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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
PLSCR1 5359 phospholipid scramblase 1  3MMTRA1B 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
20927484   2011Cell line : -

Source : Department of Colorectal Surgery, Chang Gung Memorial Hospital, Taiwan

Sample Type : CRC tumor and normal tissue

No. of Sample : 104 pairs of colorectal carcinoma and noncancerous colorectal tissue

Stage : -

Immunohistochemistry, Western blottingUp-regulation-The plasma levels of PLSCR1 were significantly elevated in patients with early stage CRC compared with healthy individuals, suggesting that PLSCR1 might be used as a noninvasive serological diagnostic and prognostic biomarker for CRC.


Gene Details



Chromosome 3 - NC_000003.12 (146515178..146544841, complement)

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Gene Type protein coding
Gene Family
Description -  
Chromosome 3
Location 3q23
Start 146515178  
End 146544841  
Strand -  
Gene Sequence

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Length 29664  
OMIM ID 604170   
HGNC ID HGNC:9092   
Unigene ID Hs.130759   
Ensembl ID ENSG00000188313   
PharmGKB ID -   

mRNA Information


mRNA ID XM_011512905.1
Exon join(105..375,11292..11372,16011..16228,19195..19237, 22789..23009,23137..23298,27675..27836,28741..29664)  
mRNA Sequence

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Length 2228  



CDS Information


   
Location join(8290..8302,11292..11372,16011..16228,19195..19237, 22789..23009,23137..23298,27675..27836,28741..28797)
CDS Sequence

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CCDS ID CCDS3135.1



Protein Information


      
Protein IDNP_066928.1
Protein Namephospholipid scramblase 1
Molecular Wt. (Da)34918
Protein Sequence

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Length 318  
Uniprot IDP17509
Ensembl Protein ID ENSP00000225648  



Post-translational Modification Information (Source : HPRD)


Residue Type site
TPhosphorylation161
YPhosphorylation69
YPhosphorylation74

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1407CRY19050NP_004066.1yeast 2-hybrid16189514   
1956EGFR579NP_005219.2in vitro;in vivo1   200   989   512   871   930   
4967OGDH8938NP_002532.2yeast 2-hybrid16189514   
6464SHC12780NP_001123512.1in vivo12009895   
6590SLPI121NP_003055.1in vitro10869562   
7704ZBTB1611762NP_005997.2yeast 2-hybrid16189514   
9721GPRIN213804NP_055511.2yeast 2-hybrid16189514   
10539GLRX310153NP_006532.2yeast 2-hybrid16189514   
11067C10orf1012558NP_008952.1yeast 2-hybrid16189514   
25796PGLS12001NP_036220.1yeast 2-hybrid16189514   
25844YIPF39852NP_056203.2yeast 2-hybrid16189514   
27332ZNF63811736NP_055312.2yeast 2-hybrid16189514   
51545ZNF58115858NP_057619.1yeast 2-hybrid16189514   
51586MED1512117NP_001003891.1yeast 2-hybrid16189514   
51655RASD18958NP_057168.1yeast 2-hybrid16189514   
54507ADAMTSL418237NP_061905.2yeast 2-hybrid16189514   
54973CPSF3L13377NP_060341.2yeast 2-hybrid16189514   
56654NPDC112048NP_056207.3yeast 2-hybrid16189514   
59277NTN410121NP_067052.2yeast 2-hybrid16189514   
64115C10orf5415160AAH20568.1yeast 2-hybrid16189514   
64773FAM113A12786NP_073597.2yeast 2-hybrid16189514   
65989DLK216855NP_996262.1yeast 2-hybrid16189514   
79050NOC4L14543NP_076983.1yeast 2-hybrid16189514   
80125CCDC339959NP_079331.3yeast 2-hybrid16189514   
80726KIAA168313882NP_001138776.1yeast 2-hybrid16189514   
83640FAM103A112845NP_113640.1yeast 2-hybrid16189514   
83755KRTAP4-1213941NP_114060.1yeast 2-hybrid16189514   
84080C16orf4813151NP_115516.1yeast 2-hybrid16189514   
92070C4orf4214480NP_443093.2yeast 2-hybrid16189514   
92595ZNF76410072NP_219363.1yeast 2-hybrid16189514   
113878DTX216841NP_065943.2yeast 2-hybrid16189514   
115817DHRS19914NP_612461.1yeast 2-hybrid16189514   
129807NEU412249NP_542779.2yeast 2-hybrid16189514   
196477C12orf1214505NP_689851.1yeast 2-hybrid16189514   
414157C10orf6216581NP_001009997.1yeast 2-hybrid16189514   


Pathway Information


No matching records could be found.

Structure Information


PDB ID1Y2A
Resolution2.2
MethodX-RAY DIFFRACTION
Chains P  
Molecule decamer fragment of Phospholipid scramblase  
Model View



Domain Information




ID Location Description
pfam0380386-307  Scramblase
cl0204386-307  Tub_2 superfamily
pfam0854942-97  SWI-SNF_Ssr4
cl0945442-97  SWI-SNF_Ssr4 superfamily
pfam12273May-79  RCR
cl13679May-79  RCR superfamily
pfam1173721-61  DUF3300
cl1322321-61  DUF3300 superfamily
PHA0337822-97  PHA03378
pfam0977017-113  PAT1
pfam12868Dec-98  DUF3824
PHA03377Oct-91  PHA03377
pfam0977010-107  PAT1
PRK1026313-97  PRK10263
PHA0337822-97  PHA03378
PHA03369Jun-92  PHA03369
pfam0711716-82  DUF1373
PRK13729Feb-76  PRK13729
PRK1408622-103  dnaA
pfam07223Apr-92  DUF1421
PHA0324722-97  PHA03247
PHA0324713-97  PHA03247
pfam1524013-98  Pro-rich
pfam0977018-104  PAT1
pfam0741518-87  Herpes_LMP2


Ontology Information


   
HPRD ID812
Molecular ClassIntegral membrane protein
Molecular FunctionBinding (GO:0005488); Immunoglobulin binding (GO:0019865); Polysaccharide binding (GO:0030247); Protein binding (GO:0005515); Complement binding (GO:0001848); Metal ion binding (GO:0046872)
Biological ProcessApoptosis (GO:0006915)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO