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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| XAF1 | 54739 | XIAP associated factor 1 | 17 | BIRC4BP, XIAPAF1, HSXIAPAF1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
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- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 17385215 | 2007 | Cell line : HCT1116, Lovo, DLD1, SW1116 (mutant p53) Source : - Sample Type : - No. of Sample : - Stage : - | Dual luciferase reporter assay, MTT assay,Hoechst 33258 staining | Down-regulation | - | The results suggest that XAF1 mediates apoptosis induced by the ERK1/2 pathway in colon cancer. |
| 17570219 | 2007 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | PCR based cloning, isoform-specificPCR, ribonuclease protection, and immunoblotting,bisulfite sequencing,colony formation, and viability assays | Down-regulation | - | Genetic and epigenetic alteration of XAF1 is a common event in colorectal tumorigenesis and contributes to the malignant tumor progression by providing survival advantages for tumor cells under various stress conditions |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a protein which binds to and counteracts the inhibitory effect of a member of the IAP (inhibitor of apoptosis) protein family. IAP proteins bind to and inhibit caspases which are activated during apoptosis. The proportion of IAPs and proteins which interfere with their activity, such as the encoded protein, affect the progress of the apoptosis signaling pathway. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012] |
| Chromosome | 17 |
| Location | 17p13.2 |
| Start | 6658716 |
| End | 6678966 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 20251 |
| OMIM ID | 606717 |
| HGNC ID | HGNC:30932 |
| Unigene ID | Hs.441975 |
| Ensembl ID | ENSG00000132530 |
| PharmGKB ID | PA162409299 |
Protein Information
| Protein ID | NP_059993.2 |
|---|---|
| Protein Name | XIAP associated factor 1 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 301 |
| Uniprot ID | Q9H2A7 |
| Ensembl Protein ID | ENSP00000293778 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 331 | XIAP | 2094 | NP_001158.2 | in vitro;in vivo;yeast 2-hybrid | 11175744 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Ontology Information
| HPRD ID | 6041 |
|---|---|
| Molecular Class | Ubiquitin proteasome system protein |
| Molecular Function | Cell adhesion molecule activity (GO:0005194) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.