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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| FXYD1 | 5348 | FXYD domain containing ion transport regulator 1 (phospholemman) | 19 | PLM |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22968445 | 2012 | Cell line : - Source : Department of Pathology of Wrocaw Medical University. Sample Type : - No. of Sample : - Stage : - | Laser capture microdissection,FFPE-FASP,SAX fractionation,LC-MSMS,Label-free quantitation. | Down-regulation | 0.32 | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The protein encoded by this gene is a plasma membrane substrate for several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity. Transcript variants with different 5' UTR sequences have been described in the literature. [provided by RefSeq, Jul 2008] |
| Chromosome | 19 |
| Location | 19q13.1 |
| Start | 35138789 |
| End | 35143055 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 4267 |
| OMIM ID | 602359 |
| HGNC ID | HGNC:4025 |
| Unigene ID | Hs.442498 |
| Ensembl ID | ENSG00000266964 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_011526594.1 |
|---|---|
| Exon | complement(579..663) | mRNA Sequence | Download Select all |
| Length | 558 |
CDS Information
| Location | join(1292..1352,1809..1841,2344..2418,2748..2784, 3684..3733,3932..3954) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS12445.1 |
Protein Information
| Protein ID | NP_001265646.1 |
|---|---|
| Protein Name | FXYD domain containing ion transport regulator 1 (phospholemman) |
| Molecular Wt. (Da) | 8384 |
| Protein Sequence | Download Select all |
| Length | 92 |
| Uniprot ID | P41279 |
| Ensembl Protein ID | ENSP00000263056 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 83 |
| S | Phosphorylation | 88 |
| S | Phosphorylation | 83 |
| S | Phosphorylation | 88 |
| A | Amidation | 44 |
| A | Amidation | 44 |
| S | Phosphorylation | 82 |
| S | Phosphorylation | 82 |
| T | Phosphorylation | 79 |
| T | Phosphorylation | 79 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 476 | ATP1A1 | 1662 | NP_000692.2 | in vivo | 14597563 |
| 481 | ATP1B1 | 1663 | NP_001668.1 | in vivo | 14597563 |
| 1760 | DMPK | 5645 | NP_001075032.1 | in vitro | 10811636 |
| 5566 | PRKACA | 3382 | NP_002721.1 | in vivo | 14597563 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| cAMP signaling pathway | hsa04024 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam02038 | 23-70 | ATP1G1_PLM_MAT8 |
| cl03413 | 23-70 | ATP1G1_PLM_MAT8 superfamily |
| COG1230 | Apr-55 | CzcD |
| cl00316 | Apr-55 | Cation_efflux superfamily |
Ontology Information
| HPRD ID | 4219 |
|---|---|
| Molecular Class | Ion channel |
| Molecular Function | Cell adhesion molecule activity (GO:0005194) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
No matching records could be found.