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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
UGT1A9 54600 UDP glucuronosyltransferase 1 family, polypeptide A9  2HLUGP4, LUGP4, UGT1AI 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
15709193   2005Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : 67

Stage : -

 Pyrosequencing, GeneScan, and direct sequencingPolymorhpism- UGT1A7 and/or UGT1A9 genotypes may be predictors of response and toxicity in CRC patients treated with capecitabine plus irinotecan.


Gene Details



NC_000002.11 (234580544..234681951)

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Gene Type protein coding
Gene Family UDP glucuronosyltransferases
Description This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenols. [provided by RefSeq, Jul 2008]  
Chromosome 2
Location 2q37
Start 234580544  
End 234681951  
Strand +  
Gene Sequence

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Length 101408  
OMIM ID 606434   
HGNC ID HGNC:12541   
Unigene ID Hs.554822   
Ensembl ID ENSG00000241119   
PharmGKB ID PA419   

mRNA Information


mRNA ID ?NM_021027.2
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS2505.1



Protein Information


      
Protein IDNP_066307.1
Protein NameUDP glucuronosyltransferase 1 family, polypeptide A9
Molecular Wt. (Da)0
Protein Sequence

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Length 530  
Uniprot IDQ9NQ36
Ensembl Protein ID ENSP00000310658  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


                                                                  
Pathway Name Pathway ID
Ascorbate and aldarate metabolism hsa00053
Chemical carcinogenesis hsa05204
Drug metabolism - cytochrome P450 hsa00982
Drug metabolism - other enzymes hsa00983
Metabolic pathways hsa01100
Metabolism of xenobiotics by cytochrome P450 hsa00980
Pentose and glucuronate interconversions hsa00040
Porphyrin and chlorophyll metabolism hsa00860
Retinol metabolism hsa00830
Starch and sucrose metabolism hsa00500
Steroid hormone biosynthesis hsa00140


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0378428-441  GT1_Gtf_like
cl1001328-441  Glycosyltransferase_GTB_type superfamily
PLN00164350-398  PLN00164
PLN02534347-412  PLN02534
PLN03004290-442  PLN03004
PLN02167260-401  PLN02167
PLN02448221-399  PLN02448
PLN02554348-441  PLN02554
PLN02207267-401  PLN02207
pfam04101367-437  Glyco_tran_28_C
PLN03007299-443  PLN03007
PLN02764351-439  PLN02764
PLN02670347-408  PLN02670
cd03785367-448  GT1_MurG
pfam0020126-521  UDPGT
PHA03392258-504  egt
COG181928-440  YjiC
TIGR0142631-440  MGT
PLN02410290-402  PLN02410
PLN02152253-432  PLN02152
PLN02173147-443  PLN02173
PLN03015264-418  PLN03015
PLN02210290-427  PLN02210
PLN02555348-439  PLN02555
PLN02992351-398  PLN02992
TIGR04516345-440  glycosyl_450act
PLN02562299-440  PLN02562
PLN02863347-398  PLN02863
COG0707360-442  MurG
PLN02208351-432  PLN02208
PLN00414298-462  PLN00414
PRK00726367-439  murG
TIGR01133367-437  murG
TIGR00661319-420  MJ1255


Ontology Information


   
HPRD ID16103
Molecular ClassEnzyme: Glycosyltransferase
Molecular FunctionCell adhesion molecule activity (GO:0005194)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
O60656DB00062Human Serum AlbuminBiotechDrug
O60656DB00313Valproic AcidSmallMoleculeDrug
O60656DB00316AcetaminophenSmallMoleculeDrug
O60656DB00327HydromorphoneSmallMoleculeDrug
O60656DB00328IndomethacinSmallMoleculeDrug
O60656DB00398SorafenibSmallMoleculeDrug
O60656DB00494EntacaponeSmallMoleculeDrug
O60656DB00502HaloperidolSmallMoleculeDrug
O60656DB00688Mycophenolate mofetilSmallMoleculeDrug
O60656DB00712FlurbiprofenSmallMoleculeDrug
O60656DB00731NateglinideSmallMoleculeDrug
O60656DB00744ZileutonSmallMoleculeDrug
O60656DB00749EtodolacSmallMoleculeDrug
O60656DB00762IrinotecanSmallMoleculeDrug
O60656DB00818PropofolSmallMoleculeDrug
O60656DB00842OxazepamSmallMoleculeDrug
O60656DB00921BuprenorphineSmallMoleculeDrug
O60656DB01015SulfamethoxazoleSmallMoleculeDrug
O60656DB01024Mycophenolic acidSmallMoleculeDrug
O60656DB01050IbuprofenSmallMoleculeDrug
O60656DB01283LumiracoxibSmallMoleculeDrug
O60656DB04953EzogabineSmallMoleculeDrug
O60656DB06204TapentadolSmallMoleculeDrug
O60656DB06292DapagliflozinSmallMoleculeDrug
O60656DB06403AmbrisentanSmallMoleculeDrug
O60656DB06695Dabigatran etexilateSmallMoleculeDrug
O60656DB06738KetobemidoneSmallMoleculeDrug
O60656DB08896RegorafenibSmallMoleculeDrug
O60656DB08907CanagliflozinSmallMoleculeDrug
O60656DB04552Niflumic AcidSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO