Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| UGT2B28 | 54490 | UDP glucuronosyltransferase 2 family, polypeptide B28 | 4 | - |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23575887 | 2013 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 665 CRC cases and 621 Caucasian controls Stage : - | Genotyping | Mutation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | UDP glucuronosyltransferases |
| Description | This gene encodes a member of the uridine diphosphoglucuronosyltransferase protein family. The encoded enzyme catalyzes the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a diverse array of substrates including steroid hormones and lipid-soluble drugs. This process, known as glucuronidation, is an intermediate step in the metabolism of steroids. Two transcript variants encoding different isoforms have been found for this gene. While both isoforms are targeted to the endoplasmic reticulum, only the longer isoform appears to be active. [provided by RefSeq, May 2011] |
| Chromosome | 4 |
| Location | 4q13.3 |
| Start | 70146217 |
| End | 70160768 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 14552 |
| OMIM ID | 606497 |
| HGNC ID | HGNC:13479 |
| Unigene ID | Hs.653154 |
| Ensembl ID | ENSG00000135226 |
| PharmGKB ID | PA37779 |
Protein Information
| Protein ID | NP_001193933.1 |
|---|---|
| Protein Name | UDP glucuronosyltransferase 2 family, polypeptide B28 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 529 |
| Uniprot ID | Q8IYU2 |
| Ensembl Protein ID | ENSP00000262903 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Ascorbate and aldarate metabolism | hsa00053 |
| Chemical carcinogenesis | hsa05204 |
| Drug metabolism - cytochrome P450 | hsa00982 |
| Drug metabolism - other enzymes | hsa00983 |
| Metabolic pathways | hsa01100 |
| Metabolism of xenobiotics by cytochrome P450 | hsa00980 |
| Pentose and glucuronate interconversions | hsa00040 |
| Porphyrin and chlorophyll metabolism | hsa00860 |
| Retinol metabolism | hsa00830 |
| Starch and sucrose metabolism | hsa00500 |
| Steroid hormone biosynthesis | hsa00140 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd03784 | 26-441 | GT1_Gtf_like |
| cl10013 | 26-441 | Glycosyltransferase_GTB_type superfamily |
| PLN00164 | 304-416 | PLN00164 |
| PLN02448 | 301-402 | PLN02448 |
| PLN02554 | 356-406 | PLN02554 |
| PLN02167 | 260-417 | PLN02167 |
| PLN03004 | 295-445 | PLN03004 |
| PLN02207 | 272-441 | PLN02207 |
| PLN02534 | 356-399 | PLN02534 |
| PLN03007 | 291-399 | PLN03007 |
| pfam00201 | 24-525 | UDPGT |
| PHA03392 | 269-506 | egt |
| COG1819 | 31-445 | YjiC |
| TIGR01426 | 42-445 | MGT |
| PLN02410 | 26-407 | PLN02410 |
| PLN02173 | 301-407 | PLN02173 |
| TIGR04516 | 344-445 | glycosyl_450act |
| PLN02992 | 277-416 | PLN02992 |
| PLN02210 | 294-400 | PLN02210 |
| PLN02555 | 266-406 | PLN02555 |
| PLN03015 | 289-414 | PLN03015 |
| PLN02562 | 256-445 | PLN02562 |
| PLN02863 | 356-399 | PLN02863 |
| COG0707 | 372-447 | MurG |
| PLN02152 | 269-402 | PLN02152 |
Ontology Information
| HPRD ID | 11146 |
|---|---|
| Molecular Class | Enzyme: Glycosyltransferase |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.