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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PPARA | 5465 | Peroxisome proliferator-activated receptor alpha | 22 | PPAR; NR1C1; hPPAR; PPARalpha |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22991505 | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Down-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Nuclear hormone receptors |
| Description | Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. [provided by RefSeq, Jul 2008] |
| Chromosome | 22 |
| Location | 22q13.31 |
| Start | 46150547 |
| End | 46243756 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 93210 |
| OMIM ID | 170998 |
| HGNC ID | HGNC:9232 |
| Unigene ID | Hs.103110 |
| Ensembl ID | ENSG00000186951 |
| PharmGKB ID | PA280 |
mRNA Information
| mRNA ID | XM_011530244.1 |
|---|---|
| Exon | join(1..106,1342..1424,26207..26290,38177..38276, 47796..48045,64627..64787,67717..67859,69266..69468, 81246..81693,84587..93210) | mRNA Sequence | Download Select all |
| Length | 10049 |
CDS Information
| Location | join(47838..48045,64627..64787,67717..67855,69266..69468, 81246..81693,84587..84834) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS33669.1 |
Protein Information
| Protein ID | NP_001001928.1 |
|---|---|
| Protein Name | Peroxisome proliferator-activated receptor alpha |
| Molecular Wt. (Da) | 52094 |
| Protein Sequence | Download Select all |
| Length | 468 |
| Uniprot ID | O15551 |
| Ensembl Protein ID | ENSP00000378577 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 21 |
| S | Phosphorylation | 12 |
| S | Phosphorylation | 21 |
| S | Phosphorylation | 12 |
| S | Phosphorylation | 21 |
| S | Phosphorylation | 12 |
| S | Phosphorylation | 21 |
| S | Phosphorylation | 12 |
| S | Phosphorylation | 21 |
| S | Phosphorylation | 21 |
| S | Phosphorylation | 12 |
| S | Phosphorylation | 21 |
| S | Phosphorylation | 12 |
| S | Phosphorylation | 21 |
| S | Phosphorylation | 12 |
| S | Phosphorylation | 21 |
| S | Phosphorylation | 12 |
| S | Phosphorylation | 21 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1647 | GADD45A | 528 | NP_001915.1 | in vitro | 10872826 |
| 2168 | FABP1 | 612 | NP_001434.1 | in vitro;in vivo;yeast 2-hybrid | 11226238 |
| 3320 | HSP90AA1 | 777 | NP_001017963.2 | in vitro;in vivo | 12482853 |
| 5578 | PRKCA | 1498 | NP_002728.1 | in vitro | 16042408 |
| 5580 | PRKCD | 1501 | NP_006245.2 | in vitro | 16042408 |
| 5970 | RELA | 1241 | NP_068810.3 | in vitro | 10542237 |
| 6258 | RXRG | 1579 | NP_008848.1 | yeast 2-hybrid | 16169070 |
| 246329 | STAC3 | 11606 | NP_659501.1 | yeast 2-hybrid | 16189514 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Adipocytokine signaling pathway | hsa04920 |
| cAMP signaling pathway | hsa04024 |
| Glucagon signaling pathway | hsa04922 |
| Hepatitis C | hsa05160 |
| Insulin resistance | hsa04931 |
| Non-alcoholic fatty liver disease (NAFLD) | hsa04932 |
| PPAR signaling pathway | hsa03320 |
Structure Information
| PDB ID | 1IGR |
|---|---|
| Resolution | 2.6 |
| Method | X-RAY DIFFRACTION |
| Chains | A |
| Molecule | INSULIN-LIKE GROWTH FACTOR RECEPTOR 1 |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd06932 | 201-467 | NR_LBD_PPAR |
| cl11397 | 201-467 | NR_LBD superfamily |
| cd06965 | 101-184 | NR_DBD_Ppar |
| cl02596 | 101-184 | NR_DBD_like superfamily |
| cd06929 | 274-444 | NR_LBD_F1 |
| cd07166 | 98-183 | NR_DBD_REV_ERB |
| cd06916 | 102-172 | NR_DBD_like |
| cd07158 | 102-172 | NR_DBD_Ppar_like |
| pfam00105 | 100-168 | zf-C4 |
| cd06940 | 284-442 | NR_LBD_REV_ERB |
| cd07165 | 102-181 | NR_DBD_DmE78_like |
| smart00399 | 102-166 | ZnF_C4 |
| cd06968 | 100-188 | NR_DBD_ROR |
| cd06961 | 101-177 | NR_DBD_TR |
| cd07167 | 102-176 | NR_DBD_Lrh-1_like |
| cd06954 | 264-464 | NR_LBD_LXR |
| cd06157 | 274-436 | NR_LBD |
| cd06960 | 102-175 | NR_DBD_HNF4A |
| cd07168 | 102-177 | NR_DBD_DHR4_like |
| cd07169 | 102-177 | NR_DBD_GCNF_like |
| cd06939 | 264-468 | NR_LBD_ROR_like |
| cd06964 | 102-175 | NR_DBD_RAR |
| cd06937 | 280-463 | NR_LBD_RAR |
| cd06956 | 102-172 | NR_DBD_RXR |
| cd06967 | 102-177 | NR_DBD_TR2_like |
| cd07164 | 102-178 | NR_DBD_PNR_like_1 |
| cd06969 | 102-172 | NR_DBD_NGFI-B |
| cd06941 | 282-464 | NR_LBD_DmE78_like |
| cd06970 | 102-179 | NR_DBD_PNR |
| cd07163 | 98-181 | NR_DBD_TLX |
| cd07154 | 102-172 | NR_DBD_PNR_like |
| cd06958 | 102-172 | NR_DBD_COUP_TF |
| cd07179 | 102-174 | 2DBD_NR_DBD2 |
| cd07156 | 102-166 | NR_DBD_VDR_like |
| cd07155 | 102-175 | NR_DBD_ER_like |
| smart00430 | 287-436 | HOLI |
| cd07171 | 102-175 | NR_DBD_ER |
| cd07161 | 102-166 | NR_DBD_EcR |
| cd07170 | 102-188 | NR_DBD_ERR |
| cd06935 | 284-463 | NR_LBD_TR |
| cd07162 | 102-171 | NR_DBD_PXR |
| cd06957 | 102-181 | NR_DBD_PNR_like_2 |
| pfam00104 | 289-448 | Hormone_recep |
| cd06959 | 102-166 | NR_DBD_EcR_like |
| cd06936 | 280-462 | NR_LBD_Fxr |
| cd06955 | 102-166 | NR_DBD_VDR |
| cd07160 | 102-166 | NR_DBD_LXR |
| cd06962 | 102-166 | NR_DBD_FXR |
| cd06933 | 283-466 | NR_LBD_VDR |
| cd06934 | 290-463 | NR_LBD_PXR_like |
| cd07157 | 102-175 | 2DBD_NR_DBD1 |
| cd06966 | 102-166 | NR_DBD_CAR |
| cd06938 | 266-464 | NR_LBD_EcR |
| cd06942 | 289-459 | NR_LBD_Sex_1_like |
| cd06943 | 250-434 | NR_LBD_RXR_like |
| cd06963 | 102-173 | NR_DBD_GR_like |
| cd07173 | 102-167 | NR_DBD_AR |
| cd07172 | 102-166 | NR_DBD_GR_PR |
| cd06930 | 289-436 | NR_LBD_F2 |
| cd06952 | 291-436 | NR_LBD_TR2_like |
| cd06945 | 269-466 | NR_LBD_Nurr1_like |
| cd07072 | 269-448 | NR_LBD_DHR38_like |
| cd06948 | 289-460 | NR_LBD_COUP-TF |
| cd07348 | 289-466 | NR_LBD_NGFI-B |
| cd06931 | 287-463 | NR_LBD_HNF4_like |
| cd07071 | 290-448 | NR_LBD_Nurr1 |
| cd06947 | 291-311 | NR_LBD_GR_Like |
| cd07076 | 284-311 | NR_LBD_GR |
Ontology Information
| HPRD ID | 443 |
|---|---|
| Molecular Class | Nuclear receptor |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| Q07869 | DB00328 | Indomethacin | SmallMoleculeDrug |
| Q07869 | DB00636 | Clofibrate | SmallMoleculeDrug |
| Q07869 | DB01039 | Fenofibrate | SmallMoleculeDrug |
| Q07869 | DB01241 | Gemfibrozil | SmallMoleculeDrug |
| Q07869 | DB01393 | Bezafibrate | SmallMoleculeDrug |