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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
UGT1A1 54658 UDP glucuronosyltransferase 1 family, polypeptide A1  2UGT1A 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
25545261   2014Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : 91

Stage : -

Pyrosequencing Polymorhpism-Simple assay to detect UGT1A1 genetic polymorphisms in routine practice before initiating irinotecan therapy. The UGT1A1*28 and UGT1A1*6 alleles were found to be similar in the Asian populations.


Gene Details



NC_000002.11 (234668919..234681945)

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Gene Type protein coding
Gene Family UDP glucuronosyltransferases
Description This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome. [provided by RefSeq, Jul 2008]  
Chromosome 2
Location 2q37.1
Start 234668919  
End 234681945  
Strand +  
Gene Sequence

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Length 13027  
OMIM ID 191740   
HGNC ID HGNC:12530   
Unigene ID Hs.554822   
Ensembl ID ENSG00000242366   
PharmGKB ID PA37181   

mRNA Information


mRNA ID ?NM_000463.2
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS2510.1



Protein Information


      
Protein IDNP_000454.1
Protein NameUDP glucuronosyltransferase 1 family, polypeptide A1
Molecular Wt. (Da)0
Protein Sequence

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Length 533  
Uniprot IDQ96RU7
Ensembl Protein ID ENSP00000217233  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


                                                                  
Pathway Name Pathway ID
Ascorbate and aldarate metabolism hsa00053
Chemical carcinogenesis hsa05204
Drug metabolism - cytochrome P450 hsa00982
Drug metabolism - other enzymes hsa00983
Metabolic pathways hsa01100
Metabolism of xenobiotics by cytochrome P450 hsa00980
Pentose and glucuronate interconversions hsa00040
Porphyrin and chlorophyll metabolism hsa00860
Retinol metabolism hsa00830
Starch and sucrose metabolism hsa00500
Steroid hormone biosynthesis hsa00140


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0378429-444  GT1_Gtf_like
cl1001329-444  Glycosyltransferase_GTB_type superfamily
PLN00164353-401  PLN00164
PLN02534350-415  PLN02534
PLN03004293-445  PLN03004
PLN02448267-402  PLN02448
PLN02167262-404  PLN02167
PLN02554351-444  PLN02554
PLN02207289-404  PLN02207
pfam04101370-440  Glyco_tran_28_C
PLN03007302-446  PLN03007
PLN02764354-442  PLN02764
PLN02670350-411  PLN02670
cd03785370-451  GT1_MurG
pfam0020128-524  UDPGT
PHA03392261-507  egt
COG181929-443  YjiC
TIGR0142644-443  MGT
PLN02410267-405  PLN02410
PLN02152236-435  PLN02152
PLN02210293-430  PLN02210
PLN03015282-421  PLN03015
PLN02173293-446  PLN02173
PLN02555351-442  PLN02555
PLN02992354-401  PLN02992
TIGR04516348-443  glycosyl_450act
PLN02562302-443  PLN02562
PLN02863350-401  PLN02863
COG0707363-445  MurG
PLN02208354-435  PLN02208
TIGR00661264-423  MJ1255
PLN00414301-465  PLN00414
PRK00726370-442  murG
TIGR01133370-440  murG


Ontology Information


   
HPRD ID18102
Molecular ClassEnzyme: Glycosyltransferase
Molecular FunctionOxidoreductase activity (GO:0016491)
Biological ProcessMetabolism (GO:0008152); Energy pathways (GO:0006091)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P22309DB00173AdenineSmallMoleculeDrug
P22309DB00227LovastatinSmallMoleculeDrug
P22309DB00295MorphineSmallMoleculeDrug
P22309DB00316AcetaminophenSmallMoleculeDrug
P22309DB00328IndomethacinSmallMoleculeDrug
P22309DB00398SorafenibSmallMoleculeDrug
P22309DB00530ErlotinibSmallMoleculeDrug
P22309DB00586DiclofenacSmallMoleculeDrug
P22309DB00641SimvastatinSmallMoleculeDrug
P22309DB00678LosartanSmallMoleculeDrug
P22309DB00688Mycophenolate mofetilSmallMoleculeDrug
P22309DB00704NaltrexoneSmallMoleculeDrug
P22309DB00712FlurbiprofenSmallMoleculeDrug
P22309DB00762IrinotecanSmallMoleculeDrug
P22309DB00773EtoposideSmallMoleculeDrug
P22309DB00783EstradiolSmallMoleculeDrug
P22309DB00788NaproxenSmallMoleculeDrug
P22309DB00818PropofolSmallMoleculeDrug
P22309DB00870SuprofenSmallMoleculeDrug
P22309DB00973EzetimibeSmallMoleculeDrug
P22309DB01024Mycophenolic acidSmallMoleculeDrug
P22309DB01045RifampicinSmallMoleculeDrug
P22309DB01048AbacavirSmallMoleculeDrug
P22309DB01050IbuprofenSmallMoleculeDrug
P22309DB01076AtorvastatinSmallMoleculeDrug
P22309DB01095FluvastatinSmallMoleculeDrug
P22309DB01420Testosterone PropionateSmallMoleculeDrug
P22309DB01544FlunitrazepamSmallMoleculeDrug
P22309DB04953EzogabineSmallMoleculeDrug
P22309DB05039IndacaterolSmallMoleculeDrug
P22309DB06210EltrombopagSmallMoleculeDrug
P22309DB06626AxitinibSmallMoleculeDrug
P22309DB06817RaltegravirSmallMoleculeDrug
P22309DB08896RegorafenibSmallMoleculeDrug
P22309DB08930DolutegravirSmallMoleculeDrug
P22309DB04868NilotinibSmallMoleculeDrug
P22309DB06589PazopanibSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO