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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| POLR2F | 5435 | polymerase (RNA) II (DNA directed) polypeptide F | 22 | RPB6, HRBP14.4 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 18505059 | 2008 | Cell line : - Source : University Hospital of Patras, Greece, Sample Type : CRC tumor and normal tissues No. of Sample : 70 CRC and 17 normal tissue Stage : - | real time RT-PCR | Up-regulation | - | POLR2F and PRNP exhibited elevated levels in carcinomas compared to normal tissue samples suggesting a possible role for these molecules in colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | RNA polymerase subunits |
| Description | This gene encodes the sixth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, this polymerase subunit, in combination with at least two other subunits, forms a structure that stabilizes the transcribing polymerase on the DNA template. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] |
| Chromosome | 22 |
| Location | 22q13.1 |
| Start | 38349674 |
| End | 38368463 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 18790 |
| OMIM ID | 604414 |
| HGNC ID | HGNC:9193 |
| Unigene ID | Hs.436578 |
| Ensembl ID | ENSG00000100142 |
| PharmGKB ID | PA33513 |
mRNA Information
| mRNA ID | ?NM_021974.4 |
|---|---|
| Exon | join(1..340,22088..22240,22352..22445,22588..22635, 24934..25018,25124..25207,25440..25474,25685..25757, 25860..25961,26197..26315,26403..26488,26563..26683, 27415..27583,27727..27849,27932..28033,28121..28308, 28676..28876,28958..29077,29161..29341,30334..30411, 31249..31352,31561..31657,31939..32008,32594..32751, 34675..34771,34903..35127,35211..35359,35902..36295, 36405..36493,36606..36793,36949..38203) | mRNA Sequence | Download Select all |
| Length | 5328 |
Protein Information
| Protein ID | NP_068809.1 |
|---|---|
| Protein Name | polymerase (RNA) II (DNA directed) polypeptide F |
| Molecular Wt. (Da) | 7514 |
| Protein Sequence | Download Select all |
| Length | 127 |
| Uniprot ID | Q9Y4A5 |
| Ensembl Protein ID | ENSP00000347733 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 2 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 5432 | POLR2C | 15945 | NP_116558.1 | in vitro | 9201987 |
| 5434 | POLR2E | 15946 | NP_002686.2 | in vitro | 9201987 |
| 5436 | POLR2G | 15995 | NP_002687.1 | in vitro | 9201987 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cytosolic DNA-sensing pathway | hsa04623 |
| Epstein-Barr virus infection | hsa05169 |
| Huntington's disease | hsa05016 |
| Metabolic pathways | hsa01100 |
| Purine metabolism | hsa00230 |
| Pyrimidine metabolism | hsa00240 |
| RNA polymerase | hsa03020 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| PLN00152 | 26-127 | PLN00152 |
| cl14651 | 26-127 | RNA_pol_Rpb6 superfamily |
| PRK01099 | 52-112 | rpoK |
| pfam01192 | 50-106 | RNA_pol_Rpb6 |
| COG1758 | 50-116 | RpoZ |
Ontology Information
| HPRD ID | 4935 |
|---|---|
| Molecular Class | RNA polymerase |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Biological_process unknown (GO:0000004) |
Drug Information
No matching records could be found.