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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19330779 | 2009 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Microarray | Up-regulation | - | The data indicate POLB is overexpressed in CRC cases with high malignant potential |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | DNA polymerases |
| Description | The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one has been described to date. [provided by RefSeq, Sep 2011] |
| Chromosome | 8 |
| Location | 8p12-p11 |
| Start | 42195973 |
| End | 42229331 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 33359 |
| OMIM ID | 174760 |
| HGNC ID | HGNC:9174 |
| Unigene ID | Hs.654484 |
| Ensembl ID | ENSG00000070501 |
| PharmGKB ID | PA276 |
mRNA Information
| mRNA ID | ?NM_002690.2 |
|---|---|
| Exon | join(1..231,558..615,6499..6565,10562..10636,11553..11611, 14065..14114,17062..17113,18715..18769,18866..18938, 22841..22911,24158..24244,30817..30881,31395..31534, 33109..33359) | mRNA Sequence | Download Select all |
| Length | 1351 |
Protein Information
| Protein ID | NP_002681.1 |
|---|---|
| Protein Name | polymerase (DNA directed), beta |
| Molecular Wt. (Da) | 261388 |
| Protein Sequence | Download Select all |
| Length | 335 |
| Uniprot ID | P51854 |
| Ensembl Protein ID | ENSP00000358928 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 44 |
| S | Phosphorylation | 55 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 328 | APEX1 | 136 | NP_542380.1 | in vitro | 9207062 |
| 5111 | PCNA | 1456 | NP_002583.1 | in vivo;yeast 2-hybrid | 12063248 |
| 5578 | PRKCA | 1498 | NP_002728.1 | in vitro | 2040602 |
| 7088 | TLE1 | 2557 | NP_005068.2 | yeast 2-hybrid | 16169070 |
| 7515 | XRCC1 | 1909 | NP_006288.2 | in vitro;in vivo;yeast 2-hybrid | 897 869 211 467 963 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Base excision repair | hsa03410 |
| HTLV-I infection | hsa05166 |
| Viral carcinogenesis | hsa05203 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00141 | 15-333 | NT_POLXc |
| cl11966 | 15-333 | NT_Pol-beta-like superfamily |
| pfam14792 | 149-262 | DNA_pol_B_palm |
| pfam14791 | 268-333 | DNA_pol_B_thumb |
| cl20004 | 268-333 | DNA_pol_B_thumb superfamily |
| pfam10391 | 97-148 | DNA_pol_lambd_f |
| cl22429 | 97-148 | ENDO3c superfamily |
| pfam14716 | 15-78 | HHH_8 |
| cl20003 | 15-78 | HHH_8 superfamily |
| cd05397 | 156-196 | NT_Pol-beta-like |
| pfam14520 | 97-141 | HHH_5 |
| smart00483 | 10-334 | POLXc |
| COG1796 | 35-333 | PolX |
| PRK08609 | 35-335 | PRK08609 |
Ontology Information
| HPRD ID | 4310 |
|---|---|
| Molecular Class | DNA polymerase |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P06746 | DB00987 | Cytarabine | SmallMoleculeDrug |