Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| POU5F1 | 5460 | POU class 5 homeobox 1 | 6 | OCT3, Oct4, MGC22487 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22528324 | 2012 | Cell line : - Source : ATCC Sample Type : - No. of Sample : - Stage : - | Gene/Polymorphism Selection and Genotyping | Polymorhpism | - | rs879882, a variant in the 5' region of POU5F1 gene which encodes a protein essential for embryonic stem cell self-renewal and pluripotency, and induced pluripotent stem cell reprogramming. |
| 23076549 | 2013 | Cell line : - Source : Xijing Hospital and the Tangdu Hospital affiliated to the Fourth Military Medical University (FMMU) in Xi'an, China. Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : - | Real time RT-PCR, Western blotting, immunohistochemistry | Up-regulation | - | OCT4 may contribute to CRC cell metastasis through EMT and serves as a promising biomarker for identifying CRC patients at high risk for liver metastases. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Homeoboxes / POU class |
| Description | This gene encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with tumorigenesis. This gene can participate in a translocation with the Ewing's sarcoma gene on chromosome 21, which also leads to tumor formation. Alternative splicing, as well as usage of alternative AUG and non-AUG translation initiation codons, results in multiple isoforms. One of the AUG start codons is polymorphic in human populations. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12. |
| Chromosome | 6 |
| Location | 6p21.33 |
| Start | 31164337 |
| End | 31170693 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 6357 |
| OMIM ID | 164177 |
| HGNC ID | HGNC:9221 |
| Unigene ID | Hs.249184 |
| Ensembl ID | ENSG00000204531 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_002701.5 |
|---|---|
| Exon | join(1..478,4647..4767,4993..5123,5408..5566,5827..6357) | mRNA Sequence | Download Select all |
| Length | 1589 |
CDS Information
| Location | join(74..478,4647..4767,4993..5123,5408..5566,5827..6093) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS34391.1 |
Protein Information
| Protein ID | NP_002692.2 |
|---|---|
| Protein Name | POU class 5 homeobox 1 |
| Molecular Wt. (Da) | 38440 |
| Protein Sequence | Download Select all |
| Length | 360 |
| Uniprot ID | P00738 |
| Ensembl Protein ID | ENSP00000348170 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 367 | AR | 2437 | NP_000035.2 | in vitro;in vivo | 11096094 |
| 2114 | ETS2 | 1263 | NP_005230.1 | in vitro;in vivo | 11689681 |
| 2130 | EWSR1 | 592 | NP_053733.2 | in vitro;in vivo;yeast 2-hybrid | 15917470 |
| 3146 | HMGB1 | 1228 | NP_002119.1 | in vitro;in vivo | 11099378 |
| 3148 | HMGB2 | 1229 | NP_002120.1 | in vitro;in vivo | 11099378 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Signaling pathways regulating pluripotency of stem cells | hsa04550 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00086 | 231-289 | homeodomain |
| cl00084 | 231-289 | homeodomain superfamily |
| smart00352 | 138-212 | POU |
| cl22952 | 138-212 | Pou superfamily |
| pfam00157 | 138-212 | Pou |
| pfam00046 | 231-287 | Homeobox |
| smart00389 | 230-286 | HOX |
| COG5576 | 208-290 | COG5576 |
Ontology Information
| HPRD ID | 7042 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Catalytic activity (GO:0003824) |
| Biological Process | Metabolism (GO:0008152) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| Q01860 | DB00368 | Norepinephrine | SmallMoleculeDrug |
| Q01860 | DB00988 | Dopamine | SmallMoleculeDrug |