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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| RNF43 | 54894 | ring finger protein 43 | 17 | FLJ20315, DKFZp781H0392, URCC |
- Evidence
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- mRNA
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- Protein
- PTM
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- PPi
- Pathway
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25961913 | 2015 | Cell line : - Source : Participants of NHS and HPFS. Sample Type : CRC tumor and adjacent normal tissues No. of Sample : 185 Stage : - | High-throughput RNA-sequencing analysis | Down-regulation | - | Knockdown of Brg-1 by small interfering RNA led to decreased RNF43 expression, increased Wnt signaling and increased CRC cell migration and invasion. |
| 25344691 | 2014 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | DNA sequencing | Mutation | - | RNF43 is one of the most commonly mutated genes in colorectal and endometrial cancers. |
| 26297255 | 2015 | Cell line : - Source : - Sample Type : CRC tumor No. of Sample : 130 Stage : - | Immunohistochemistry,SSCP, DNA sequencing | Mutation | - | RNF43 gene harbored not only exceedingly high mutations but also mutational ITH, which together might play a role in tumorigenesis of GC and CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | RING-type (C3HC4) zinc fingers |
| Description | The protein encoded by this gene is a RING-type E3 ubiquitin ligase and is predicted to contain a transmembrane domain, a protease-associated domain, an ectodomain, and a cytoplasmic RING domain. This protein is thought to negatively regulate Wnt signaling, and expression of this gene results in an increase in ubiquitination of frizzled receptors, an alteration in their subcellular distribution, resulting in reduced surface levels of these receptors. Mutations in this gene have been reported in multiple tumor cells, including colorectal and endometrial cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015] |
| Chromosome | 17 |
| Location | 17q23.2 |
| Start | 56431037 |
| End | 56494931 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 63895 |
| OMIM ID | 612482 |
| HGNC ID | HGNC:18505 |
| Unigene ID | Hs.584916 |
| Ensembl ID | - |
| PharmGKB ID | PA34441 |
Protein Information
| Protein ID | NP_001292473.1 |
|---|---|
| Protein Name | ring finger protein 43 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 783 |
| Uniprot ID | Q9HAV0 |
| Ensembl Protein ID | ENSP00000232564 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00162 | 272-316 | RING |
| cl17238 | 272-316 | RING superfamily |
| pfam13639 | 270-312 | zf-RING_2 |
| smart00184 | 272-312 | RING |
| pfam00097 | 272-312 | zf-C3HC4 |
| pfam13923 | 272-312 | zf-C3HC4_2 |
| cd00538 | 87-186 | PA |
| cl10459 | 87-186 | Peptidases_S8_S53 superfamily |
| COG5540 | 272-312 | COG5540 |
| pfam12678 | 271-312 | zf-rbx1 |
| PHA03247 | 570-747 | PHA03247 |
| PTZ00449 | 566-756 | PTZ00449 |
| PHA03307 | 312-669 | PHA03307 |
| PHA03247 | 575-756 | PHA03247 |
| PHA03247 | 361-769 | PHA03247 |
| PHA03247 | 361-745 | PHA03247 |
| PRK07994 | 579-742 | PRK07994 |
| PHA03247 | 354-769 | PHA03247 |
| PRK10263 | 569-700 | PRK10263 |
| PHA03247 | 568-677 | PHA03247 |
| COG5243 | 267-312 | HRD1 |
| PHA02929 | 272-312 | PHA02929 |
Ontology Information
| HPRD ID | 2230 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Receptor activity (GO:0004872); Transcription regulator activity (GO:0030528) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165); Apoptosis (GO:0006915); Transcription (GO:0006350) |
Drug Information
No matching records could be found.