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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
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- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 18519671 | 2008 | Cell line : HCT116 Source : - Sample Type : - No. of Sample : - Stage : - | Chromatin immunoprecipitation,Promoter reporter assay,TaqMan RT-PCR,Western blotting,Real-time RT-PCR,Gene expression microarray analysis,Methylation analysis | Methylation | - | miR-34b/c and BTG4 are novel tumor suppressors in CRC and that the miR-34b/c CpG island, which bidirectionally regulates miR-34b/c and BTG4, is a frequent target of epigenetic silencing in CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein can induce G1 arrest in the cell cycle. [provided by RefSeq, Jul 2008] |
| Chromosome | 11 |
| Location | 11q23 |
| Start | 111338255 |
| End | 111383105 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 44851 |
| OMIM ID | 605673 |
| HGNC ID | HGNC:13862 |
| Unigene ID | Hs.128180 |
| Ensembl ID | - |
| PharmGKB ID | PA25453 |
Protein Information
| Protein ID | NP_060059.1 |
|---|---|
| Protein Name | B-cell translocation gene 4 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 223 |
| Uniprot ID | Q9Y6N5 |
| Ensembl Protein ID | ENSP00000260324 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| RNA degradation | hsa03018 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam07742 | 1-118 | BTG |
| cl15439 | 1-118 | BTG superfamily |
| smart00099 | 1-108 | btg1 |
Ontology Information
| HPRD ID | 6016 |
|---|---|
| Molecular Class | Cell cycle control protein |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.