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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
PPARD 5467 peroxisome proliferator-activated receptor delta  6NUC1, NUCII, FAAR, NR1C2 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
24391853   2013Cell line : SW480,SW620

Source : University Hospitals in Link ping and Vrinnevi Hospital in Norrping

Sample Type : CRC tumor

No. of Sample : 303

Stage : -

 PCR, direct DNA Sanger sequencingMutation-Somatic and/or missense variants detected in CRC patients are rare but indicate the clinical importance of the PPARD gene.

24681603   2014Cell line : -

Source : -

Sample Type : villin-PPAR-d founder mice

No. of Sample : -

Stage : -

Generation of Villin-PPAR-d Mice,Whole-Mouse Gene Transcriptome StudiesUp-regulation-PPAR-d upregulation profoundly enhances susceptibility to colonic tumorigenesis


Gene Details



NC_000006.11 (35310335..35395968)

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Gene Type protein coding
Gene Family Nuclear hormone receptors
Description This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]  
Chromosome 6
Location 6p21.2
Start 35310335  
End 35395968  
Strand +  
Gene Sequence

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Length 85634  
OMIM ID 600409   
HGNC ID HGNC:9235   
Unigene ID Hs.696032   
Ensembl ID ENSG00000112033   
PharmGKB ID PA33557   

mRNA Information


mRNA ID ?NM_001171818.1
Exon join(1..124,4510..4593,54941..55036,68430..68660, 77570..77724,79263..79401,81389..81591,81772..82222, 83275..85634)  
mRNA Sequence

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Length 3845  



CDS Information


   
Location 406..1731
CDS Sequence

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CCDS ID CCDS4803.1



Protein Information


      
Protein IDNP_001165289.1
Protein Nameperoxisome proliferator-activated receptor delta
Molecular Wt. (Da)36314
Protein Sequence

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Length 441  
Uniprot IDQ92560
Ensembl Protein ID ENSP00000417132  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                    
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
4093SMAD94484BAA21128.1yeast 2-hybrid15231748   
5037PEBP16850NP_002558.1in vitro15001550   
5629PROX13330NP_002754.2yeast 2-hybrid15604093   
6256RXRA1577NP_002948.1yeast 2-hybrid15604093   
6257RXRB1578NP_068811.1yeast 2-hybrid15604093   
6258RXRG1579NP_008848.1yeast 2-hybrid15604093   
6714SRC1819NP_005408.1in vitro15001550   
8204NRIP13927NP_003480.2in vitro15001550   
8431NR0B25219NP_068804.1yeast 2-hybrid15604093   
9588PRDX63817NP_004896.1yeast 2-hybrid15604093   
9611NCOR12911NP_006302.2in vitro15001550   
10048RANBP94835NP_005484.2yeast 2-hybrid15604093   


Pathway Information


                        
Pathway Name Pathway ID
Acute myeloid leukemia hsa05221
Pathways in cancer hsa05200
PPAR signaling pathway hsa03320
Wnt signaling pathway hsa04310


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd06932173-440  NR_LBD_PPAR
cl11397173-440  NR_LBD superfamily
cd0696573-156  NR_DBD_Ppar
cl0259673-156  NR_DBD_like superfamily
cd06929244-417  NR_LBD_F1
cd0691674-144  NR_DBD_like
cd0716670-155  NR_DBD_REV_ERB
cd0715874-144  NR_DBD_Ppar_like
pfam0010574-140  zf-C4
cd0716574-153  NR_DBD_DmE78_like
cd06157249-409  NR_LBD
cd06940257-415  NR_LBD_REV_ERB
cd0696173-157  NR_DBD_TR
cd0696874-158  NR_DBD_ROR
smart0039974-138  ZnF_C4
cd0696074-147  NR_DBD_HNF4A
cd0716774-148  NR_DBD_Lrh-1_like
cd0716872-149  NR_DBD_DHR4_like
cd0696474-147  NR_DBD_RAR
cd0696774-149  NR_DBD_TR2_like
cd0716974-149  NR_DBD_GCNF_like
cd06939228-441  NR_LBD_ROR_like
cd0696974-144  NR_DBD_NGFI-B
cd0695674-144  NR_DBD_RXR
cd0717974-146  2DBD_NR_DBD2
cd0716474-149  NR_DBD_PNR_like_1
cd06954253-437  NR_LBD_LXR
cd06935262-433  NR_LBD_TR
cd0715474-144  NR_DBD_PNR_like
cd06937255-436  NR_LBD_RAR
cd06941255-437  NR_LBD_DmE78_like
cd0697069-149  NR_DBD_PNR
cd0695874-144  NR_DBD_COUP_TF
cd0716370-149  NR_DBD_TLX
cd0715674-138  NR_DBD_VDR_like
pfam00104262-418  Hormone_recep
cd0715574-147  NR_DBD_ER_like
cd0717074-148  NR_DBD_ERR
cd0717174-147  NR_DBD_ER
smart00430260-409  HOLI
cd06933256-439  NR_LBD_VDR
cd0695974-138  NR_DBD_EcR_like
cd0695774-149  NR_DBD_PNR_like_2
cd0716174-138  NR_DBD_EcR
cd0716274-143  NR_DBD_PXR
cd0716071-138  NR_DBD_LXR
cd0695574-138  NR_DBD_VDR
cd06938253-437  NR_LBD_EcR
cd06943249-407  NR_LBD_RXR_like
cd06936246-435  NR_LBD_Fxr
cd0715774-147  2DBD_NR_DBD1
cd0696674-165  NR_DBD_CAR
cd0696274-138  NR_DBD_FXR
cd07072236-420  NR_LBD_DHR38_like
cd06934257-436  NR_LBD_PXR_like
cd06930262-409  NR_LBD_F2
cd0717374-139  NR_DBD_AR
cd0696374-145  NR_DBD_GR_like
cd0717274-138  NR_DBD_GR_PR
cd06942257-432  NR_LBD_Sex_1_like
cd06945243-422  NR_LBD_Nurr1_like
cd07348230-439  NR_LBD_NGFI-B
cd06931260-436  NR_LBD_HNF4_like
cd06948262-433  NR_LBD_COUP-TF
cd07071242-420  NR_LBD_Nurr1
cd06952264-409  NR_LBD_TR2_like
cd06950264-412  NR_LBD_Tlx_PNR_like
cd07068258-436  NR_LBD_ER_like
cd06953255-407  NR_LBD_DHR4_like
cd07069255-409  NR_LBD_Lrh-1
cd06946258-408  NR_LBD_ERR
cd06944262-409  NR_LBD_Ftz-F1_like


Ontology Information


   
HPRD ID4558
Molecular ClassNuclear receptor
Molecular FunctionG-protein coupled receptor activity (GO:0004930)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
Q03181DB00159IcosapentSmallMoleculeDrug
Q03181DB00374TreprostinilSmallMoleculeDrug
Q03181DB00605SulindacSmallMoleculeDrug
Q03181DB01393BezafibrateSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO