Search results:
General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22648245 | 2012 | Cell line : SW1116 Source : Ruijin Hospital, Shanghai Jiaotong University School of Medicine, China. Sample Type : CRC Tumor and normal tissue No. of Sample : 56 Stage : Duke Stage A-D | RT-PCR, Western blotting, immunohistochemistry | Up-regulation | - | PLK1 might be involved in metastasis and invasion of colorectal cancer. Therapeutic strategies targeting PLK1 may be a new approach to colorectal cancer. |
| 24876664 | 2014 | Cell line : - Source : - Sample Type : CRC Tumor and normal tissue No. of Sample : 26 CRC and adjacent normal tissues and 77 ductal breast cancer from grade I - III Stage : TNM Stage I-III. | Real-time quantitative PCR, | Up-regulation | - | - |
| 11597015 | 2001 | Cell line : - Source : - Sample Type : CRC Tumor and adjescent tissue No. of Sample : 74 Stage : - | real time RT-PCR | Up-regulation | - | The polo family mitotic regulators SAK and PLK are both aberrantly expressed in colorectal cancer. |
| 12708489 | 2003 | Cell line : - Source : Second Department of Surgery, Gifu University School of Medicine. Sample Type : CRC Tumor and adjescent tissue No. of Sample : 78 CRC and 15 normal tissues Stage : Duke Stage A-D | Immunohistochemistry | Up-regulation | - | Overexpression of PLK1 might be of pathogenic, prognostic and proliferative importance, so that this kinase might have potential as a new tumor marker for colorectal cancers. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of this protein in cancer cells dramatically inhibited cell proliferation and induced apoptosis; hence, it is a target for cancer therapy. [provided by RefSeq, Sep 2015] |
| Chromosome | 16 |
| Location | 16p |
| Start | 23690201 |
| End | 23701688 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 11488 |
| OMIM ID | 602098 |
| HGNC ID | HGNC:9077 |
| Unigene ID | Hs.592049 |
| Ensembl ID | ENSG00000166851 |
| PharmGKB ID | PA33410 |
mRNA Information
| mRNA ID | ?NM_005030.5 |
|---|---|
| Exon | join(1..519,1263..1431,2093..2237,3243..3336,5049..5268, 8648..8803,9847..9924,10417..10571,10673..10855, 11039..11546) | mRNA Sequence | Download Select all |
| Length | 2293 |
Protein Information
| Protein ID | NP_005021.2 |
|---|---|
| Protein Name | polo-like kinase 1 |
| Molecular Wt. (Da) | 97420 |
| Protein Sequence | Download Select all |
| Length | 603 |
| Uniprot ID | P39687 |
| Ensembl Protein ID | ENSP00000417864 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 210 |
| T | Phosphorylation | 210;- |
| T | Phosphorylation | 214 |
| S | Phosphorylation | 387 |
| T | Phosphorylation | 498 |
| S | Phosphorylation | 461 |
| T | Phosphorylation | 464 |
| S | Phosphorylation | 375 |
| S | Phosphorylation | 330 |
| S | Phosphorylation | 450 |
| S | Phosphorylation | 103 |
| T | Phosphorylation | 6 |
| S | Phosphorylation | 2 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 675 | BRCA2 | 2554 | NP_000050.2 | in vitro;in vivo | 12815053 |
| 699 | BUB1 | 3907 | NP_004327.1 | in vitro;in vivo | 16760428 |
| 891 | CCNB1 | 454 | NP_114172.1 | in vivo | 11242082 |
| 995 | CDC25C | 1146 | NP_001781.2 | in vitro;in vivo | 1 120 290 612 595 690 000 000 000 000 000 000 000 000 |
| 1894 | ECT2 | 11860 | NP_060568.3 | in vitro | 16247472 |
| 4171 | MCM2 | 303 | NP_004517.2 | in vivo | 15654075 |
| 4176 | MCM7 | 1154 | NP_005907.3 | in vitro;in vivo | 15654075 |
| 4189 | DNAJB9 | 7047 | NP_036460.1 | yeast 2-hybrid | 16169070 |
| 4661 | MYT1 | 2659 | NP_004526.1 | in vitro | 12738781 |
| 4869 | NPM1 | 1246 | NP_002511.1 | in vitro;in vivo | 15190079 |
| 5300 | PIN1 | 3031 | NP_006212.1 | in vitro | 949 940 516 118 204 |
| 5684 | PSMA3 | 1463 | NP_002779.1 | in vivo | 11205743 |
| 5686 | PSMA5 | 1464 | NP_002781.2 | in vivo | 11205743 |
| 5689 | PSMB1 | 3603 | NP_002784.1 | in vivo | 11205743 |
| 5693 | PSMB5 | 2629 | NP_002788.1 | in vivo | 11205743 |
| 5694 | PSMB6 | 2630 | NP_002789.1 | in vivo | 11205743 |
| 7178 | TPT1 | 15979 | NP_003286.1 | in vitro;in vivo | 12167714 |
| 7248 | TSC1 | 5594 | NP_000359.1 | in vivo | 16339216 |
| 7277 | TUBA4A | 1851 | NP_005991.1 | in vitro;in vivo | 10191277 |
| 7283 | TUBG1 | 1853 | NP_001061.2 | in vitro;in vivo | 10191277 |
| 7465 | WEE1 | 1907 | NP_003381.1 | in vitro | 15070733 |
| 9055 | PRC1 | 17899 | NP_003972.1 | in vivo | 17351640 |
| 9088 | PKMYT1 | 3920 | NP_004194.3 | in vitro | 12738781 |
| 9400 | RECQL5 | 4806 | NP_004250.4 | yeast 2-hybrid | 16169070 |
| 9500 | MAGED1 | 2202 | NP_001005333.1 | yeast 2-hybrid | 16169070 |
| 10726 | NUDC | 10122 | NP_006591.1 | in vitro;in vivo | 12852857 |
| 11200 | CHEK2 | 5084 | NP_001005735.1 | in vitro;in vivo | 1 249 375 411 901 150 000 000 000 000 000 000 000 000 |
| 22981 | NINL | 11120 | NP_079452.3 | in vitro | 12852856 |
| 51608 | C7orf20 | 12909 | NP_057033.2 | yeast 2-hybrid | 16169070 |
| 203068 | TUBB | 1852 | NP_001060.1 | in vitro;in vivo | 10191277 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cell cycle | hsa04110 |
| FoxO signaling pathway | hsa04068 |
| Oocyte meiosis | hsa04114 |
| Progesterone-mediated oocyte maturation | hsa04914 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd14187 | 45-309 | STKc_PLK1 |
| cl21453 | 45-309 | PKc_like superfamily |
| cd13118 | 407-494 | POLO_box_1 |
| cl02916 | 407-494 | POLO_box superfamily |
| cd13117 | 509-590 | POLO_box_2 |
| cl02916 | 509-590 | POLO_box superfamily |
| cd14099 | 58-305 | STKc_PLK |
| cd14189 | 58-305 | STKc_PLK3 |
| cd14188 | 59-305 | STKc_PLK2 |
| cd05117 | 59-304 | STKc_CAMK |
| cd14003 | 59-304 | STKc_AMPK-like |
| cd14007 | 58-306 | STKc_Aurora |
| cd05123 | 59-305 | STKc_AGC |
| cd06606 | 58-305 | STKc_MAPKKK |
| cd14186 | 58-304 | STKc_PLK4 |
| cd00180 | 59-303 | PKc |
| cd08215 | 59-305 | STKc_Nek |
| cd14079 | 59-305 | STKc_AMPK_alpha |
| cd05122 | 59-305 | PKc_STE |
| cd14008 | 59-305 | STKc_LKB1_CaMKK |
| cd05581 | 59-305 | STKc_PDK1 |
| cd14081 | 59-305 | STKc_BRSK1_2 |
| cd14663 | 58-304 | STKc_SnRK3 |
| cd14080 | 59-305 | STKc_TSSK-like |
| cd06627 | 59-305 | STKc_Cdc7_like |
| cd14009 | 59-309 | STKc_ATG1_ULK_like |
| cd14014 | 59-302 | STKc_PknB_like |
| cd14084 | 59-301 | STKc_Chk2 |
| cd14093 | 74-305 | STKc_PhKG |
| cd05580 | 59-305 | STKc_PKA_like |
| cd05572 | 59-293 | STKc_cGK |
| cd14095 | 59-303 | STKc_DCKL |
| cd05579 | 61-306 | STKc_MAST_like |
| cd14073 | 59-302 | STKc_NUAK |
| cd14078 | 59-301 | STKc_MELK |
| cd14069 | 59-305 | STKc_Chk1 |
| cd13999 | 59-301 | STKc_MAP3K-like |
| cd05570 | 59-293 | STKc_PKC |
| cd14116 | 59-300 | STKc_Aurora-A |
| cd14092 | 58-347 | STKc_MSK_C |
| cd14098 | 59-304 | STKc_Rad53_Cds1 |
| cd05578 | 60-305 | STKc_Yank1 |
| cd14086 | 59-301 | STKc_CaMKII |
| cd14006 | 59-300 | STKc_MLCK-like |
| cd06632 | 58-304 | STKc_MEKK1_plant |
| cd06614 | 59-306 | STKc_PAK |
| cd08217 | 59-305 | STKc_Nek2 |
| cd14083 | 59-302 | STKc_CaMKI |
| cd14097 | 59-304 | STKc_STK33 |
| cd14072 | 59-304 | STKc_MARK |
| cd05573 | 59-293 | STKc_ROCK_NDR_like |
| cd08530 | 58-301 | STKc_CNK2-like |
| cd06612 | 59-305 | STKc_MST1_2 |
| cd14121 | 59-304 | STKc_ULK3 |
| cd06623 | 58-304 | PKc_MAPKK_plant_like |
| cd14070 | 59-304 | STKc_HUNK |
| cd14161 | 59-299 | STKc_NUAK2 |
| cd14119 | 59-305 | STKc_LKB1 |
| cd14209 | 59-293 | STKc_PKA |
| cd14091 | 59-322 | STKc_RSK_C |
| cd13996 | 59-303 | STKc_EIF2AK |
| cd14071 | 59-301 | STKc_SIK |
| cd14105 | 59-301 | STKc_DAPK |
| cd14166 | 59-300 | STKc_CaMKI_gamma |
| cd05584 | 59-293 | STKc_p70S6K |
| cd07829 | 59-305 | STKc_CDK_like |
| cd14096 | 59-302 | STKc_RCK1-like |
| cd08529 | 59-300 | STKc_FA2-like |
| cd06625 | 59-305 | STKc_MEKK3_like |
| cd05582 | 59-307 | STKc_RSK_N |
| cd14077 | 59-304 | STKc_Kin1_2 |
| cd13994 | 59-305 | STKc_HAL4_like |
| cd14162 | 59-305 | STKc_TSSK4-like |
| cd14167 | 59-300 | STKc_CaMKI_alpha |
| cd14075 | 59-304 | STKc_NIM1 |
| cd05571 | 59-293 | STKc_PKB |
| cd05612 | 59-293 | STKc_PRKX_like |
| cd06613 | 59-305 | STKc_MAP4K3_like |
| cd05595 | 58-307 | STKc_PKB_beta |
| cd14179 | 59-308 | STKc_MSK1_C |
| cd14117 | 59-293 | STKc_Aurora-B_like |
| cd05599 | 60-305 | STKc_NDR_like |
| cd14181 | 77-305 | STKc_PhKG2 |
| cd05118 | 59-305 | STKc_CMGC |
| cd14074 | 59-302 | STKc_SNRK |
| cd05592 | 59-293 | STKc_nPKC_theta_like |
| cd06610 | 96-305 | STKc_OSR1_SPAK |
| cd14118 | 79-299 | STKc_CAMKK |
| cd14165 | 59-305 | STKc_TSSK1_2-like |
| cd14194 | 59-300 | STKc_DAPK1 |
| cd06609 | 59-304 | STKc_MST3_like |
| cd14002 | 60-304 | STKc_STK36 |
| cd08222 | 59-304 | STKc_Nek11 |
| cd05591 | 59-293 | STKc_nPKC_epsilon |
| cd14185 | 59-300 | STKc_DCKL3 |
| cd05589 | 59-293 | STKc_PKN |
| cd14120 | 59-306 | STKc_ULK1_2-like |
| cd05611 | 61-293 | STKc_Rim15_like |
| cd14103 | 59-300 | STKc_MLCK |
| cd14087 | 59-304 | STKc_PSKH1 |
| cd14010 | 93-304 | STKc_ULK4 |
| cd07834 | 101-318 | STKc_MAPK |
| cd13990 | 59-304 | STKc_TLK |
| cd08219 | 59-300 | STKc_Nek3 |
| cd14196 | 59-301 | STKc_DAPK2 |
| cd05604 | 59-307 | STKc_SGK3 |
| cd05594 | 58-307 | STKc_PKB_alpha |
| cd05587 | 59-293 | STKc_cPKC |
| cd05588 | 59-293 | STKc_aPKC |
| cd08225 | 59-305 | STKc_Nek5 |
| cd06611 | 59-307 | STKc_SLK_like |
| cd06631 | 59-304 | STKc_YSK4 |
| cd14089 | 59-301 | STKc_MAPKAPK |
| cd14195 | 59-300 | STKc_DAPK3 |
| cd05583 | 59-307 | STKc_MSK_N |
| cd14168 | 59-300 | STKc_CaMKI_delta |
| cd05614 | 59-293 | STKc_MSK2_N |
| cd14665 | 59-304 | STKc_SnRK2-3 |
| cd08218 | 59-304 | STKc_Nek1 |
| cd05575 | 59-307 | STKc_SGK |
| cd05616 | 59-293 | STKc_cPKC_beta |
| cd14106 | 59-301 | STKc_DRAK |
| cd14182 | 75-305 | STKc_PhKG1 |
| cd05618 | 59-293 | STKc_aPKC_iota |
| cd14200 | 59-306 | STKc_CaMKK1 |
| cd05574 | 59-293 | STKc_phototropin_like |
| cd14004 | 59-305 | STKc_PASK |
| cd06629 | 59-304 | STKc_Bck1_like |
| cd05590 | 59-293 | STKc_nPKC_eta |
| cd06624 | 59-304 | STKc_ASK |
| cd05615 | 59-293 | STKc_cPKC_alpha |
| cd14169 | 59-300 | STKc_CaMKI_beta |
| cd05620 | 59-293 | STKc_nPKC_delta |
| cd14113 | 59-305 | STKc_Trio_C |
| cd05598 | 59-307 | STKc_LATS |
| cd07840 | 59-305 | STKc_CDK9_like |
| cd08224 | 59-301 | STKc_Nek6_7 |
| cd14662 | 59-301 | STKc_SnRK2 |
| cd14107 | 59-305 | STKc_obscurin_rpt1 |
| cd05617 | 59-293 | STKc_aPKC_zeta |
| cd00192 | 59-301 | PTKc |
| cd06626 | 58-304 | STKc_MEKK4 |
| cd06630 | 59-306 | STKc_MEKK1 |
| cd06648 | 84-305 | STKc_PAK_II |
| cd05593 | 58-306 | STKc_PKB_gamma |
| cd06643 | 59-307 | STKc_SLK |
| cd14076 | 59-301 | STKc_Kin4 |
| cd05603 | 59-306 | STKc_SGK2 |
| cd05613 | 59-293 | STKc_MSK1_N |
| cd05602 | 59-306 | STKc_SGK1 |
| cd13985 | 59-301 | STKc_GAK_like |
| cd06628 | 59-304 | STKc_Byr2_like |
| cd06652 | 58-304 | STKc_MEKK2 |
| cd14114 | 59-300 | STKc_Twitchin_like |
| cd14184 | 59-301 | STKc_DCKL2 |
| cd14178 | 59-300 | STKc_RSK3_C |
| cd05619 | 59-293 | STKc_nPKC_theta |
| cd14175 | 59-306 | STKc_RSK1_C |
| cd14131 | 58-304 | PKc_Mps1 |
| cd06644 | 59-307 | STKc_STK10 |
| cd14180 | 59-316 | STKc_MSK2_C |
| cd08220 | 59-300 | STKc_Nek8 |
| cd08221 | 59-305 | STKc_Nek9 |
| cd14199 | 96-299 | STKc_CaMKK2 |
| cd14202 | 58-305 | STKc_ULK1 |
| cd14201 | 98-305 | STKc_ULK2 |
| cd13983 | 59-305 | STKc_WNK |
| cd05600 | 59-305 | STKc_Sid2p_like |
| cd06653 | 58-304 | STKc_MEKK3_like_u1 |
| cd13982 | 99-305 | STKc_IRE1 |
| cd06608 | 60-304 | STKc_myosinIII_N_like |
| cd05601 | 59-307 | STKc_CRIK |
| cd14046 | 58-303 | STKc_EIF2AK4_GCN2_rpt2 |
| cd14177 | 59-306 | STKc_RSK4_C |
| cd13997 | 59-300 | PKc_Wee1_like |
| cd05577 | 59-293 | STKc_GRK |
| cd05585 | 59-336 | STKc_YPK1_like |
| cd14176 | 59-300 | STKc_RSK2_C |
| cd07841 | 58-307 | STKc_CDK7 |
| cd05609 | 62-293 | STKc_MAST |
| cd14085 | 59-306 | STKc_CaMKIV |
| cd06639 | 59-304 | STKc_myosinIIIB_N |
| cd05624 | 59-286 | STKc_MRCK_beta |
| cd14090 | 58-301 | STKc_Mnk |
| cd14082 | 59-300 | STKc_PKD |
| cd14108 | 59-305 | STKc_SPEG_rpt1 |
| cd14191 | 59-300 | STKc_MLCK1 |
| cd05608 | 59-293 | STKc_GRK1 |
| cd06651 | 58-304 | STKc_MEKK3 |
| cd13993 | 59-301 | STKc_Pat1_like |
| cd14005 | 59-305 | STKc_PIM |
| cd06642 | 59-306 | STKc_STK25 |
| cd08223 | 59-304 | STKc_Nek4 |
| cd14094 | 58-304 | STKc_CASK |
| cd07830 | 59-305 | STKc_MAK_like |
| cd05630 | 59-293 | STKc_GRK6 |
| cd14183 | 59-307 | STKc_DCKL1 |
| cd14172 | 59-301 | STKc_MAPKAPK3 |
| cd14047 | 59-300 | STKc_EIF2AK2_PKR |
| cd06638 | 59-304 | STKc_myosinIIIA_N |
| cd07833 | 59-305 | STKc_CDKL |
| cd14197 | 59-300 | STKc_DRAK1 |
| cd07858 | 101-340 | STKc_TEY_MAPK |
| cd07832 | 59-251 | STKc_CCRK |
| cd05605 | 59-293 | STKc_GRK4_like |
| cd07851 | 58-305 | STKc_p38 |
| cd05596 | 59-305 | STKc_ROCK |
| cd06641 | 59-304 | STKc_MST3 |
| cd14109 | 59-305 | PK_Unc-89_rpt1 |
| cd05626 | 59-285 | STKc_LATS2 |
| cd14173 | 59-300 | STKc_Mnk2 |
| cd14137 | 60-305 | STKc_GSK3 |
| cd06659 | 89-311 | STKc_PAK6 |
| cd14088 | 64-304 | STKc_CaMK_like |
| cd07836 | 101-305 | STKc_Pho85 |
| cd13987 | 59-300 | STKc_SBK1 |
| cd07855 | 101-326 | STKc_ERK5 |
| cd08528 | 59-299 | STKc_Nek10 |
| cd14198 | 59-295 | STKc_DRAK2 |
| cd08228 | 59-296 | STKc_Nek6 |
| cd06655 | 59-305 | STKc_PAK2 |
| cd14164 | 59-299 | STKc_TSSK6-like |
| cd06640 | 59-304 | STKc_MST4 |
| cd13974 | 107-302 | STKc_SHIK |
| cd14171 | 74-300 | STKc_MAPKAPK5 |
| cd13112 | 409-486 | POLO_box |
| cd07838 | 59-305 | STKc_CDK4_6_like |
| cd05629 | 59-306 | STKc_NDR_like_fungal |
| cd05597 | 59-305 | STKc_DMPK_like |
| cd14048 | 59-303 | STKc_EIF2AK3_PERK |
| cd14111 | 60-301 | STKc_SPEG_rpt2 |
| cd06605 | 59-306 | PKc_MAPKK |
| cd07880 | 89-307 | STKc_p38gamma |
| cd07843 | 101-305 | STKc_CDC2L1 |
| cd13978 | 59-301 | STKc_RIP |
| cd14163 | 59-299 | STKc_TSSK3-like |
| cd05623 | 59-286 | STKc_MRCK_alpha |
| cd05627 | 59-263 | STKc_NDR2 |
| cd06657 | 80-312 | STKc_PAK4 |
| cd07849 | 101-325 | STKc_ERK1_2_like |
| cd06658 | 84-312 | STKc_PAK5 |
| cd14174 | 58-300 | STKc_Mnk1 |
| cd05628 | 59-263 | STKc_NDR1 |
| cd14170 | 59-306 | STKc_MAPKAPK2 |
| cd05631 | 59-293 | STKc_GRK4 |
| cd05622 | 59-293 | STKc_ROCK1 |
| cd06647 | 94-305 | STKc_PAK_I |
| cd14115 | 59-295 | STKc_Kalirin_C |
| cd13991 | 59-299 | STKc_NIK |
| cd06645 | 59-306 | STKc_MAP4K3 |
| cd13986 | 59-301 | STKc_16 |
| cd06633 | 59-304 | STKc_TAO3 |
| cd05586 | 59-293 | STKc_Sck1_like |
| cd06654 | 59-305 | STKc_PAK1 |
| cd05625 | 59-307 | STKc_LATS1 |
| cd13112 | 509-590 | POLO_box |
| cd06607 | 59-307 | STKc_TAO |
| cd14110 | 61-300 | STKc_obscurin_rpt2 |
| cd06646 | 59-304 | STKc_MAP4K5 |
| cd14037 | 59-304 | STKc_NAK_like |
| cd06917 | 59-304 | STKc_NAK1_like |
| cd14190 | 59-251 | STKc_MLCK2 |
| cd13976 | 72-300 | PK_TRB |
| cd06656 | 59-337 | STKc_PAK3 |
| cd14052 | 59-300 | PTKc_Wee1_fungi |
| cd14050 | 59-301 | PKc_Myt1 |
| cd06636 | 59-304 | STKc_MAP4K4_6_N |
| cd05632 | 59-293 | STKc_GRK5 |
| cd14062 | 92-302 | STKc_Raf |
| cd14104 | 59-308 | STKc_Titin |
| cd07845 | 59-251 | STKc_CDK10 |
| cd07852 | 135-315 | STKc_MAPK15-like |
| cd14066 | 101-300 | STKc_IRAK |
| cd07857 | 148-300 | STKc_MPK1 |
| cd14192 | 59-251 | STKc_MLCK3 |
| cd13995 | 58-303 | STKc_MAP3K8 |
| cd07847 | 59-305 | STKc_CDKL1_4 |
| cd07846 | 81-305 | STKc_CDKL2_3 |
| cd14049 | 58-303 | STKc_EIF2AK1_HRI |
| pfam00659 | 417-480 | POLO_box |
| cd07853 | 118-308 | STKc_NLK |
| cd07878 | 59-315 | STKc_p38beta |
| cd05610 | 59-305 | STKc_MASTL |
| cd07879 | 77-307 | STKc_p38delta |
| cd06634 | 59-304 | STKc_TAO2 |
| cd06637 | 58-304 | STKc_TNIK |
| cd07877 | 59-316 | STKc_p38alpha |
| cd14023 | 90-305 | PK_TRB1 |
| cd07856 | 76-316 | STKc_Sty1_Hog1 |
| cd13989 | 59-293 | STKc_IKK |
| cd08229 | 59-296 | STKc_Nek7 |
| cd14193 | 59-300 | STKc_MLCK4 |
| cd14038 | 59-294 | STKc_IKK_beta |
| cd05633 | 59-293 | STKc_GRK3 |
| cd14059 | 78-252 | STKc_MAP3K12_13 |
| cd05621 | 59-305 | STKc_ROCK2 |
| cd05148 | 59-299 | PTKc_Srm_Brk |
| cd14223 | 59-293 | STKc_GRK2 |
| cd07866 | 59-305 | STKc_BUR1 |
| cd14134 | 58-305 | PKc_CLK |
| cd07854 | 59-305 | STKc_MAPK4_6 |
| cd06635 | 59-304 | STKc_TAO1 |
| cd14036 | 59-301 | STKc_GAK |
| cd14133 | 58-305 | PKc_DYRK_like |
| cd14041 | 58-305 | STKc_TLK2 |
| cd14039 | 59-274 | STKc_IKK_alpha |
| cd05606 | 59-293 | STKc_beta_ARK |
| cd13979 | 58-300 | STKc_Mos |
| cd07831 | 101-305 | STKc_MOK |
| cd14151 | 92-251 | STKc_B-Raf |
| cd14040 | 58-305 | STKc_TLK1 |
| cd14019 | 59-305 | STKc_Cdc7 |
| cd14022 | 136-305 | PK_TRB2 |
| cd14150 | 92-251 | STKc_A-Raf |
| cd14063 | 101-254 | PK_KSR |
| cd07842 | 58-305 | STKc_CDK8_like |
| cd05038 | 59-245 | PTKc_Jak_rpt2 |
| pfam00659 | 515-584 | POLO_box |
| cd05034 | 59-295 | PTKc_Src_like |
| cd14024 | 106-300 | PK_TRB3 |
| cd14149 | 92-251 | STKc_C-Raf |
| cd07873 | 101-307 | STKc_PCTAIRE1 |
| cd14031 | 59-305 | STKc_WNK3 |
| cd05080 | 59-300 | PTKc_Tyk2_rpt2 |
| cd05056 | 92-299 | PTKc_FAK |
| cd06621 | 62-254 | PKc_Pek1_like |
| cd06617 | 59-306 | PKc_MKK3_6 |
| cd14664 | 59-300 | STK_BAK1_like |
| cd14101 | 58-302 | STKc_PIM2 |
| cd05607 | 59-252 | STKc_GRK7 |
| cd14158 | 59-300 | STKc_IRAK4 |
| cd07859 | 101-305 | STKc_TDY_MAPK |
| cd07865 | 59-305 | STKc_CDK9 |
| cd07864 | 59-304 | STKc_CDK12 |
| cd14027 | 59-309 | STKc_RIP1 |
| cd14065 | 59-300 | PKc_LIMK_like |
| cd07835 | 101-305 | STKc_CDK1_CdkB_like |
| cd05039 | 90-301 | PTKc_Csk_like |
| cd14061 | 159-300 | STKc_MLK |
| cd14033 | 59-305 | STKc_WNK4 |
| cd05072 | 101-307 | PTKc_Lyn |
| cd07871 | 101-258 | STKc_PCTAIRE3 |
| cd14146 | 59-300 | STKc_MLK4 |
| cd07860 | 101-305 | STKc_CDK2_3 |
| cd14060 | 78-300 | STKc_MLTK |
| cd07872 | 101-307 | STKc_PCTAIRE2 |
| cd14011 | 148-307 | PK_SCY1_like |
| cd14205 | 59-245 | PTKc_Jak2_rpt2 |
| cd05068 | 101-306 | PTKc_Frk_like |
| cd05082 | 101-299 | PTKc_Csk |
| cd06650 | 59-315 | PKc_MEK1 |
| cd14148 | 59-300 | STKc_MLK2 |
| cd14030 | 59-305 | STKc_WNK1 |
| cd06620 | 75-305 | PKc_Byr1_like |
| cd13988 | 59-251 | STKc_TBK1 |
| cd06622 | 59-307 | PKc_PBS2_like |
| cd14222 | 59-299 | STKc_LIMK2 |
| cd14154 | 59-259 | STKc_LIMK |
| cd14032 | 59-305 | STKc_WNK2_like |
| cd14210 | 58-305 | PKc_DYRK |
| cd14156 | 59-304 | PKc_LIMK_like_unk |
| cd07861 | 101-305 | STKc_CDK1_euk |
| cd14214 | 59-305 | PKc_CLK3 |
| cd06619 | 59-304 | PKc_MKK5 |
| cd14145 | 59-301 | STKc_MLK1 |
| cd07839 | 59-305 | STKc_CDK5 |
| cd05079 | 59-245 | PTKc_Jak1_rpt2 |
| cd05083 | 101-299 | PTKc_Chk |
| cd05040 | 71-238 | PTKc_Ack_like |
| cd14147 | 159-300 | STKc_MLK3 |
| cd07844 | 101-305 | STKc_PCTAIRE_like |
| cd14064 | 101-302 | PKc_TNNI3K |
| cd07863 | 157-305 | STKc_CDK4 |
| cd07850 | 120-312 | STKc_JNK |
| cd07848 | 59-251 | STKc_CDKL5 |
| cd05032 | 59-301 | PTKc_InsR_like |
| cd07870 | 101-263 | STKc_PFTAIRE2 |
| cd05053 | 59-302 | PTKc_FGFR |
| cd05103 | 145-300 | PTKc_VEGFR2 |
| cd05055 | 59-299 | PTKc_PDGFR |
| cd14112 | 71-304 | STKc_Unc-89_rpt2 |
| cd05059 | 101-300 | PTKc_Tec_like |
| cd05099 | 110-299 | PTKc_FGFR4 |
| cd05085 | 58-302 | PTKc_Fer |
| cd14026 | 58-295 | STKc_RIP2 |
| cd05098 | 110-302 | PTKc_FGFR1 |
| cd14102 | 59-301 | STKc_PIM3 |
| cd07876 | 89-312 | STKc_JNK2 |
| cd14207 | 91-300 | PTKc_VEGFR1 |
| cd05044 | 58-251 | PTKc_c-ros |
| cd05041 | 59-301 | PTKc_Fes_like |
| cd14221 | 59-299 | STKc_LIMK1 |
| cd05093 | 59-301 | PTKc_TrkB |
| cd14139 | 101-299 | PTKc_Wee1b |
| cd05114 | 101-300 | PTKc_Tec_Rlk |
| cd14051 | 96-302 | PTKc_Wee1 |
| cd05069 | 59-304 | PTKc_Yes |
| cd05061 | 59-301 | PTKc_InsR |
| cd14000 | 129-302 | STKc_LRRK |
| cd05092 | 59-299 | PTKc_TrkA |
| cd06649 | 59-258 | PKc_MEK2 |
| cd05084 | 59-302 | PTKc_Fes |
| cd14100 | 59-301 | STKc_PIM1 |
| cd05071 | 59-307 | PTKc_Src |
| cd05075 | 156-302 | PTKc_Axl |
| cd14203 | 101-299 | PTKc_Src_Fyn_like |
| cd05062 | 59-301 | PTKc_IGF-1R |
| cd14132 | 59-306 | STKc_CK2_alpha |
| cd14213 | 159-305 | PKc_CLK1_4 |
| cd05063 | 90-301 | PTKc_EphR_A2 |
| cd07837 | 59-305 | STKc_CdkB_plant |
| cd14068 | 58-301 | STKc_LRRK2 |
| cd14025 | 59-299 | STKc_RIP4_like |
| cd05101 | 110-302 | PTKc_FGFR2 |
| cd14012 | 101-304 | PK_eIF2AK_GCN2_rpt1 |
| cd08216 | 64-305 | PK_STRAD |
| cd05081 | 59-245 | PTKc_Jak3_rpt2 |
| cd14215 | 152-253 | PKc_CLK2 |
| cd07869 | 59-314 | STKc_PFTAIRE1 |
| cd14206 | 59-299 | PTKc_Aatyk3 |
| cd05576 | 66-293 | STKc_RPK118_like |
| cd07862 | 159-251 | STKc_CDK6 |
| cd05100 | 110-302 | PTKc_FGFR3 |
| cd05073 | 101-299 | PTKc_Hck |
| cd05070 | 59-307 | PTKc_Fyn |
| cd05066 | 94-301 | PTKc_EphR_A |
| cd14135 | 58-248 | STKc_PRP4 |
| cd07875 | 89-251 | STKc_JNK1 |
| cd14058 | 59-299 | STKc_TAK1 |
| cd13992 | 80-296 | PK_GC |
| cd14159 | 110-299 | STKc_IRAK1 |
| cd05112 | 96-300 | PTKc_Itk |
| cd05054 | 59-299 | PTKc_VEGFR |
| cd14001 | 82-301 | PKc_TOPK |
| cd05102 | 156-300 | PTKc_VEGFR3 |
| cd06618 | 75-307 | PKc_MKK7 |
| cd05067 | 82-307 | PTKc_Lck_Blk |
| cd14212 | 59-251 | PKc_YAK1 |
| cd13975 | 98-248 | PKc_Dusty |
| cd07874 | 89-314 | STKc_JNK3 |
| cd14138 | 101-300 | PTKc_Wee1a |
| cd06615 | 59-315 | PKc_MEK |
| cd05058 | 159-302 | PTKc_Met_Ron |
| cd05045 | 59-302 | PTKc_RET |
| cd05094 | 59-251 | PTKc_TrkC |
| cd05035 | 160-299 | PTKc_TAM |
| cd05043 | 94-300 | PTK_Ryk |
| cd05111 | 107-313 | PTK_HER3 |
| cd14155 | 59-241 | PKc_TESK |
| cd14136 | 59-247 | STKc_SRPK |
| cd14224 | 59-251 | PKc_DYRK2_3 |
| cd05060 | 92-299 | PTKc_Syk_like |
| cd14153 | 90-253 | PK_KSR2 |
| cd05052 | 101-299 | PTKc_Abl |
| cd05074 | 156-299 | PTKc_Tyro3 |
| cd05113 | 101-300 | PTKc_Btk_Bmx |
| cd14211 | 58-255 | STKc_HIPK |
| cd14229 | 58-249 | STKc_HIPK3 |
| cd05108 | 159-343 | PTKc_EGFR |
| cd05087 | 59-299 | PTKc_Aatyk1 |
| cd05047 | 110-300 | PTKc_Tie |
| cd14053 | 160-252 | STKc_ACVR2 |
| cd05109 | 159-313 | PTKc_HER2 |
| cd05046 | 59-301 | PTK_CCK4 |
| cd05057 | 101-313 | PTKc_EGFR_like |
| cd05089 | 110-299 | PTKc_Tie1 |
| cd14067 | 159-294 | STKc_LRRK1 |
| cd07867 | 59-305 | STKc_CDC2L6 |
| cd05116 | 92-294 | PTKc_Syk |
| cd05049 | 59-254 | PTKc_Trk |
| cd14018 | 153-297 | STKc_PINK1 |
| cd05065 | 93-301 | PTKc_EphR_B |
| cd14017 | 59-260 | STKc_TTBK |
| cd07868 | 59-305 | STKc_CDK8 |
| cd14204 | 156-299 | PTKc_Mer |
| cd14152 | 59-251 | STKc_KSR1 |
| cd05048 | 59-242 | PTKc_Ror |
| cd05042 | 59-251 | PTKc_Aatyk |
| cd13980 | 59-301 | STKc_Vps15 |
| cd13977 | 125-299 | STKc_PDIK1L |
| cd05090 | 159-299 | PTKc_Ror1 |
| cd05105 | 159-299 | PTKc_PDGFR_alpha |
| smart00220 | 58-305 | S_TKc |
| pfam00069 | 59-305 | Pkinase |
| COG0515 | 58-338 | SPS1 |
| PTZ00263 | 59-293 | PTZ00263 |
| smart00219 | 59-300 | TyrKc |
| pfam07714 | 59-302 | Pkinase_Tyr |
| smart00221 | 59-301 | STYKc |
| PTZ00426 | 59-293 | PTZ00426 |
| PTZ00024 | 58-320 | PTZ00024 |
| PTZ00267 | 82-305 | PTZ00267 |
| PTZ00283 | 143-301 | PTZ00283 |
| PHA03212 | 60-315 | PHA03212 |
| PTZ00266 | 59-254 | PTZ00266 |
| PLN00034 | 95-304 | PLN00034 |
| PHA03390 | 138-305 | pk1 |
| PHA03209 | 85-306 | PHA03209 |
| PTZ00036 | 59-326 | PTZ00036 |
| TIGR03903 | 93-293 | TOMM_kin_cyc |
| PLN00009 | 101-305 | PLN00009 |
| PHA03210 | 152-245 | PHA03210 |
| PHA03207 | 101-306 | PHA03207 |
| PRK13184 | 59-302 | pknD |
| PHA03211 | 141-242 | PHA03211 |
Ontology Information
| HPRD ID | 3570 |
|---|---|
| Molecular Class | Serine/threonine kinase |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.