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General Information
- Evidence
- Gene
- mRNA
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- Protein
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- Enzyme
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- Domain
- Ontology
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23819542 | 2013 | Cell line : - Source : South-Swedish Colorectal Cancer Biobank (STABB) Sample Type : - No. of Sample : - Stage : - | Immunohistochemistry | Up-regulation | - | Analysis of PODXL expression in the primary tumour is sufficient for its use as a prognostic and treatment predictive biomarker in CRC, also in patients with metastatic disease. |
| 22769594 | 2012 | Cell line : - Source : Skne University Hospital in Malm, Sweden, central district Hospital in Vsters, Sweden Sample Type : - No. of Sample : 270 CRC patients (cohort 1) and a prospective cohort of 337 CRC patients (cohort 2) Stage : - | Real time RT- PCR, tissue microarray, immunohistochemistry | Up-regulation | - | Underline the potential utility of PODXL as a biomarker for more precise prognostication and treatment stratification of CRC patients. High PODXL protein expression was significantly associated with unfavourable clinicopathological characteristics in both cohorts. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | |
| Description | This gene encodes a member of the sialomucin protein family. The encoded protein was originally identified as an important component of glomerular podocytes. Podocytes are highly differentiated epithelial cells with interdigitating foot processes covering the outer aspect of the glomerular basement membrane. Other biological activities of the encoded protein include: binding in a membrane protein complex with Na+/H+ exchanger regulatory factor to intracellular cytoskeletal elements, playing a role in hematopoetic cell differentiation, and being expressed in vascular endothelium cells and binding to L-selectin. |
| Chromosome | 7 |
| Location | 7q32-q33 |
| Start | 131500262 |
| End | 131556617 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 56356 |
| OMIM ID | 602632 |
| HGNC ID | HGNC:9171 |
| Unigene ID | Hs.744213 |
| Ensembl ID | ENSG00000128567 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_005397.3 |
|---|---|
| Exon | join(1..358,45185..45790,47033..47253,47590..47667, 49892..50039,50297..50358,50583..50750,52110..56356) | mRNA Sequence | Download Select all |
| Length | 6007 |
CDS Information
| Location | join(259..358,45185..45790,47033..47253,47590..47667, 49892..50039,50297..50358,50583..50750,52110..52307) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS47714.1 |
Protein Information
| Protein ID | NP_001018121.1 |
|---|---|
| Protein Name | podocalyxin-like |
| Molecular Wt. (Da) | 56360 |
| Protein Sequence | Download Select all |
| Length | 558 |
| Uniprot ID | P09629 |
| Ensembl Protein ID | ENSP00000239165 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 487 |
| S | Phosphorylation | 519 |
| S | Phosphorylation | 505 |
| S | Phosphorylation | 537 |
| S | Phosphorylation | 497 |
| S | Phosphorylation | 529 |
| T | Phosphorylation | 267 |
| T | Phosphorylation | 299 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam06365 | 358-558 | CD34_antigen |
| cl05715 | 358-558 | CD34_antigen superfamily |
| pfam05109 | 27-354 | Herpes_BLLF1 |
| pfam05109 | 46-334 | Herpes_BLLF1 |
| PHA03307 | 39-333 | PHA03307 |
| COG3889 | 186-324 | COG3889 |
Ontology Information
| HPRD ID | 770 |
|---|---|
| Molecular Class | Integral membrane protein |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.