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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| TREM1 | 54210 | triggering receptor expressed on myeloid cells 1 | 6 | TREM-1, CD354 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23810411 | 2013 | Cell line : - Source : Zhejiang Provincial Laboratories Sample Type : Mouse model C57BL/6 No. of Sample : - Stage : - | real time RT-PCR, ELISA | Up-regulation | - | TREM-1 plays critical roles in colon inflammation and tumor and targeting TREM-1 may represent a novel therapeutic strategy for colon inflammation and associated cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | CD molecules, "Immunoglobulin superfamily / V-set domain containing" |
| Description | This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011] |
| Chromosome | 6 |
| Location | 6p21.1 |
| Start | 41242999 |
| End | 41254457 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 11459 |
| OMIM ID | 605085 |
| HGNC ID | HGNC:17760 |
| Unigene ID | Hs.283022 |
| Ensembl ID | ENSG00000124731 |
| PharmGKB ID | PA38467 |
Protein Information
| Protein ID | NP_001229518.1 |
|---|---|
| Protein Name | triggering receptor expressed on myeloid cells 1 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 234 |
| Uniprot ID | Q9ULD2 |
| Ensembl Protein ID | ENSP00000262102 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 7305 | TYROBP | 4996 | NP_003323.1 | in vivo | 10799849 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd05716 | 33-118 | Ig_pIgR |
| cl11960 | 33-118 | Ig superfamily |
| pfam07686 | 97-133 | V-set |
Ontology Information
| HPRD ID | 17086 |
|---|---|
| Molecular Class | Cell surface receptor |
| Molecular Function | Ubiquitin-specific protease activity (GO:0004843) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.