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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
UGT1A6 54578 UDP glucuronosyltransferase 1 family, polypeptide A6  2HLUGP, GNT1, UGT1F 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22901212   2012Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : 69 CRC and 112 controls

Stage : -

PCR-RFLPPolymorhpism-UGT1A6 polymorphisms may strongly increase CRC risk through the formation of carcinogens not associated with smoking.


Gene Details



NC_000002.11 (234600321..234681951)

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Gene Type protein coding
Gene Family UDP glucuronosyltransferases
Description This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenolic and planar compounds. Alternative splicing in the unique 5' end of this gene results in two transcript variants. [provided by RefSeq, Jul 2008]  
Chromosome 2
Location 2q37
Start 234600321  
End 234681951  
Strand +  
Gene Sequence

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Length 81631  
OMIM ID 606431   
HGNC ID HGNC:12538   
Unigene ID Hs.554822   
Ensembl ID ENSG00000167165   
PharmGKB ID PA37181   

mRNA Information


mRNA ID ?NM_001072.3
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS2507.1



Protein Information


      
Protein IDNP_001063.2
Protein NameUDP glucuronosyltransferase 1 family, polypeptide A6
Molecular Wt. (Da)0
Protein Sequence

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Length 532  
Uniprot IDQ8IYD8
Ensembl Protein ID ENSP00000267430  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


                                                                  
Pathway Name Pathway ID
Ascorbate and aldarate metabolism hsa00053
Chemical carcinogenesis hsa05204
Drug metabolism - cytochrome P450 hsa00982
Drug metabolism - other enzymes hsa00983
Metabolic pathways hsa01100
Metabolism of xenobiotics by cytochrome P450 hsa00980
Pentose and glucuronate interconversions hsa00040
Porphyrin and chlorophyll metabolism hsa00860
Retinol metabolism hsa00830
Starch and sucrose metabolism hsa00500
Steroid hormone biosynthesis hsa00140


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0378449-443  GT1_Gtf_like
cl1001349-443  Glycosyltransferase_GTB_type superfamily
PLN03004269-444  PLN03004
PLN00164352-400  PLN00164
PLN02534349-414  PLN02534
PLN02448141-401  PLN02448
PLN02167263-403  PLN02167
PLN02554350-443  PLN02554
PLN02207240-403  PLN02207
pfam04101369-439  Glyco_tran_28_C
PLN03007301-445  PLN03007
PLN02764353-441  PLN02764
PLN02670349-410  PLN02670
cd03785369-450  GT1_MurG
pfam0020127-523  UDPGT
PHA0339215-506  egt
COG181945-442  YjiC
TIGR0142645-442  MGT
PLN02152266-434  PLN02152
PLN02410292-404  PLN02410
PLN02210292-429  PLN02210
PLN02173266-445  PLN02173
PLN02555350-441  PLN02555
PLN03015225-420  PLN03015
PLN02992353-400  PLN02992
TIGR04516347-442  glycosyl_450act
PLN02562301-442  PLN02562
PLN02863349-400  PLN02863
COG0707362-444  MurG
PLN02208353-434  PLN02208
PLN00414300-464  PLN00414
PRK00726369-441  murG
TIGR01133369-439  murG
TIGR00661321-422  MJ1255


Ontology Information


   
HPRD ID9836
Molecular ClassEnzyme: Glycosyltransferase
Molecular FunctionProtein serine/threonine kinase activity (GO:0004674)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P19224DB00313Valproic AcidSmallMoleculeDrug
P19224DB00316AcetaminophenSmallMoleculeDrug
P19224DB00688Mycophenolate mofetilSmallMoleculeDrug
P19224DB00818PropofolSmallMoleculeDrug
P19224DB01024Mycophenolic acidSmallMoleculeDrug
P19224DB08826DeferiproneSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO