

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Length 3514  



CDS Information


   
Location127..2928
CDS Sequence

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CCDS ID CCDS11057.1



Protein Information


      
Protein IDNP_001230037.1
Protein Namephospholipase D2
Molecular Wt. (Da)68124
Protein Sequence

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Length 933  
Uniprot IDO14519
Ensembl Protein ID ENSP00000261692  



Post-translational Modification Information (Source : HPRD)


Residue Type site
YPhosphorylation179
SPhosphorylation609

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                             
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
60ACTB32NP_001092.1in vitro;in vivo11373276   
87ACTN120NP_001123476.1in vitro;in vivo10801846   
226ALDOA70NP_000025.1in vitro;in vivo11876650   
230ALDOC2386NP_005156.1in vitro11876650   
273AMPH2687NP_001626.1in vitro10764771   
274BIN13150NP_647593.1in vitro10764771   
375ARF154NP_001649.1in vivo1   251   979   010   801   840   
857CAV13028NP_001744.2in vitro;in vivo10675563   
1445CSK496NP_004374.1in vitro;in vivo12697812   
2534FYN655NP_002028.1in vivo12697812   
2597GAPDH713NP_002037.2in vitro;in vivo12753082   
2760GM2A2034NP_000396.2in vitro11672434   
3932LCK1080NP_005347.3in vivo12697812   
4988OPRM12484NP_001138751.1in vitro;in vivo12519790   
5335PLCG11398NP_002651.2in vitro;in vivo12646582   
5578PRKCA1498NP_002728.1in vivo11042115   
5580PRKCD1501NP_006245.2in vitro;in vivo11744693   
6812STXBP14235NP_003156.1in vitro;in vivo14744865   
57521RPTOR6184NP_065812.1in vitro16837165   


Pathway Information


                                                                        
Pathway Name Pathway ID
cAMP signaling pathway hsa04024
Choline metabolism in cancer hsa05231
Endocytosis hsa04144
Ether lipid metabolism hsa00565
Fc gamma R-mediated phagocytosis hsa04666
Glutamatergic synapse hsa04724
Glycerophospholipid metabolism hsa00564
GnRH signaling pathway hsa04912
Metabolic pathways hsa01100
Phospholipase D signaling pathway hsa04072
Ras signaling pathway hsa04014
Sphingolipid signaling pathway hsa04071


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd09845614-795  PLDc_vPLD2_2
cl15239614-795  PLDc_SF superfamily
cd01254180-309  PH_PLD
cl17171180-309  PH-like superfamily
cd09141614-795  PLDc_vPLD1_2_yPLD_like_2
cd09843335-475  PLDc_vPLD2_1
cl15239335-475  PLDc_SF superfamily
cd09844619-795  PLDc_vPLD1_2
cd09138335-475  PLDc_vPLD1_2_yPLD_like_1
cd0729762-192  PX_PLD2
cl0256362-192  PX_domain superfamily
cd09842335-476  PLDc_vPLD1_1
cd0689562-192  PX_PLD
cd0729662-192  PX_PLD1
cd09105619-793  PLDc_vPLD1_2_like_2
cd09104335-474  PLDc_vPLD1_2_like_1
cd09142617-788  PLDc_pPLD_like_2
cd09199617-789  PLDc_pPLDalpha_2
cd09200618-789  PLDc_pPLDbeta_2
pfam0078768-192  PX
cd09140339-467  PLDc_vPLD1_2_like_bac_1
cd09139338-472  PLDc_pPLD_like_1
cd09143626-792  PLDc_vPLD1_2_like_bac_2
cd09197348-472  PLDc_pPLDalpha_1
smart0031271-190  PX
cd09198350-472  PLDc_pPLDbeta_1
cd09110339-473  PLDc_CLS_1
cd0687564-190  PX_IRAS
cd0609366-190  PX_domain
cd09155339-473  PLDc_PaCLS_like_1
cd00138346-466  PLDc_SF
cd00138625-791  PLDc_SF
cd09112754-796  PLDc_CLS_2
smart00155752-778  PLDc
cd09154338-481  PLDc_SMU_988_like_1
smart00233205-311  PH
cd09131755-802  PLDc_unchar3
cd09128749-795  PLDc_unchar1_2
pfam00614756-778  PLDc
cl23414756-778  PLDc superfamily
cd09126336-467  PLDc_C_DEXD_like
cd09159755-793  PLDc_ybhO_like_2
cd09113755-795  PLDc_ymdC_like_2
pfam00614437-464  PLDc
cl23414437-464  PLDc superfamily
cd09127338-456  PLDc_unchar1_1
cd09111387-457  PLDc_ymdC_like_1
cd09162755-780  PLDc_CLS_unchar1_2
cd09106755-793  PLDc_vPLD3_4_5_like_1
cd0687487-175  PX_KIF16B_SNX23
cd00821205-306  PH
cd0687267-114  PX_SNX19_like_plant
cd09124337-467  PLDc_like_TrmB_middle
cd09160754-779  PLDc_SMU_988_like_2
smart00155437-464  PLDc
cd09127748-796  PLDc_unchar1_1
pfam00169205-309  PH
cd09157387-473  PLDc_CLS_unchar2_1
cd09163756-779  PLDc_CLS_unchar2_2
PLN0286666-918  PLN02866
PLN02352348-813  PLN02352
PLN02270348-789  PLN02270
COG1502287-795  Cls
PLN03008351-789  PLN03008
pfam13091755-795  PLDc_2
TIGR04265338-472  bac_cardiolipin


Ontology Information


   
HPRD ID2552
Molecular ClassEnzyme: Phospholipase
Molecular FunctionTransporter activity (GO:0005215)
Biological ProcessTransport (GO:0006810)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
O14939DB00122CholineSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO