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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21193546 | 2010 | Cell line : - Source : Cooperative Human Tissue Network, funded by the National Cancer Institute. Sample Type : - No. of Sample : - Stage : - | real time RT-PCR, Immunohistochemistry, Flow cytometry , ELISA, and immunofluorescence assay | Unknown | - | DLL4 inhibition in colon tumor cells reduces tumor growth and stem cell frequency. Findings provide a rationale for targeting CSCs and tumor vasculature through inhibiting DLL4 as a new therapeutic approach in the treatment of CRC. In contrast to anti-EGFR, anti-DLL4 was equally efficacious in both KRASWT and KRASMT tumors. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. [provided by RefSeq, Jul 2008] |
| Chromosome | 15 |
| Location | 15q14 |
| Start | 40929333 |
| End | 40939060 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 9728 |
| OMIM ID | 605185 |
| HGNC ID | HGNC:2910 |
| Unigene ID | Hs.511076 |
| Ensembl ID | ENSG00000128917 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_019074.3 |
|---|---|
| Exon | join(1..402,515..784,1293..1350,2171..2434,2839..2899, 2985..3115,5216..5385,5566..5785,6896..7598,8086..8194, 8697..9728) | mRNA Sequence | Download Select all |
| Length | 3420 |
CDS Information
| Location | join(337..402,515..784,1293..1350,2171..2434,2839..2899, 2985..3115,5216..5385,5566..5785,6896..7598,8086..8194, 8697..8702) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS45232.1 |
Protein Information
| Protein ID | NP_061947.1 |
|---|---|
| Protein Name | Delta-like 4 (Drosophila) |
| Molecular Wt. (Da) | 71925 |
| Protein Sequence | Download Select all |
| Length | 685 |
| Uniprot ID | P55075 |
| Ensembl Protein ID | ENSP00000321797 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 4851 | NOTCH1 | 1827 | NP_060087.3 | in vivo | 1 083 702 411 739 180 |
| 4855 | NOTCH4 | 1290 | NP_004548.3 | in vitro;in vivo | 12814948 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Notch signaling pathway | hsa04330 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00054 | 327-360 | EGF_CA |
| cl21504 | 327-360 | EGF_CA superfamily |
| cd00054 | 284-322 | EGF_CA |
| cl21504 | 284-322 | EGF_CA superfamily |
| cd00054 | 447-476 | EGF_CA |
| cl21504 | 447-476 | EGF_CA superfamily |
| cd00054 | 403-438 | EGF_CA |
| cl21504 | 403-438 | EGF_CA superfamily |
| pfam07657 | 26-91 | MNNL |
| cl06622 | 26-91 | MNNL superfamily |
| pfam01414 | 155-217 | DSL |
| cl19567 | 155-217 | DSL superfamily |
| smart00051 | 155-217 | DSL |
| smart00179 | 327-360 | EGF_CA |
| smart00179 | 284-322 | EGF_CA |
| smart00179 | 447-476 | EGF_CA |
| cd00053 | 327-360 | EGF |
| smart00179 | 403-438 | EGF_CA |
| cd00053 | 407-438 | EGF |
| cd00053 | 288-318 | EGF |
Ontology Information
| HPRD ID | 634 |
|---|---|
| Molecular Class | Ligand |
| Molecular Function | Transmembrane receptor protein tyrosine kinase activity (GO:0004714) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.