CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
PPL	5493	Periplakin	16	-

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
20089989	2010	Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : -	Biochemical isolation to nano-LC-MS/MS analysis	Up-regulation	-	This genes are differenitially expressed between colorectal adenoma and Colorectal cancer tissue. CRC tissue was collected at the VU University Medical Center, Amsterdam, The Netherlands.

Gene Details

Chromosome: 16; NC_000016.9 (4932508..4987136, complement)
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Gene Type	protein coding
Gene Family	-
Description	The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling. [provided by RefSeq, Jul 2008]
Chromosome	16
Location	16p13.3
Start	4882507
End	4937135
Strand	-
Gene Sequence	>gi\|568815582:c4937135-4882507 Homo sapiens chromosome 16, GRCh38.p2 Primary Assembly CGCGCCGCCGCTCGCTCACCTGCGCTCCCGCCCGCCCCTCGGTGCGCGCCCGGCCCGCCAGCCGCCGCCG CCCGCACCCCGAGCGCCACCATGAACTCGCTCTTCAGGAAGAGAAACAAAGGCAAATACAGCCCCACTGT GCAGACCCGGAGGTGAGGAGGCGCCCACAGCTCCGCTCCGGGACGCTCTTGCCCCTGTGGGCGCACAGGA CCTGGAAGACCTCCCGGGCAGTGTAGGAATGGGGGGTACGGGGGTCCAGGAACCGGGAACTGAACCCGGA GTGCGGGACTCTCGGGAACGCGGGACCGAGGCCACCCTGAAGCTGGGAAGCGCCGCCAGGTGGGAAGGGA CTGGCTGGGGTCCCCGAGGGGGAGCATAACACAGGGGACTCCGGGAGCCCAGGGAGCATTGCCTTGAGGG CCTAGGGCACGGGCAGCTGAGCTGGGGGTACAGGGCACCCCCGTGTCCCAGGGTCGCTCTTGCGCAGAGG GTCGCACAGGACCGGGAATAGTCACCTGGATGAGGGGGCGGAGTTTTTGGAGGACCGGGCACTCAAGGCG GGGTCGCTGCGGGCGACCCAGGAAGCTCCGTCCAGGGGGCGCCCTGAGGCAGGGAAACTGAGCTGGCGTC GGGGGGCGCTCTCCAGCGCCTCTGAGACCGCGCAAGTGTTCCTGGCGTCGGGGAGGCGAGGGATGGGTGT CCGGAGGGGGCGGGCCACCCGCCGCTGCACTTCCCGGCACCTGCCACCCTGCGCGCCAGAGCCGCGCCCG GAGGCCCTGGGGGGTGTGGGGTCGGGTCGAGGGGCACAGGGGGAGGCACCCCCTTACCTCCCCACCCTCT GGGTTCTGAGCGGAGGTTGGGCGGCTTCGGGGCCTCCTCTTCGAAGCTCGGTTTCGCAGGGGTGTGGCTC CCTGCCCCCACCCCAGCCCCGAAACTGGCGGCGTCTCTGAGCCGCGGGTTCCCAGGGCGGCCTGGGAGGG GAATGGCATGTCTTGATGTGTTTGCAGGGAGAAGCAGCCCACGTCCCTTTTGATAAGCCTAATGTGTTCA CTTAATAACCGGTTTAGGGGAGCCTGGTGGAGATGCTGAGATTGACGGAGGGGGTGGGAATCCAGCCCCT GCCTTATATCCCCACTTCGGAAAATAGAGTGGGGGCTCTGGGCTAGCAAGGACCATTTTGCCAGCTTCTC GGACAAGAGGCTTCAGGCAGGTGAGGGGCCCGCACATTACATGGCTCTCCTGTCTGGGAGTTCTGCCCCC AAGCTGCTCTCACTGGGAGCCCCCACTGTGCCCTCAAGCAGCTCCTCACTTCTTCCCTAGGCAAGGAGAG GCCTCTGGGCCCAGGGCTCCCACTCAACCCCTGCAGTCCGGCCTAGGCCGACCAGTCGGACAGGTGCAGG CGGCGGGGCCCTAGCACGCTGGAGTGCGACACTCCATTCCGGGGCCTTCCAGCCCTTTCAGAAACCCCCC TGCCCTGTGATCCCACCCACCCGTATCTCCGTTTGGGCTCTTTCAAGCTCAGAGGCATTACCCGCCTTTA GAGATTTCCCCACCCCTCCCCTATCTTTCACAACCCCAGAGACTGGGCAGGGCCTGCACACCCCTCCTCC ATGGCTGCGTCCAGCTGGCACTCAGACCCAACCAGAGGCCCGTCCAGTCCCTGCACTGTTCCCTGGGGCA TTGCACAATTGGATGCTCCGTGCCAGCCGTGGAGAACCGTTCTGTCCTCTCCACCCCAGAGACTAGACCC ATCCAGTCCTTCACACATGCAGACACCCACATACCAGTGGTGGGGCCAGGCCTCGCCCCGCCCTCTGCCT CCTCCCAGCCTCCCTCCTTCGTGCAGCTCTCCATCCTGAAGGCCCCAGCTTGGACCTAACAAAAGGTTCT AATGAACCCAGACAAGCTGGGAGGGGTGCGGGCTTTCCCAGAAGCATGAGGATGAAAGGCATCCCATCCT TTATAGCTGCAGGGACTGGGAGGGTCTGGGGTGGCAAAGATTTGGGGTCCTGCCACTCTCTGTATATCTG GCCCAAGGCAGCCACGGTCTGTCCTAGGCTGATAGCCATTGGTCCCAGATCTCCATTTAGACGTCTCTTT CTCCAGGAAGCCCTCCTGATTCTCTCCCCAGCCTGGGGTGCAAGACCATTCCTTTGAGCCTTGCCACCCC AGCACAGAATGAGCACAGCCACAGCCCTGAGCAGATGTCAGATGCCTCCCCGGGTGGTCTCCAAGCCCAG TGCATCCCTCTGCCCCCTCCCCTTAGTGGGGACTAGTTCGCAGACTGGATTGTGGGGTGGGGGTAGCCCT GTACCCCATCCTCTCAAACGCATCTCTTGAACATTGCCTGATGCCCAGCCAGCCCCATAGCAAGTGTCTT GGTGGGGGGGTGGAGGGGACAGACTTGCGGCTCTAGGCTGTGGTCGCTGGTCACAGGGAGTGGATCCCCA AGTTATTCCTTCACTCTGAGTTTTCCAGGGGCCCGCTCCATTGTCTGGGGGAGGACAAAATTGCTGGTGA GATTCAGCATGGGGGGCAGTAGGAGCTCCAGCACTGAGAGCAGAATGCCTCACTGTTGATCCTGGCATCT CCACCCTGGAGCCTCTCGAAGCCTTGTTTTCCCTTTCTGCACAGCACGGGTGGTAATACTGAGTGTCTCA TGCATAGGGCTGCTGGGAGGAGCAGTGCTGTAGCACACAGGAGGTGCCCGGATGAGGGTAGCAGCCCTTT CCGAGCCCAGGGGACCCAGGAGCCCCAAGTGGTGACTTTCATACCCAAGGTAGTCAGGCCTTTGGACTAC AAAGTGTGGATTAGTGAACGGAACACCCCACCGAGAAAGCCACCCCTTCCAGTTTGTCTGCCTTTTAGCA GCTGAAGCTGGGGAGGGCCGGGACAGGGTGTGAACCCCGTTGCTCCCGTTGCCCGGGTTCCTAATGACAG GTGTGGGAGTTGATGTTCACACCTGAGCTAATGACAGAGTCAGGCCAGATGGTGCAGGTGACCGAGGACA GCCTCCAGCCTAGTAGAGAGGCCCTGGAGGAGACCCGCTGCCACCCTCCTGGCTGTGCGACCTCAGAGGA GCTGCTTGGCTTCTCTGAGCCTGTTTTCTCACCTGTGGGATGGGAATAAGCACGGTGCCTGCCTGGCGAT GTTGGCTCAGGATTAAATGAAATAATGCAGGGGAAAGGTTGTGAATGATAAGCGGCCGCAGGTAATAGCA TCTGTGACGATTACAGTTATTAAGCAAATGCGGGCAAGCTAGCTGTGGTGTACCCAGGGTTAAACTTGAT ATCATGGTGGACAGGCTGTGCACTGCACAATTCCATAGGCACTGTTGCTGGGTTTTAGCACGTGGTCGTG GAGGAGACGTGGACAACCTCCCTGCACTTGAGTCGCTGGCAGTCACATCACAGAGATAAGATGGAGTTAA GCTTCAGTACATGTATGGTTACATGAGCGTCGGACTGATGGGGCCAGGCAGGAGCAATGGAGCATAGAGC CGGACAGATGAGGTCTCCACCCTGGCCACTCACATACTTTGTGACAGGCCTCAAGTGAGAGTTGTCACAG TCAGAGCACAGATGCTGGGAGGTGAGGGAGGACTTCACAGAGGAGGCATCTGACCTGTCACGGGGTGGGA TGGAGTGGCCAAGACCCAGCTCTGCAGTCAGGCTCAATTCTGCCTCTGCTTGAAAAGAAACATAGCATCC CTGAGCCCCAGCGCTTCTGAATTTGTTGAATGGGATTAATCTTGCCCCTCCACCCAGACCTGGGTCCCAG TAAACACCCAGCAGCCTGGCCTTGCCTAGACGGGTCTTGCAACACTGGGGCCGCCCTGATGGAGCGCTCC TGCATGGGAGGCAGGACCCCAGGCTTTGAGGGGAGAGCTGGCAAAAGGGAAGCATGCTCTACTGGGAGGC ACCTGGGGTACCCTGAGCCTCTTAGTGGTTAAGAACACAGTGTTTTATTAGCTGGGCATGGGGGTGGGTG CCTGTAGTCCCAGCTACTCAGGAGGCTGAAGCAGGAGAATCCCTTGAACCTGGGAGGCAGAGGTTGCAGT GAGCTGAGATTGTGCTACTGCACTCCAGCCTGGGTAAAAGAGTGAGACTCTGTCTCAAAAAGAAAAAAAA AAAAGCAAGAACACAGTGTTTGATGCTAGCTGGGCATGAGTTCAGGCCGCAGCTCTGGGTCTCTTAAGCT GTTTGATCTTGGGCAAGTCACTTAATGTCTCCGAGCCTCAGTTTCTTCATCTATGAGGTGGGGTGACAAC AGCAACCCCCAGTTGGTGAGGCTGCTGGGTAGATCAAATGAGGGGATGCACATGATGGGTCCAGCCCATG ACCTGGTTCAGAGCGAGTGCCCGGCAAATCATAGCAGCCAATACTAGGAAGCACACACTGCTATTAAGAG TCATGACGGGCTGGGCGCGGTAGCTCACGCCTGTAATCCCAGCACTCTGAGAGGGTAAGGCGGACGGATC ACTTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAATCCCATCTCTACAAAAATAAATATT AAAAATTAGCTGGGTGTGGTGGCGGAAACCTGTAATCCCAGCCAGATACTGGGGAGGCTGAGGCAGGAGA ATCACTTGAACCTGGGAGGCAGAGATTGCAGTGAGCCGAGATCACACCACTGCACTCCAGCCTGGGAGAC AGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAAGATTCATGACTGAGCCAAGCCCAGAGCTGACCAGGG AGCTGACTCAAGCAGACACGCACATGCACCCATCGATCAGTGTTGGTAGGAACGCCTGATCGATATGGGA GGGGACCCATGTGGGTAACAGCTTAGAGAGAGCCGCCCCGCCATTTCTCAGGCACATACTGTGAGCCCAG CAAGGCCATGGATGTTACATCTCATTCTGACAGCGGGCCTGCCATGCAGGTGGAAGTGTCCTGTTTCACA GAGGGCTCACATTCACCTTGAGCTCACAGCTCACAAATGGCTGATGCTGGAAGTCCAGGGGGGCCTGGGG AAGCAAATGAGGCCTCCCCACTCGTACCTGGATCTGGCAGCAACTGTGCCTGGGGACTGCTCCAGGCCAA ATGGTAGAGTCATTGGTGTTTGTGCTCACTGCCTCTACCCCCAGCAACCCCCTCTACCTCTCTTCTCTCT AGCTTTGCCCCTCCATCCCTTGCCCAGTTCTCTTGGAAGAAGGAATGAGACTGGATAAATTCGATTCAGG ACAGAGCTGAGCTTACCTGGAGGAACAGCTGCTAATGGTAGCATTTCAGGCACTGTCGGGCGGATCATGT TGGGAAAGGGTATTTTGGGGGAGAGACTCAGCTCCGTCCACACCCTTTAAGCAATACCCTAAGGGTGTGG TTGGGGGAGGCCCTGGAAGTAGGGGACCTGGGGGAGAAGCTGCTTTAGAGAGCTTCCAAAGCTCCTCGTC TGGGGAAGAGAACCCTGGCTTCCCAGCGTGCAGCTGCTCTCTGCTCCCGGCAGGTCTGTGCCGGTGTTAC CGGCACCACCTTGCATCCTCCCAGCCTGCCTGCCCCGGCCTGTCTTGGGAGCGAATGGGGAAACGGCCTC TGGTCTTTGTTCTCCCGGCTTCTGATGGGTTGCTGTGCTGCAGCCTCTGGAGCCCGGGAGGCCACCTGGT GCCCCTTTCTGCCTCCGGGTGGGACAAAGCTCTCTTCAGGTCCCAGCCCTGCCCTTCCCTACCCCAACCT ATTTTTTTTAAGTGTTCTTTCTTTATTCTTTAGAGACAGGCTGTCACTGTATCACCCAGATTGGAGTGCA GTGGTGCGATCATAGCTCACTGTAGCCTTGAACTGCTGGGCTCAAGCAATCCTCATGCCTCAGCCTCCCA AGAAGCTGGGACTACAGGTGTGCACACCACCGTGCCCCGCTAATTTTTAATATTTGTAGAGATGGGGTCT CACTATATTGCCCACTCTGGTCCTGAACTCCTGGGCTCAAGTGAGCCTCTTGCCTTAGCCTCCCAAAGCA CTGAGATTACAGCCATGAGCCACTGCACGCAGGCCCTTTCCCTTTAAATGGATCCCCACTTCTCCCTGCC TGCAGAGCCAGCAGCCCAGCAGGCCTCCAGTCCCTCTTCACTGTTCCTTCTTCCACTCCAGCGCTCCAGT CCCTTCTCCCCATGGCAGCCAGGGAGCTCCTTACGACATAAATCTGACCATACCTCCAGCTGCTTAACCC CTGCCCCAGACCTCTCTTTGCTCTTAGGCCCTGGGAGCTGGTGCCCTGCACATCAACATGTGCCTGTCAC CGTCTTGTTTCCACGCTGTGCCCGGCCACAAGGCCTTTCCCTCTGCCATTCCTGTTGCCCAGAATGCCCC TCCCACCCCTTTTCACTGCTTCTCTTCCACTTCCAGGTTTACCTTCTGTTCCTCAGGGAAGCCTTCCCCA ACCTCTCTGCTGGGGTAGATCCACCTATTCTATGGACTCCCCTTCTCCTTGGTAGCTCTTATCTCAGCAG CTATGTGACTCCGGGGTAGCCACATGTGGCTGTGTGGCTGCCTTCCCCCAGACACTGGTGCTACACGCGT GCTGAATGAATGAATGAATGAGAGTAAGCCATGGGGGACTGCTAAGATTCTCCCCTTCCCTCAGCATTTC AAGAGAGCATACATTGCCCTGCGCTTCACACCCCAGGACCAGCAGAGCCCGGAGGTGGGGATGAATGGGG CAGGGGTTCCAGCTAGTGGAAAGGAGTGCGAGGCCTGAGCAGGCTGCCCCCTGCCCTGTCCCCATCCAGT CACCTCCTGCGTGCAGGACGGTGAGCAGAGAGTTGGCTGAGTACACAGCTGGCAGCAATGCGGAGTGATA GTGAGATAAAGGAGGGCCCTGACCCAGCCACACAGGCTTCTTCAGGAGAGGTCCTCCACGCCGAACCCGG GGATCAGTTGGAGATGAGAGGATAAAGAGAGTGCAGTTGACAGAAGGTGACGGGGATGTGTGTATCCACG ACCCGAAAAGGCATGACAGTGAGCAAGCAAAGCAAGTTGATGAAGGATGCAAAGATGATGCTTGCATATA TACATTTTTAGAAACATACACAGAGCAATTCCACTTACTCTTCCTGAATGCAGATGTGTCTATGTATTGG AAAGCTTAGGGAACCAGGTGCAGTGGTTCGCACTTGTCCTAGCGCTTTGGGAGGCCAAGGCGGGAGGATG ACTTGAGGCCAGGAGTTGAAGACGAGCCTGGGCAACATAGTGAGACCCTATTTCTACCAAAAAAAAAAAA AAATTAGCTGGGCATGGTGGTGCATGCCTCTAGTCTTAGCTACTCAGGAGGCTGAGAGGGGAGGATCCCT GAGTCCAGGAATTCAAGGCTGCAGTGAGCTGTGATTGTGCCACTGCACTCCAGCCTGGGCAACAGAGCAA GACCCTGTCTCTAAATAAATAAAATAAAACAGGCTTAGGAAGAACCAGTAAATCTAAAATTCTGCTACTC CTAAGAAGGGGCCTGAAAGGATAATGAACAATAACATTTCTCTTCCTTTTTAGAAAAATCTGCAGCAAAG ATGGTACTGTGAAAACATCAACCAAACCGTGGTGGTGGGGACATGCGTGGCTGATTCTTTTCAGTACTTT TCTGCATGTCTGAGTAGATCACGAGTTTTCCAGTTTAGGTGAAGGGTGGAGTAGAGAAGGCGAGCTGGCG TGGGGCACAGCTGGCGGGGGGCACAGCGTGGGAAGAGCCTGCAGGCAAGCCCTGAGTCCTGGGTCTCAGA GTCCAGTCCATAGCAAAATAAAAGGTCTGGGAGAGGAAGAAGAGGGACCTCAGGAAGCAAAGGGGGCCCA GTCCTGGAAGGCAAGCAGGCAGGTTCTGGATGGGGAGACAAAAATGGAGAGTCTCTGCAAGGAAGTGAGA GGGGAGGGGACCAGAACTGGGAAAGGTATGAACACAGAAAGGCCTTGAGGTTGGGTGCTAGCTTAAAACC ATCACCCTAAATTATGATTATTACATTGTCTGAGATAAATTCTACCCTCAGCTCTCGTTCCAAGTGAGGC TCAGAGAGTTTGAGTGACTCGCTCCAGGACTCTCGGCAGATCTTTTTTTTTTTTTTTTTTTTTTTTTTTT TTAAGGTAGAGTTTCACTTTTGTTGCCCAGGCTGGAGTGAAGTGACACAATCTCAGCTCACTGCAACCTC TCTGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCGCCCACCA CCACGCCTGGCTATATTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAGGCTGGTCGCAAA CACCTGACCTCAGGTGATCCACCTGCCTCGGCTTCCTAAAGTGCTGGGATTACAGGCATGAGCCACTGCT CCCAGCCAAATAGAGTTTCTTATCTGAGATTGAAGCAGGGTTGAAGCCCTGTCTCTTCTTTGTGGTACAA ACTTGGAATCCTTTCCCACCCTTCGATGGGAAACAAACCATCGCCATGGCGAAGGCAGAGAATTTGAAAC CCTAAAAGGTATCAGCCTGAAATCCTAGCCCAGGCAGTGGGGGCAGCAAAAAATTCTGCAAGTTCTATTT CTCCCACAGCCCTGCGGCCTTGCAGGCTCAGCCAGCAGCTCTGGTGTGTTTTATCTTACAAAGCATGACA AAAACCCTCTGCCTAGGAAAGGATGGGCGGGGCGGCCAGGACACCCTGCCAGCCCTCTCAAAGTGTCTGG GTAAGAACTGCTGAGATGGCCGGGCACAGTGGCCCATGCCTGTAATCCCAACACTCTGGGAGGCCTAAGG TCAGGTGTTGGAGACCAGCCTGGCCAACATGGTGAAACCCTGTCCCTACTAAAAATACAAAATATATTTT GTGTTTGAGCCCAAGAGTTGAAGGCTGCAGTGAGTGAAGTGCAGCAATGCACTTCAGCCTGAATAACAGA GCAAGACTCTGTCTCAAAAAATGAAAAAGGAGGCTGGTGCTCTTTCTCCAGTGGTCCTGAACCCAGAGTG ACATCCTGATGCCTTGGGGCACCAAAGTTGGCTTGAGCCCTGTTTATCCCCCGAGTCTAGGAATTCAAAG CTGCAGTGAGCTATGAATCCTCCCACCTCAGCCTCCTGAGCAGCCAGGACTAGAGGCATGCACAACCATG CCCAGCTAATTTTATTTATTTATTTATTTTTGGTAGAAATAGGGTCTTGCTGTGTTGCCCTGTCTTCAAG ACCTGCCTTGGTGTTACCTGAAGCAGCTTGAACTTCTGTATGTTTGTAAAAGGAGCCCAAAAGCACTCAC CTGACACAGAACCCTAGGCCCCATCAGAGGCCTGGAGGCAGGGCGGCCTTCCCTGGGCAGAAACAGATTA GGCCTTAAAAACAGACCTGGAATTACTACACCAGCAACCTTCTCATCTTAGGATATATTTCCACAGGATT AATAGCTGGGTGTGAGGACATTTACTGTCTAATTAGCACAGGAGTTTCTAGTAGTGAGAGAATCAGTCAA TTGACCAATCAATCTGGTATTCATTGGGCACATTCTGTGTACTGCTTTCTCACAGGGCTTCCTTCCTATA GAGATCTAGGATTCTTCGGCATCTTGCTTCTTTTAAACCTTGCTGTGGTTCAGTTCCTTGTTCTCATCCC TGGCTGTACATTAGAATCACCTGAGGAGTTTTGAACAGCATGTCAGAGCCCTTTCCAAGACCAGTTAAGT CAAAATCTCCATGGACATGGGTCCAGACATCATTCTTTTGATGTGCAGCTGTTGGGAACCACATAGTTAC ATGGATTGCCTCGCTCCCTCTTGTCTTTGAGATATATGGACAGTGCTTTCTCTCTTCAGTATCAGTTGCC TGGTATGTCACTCTCCATTCTTTATTCTCAACCTTCCTGTATCATTTAGTTTCAAGTGTGTGTGTCTTAT AAAATGGCATATAGCTTGGGGAAGGTGTGTGTTTTGTAATCTCACCGGAGAGTCTTTTATCTTTTAATAG GCAAAATTAACTCATTTACATTTATTGTAATGACTAATGTGTTTGAACCTACTCCACCATAGTGCCCTAT TTATCATGCTTTCCCTTTGTTTCCATTTTGCTCTTTTCCTGGTTTTTACTGGATTGAGTATATTTTCATC ATTAAAGTTAGATTATAAGGCCTAAATGGAACACAGTGGATGAAAATACCCTGGTGTAAGTGATCTAAAA TCTTTGTTTTTGGTTTTTTTTTGTTTTTTTTTTTTTTGAGACAGAGTCTTGCTCTGTTGCCCAGGCTGGA GTGCAGTGGCACAATCTCAGCTCACTGCAAGTTCTGCCTCCCAGGTTCACGCCATTCTCCCGCCTCAGCC TCCCAAGTAGCTGGGACTACAGACGCCTGCCACCACGCCCGGCTATTTTTGTTTTTGTATTTATCGTAGA GATGGGGTTTCACCATGTTAGCCAGGATGGTCTCAATCTCCTGACCTCGTGATCTGCCCGCCTCGGCCTC CCAAAGTGCTGGGATTACAGGCATGAGTCACCGCGCCAAGCCAAATCTTTGTAATTATACCCATTGGGGT GTTTTTCCTTAACCTACCTACTAGCTTACAAGCTTTTGAATAGTTGGGATTTACTCATCTTTTGGGAGAG GGCCTTCTGTTGTCCTTAATTCCAGGCCTTACATAAGCTTGGGGCTCCATAAATAGGTGTGAAATTGAGC AGGTATTTTATAGCATGTGGACAATTCATATCTCTGGGGGCTTGTTAATGGTGAAGGGCCTGTTGCCAGG GCCTGTAAGGGGCAGAGAGATGACAAAGAGTTGGTGGGGTGGGGTCGAAAATTTATTTGGCAATTACTGA ATATCTAGAAAGTGCCCAGTTGGGGCTGCAGCAGTTACAAGCATAGACCTCTTACTAACCTATTGACCCT GAGCAAGTGGTCTTCCTGAGGCTCAGTTTCCTCATCTGCAATGGAGCTATGATAGCACGTACCTCAACTA GTTGTTATAAGGATCAGAGATGAAACCTGCTTCCGGTGCTAGGGTAGGGTGTGGGCCAGGAAGGTGCTCA CTCAATGGCAGTTGCTTCCGCCTGAAAGGTCTGTTTGGAGGGACAGGCTGGGAGTCCCTTGTGGGGACAA CTTAGGAGAATGACTCAGTCTCCGTTTACCATCACTAATCCTTACCCAACCAACCACTGGGATTAATTGT ACTGATGAAAATGACAACAAACTGTAAATCACTCTGCTTCCCTGGGTGGTGAATGCCTGGTCCCATCATC CTGTCTCTCCGATGTCTCTTGTCCCTTTGTCTGTAAGGGGTGGGTGTGGATTGATACTGATGTCCCCTTT GTACTGAGAAGGTGGCTTTTTGAAGCCCGTCTTCATGGGTTCGAATCTTGGCACCACCACTTCCCAGCTG TGTAAACTCGGACCAGTTTCTTAACTTCTGTGAGCCTCAGTTATCTTCACCTAGAACACAGAGACATAAG AGTTACCGAATTGCATTAAAACATCTGCTCAGTTCAACACCTATTTATTGAGCCCAGCCCTACGCAAGGT GTGGAATTAAGGTTATAGAAGGGCCCCCAAAAAGGTGAGTAAGTTCTTTTTGTCCAAAAATTTAATAGCC TAATAGGTAGGATTAAGAGCCCCAGTAACACTAAGGGTGGCTACTTCCTAGGGCTATGAGACGTCAATGG GTGATGCACAAAAGGACTGAGCGGTCGCTGGGCACCCAGTAGGTGCCCTCAGTGTTGTTACTATTCATCA GTTATTTCCTGAGTGTCCACGGTGGTTGCCTTTGTGTCAGAGCCAGGGCAGATGTTTCAGGAGCCAGGCA GTGTTTAAAGAAGGTAGGGGCAGAGGGCTACTCGGCACCGGAGGTGCACCTCCCCCAAGCTGGCCCTCCA GGCAGGCAGGACGCCAGAAGAGGATGACCGTGGTGGCAGGAGGCCCAGCCCCTTCTCTGGGCTCTGGGAC AGGTGAGGCTGGTTCCAGGGAGGGGTGTACCCTCCTGTGCGTTCCAGACATTCCAGCAGCAATGCAACCC CAATACACACCCACTGAGACAGAATTAACCCCCAGAGGAAGGAACTGCAGATGTGATCAAAGGCCAGTGG CCCTGGCCAGGCAGGGAGTGCTGAGCCTGCAGGGACCTGTGTCCACACATGGGAGGAGAGTGCAGGCTGG GCTGTGAGCCAGCAGGGGACACAGCAGTTCTGGGCGACAGGGACAGCTGGGGTGGAGGTGATGGCAGGAA CGTGGCCCCTCCGATGTTGCTAAAGTATGATCTGTTACCGGGGTGGCTGCTCTCGCAGCCTGGAGAAGGG GATGGCTGTGAGCAGGCCAGGTGCCTCCAGCACAGCCCCATGGCCTATGGACAGGGTTGCAGGGGCTCTG GGGACCTGGGGAAGGGTGTCTTGCTGCGGTCTTCGTGCCAGGGTCCTCCACACCCAGGCACCAGGCTCCA GTGGGCACAGTGGGGAGCCCCAGGTTGTTTTGGAGTCAGGCAGCCAGGGAGGGACCCACAGAGGAGACCC TGTCCTGGGGCAGACATCTAATCAGTGAGTGTGGGCAGGAGGAGTCACGGGGTTCAAAGAGAATGAGCAT TTATTAGGTGTCCCTGGGTACCAGGCACCGAGTGAGACTGGAAGATGCTCTGAGCGCCCATCAGCTTTCC TACAGCAGAACTGAGAGACTGTGGTCACTGCGGGCTTAGAGCAAAGCAGGTCCGGGTGCCCCAGAATCAC CTAGAATCTCGCAGTCCTATTCAGTAATTACTGGCCCCGTGACATGGGCTGTGCACGTATGTCTGTGTGC CAGGGTTTGAAGACTTAGTGTGAAAAAGAGAATGTAAAATATCCGTTAATAATGTTCTGTTGACCACCTG TCAAATTGATCATATTTTGGATATATTAGGTTAAATAAAATAGAAAAAAATTCGCTCATTTCTTCTTACT CTTTTCACGTGGCTACTAGAAAAATGTAAATTCTGTGTGGCTCAGGTTCAGTTTCTGTTGAACAGTGCTG GCCTTGCATACAAAGCAACTTAATACCTGAACTCCTGTGGGAATGTTTTCCAGCTGTTGAGTGTCTTTCT GCTTGTTCCGTGACAAGCAGGCATGATAACCCCATTTATGTTGAAAGAAATTAAGGCTGAGACAGGTGGA GTAATACATGCTGTTATTCCAAAAGCCAGCATAGTTCATTCAGTCTGATGGGCGCTACGGACATGGCAGT GAACAACAGACAAAGAGCCCTGCCCTGGCAAGGCCCCCACCAGTGACACGGAGGAAGAGGATGAAACCCA GTTATCCTAATCATGGTGCGGCCACACCCAAAGCGCTTTCATTTATAAGGGTTATCTCCTTGAATTATCT CAACCCTCTGCAGTGGGATCAATTCCTATCCCTGTCTCAGAGATGAGGAAACTGAGGCACAGAGAGACTA AGGAATCTGCCCGAGCCCACACCTGGGTTAGAGCCACAACACAGGCTACGTTCCCTGCCCTGGCCAGGCT GCCTCAGTTTCCTCCCCTGCAGGCAGGGTAGAAAGAATGGGCCAGTTGGTGCCATGTGACTTGAACAGGT ACAGCTGAAGACATCAAGGGTGGCTCTTGAAGCCACCCCCACCCAGGGAGCCCCCTTCCAGGTCGCTGAT GGCTGGAAGGTTGCCATTCATGGTGTCCTTGGAGGGTCCACGTCTCTCCTGGGGGCAGGAGGCCGGGAAG CATATCTCCCCAACTCTTAGGTCTTTGTATGATGCAACCAGATCATCCCATCATCCAAACTAAAACTTAC CTGTGCTCCCAAATGCTCTCAGAAAAGAGAGTGGGTGGCTGTTGCATTGGGCCAGGTAAGAAGTGGTGAC TTTGATCAAGGTGAGGCCAGAGGGGCAGATGGAGGAGGATGCGCAGGAGACGCGTTCCCAGGTAGAACCA GTGGAGGGAGAAGCAGGGACAGGTCTCAGGGATCTGTTGGCATAACCGGGTAGACAGGTCCTCCCCACCC TCCCCTTCTGCAGTTTCCCTTATGCGGACGGAAGAACGTTCTCAGAGCAGTGGGAACACCCTGTACCCTT CAAATCCCCAAACCTACTGACTCTGATCCTTAGCCCAAACCCAAGACAGCTGAAGCGGGCTGTGCGTTTG TCCCCCAGCTAGGCCCAGGGAGTGGGCATCTGGGACGCAGGATCTCCTGTCCTCCCGACACCTCATTACC CATATATGGGCACCAGCCTCTCCTCGCAGATGTTGGAGGAGATGGTTCCAAATTCTGAGGTTAGTTGTGA ATTCCACGTGCCCCGGCAAGGCAACATTCACAGGGCAGAAGCAAAGCACGTCTGGGCTTGCACCAGGATC AGCGTGAACAGTGTGGACGGCCGGGGGTCTGCTTTCATCTCCCAGGTGCTGGAGGATTCTAACTTCAGGC CTTGGCTTCTGGCTTTTTGTTTGTTTCTAGGGTTTTTTTGTTTTGTTTTGTTTTGAGATGGAGTCTTGCT CTGTCACCCAGGCTGGAGTGCAGTGGCACAGTCTCGGCTCACTACAACCTCCGCCTCCCAGGCTCAAGCG ATTCTCCTGTCTCAGTCTCTCCAGTAGCTAGGATTATAGGTGCCCACCACCATTCCCGGCTAATTTTTGT ATTTTTAGTAGAGACAGGGTTTCACTATGTTGGCCAGGCTGGTCTGGAACTCCTGACCTCAGGTGATCTG CCCACCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCACGCCCAGCTGGCTTCTGGCTTTT ATCAGCTCCTTAAAAGGAGCCTAAATCCCTGGATGGTGGACCCAGGTCAAGGCAGAGCCGGGCTCCTCAG AGGCAGCACCCCATATCTGTTCTCTCAGTCACCCCCACCACAGCCCTGTGGCATGCATACTGTGATGACT CTCATTTTACAGCTGGGGAAACTGAGGCTCAGAGAGGCTAAGTAATTTACAGTTTATTAAGAGCAGAGGC AGGATTTGACCCCGGGCTGTCTGGCTTTGGTCTGGGTGCTTAACCACTGGGCCACACTGCCCTTCCAGCT GAAAGAAAGTGCCAGTGGCACCCGCACAAAATTAAAGCAGGAAGAGAGACCCAGGAGGTGGAGAGCGAGG GTCCCCCGAGACACCTGTGTTATCTTTCTCTGCCCACGTGGAGCATCGGTGGTGTGTCAAGGCCAGGGTG CTACCTCTGTCCCAGCTCCTCTCACGGGCATCCCTGCTGGCCCTCTGAGGACTGTGTGCTGTCCTGGCGG CCAGGACAGCACACAGTCCTAGGTTCGAGTCCCAGCTCTCCACTTTGCAGCTGGGCTTACTGAGCCACTG GGTCCTCAGCCTCGAGTTGCCACCTCTAATGCAGGCTGGGGCCAGGCACAGTGGTACACACCTGTAATCC CAGCATTTTGGGAGGCCGAGGCGGGCAGATCACTTGAGGCCAGGAGTTCGAGACCAGCCTGGCCAACACG GTGAAACCCCATCTCTACTAAAAATACAAACATTAGCCGGGCGTGGTGGTGCATGTCTGTAATTCCAGCT GCTCGGGAGGCTGAGGCACGAGAATTGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCAAGATCATGC CACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCAGTCTCAATCAATCAATAAAGCAGGTCGGGCTGTG TCTACTGAGGCTCTGACTCCTGGCGACAGAGCCAGGAGACCTGATGCCATCTGAGGCCCCCAGGCCCCCT CCCTAGTGGTTCCTCTGCTCTGAGTATGTCCTGGGACACAAGAAGATGGCTGTTCAGGCTCAAGCCTGCG GGCTCAGACCCAGGAAGCCCTTGTCTGGTCCCTGGGAGTACCCTCAAACACAGCCCTGGAACTCCGAGGA GGAACCGGGCAGCCTCCTGACCTGCTGGTTCCATTTTTCCTTGCTTGCATCAAGAGCCTCATATGCAGAC CAGGCCAAGAAAATGGGGCTCTGTGAGACTGCTCAGGATTGTCCCAGACTCTGGCATCCCCAGCCCAGAA GGAAAAAGCTAGGGAAAAACAGCCTCAGTCGACTCGAGGTGACTCGTAGAGGCTTGCAAAACCCATCTAG CAGGCAGCCCCTGACCCACAGCGTCAACAAGGCTGAGGGGGCTGTTTCTGCTGCCAACCAAGTTCTGGGT CCTCATTCAGGCCCACTGGTGAAACAGCCAGCAAGGCCCGAATTGTATAAACAATGTAAATGAGCCAGGC ACAGTGGGCTCATGCCTGTAATCCCTGTACTTTAGGAGGCCAAGTCAGGAGCATCCCTTGAGCTCAGGAG TTTAAGACCAGCCTGGGCAACAGAGAGAGACTCCATGTCTACAAAAAAATTAAAAAATTAGTTGAGGCCG AGTATGGTGGTTGACACCTGTAATTCCAGCACTTTGGGAGGCCGAAGCAGGCAGATCACCTGATCAGGAG TTCAAGACCACCCCGGCTAACATGGCGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCCAGGCATGG TGGCGTGCGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGTAGAATCACTTGAATCCAGAGACGGAG GTTGCAGTGAGCCAAGATTTTGCCACTGCACTGCAGCCTGGACAACAGAGCAAGACTGTTTCAAAATTTT AAAAAGAGTATAAATGATCTCAAGTCTGTTTCAGGGACGCTGCTCTGAACCTCCAGTTCAGTCCTTGAAC CACAAAGGTGTCTTTGAAATTTGACCGAGGTGTCCTTTCTTTCTTTCTTTCTTTCTTTCTCTCTCTCTCT CTTTCTTTCTTTCTTTTCTTTCCTTCTTTCCTTCTTTCTTTCTTTCTTTTTTTGAGACAGAGTCTTGTTC TGTTGCCAGACTGGAGTGCAGTGACTCAATCTCAGCTCACTGCAACCTCCACCTCCCAGGTTCAAGCAAT TCCCCGGCCTCGGCCTCCCAAGTAGCTGGGACTACAGGTGTGTGCCACCATGCCCAGCTAATTTTTTGTA TTTTAGTAGAGACGGAGTTTCACCAGGTTGGCCAGGATGATCTCGATCTCCTGACCTCGTGATCCACCTG CCTCGGCCTCCCAAAGTGCTAGGATTACAGGCGTGAGCCACCGTGCCTGGCCTGACTGAGGTGTTTCTAA AAGTGACCCTGATTACCCCCACCCCACAAATACACTTTTTTTGGTTTTAATTTGAGACAGGGTCTTTCTC CATCTCCCAGGCTGGAATGCAGTGGTGCGATCTCACTCAGCTCACTGCAGCCTTGACCTCCTGGGCTCAA GCGATTCTCCCACCTAAGCTTCTCAAGGAACTGGGACTACAGGTGCACACTACCACATCTGGCTAATTTT TGTATTTTTTGTAGAGACAAGGTCTTCCTATTTGCCCAATTTGGTCTCGAACTCCTAGGCTCAAGAGATG CTCCTGCCTCAGCCTCCCAAAGTGGTGGGATTACAGGTGTGCACTCCTGTGCCTGGGCCCATACATGAAC ATAACTAGAGAGGATTTCTTGCTCACATTTCACAGATGATGAAACTGAGACTCAGAAATACAGAGTGGCT GGCCAGGCATATTGTGGCTCATACCTGTAATCCTAGCACTTTGGGAGGCCGAGATGGGAGGATCACTTGA GGCCAGGAGTTCGGGACTAGCCTGGTCAACATAGTGAGAAACCATCTCTATTTAAAAATTTGAAGAAAAT ATAAAAAGATTAAAAAAGAAATACAGTGTAGCTCCTCTGTCACACTGTCACAGGGTCACATTGCTGGTTG GTGCAGTCAGGATCTGAACCCTATCTGACTCCAGACCTGAAGTCTTTCTCCTACACAGGCTGCCCTCCCA AGTGATCCTGGGTAGTGACTTCACGTCCGGGACCTTGGTTTGCTCATCTGGGTAATGAGCAGGTGGGGCT GGATGGCTTCTGAGGCCCCTTCGAGGGCCAGCGGCCACTGCCCTCAGCACGTGTGTCCGTGTTACCCTCT GAGTAAGAAAAGGGAGGGCTGGGCGTGTACCCTCGGCTGTCACTCAGGCCCTTTCCCTTTTCCGGTGTGT GTGTGGGGAGGGGGGATATCTTTGTGTTCCTGGCTCAGGCAGGTGGCTGCTGTCTGTGTCTGCATGGGCA GGACAGGGCTGTGTCTCGGCCTCCATCAGTGGGGCTGATGGCCCAGGGGTGCCACGTCTGGCTGCCCCGA TGCGGCTCATTACCGAGATGAAAAGCTGGACCAGCCTAGCCGGTTTCCCAGCACTCCTGGGACCTGTCCC CTTTCCTGCAGGTTCCTGCCCCACCCACATTCCTGCTGGCTTCCTAGCATGGGGCTCCATAGCTCTCCAA GGGGCACACATGGTTGATTCCTGCGGCCAGCTGGATGGTGGGGGGAACACAGGACCGCAAAGCTACAGGG CAAAAACGCTGAGACTGTGCTTCCGGAGGCCTGGATTCGAATCCCAGCTCTGCCTTGCTTGCTGGCAGTG GAACTGTGGCCAAATGATGGAATTTCTTTGTACCTCAATTTCCCCATCTGTAACTGAGTGAATTGCATGG TATATGAATTCCATGCAATTCACTCACTTAAAGTTGTAATCCTCCAACTTTTGAGAATAATGGTACTTAC TTAGAGGCTGGTAGGATTGATGAGCTAATATATATGTGACTTGCTTCGCAGTGGGCAGGACAAATAGCTC TCTAGGAGTTAACTAGCATCTTCCAGGCTGCTGGGGGATTACCTGCAGCTGGCCAGCTTCCCTGGAGAAT GAGACAAGAGGCAGGACCTGACTCAGGAGAGAAGAAACAAACCCCTGTCATTTCTAAATGGCACTTGCCT TTTTTTTTTTTTTGAAATGGAGTCTTGCTCTGTCGCCCAGGCTGGAGTGTAGTGGTGCAATCTCGGCTCA CTGCAACCTCCACCTCCCGGGTTCAAGCAATTCTTCCACCTTAGCCTCCCAAGTAGCTGGGATTACAGGT ACCTGCCATCATGCCTGGCTAATTTTTGTGTTTTTAGTAGAGACGAGGTTTCACCATGTTGGCCAGGCTG GTCTTGAACTCCTGACCTCAGGTGATCTGCCCGACTCAGCCTCCCAAAGTGCTGGGATTACAGGCCTGAA CCACCATGCCCAGCTGCCTTTTTTGTGTTTTTTTTTTTTGTAGCAGCTTTACTGTGATGTAATTCATATA TCATCCAGTTCACTCATTTAAAGTGTTCAGTTCAGTGTTTTTGTTTTTGTTTTGAGACAGGGTCTCACTC TCATTGCCCAGGCTGGAATGCAGTGGCGAAATCTCGGCTCACTGCAGCCTCAACCCCCTGGGCTCAAGTA ATCCTCCTACCTCAGCCTCCCGAGTATCCAGGACTACAGGTGTGCATCACCATGCCCAGCTAATTTTTTG TATTTTCAGTAGACATGGGGTTTCACCATGTTGCCCGGGCTGCTCTCAAACTCCTGGTCTCAAGCGATCT GCCCACCTCGGCCTCCCAAAGTGCTGGGATTATAGGTGCGAGCCACCACGCCCAGCCCAGTGGATATTAA TATAGTCACAGAGTTGTACAGCCATCCCCACGATTGATTTTAGAACATTTTTATCACCCCAAAAAGAAAT CTGATACCCCTTAGCAATCACTGTCCATTTTACATCCTCCTGGGCCATGGCAACCACTCATCCACTTTCT GCTCCTGTAGATTTCTGCATTCTGGACGTTTCTTATCAATGGAATAATATGTGAGCTTTTGTGTCTGGCT TCTCTCACTGAGCATAACATTCTCGAGGTTCCTGAGGCTGTAGCAGCTGTCAGTCCTGCCTTCATTCTTT GGCCGAATAATAGAGATAGACCACGTTTGGTTTATATTTTCATCAGTTGATGAATATTTGAGTTGTTTCC ACTAAAAAGTGGAGGCCAAAAGGCTATTATGAATCATGCTGCTGTGATTCATCTATGTACAAGTTTCTGT GCAGGCATAGATTTTTTTGTTTTTTTGTTTTTGTTTTTTTGTTTTTTATTTTCTGAGATGGAGTCTTGCT CCATCACCCAGGCTGGAGTGCAGTGGCGCCATCTCAGCTCATTGCAACCTCCGCCTCCCAGGTTCAAGCG ATTCTCTTGTCTCAGCTTCCCGAATAGATGGGATTACAGGCACATACCACCACGCCCAGCTAATTTTTTT GTACTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATC CACCTGCCTCGGCCTCCCAAAGTGCTGGGATTGCAGGCGTGAGTCACCGCATCCAGCCCAGACATAGGTT TTCATTTCTCTTGGATAGATATGTAGGGGTGGGCTGGGTGCAGTGGCTCACGCCTGTAATCCTAATATTT TGGGAGGCCGAGGCAGATAGATTGCTTGAGCCCAGGGGTTCAAGACCAGCTGGGGCAACATGGCGAAACC TCCCTCTCTGAAAAAAAAAAAAAATTAGCTGGGCACGGTGCCAGGCGCCTGTAGTCGCAGTTACTCGGAG GCTGAGGTACAAAGATTGCTTGAGACTGGGAGGTCAAGGCTGCAGTGAGCTAAGATTGCACCACTGCAGT CCAGCCTGGGCAACAGAGTGAGACCCTGTCTCAAAAAATAATAAGGCTGGGCGCAATGGCTCACACCTGT AATCCCAGCACTTTGGGAGGCCAAGGCAAGTGCATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCA ACATGGCAAAACCCCGTCTCTACTAAAAGTACAAAAGTTAGCCGGGTGTGGTGGCACACACCTGTAATCC TAGCTACTCGGGAGGCTGAGGTAGGAGAATCATTTGAGTCTGGGAAGCGGAGGCTGAGTGAGCCGAGATC ATGCCAGTGCACTCCAGCCTGGGCAACAGGGTGAGACCCTGTCTCAAAAAAATAAATAAGTAATAAAAAT AAAAAAAATACGTAGGGGTGGACTTGCTGGGTCTTATGGTGACTGCTTAACTTTTTGTGGAATTTCTAGA CTGTTTTCCACAACTGTACACCATTTTGCATCCCCACTAGCAAGGCACGAGGGTTCCAATTTCTCCACAT TTTTGCCAACACTTGTTATTGTCTTTTTTATTATAGCCATTGTAGTGGATGAAAAGTGGCATCCCGGTGT GGTTTTGGGCTCTTGGCATTTTAAATTAATCTGTGAAGTACCTACTGTGTGCTGGGAGCCCTGTAAGATC GTCACATGGAATTGTTAAGGGCCTAGAGTCCTGGCTCTGCCATCTAATTGCTGGGTGACTTTGGGAGAGT TATTTAACCTCTCTGATCCTCAGTTTCCACACCCATAAACGGGGATAATAATACAATTACCTACCATGCT AACACCCAGCTCTCAGGGTTGTCATGAAGATTGAGTCAGAAACAGTGAGGAGCCTGGCACGTAGAGAGTA AGTATTAGCTCATATTACGATGGTGGAGATTGTTATTGGTGTGATTTTCCTAGCATCCCCATGAGTAACT TCTAGCCCAGTCGATCACATGCCTCTGGAGTGAGATTGCTTGCGGGGAGAATCGCGGTTCACCAGCTGTG TGACCCTGAGCAAGTGCTTTGATGTCTCAGAGTCTTGGTTTCTTCATCCCCTTCTTCAAAGGGGCACACC AACCTCCCCGGGGACTTAGGGCAAGGATGATATTGAGCTGGTGCCTGTGAATATGTCTGAGGTCTGGCAA AGCCCACAGCAAGTGGCAAATGCCCAGGATGCCTTTGTGGTCATCGCCAGAGGACAGATGGAGAAGCGGA GGCTGTACGAGGGTAGGGCACTTGCCTGAGGCTGTCTAAGCAGCAAGCAGCCCAGTGGGCCTTGGGCCTG GCCTGTCTGCTCATAGCTTCCTGCTACCGCTCACAGCTTTGTCCCATCAGGAGTCCAAGGTCCCTGAGGC AGTGGTCATTGCCCCACAACTCCCATGTCCTCTGGGGGGCTTCGGCTGGAACAACAGGCCCAGCCAGGAT AGAGTCCAGAAGGTGGCTTTTCTTGCATCTGCCACAATCCATGAAAGGGCTGGTTTGGGAGCTGGCCCTG TGCCTGAGGTGGGACTGGGCCCAAGAGAGACAAAGGCCCCCACTTGAGCCACAGTACAGACCCTAACGAT GCACTGCAGAGTCAGGGGTTAAATATTTGGGGTGAGACTCACCGCCTCTAGGTGCAGCTGGCCTGGCAGA TGGTCAGTGACTGGGGTGGGAGTGTGGGGGCCCAGAAACTCACATTCTCCATGTGGCCTGCCCAACCAGG AAGTGGGGGGTTAGGGAATGAGGGAGGAGTCGGGTGGACCCCTGACCTGGCTGTTCTAGAAGCCCACCTT ATCCCTTCTTACCGAGATCCTCCATCCAAAGCCCCCCACTGCTAAGCCTTCCTGGCCACCCCGCCAAACA CTGGCTTTCTCCACTGCAGGACTTGTCAGTGCCTTTGCTGGCTCATGAACATATCAAGGATGGGGTTTTC CTAAGTGCCTTGACCAAGGAAGAATAAGACTTGTAAGAGTTGGGTTCCTGGGACCCCACTTTGGGACAGG CTGCCCCCAGTTGACCTTGCAGAAGGTATGGCTTGGGTCCTGTTCCCTCAAGATCCCCCAGCTCCGGTGT ATCCAGGTCTGCCACAAAGCTGGCCCTTAAGCAAGGTGTGGAACCTAGACGGATGGATCCCCAGCATGTT GGCTGCTGCCATTTCTGCCCCCAATGCCCCCAACATCAACAGCACCTGCATTGCTGGTCCATGACTCCGG TAGGTGTCCAGGTACCCTGGGGAACCTGCAAAAATAGTAATAATAATACAGCTTCCTGGGCCCAGCTCTG GAGACCTGGGTTCAGCAGGTCTGGGTTAGTGGCCGGGAATCTGAATTTTTCATGCTAGGCCCCAGAACCT TGATCTGGGGAGCATCACTCGAAAGGGCTGGTGGTCCCCTCTGCCTTGACGGTCAAGAACCCCGCCCTGG CCCACCCCACGGGACGTGCCAGGACCTGCCTCTCTCTATGGCGTGTCCTCATTGGAGCCTTCTGCACAGG AACACCAAATTCTTCCTTTTGCTTTAGCACCCAGCCGACACCACCTCCTCCAGGAAGCCTTCAGTGACCA CCGCTGTCCCCACCCAGCCAGTCCAGAGGTTCCCCTGGGCATCCCCAGCCTCCAGGCCTGCCTCAGTCTC GTGACTGTTTCTATAAATACTGATTTCCTCCTGGTCTGTGGGGTGGATCAGGGAGGGAGAGGCTTGTCTT TGTGAGGTGCAGGGCCCGCACACAGCAGGTGCTTAATGAGTGTGAGTAGAAGGCAACTTCTGCGTGCCTA GCCACTCAGGCCCCACTGTGGGTCTTCAGTGGAGACAGGGGAGCTATCATCGCTGGCTAACTGGGTGACA ATGGCCAAGTTGGTTTCCCTTTCTTTCTTTGTTTAAAGAAAACAACAGAAGGAGGCTGGGCATGGTGGCT CACACCTGTAATCCCAGCTACTCAAAAGGCTGAGGCAGCCGAATCACTTGACCCCAAGAAGTGGAGGTTG CAGCGAGCCAAGATGATACCACTGCACTTCCAGCCTGGGTGACAGAGTGAGACTCGGTCTCAAAACCACA GAGGCAGAGCTGGGTGATCTCTAAGGCTCCTTGACAACTAAAATCACAAACCTTTGTTCAGACTTATTCT GTGCCCGGCTCTATGCACAGTCCTTTGGTAGTGTAACCTCACTTCCATTCATAACCCCTGCCACCCTGGC CCCGGGAAAGGACTGTTACTCTAGTCCATCGGATTGGGAGACAGAGGCACAGATAGGCAAGGGAGCTGGG CCAAGTCACACAGCCACTAAGTGGCTGATGGGAGCCAAGATCTGAACCCACAGCTAACCCCAGGGCCAAA GTCTTAACTAACTCCCATTAGAGCATTTTCCAGAGTGGTCTGTCTGTGGTTCTGGGGGACGGGGGGCAGT AGACAAATGTGACAGGAGGGGACACAGAGACAGTGAGGGAGAGGGCCAGTCTGCTTTCAAGACTTTTTTT TCTTTTCTTGTTTTTTTTTTTCGAGATGGAGTCTCGCTCTGTTACCCAGGCTGGAGTGCAGTGGTGCAAT CTCAGCTCACTGCCACCTCCACCTCCCAGGTTCAAGCAGTTCTCCTGCCTCAGCCTCCCGAGTAGCTGGG ACTACAGGCGCATGCCACCACACCTAGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTG GCCAGGCTGGTCTCAAACTCCTGATCTCAGGTGATTCGCCCGCCTTGGCCTCCCAAAGTGCTGGGATTAC AGGTATGAGCCACCACACCGGGCCTCAAGTCTCTTTCAGGCGCTCTGAGAAGATCAGGAGAAAGGCTGGG CCTGACGCCACCACGGCTGTCACACCTCCTGACTTGTAACAGCGGGCAGCCCAGTGTCACCACGGAACCC AGTGCCACTGCGTTCCCATGAAATTTATTTTGGCAGCTAATTCACTCATGGTGAGGGCTTCTGATTTCTG ATTAAAATGGGGAGAGAAGTTACCTTTGTAAACACATTTAACTCTAAAATAAAACGAGTAGGTTGAAAGA AAAATATCAGGTAATTAAAAATAAGACTGCTCACACAAAAGCTTGTTCCCGAACGTTCATAGCAGCGTGA TTCTCACGATGGCCCAAAGGTGGAAACGGCCCAGATGGTTGTCAGCTGTTGAATGAATAAGCAAAATGTG AAGTAGCCACGTGATGGAATATTATTCAGCCATAAAAAGAATGAAGTTCTAATAGATGCTGCAATATGCA CAAAGCTTGAAAACATTATGCTGAGAGAAGGCAGACGCAAAAGGCCACGTGTTGTGTGATTCTATTTATA TGAAATGTCCAGAATAGGCAAATCCATAGAGAGAAAAAGTAAATTCCTGGTTGCCAGGGGCTGGAGCGGG TGGGGAATAGGGAGTGACAGCTTGTGGGTGTGGAGCTTTGGGGTGATAAAAATGTCTGGAATGAGATAGT GGTGATGGTTGCACGATTCTGAATGTGTAGTACTAAAAGCCAGTGACTGTGTATTTTAAACAGGTGAATT TTACGGTATGTGAGTTATCTCCCAATTTTTCAAATATGGTGCGTTTTGCCAACATGGCAAAATAGAAGCA TTAGAAGCTGGGTGTGCTGGTGGTGCCAGTGGTCCCAGCTACTCAGGAGGTGGAGGTAGGAGGATTGCTT GAGCTCAGGAGTTCGAGGCTATAGTGAACTATGATCACGCCACTGCACTCCAGTCTGGGTGACAGAGTGA GACCCTATCTCTCACAAAAAAATATGTAGTCGGGGCCTGGTGGCTGACATCTGTAATCCCAGCACTTTGG GAGTCCAAGGTGGACGAATTGCTTGAGCTCAGGAGTTCGAGACCAGCCTGGGTGACATGGTGAAACCCCT TCTCTACCAAAAGAAATGTAAAAGTTATGCAGGAGTGGTGGCATGTGCCTGTAGTCCCAGCTACTTGGGA GGCTGGGCTAGGAGGATTGCTTGAGCCTGGGAGATAGAGGCTGCAGTGAGCCATGACTGTGCCGCTACAC CCCAGCCTGGGCAAGAGTGTGAGACTCCGTCTCAATAAAATGAATGAATGAATGAATGAATGAACGAATG AATGAATAAAAATAAAAAATAGAAGCATTAGAGAGAATGATCAAAGTGGAGGCTGGGCGGGCGCGGTGGC TCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGATAGGTGGATCACTTGAGGTCAGGAGTTCAAGACC AGCCTGGCCAACATGGTGGAACCCCATCTCCACTAAAAATACAAAAATTAGCCAGGCTTGGTGGTGCATG CTTGTAATCTCAGCTACTGGGGAGGCTGAGGCATGAGAATCATTTGAACCCAGGAAGTGGAGGTTGCAGT AAGCTGAGATCACGCCACTGCACTTTAGCCTGGGTGACAGAGCAAGACTCCATCTCAAAAAAAAAAAAAA AAAAAAAAAGGAGGCTGACCGCCTGCCAGGCGCTGCCTTGTCTCTGTGGCTTTAGTGATGTTGCCCTATG GGAACAGCCCAACTACCTCAAAGGCTCTGTGGGCAGCTCCTGCTCAGAGCGTGGGGCCGGGGCCAGCCAG AGGATGGGGTGCTGGTGGGGACATAGCCCCCACCCACCAGGCACCCCGCCCATCTCCCCTCGGCTTCTGC CCGCAGCATCTCTAACAAGGAGCTCTCGGAGCTGATCGAGCAGCTGCAGAAGAATGCCGACCAGGTGGAG AAGAACATCGTGGACACAGAGGCCAAGATGCAGAGTGTGAGTGCCCCCACTCCCACTCCCACCTGGGTGC CCCGTGCTGCCAGCCCTGTTCAGGACCAGGATCTGTTTGGAATCGGTGATTCTCACCCAGGGGTGATTGT GGCCCCGAGGGAACATGCAGAGACATTTTGGTTGTCACTGCTTGGAAGGAAGGTCCTCCTGGCGTCCAGT TGGGGAGGGGAGACAGGGATGCTGCTGAACACCCTACCGTGCACTGTAGGGCAGGGGTGCCAAGGTCAGG AAGCCCTGCTCTGTGAGAGGAACCTGGCCATTGTCGTTAATACTAGTACCTCCCGGATACTAAGTTCCTC CCTCTTCCTGGGCCCTGTGGAAAGCGTCTCCTGCCTGGAGGAGTGCCATGGGGTCAGGCTCTATGGAAAC AGCCCAGCCTTGTCCTTGCTGGGTGACCTTGGACAAGTGAGCCATCCCACCTCCCCATGAACGAGATTCT CTCTAAGCAGGCAGGAGTGATGGTTCCCATTTGGCGGGGTGGTTGTAAAGATTAAATGAGATTATGCAGG TATAGGACAGGGCTATTATCGTCAATATCATTCTCACTGCTCATCCTACTGCTGCCAGCACTCAGGGTGC AGGTCTTTCTCCACCTTTTTTGGAGAAGAGAGATAAAATAGCTGGGCAAATCACTTTCCCCTATCTGTGC CTCAGTTTCCCTTTCTGTAACATGGGGATAACAACTGCCCAGTGGACTCAACGGCATGAAGCCTCTGTAC CCTGAGGGACTCACGAGCCGCTGGAATGGTCACCTTCTCTTTAAACCTTCCACCAGCGCCAGCCCGGTGC GATTGGGTTGATGCCTGTTTTGTACCCTGGAGCAACTGAGGTTTAGAAGGGGCTGGGATGATGAGTCAGT GACAGAGATGGTGCCAGCATCGGCCTGCAGGTGGAGTTACCAGATTTAGCAAATAAAATATGAGATGCCC AGTTACATTTGAATTTCAGAACACAAATCATGTTTTAGTAGCAGGAAAGCCCATGTGTTATTAGGGAAAG GCTTATGCTAAAACATTATTTATTGTTTATCTGAAAATCAAGTGTAAGTGGTGATCTGTATTTCATCTGG CATCCCTATGCAGGGGCGACTAAGAAGTGGGACCAGGCCAGGTGCGTAATGGCTCACACGGCCGTAATCC CAGTACTTTGGGAGGCCGAGGTGGGTAGATCACTTGAGGTCGGGAGTTTGAGACCAGACTGGCCAATGTG GTGAAACCTCATCTCTACTAAAAATACAACAATTAGCTGGGCGTGGTGGTGCACACCTATAATCCCAGCT ACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCCAAGATCGTGC CACTGCGCTCCAGCCTGGGCAACAGAGTAAGACTGTCTCAAAAAAAAAAAAAAAAAAAAAAGGTGGGACC AGAGGAGTGGGAGGCTGAGGGTGGGGAGGTCAGGAGGGAGGTCAAGGTCTACCCGGCCAAGCTGCTGTCC CCAGGCCCAGCCATAGGTATCCAACCCCCTTGGCTGCTCCTGATGGCCCAGTTGCCCACCCTCTGAAGGC CTGTCCACAGCAGCCAAGAGACCCAAGCGGGTAGGTGGGCTGGGGTGGGCACAGTCCACGGGGGTGTAGG GGGCAGATAAGTGGAGACTCTGTTCTCTGCCACCAGCTATCCCCTGCAGGGGCCCCAGGAGTGGGCCTTG CCCTGGCCTCCTGCCTGGGGCCCCCGCCTCCATGCCCCCCTGGGCCTCCACCTCCTGCCTCCCTGGCCTC TGCCTGGCCACCCCACACCTGTTCCCTCCCATCAGCTCCCCTTGTCATTTGCAGTTACATCCTCTGCCAT CTGAGGCCCCCTGTGGTGGTGGATTTCTTTCCTTCTTAAATGGAAAACATCTTTTGGGGGTGTGTCTCTT TTTTCCTCATAACAAAAATAATATGTGTTCATCACACACATTTCACGATGGATAAACAAGCATAACAAAG TGAATTAAAATCATGAGCCGGGTGCGGTGGCTCGCGCCTGTAATCTCAGCACTTTGGGAGGCCTAGGCAG GCAGATCACCTGAGCCCAGGAGTTTCAGACAAGCCTGAGCAACATGGTGAAACCTCGTCTCTACAAAAAA TATGAAAAATTTGCCAGGTGTGGTGGTGTGTGTGCCTGTAATCCCAGCTCCTTGGGAGGCTGAGGTGGGA GGCTCGCTTAAGCCCGGAAGGTTGAGGCTGCAGTGAGCAGAGATGACACCACTGCACTCCAGCCTGGGCA GCAGAGGGACACCCTGCCTCAATCAATCAATCAATCAATAAAGTCAGTCATGTAGAATTCCACCACCAGA GGTATCTACTGACTATTAACATATTGGTGTATATCTGTTTGACCTTTGTGTATGTGTGTGAGAGAGAGAG AGAGAGAGAGAGAAAGAAGGAAGAGGGTTTAACCTTCTCATTTTATTTCCCTGAAGTATTGACTCAAAAT AGGTAATTTTGAACCATTTTTATTTTATTTTTTTGCAGAGACAGAGGTCCTTGCTATGTTGTCCAGGCTG GTCTTGAACTCCTGGCCTCAAGCCATCCTCCTGCCTCAGCTTCCCAAAGTGCTGGGATTTACAGGCATGA GCCACTGTGTGCTTGGCCTGAACAATTTTTTCTTTCTTTCTTTCTTTTTTTTTTTTTTTTTTTGGAGACA GTCTCTCACTCTGTTGTCCAGGCTGGAGTGCAGTGGTGCTATCTCGGCTCACTGCAACCTCCACCTCCCG GGTTCAAGTGATTCTTCTGCCTCAGCCTCCCAAGTAGCTGGGACCACAGGCAGGCACCACCACGCCCAGC TAATTTATTTATTTATTTATTTTCAGTAGAGATGGGGTTTCATCACATTGGCCAGGCTGGTCTCAAACTC CTGACCTTGTGATCTGCCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACTGCACCCGG CCTATTTTTTTAACTTCAACTGAACCCACTTGAAAAAAGAAGCTAGGCTTTGAAGACTACATGGATCACA CAATCTTTTTCTTATGTTCTTTTTGCTAAAGATACTACTATTTATTTCATTTCCCAGTTCTGTTGAATTT TCCATTTTTTTTAATTGAGGGGAGATTCACATAACATAAAATTAACCATGTAATGTGTACAAGTCAGTGG CATTTCATACATTCACAATGTTACACAACCATCTCCTCGATCTAGTTCCCAAACATTTCCCTTACCCCAG AGCCAAACCCCACACCCTTAACAGTTACTCCCCACCTCCCCTTTCCCCCTGGCAGCAACTAATCTGCTTT CTCTCTGTGGATTTATTTATTCTGGATATTTCACATAAACAGAATCATACACTGCATCACACATTTATTC AAATGCTAAACATGCAGAAAACCGTACAGCGAACACCCATATCCCACCACCTGATCCTACAAGGAACGTC TGCTGAATTGGCTTTATCATGTATCTGTCCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGT GTGTGTGAGATTAGATATATCAGTCCCTATAATTTTTTATTTTTATTTTTTATTGAGACAGGGTCTTGCT CTGTCACCCAGGCTGGAGTGCAGTGGCGCAATCACGACTCACTGAAGCCTCAACCTCCTGGGCTCAAGCA ATCCTCCCACCTCAACCTCCCAAGTAGCTGGGACTACAGGCGCATGCTACTATGCCTGGCTCATTTTTGT ATTTTTTTTTTTTTTTTTTTTTTTTTAGAGATAGGGTCTCACTATATTGCCCGGGCTGGTCTCCAACTCC TGAGCTCAAGCAATCCTCCCGCCTGGGCCTCGCAGAGTGCTGGGATTATAGGCGTGAGCCACTGCACCTG GCCCCTGTGACTTTAAAAAACTTTTTTATCAAGGTATAACTTATATAAACTCTAGAGAAGTGTCTACATT CGCAGACTTCACCTGGGTGAATTTTTGCATCAATAGGTACCCAGATAACCACTGTCTGTGGCAAGATGGG TAACTGTCTAGAAAGCTCCCGGGCCATCTCCCTAGTTGATATCCCTCAGGGGTCAACCCTATGCTGATCT CTCTCACCATCGATCAGTTCTGCCCGACTTTGAACTTTCGAACACTAGCCTCCCTCAGCTAGATGTTCTC TTTCTCTCTCAGCCAGTGTTTTGAGAGAACTTGCATTCCCACCGGGCACCTTCACGAATTAGGCAATGAT TAATGGACTTCCTCCTTTTGCAAAATTAATCTTTGATCTGCAGCTCAGGGAAGCTGGTGATAATGGAGTG AATAAAATTCTACTCCAAGCAGGCCGGGCGCGGTGGCTCACGCCTGTAATCCCAGAACTTTGGGAGGCCG AGGCGGGTGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTA AAAATACAAAAAAATTATCCAGGCATGGTGGTGGGCGCCTGCAGTCCCAGTTACTTGGGAGGCTGAGGCA GGATAATGGTGTGAATCCGGGAGGCAGAGCTTGCAGTGAGCCGAGATCGTGCCACTGCACTCCAGCCTGG GCAACAGAGTGAGACTCCATCTCAAAAATAAAAAAACAAAAAAAATTTAAAAATTCCACTCCAAGTCAAG AAGCTGATGTTTTGTTGTAATTAACGGGCCAGCCTACCCCAGGGTTGGGGGATGCCTGGTTCCATTGGCT TTTTGGATTGGTTGGTTTGAGGTAGGGTCTCGCTCTGTCGCCAAGGCTGGAGTGCAGTGGTGCAATCTTA GCTCATTGCAGCCTTGAACTCCTGGACTCAAATGATTCTCCTGCCCCAGCGTCCTGAGTAGCTAGGACTA TAGGTGCATGCCATCACACCCAGCTACCTTTTAAAAATATTTTTTAATAAATGGGGTCTCACTATATTGC CCAGGCTGGTCTTGCACTCCTGGGCTCAAGCCATCCTCCTGCCACAGCCCCCCAAAGTGTTAAGATTACA GATATGAGCCACTGTGCCTGGCCTCCAGCGGCTTTTCGGGACATCAGCCTCATCTCCAACCCCCTGGGGA GTCAGGCCTGTTCACCCTTCAGCCCTTCCAGACTTAGCCAGGCAAAGGCACTCTTGACACATTTTCTTCC TCCAAGAAGAAGCCAAGTCTTTACTTCGTACCAGGCACCACGTCACCCCTGTGTATTTCTCGTTTTTCTT CCTTTTGCTTTTTCTTTTTAAAAAACAACTGTATGGAGACATATTTCACTTAAAAAAGGCTCCCACTGCA AGTGTACAAGTCAATGATTTTGAGTAACTTTAGCAAGGGGCAGAACCACGCCCATGAATCAGTTTCAGAA TATTTTCATCCCGTGCAAGATCTCTTGTGCCTATTTACTGTTAATGCCTCTTCCCAGCCCTGCCCCAGGC AACCACTTAAGAGACAGTGACTTTCCATCTCTCTGGACTTGCCTGTTCGGGACACTTCACATCAATGGAT CCCACACCATGTGGGCTCTGTCTGGCTTCTTTGCCTTTGAATAACGTCTTCCAGGCTTGTTCAGATGGAG CACGGTCCGTAGTTCCTGCTCTTTGTTGCTAAGTGGTATTTCTCAGTTCACTTCATAAGCGGGTATTTTC CTTATGCCCATTATAGAGATGGGAATGCTGAGACCCAGCTAGGGGAAGGGACCGGCGGCCGGCTCTGAGT GCCCCAGCGTCAGCCAACCTGCACTCATTCCCCTCAGTGACATGTCACTGCCTCCCCTGCGGGACTGGGG ATCCCTCAGGGATTCATCCCCAGGACCTAGCATGGTGTAGACTCACAGCCAGACTTCTTGAATATTGACA CAGTGAATTAACCCGCTGTGATTAGAAACCTACTGTCCCGGCTGCCATTCATTGCTCTTCCCTAAACGAA CAGAAGCCCTGTACTCATCAGCAACCATCGACGGCCCCTTCCAGATATCCCCCCGGCTCTGTTCCTTCTT GCTGGTGCCACCTCGCTGTCACCTGGCTGCTGCCACAGACCACTGCCTGCCCTCCCAGCCCACACCCTTG CTGTCCTCTCTGCAGAGCCCCTGGAGGCATCGCCTTTAAGCACAAATGGAGCTGTGCAGGATCCCTCCTT GCAGCCATTGTGTGTTCTAGCTGCTCACCCTCCCCGCCCCCCGCCTGCCCTGTTTCCTCCCTATCCACAG AGACCTTTTCACTATGGCCCAGTCGTAGCTCGCTCTCTCCTGCCTCAGGACCTTTGCACAGGCTGTTCCT GTGGCTGGAACACTGTCCCTTTCATCCTTTGTTCTTAGCTTGTGTCTCCACCACGAAGAGGCTTCCCTGA CCACCAGAGCTGAAGTAGGTCCCCTCGTTCCACCTCTGGAGCATTTCTTTCATAAACACTGACTTGGAGG GACTTGCAGTCACCTCCATGAGGCTCATCCTTTGACTGGCCTTCCTGGTGGCCTTGCAGACTGGGTTGTG AGTGCCAGGCAGGGAGGCCATGTCTCTTCTGTTCACAGCTGTGTCCCAACTCCTTGCATACAGTAGGTAC TTGAGCTCTGTTTGCTGAGTGGCTGGAGGACAGGCTGGAGGGGGCATAAGAGAAATACCTGCTTTGCAAA GTGAACTTGAGAAATACCACGTAGCAGCAAAGAGATGGAACTACCGACTGCGCTCCATATGGACAAGCCT GGAAGACGTTATTCAAAGGGAAAGAAGGGGAGCACCCTGCTGACCCCTTTCCTCCCACCCCTCCCATTGC CACCGTGCCCGCTCTCGGCTCCTGTTCATTGTCCCCTCTCTTGTGACCCTCACAGGACCTGGCTCGGCTG CAGGAGGGTCGGCAGCCTGAGCACCGGGACGTGACCCTGCAGAAGGTGTTGGACTCTGAGAAGCTGCTCT ATGTGCTAGAGGCGGATGCGGCCATTGCCAAGCACATGAAGCACCCACAGGGGGACATGATCGCCGAGGA GTAGGTCCCTTCTGCTTCTTACCCCAGGGGAGCCATTGGGGGCTATGGGCCAGGGCGGGGGGTCCTGTTC AGCATTTGGGAGCCCGAGTCAGGGGTTATCAAGGGCTAATTAGGTGCCAGGCACGTGCCAAAGGCTTCAC ATGATCCTTTCTTTTTTTTTTTTTTGAGACGTAGTTTTGCTCTTGTTGCCCAGGCTGGAGTGCAATGGCA TGATCTTGGCTCAGCGCAATCTCTGCCTCCCCAGTTCAAGCTATTCTCATGCCTCAGCCTCCCAAGTAGC TGGAATTACAGGCATGCACCACCATGCCCGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCTCCAT GTTGGCCAGGCTGGTCTCAAACTCCAGACCTTAGGTGATCCGCCTGCCTCGACCTCCCAAAGTGCTGGGA TTACACAAAGTGCTGGGATTACACATGTGAGCCACCGCGCCCAGCCTCACATGATCCTCTTGATGACCCT ATTTTGCAGTTGGGGAAATGGAGGCTTAGGGAGTTGATATCCCTTGTTCTGGAGCCACCAGCCTGACCTG TGAGCTTTTGAGCGAGCTCTTCCGCTGCCTGGTGCCCTGTCCCTGGCTTCCTTGGCTCACGACTCCCAGT TCATTTTATCGTGGATGAATCAGCCCCCCTGACTCCTGCCTTGTCCCATGCCCTATCTCCACCCCGGCAA GGGCAGGGCTCTCTCGGTGCCCCACGACCCTTGGCACTTGTCCTTGGCATGGCATGCACCACACTGTGGG CCCTGCTGGATGGCAGACTCCAGAAAACAAGATCTTTCCTGCTTATTCCAGAACTTTCTATCATTCTGGC ACATAGTAGGCCCTCAGGAAACTGATGGGGGAAGGAAGGTTGAGGGAAAGTGGGTGGGGCCAGGCACGGT GGCTCACGCCTGTGATCCCAGCACTTCGGGAGGCCGAAGCGGACGGATCACCTGAGGTCAGGAGTTCGAG ACCAGCCTGACCAACATGGTGAAACCCCGTCTCTACTGAAAATACAAAATTACCCAGGCGAGGTGGCACA TGCCTGTAATCCCAGCTACTCGGGAGGTTGAGGCAGGAGAATTGCTTGAACCTGGGAGGCGGAGGCTGCC ATGAGCTGAGATGACGTCACTGTACTCCAGCCTGGGTGACAGAGCAAGACTCTGTCTCAAAAAAAAAAAA AAAGTGCATGGGAGGAGGGGTGAGAGGATGCTGTGATTGTCTGGAACCCAAGGCCATATGGTCACTGTGT CCTTCCAGGACACTGAGGCCGGGGTCTGGGTGGGGGGCCCCTCCTGGGGTGCAGGCAGTGCCAACCAGCC CCACTAAGTGGGAGCCTCTCTCCCATCAGTATCCGCCAGCTGAAGGAGCGTGTGACCAACCTGCGCGGGA AACACAAGCAGATCTACAGGCTGGCGGTGAAGGAAGTGGATCCACAGGTCAACTGGGCGGCACTGGTGGA GGAGAAGCTGGTATGGCCTGGACGGGGCCGCTGGCTCCAGGGTTTCAGCTGGGGAGGGGGCTGTGCGTGT GCAGGGAGAGCCTACCCATGTAATGGGCATCCCGGGTCTTACCAGGGAGACAGTCGTGGTCCTGATGGTT TTCCAGTGTGCCCATGAGAAGAGTGAGGCTCAGAGAAGTGCAGCACGAAGTCAGGGTCACACAGCTCAAG CGGTGGAGATTCGGACTCTGTCCCCTGTCAGCCACACCTCGCTGCTGCTCCTGGGTCCCACTTTCCAACC CTGGCATGTTGGGGTCTTGGTGACATTTTGTGGGCAGGCTGGGGCGGAAGCGGCCAGGCTTCTGGCCTGT CGCTCCCTTTCCTGGGTGCTCACCACAGAGAAGCACACAGCCACTGCAGCTAGGTGTCCCGGGTTCAAGC CTTAGCTTCCCCAGTTTTATTTATTTATTTATTTATTTATTTATTTATTTATTTTTGAGACAAGGTCTCA CTCTGTCGCGCAGACTAGAGTGCAGTGGCATGATCATGGCTCACTGCAGCGTCAACTTCCCAGGCTTAGG TGATCCTCCCACCTCAGCCTCCCAAGTAGCTGGAATTACAGGTGCACGCCATCATACCTGGCTAATATTT TGTATTTTTATAGAGACGGGGCTTTGCCACATTGGCCAGGCTGGTCTCAAACTCCTGAGCTTCCCCAGTT TTATTATTTATTTATTTATTTATTTTTGACACAAGGTCTCACTCTGTCTCCCAGGCTGGAATGCAGTGGC ATGATCACGGCTCACTGCAGCCTCAACTTCCCAGGCTTAGGTGATCCTCCCACCTCAGCCTCTCAAGTAG CTGGGATTACAGGTGCATGCCACCACACCTGGCTAATTTTTTGTATTTTTGTAGAGATGGGGCTTTGCTA CATTGGCCAGGCTGGTCTCAAACTCCTGGGCTCAAGCGATCCGACCCCATTGGCCTCCCAAAGTGCCTGG ATGACAGGCATCAGTCACCATGCCTGGCCAGCTTTCCCAATGTTACTGGCGTGACCCTGGGCAGGTGACT GGCCCTCATTCAGCCTCAGCCTCTGTGTCCTCATCTGAGAGATGGGACAGTAACCATGTGGACCCCTGAG GCTCTGTGAGATGAAAGATGATATAGGTCAGTGCTCAGCAAACAGAACCTCAGGGTTGAAGGTGTGGCCA GCATCTCCTTGTGGCTCTGCAGGGCCCCGTGAAAAAGAGAGCACCATCATGCCCACCCCCGAGGCTCCTG GGGTGGCCACACGTCCCCAGCCCTCAGCCCACCCTCTCCTTATTGCTTCTCTGCCCTCCTGGCCAGGACA AGCTGAACAACCAGAGCTTTGGGACTGACCTGCCGCTGGTGGACCACCAAGTGGAGGAGCATAACATCTT CCACAATGAGGTCAAGGCCATCGGGCCCCACCTGGCCAAGGACGGGGACAAGGTGGGGCGTGTGCTGGTG TGGTGGGGACCCAGGGATGGAGGGGGCCGCGCCTGCTTCCTGGCCCTGACCCATGCCCTCGGCTCTGTCC TCAGGAGCAGAACAGCGAACTCCGGGCCAAGTACCAGAAACTGCTGGTGAGGAGCTCCCTGGGGGAAAGG CCTCATGGGGAGAGGAGAGGATGGGAAGCTTGGAGTCGGGGGGACAAGGATGTATTGTTTTAAAAATGAC ATAGGCAGCTGGGCATGGTGGCTCACGCCTAGCACTTTGGGAGGCAGAGGCAGGAGGATCACTTGAGCCC ACGAGTTTGAGACCAACCTGGGCAACATAGTGAGACTCCAGCTCTACAAAACATTTAAAAATTAGCTGGG CTTGGTGGCATGCCTGTGGTCCCAGCTACTTGGGAGGCTGAAGTGGGAGGATCGCTTGAGCCCAGGAGGT GGAGGCTGCAATGAGCTGTGATCGTGCCACTCCACTCCAGCCTGGGAAACAGAGCAAAACCCTGCCTTTA AAAAAAAAAAAAAAAAAAAAAGGCGTGCAGTAAACGTTTCAATCAGGAGAGGGGTTGAGGCGGGAAGAGA GGTGCCCCAGCCTTTTCCTGAGCGGCTGCAAGGTCTGCCCTGGTTGTTCAGGGAAAACCCTAACAGGCCC CAGGGGTACAGCCTGTCCTGCTCATTTCTTTATTATCTGCTGTGTGCCAAGTATGATGCCACTTGCTTTC TATACAAAAGCTTTCCATTTTCCTTCCCAAACCTTTAAAGAATGCATTCTTTTAAAAATTGCATAAGTGT TATGCAAACGCTTCCTTGTTGCCAATGTTTCAGACAGAGAATACAGAGGCAGCATTGTGTCGCTATAAGG AGCCATGCTTCCTCTGCTCCTTAGTGTTAGTGGTGACACCTTGAGCGAGTTACTTAGCCTCCGGGAGCCT CAGTTTCCTCATCTGAGAAATGGAGCTCCTACATGTTCCTGTCTCATAGGGTCGCTTTGAGGATGAAATG AGTCAATGTTGCAGAAGTTCATCAGGCGTGGAGGGCCCCACGTACCAAAATGCAAACATCCCTCCTTTCC CTTGCACACCCGCTTCTCAGACGTACAGTGGTGCTTTCCTTCCAGCCCTCTATAAGACGATCATGATACA GATAAAAGTAGAAGCTATAGTTACTGATATTTGTTGAGCACCAACTATATGCCAGTCTCTGTACGCTGTG AGGTCAGGACTGTCATCTTCCCCATTTACAGATGGGCGAACTAAGCCTTCACAAAAATGTCAGTTCCGTA AGGGTTTTGTGTGTTTCGTTTGCTGTATCCCCAGTGTCTGGAGCCATGTCCAGCATGTAGTAGATGCTCA GTAAACATTTACTGAATGAATGAATGAATGAATGAATGAGTTTCAGGGGTTCAGGTGACTTGTCTAAGGG GGACTGGCCTGGACGTGGCTAAGCTGGGCTTGTCCTCAGGCCACCCATAGCTGGGCTTGTCCTCAGGCCA GCCATAGCTGGGCCCTGCAGGAGGTAGGGAAGGAAGCGAGCAGTGGCAGCGGGCTGAGGACGCAGCCCTT TCCTTGCCCCGGCCCCTTCAGGCAGCATCACAGGCCCGGCAGCAGCACCTGAGTTCGCTGCAGGACTACA TGCAGCGCTGCACCAATGAGCTGTACTGGCTGGACCAGCAGGCCAAGGGCCGCATGCAGTACGACTGGAG TGACCGCAACCTCGACTACCCCAGCCGCCGGCGCCAGTATGAGGTGGGTTCTGGGGGCCTGGGGCATCAG GGAGGAGGCAGCCCTGGAAGGAGCACGGGACCGCCAGGCTGGGCACTGAGGCCCCTCCACTGCCCCCCAC TGCAGAATTTCATCAACCGGAACCTGGAGGCCAAAGAGGAGAGAATCAACAAACTGCACAGCGAGGGCGA CCAGCTGCTGGCGGCCGAGCACCCCGGGAGGAACTCCATTGAGGTTCATGCACCCCGAGACCAGACACCT CCCCCAGGGTGGCTTCTGGTTGGCCGCTGCCTGTGGGCCGCCTGGAGCTCGGGCAGACCCCGGAGCTGGG GGTCCTGCAAGCTGCATCTTGTGTCTGTCTGTCTCTTTCTTGCTGTGTCTGACTCTGCCTCCTCCATTTA TCCTGATCCGTTGACACTTCTGCCCTCAGCCCCTGGACTTCTGAAGCCCCTGTGGGGTCTGTATTAGTTT CCTAGAGTTGCTGCAACAAGTTAAAACAAACTTAGTGGCTTTAAACAACAGAAATTCATTCTCTCAGAGG TCTGTGGGCTGTAAGTCTGAAATCAAGGTGTCTTAGGGCCTCATTCCCTCTGGAAGCTCCAGGACATGTG CCTTCCTTGCTCTTCCGGCTTCTGGGGGTTGCCAACAGCCCTTGGCTTGTGGCTGCATCATTCCAGTCCC TTCCTCCGTCTTCACATGGCCTTCTCTCCCCATGTCTCTCTGTATCCTCTCTTCTTATAAGGATATCAGT CAGTGGATTTAGGGCTCACCCTAATTTCAGGATCCTTAACTAATGACATCTGCAAAGATCTTATTCCCAA ATAAGGTCGCATTCTTCCCAACCCCCACAATGCCACCAACCCCGCCTGAGATGGAGTTTCGCTGTTGTTG CCCAGGCTGGAGTGCGATGGTGTAATCTTGGCTCACTGCAACCTCCACCTCCCGGGTTCAAGCAATTCTC CTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCGCACACCATCATGCCCAGCTAATTTTTGTATTTTT AGTAGAGACAGGGTCTCATCATGTGGGCCAGGCTAGTCTCAAACTCCTGACCTCAGGTGATCCACCCGCC TCGGCCTCCCAAAGTGCTGCGATTACAGGTGTGAGCCACCATGCCTGGCCAGGGTCATGGATTTGGTGGG ACACTGTTCGGTCCATGACAGTGCCTTTGTACAGATTTGCCGAAGGCACCACAGCCCCCACTTGCCCTTT GTGCACTGCACAGCCTGGGCATCCGTATGTGGCATCCCTGTTTGGCTCCTTGACGTGACCCCTCTCTCCT CCTCCCACTCCTGAGCAGAAGCTGGCTACCCCTGTGGTAGCCACACCCAGACAGATGCCAGATGCCTCCC TCCCCCGCCATGCCCCAGCCCAATATCCCAGCAGTCCCTCCCTTGGTGTCTGCAGTACCTGCCCAGTGGT GACCGGCCCCTTCTCTTCCTGGCAGGCGCACATGGAGGCTGTGCACGCAGACTGGAAGGAGTACCTGAAC CTGCTCATCTGCGAGGAGAGCCACCTCAAGTACATGGAGGACTACCACCAGGTACTTACCTTTCCTGGGA GTCCCCCCAGCACCGGGGGTGCTACTCTCTGAGAGCGCTCAGTGCCTACCTGGCTCATGTGTGGCCTCGT GCTCCTTGGTCCAGGAGCCTTGCGGGGCAGCCATCCCAGGCCCCCAGCACCCATGCTTCTGATGGCGTGT GCAGACATGTCCCAAGCTTGCCGGCCCCTGTCCAACTTCCCTGGGGACCAGGGCCAGAGTCTGATTCCCC AGGTCACATGGGGCCCAGGGTGAGTGTGTAGGGTTTTAATTTTGGTAAAATCTATAATATACATGCAGAT ACATAAAACAAAATTTGCCTTTTTTTTTTTTTTTTTTTTTTTTGAGAGAGTCTTGCCCTGTCACCCAGGC TGGAGTGCAGTCGTGCCATCTCGGCTCACTACAACCTCCACCTCCTGGGTTCAAGTGATTCTCCTGCCTC AGCCTCCTGAACAGCTGGGATTACAAGTGCCCACCACCACACCCAGCTAATTTTTGTATTTTCAGTAAAG ATGGGGTTTCGCCATGTTGGTCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCTCCCGCCTCGGCCT CCTAAAGTGTTGGGATTACAGGTGTGAGCCACCACACCCGGCCAGTTTGCATTTTTAAGTGTACAATTCA GTGGCATTCATTGCATTCGCAATGTTATGCAACCATCACCACCATCTACTTGCAAAACTTTCCATCACCC CAAACAGAAACCCTATACCCTGGCTGGGCACGGTAGCTCATGTCTGTAATTCCAGCACTCTGGGAAGCCG AGGCGACTGGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGATGAAACCCCATCTCTAC TAAAATACAAAAGTTAGCCAGGTGTGGTGGCCCATATCTGTAGTCCCAGATGGGAGGCTGAGGCAGGAGA ACTGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCTGAGATCGCGCCATTGCACTCCAGCCTGGGCGAC AGAGTGAGTCTCCGCCTCAAAAAAAAAAAAAAAAAACAACCCCGTACTCATTAGGCAGTAAGTTTTCCAT TCCCACTCCCCCAGCCCCAGGTCACCTTTGGTCTTCTTGCTGTCTCTATGGACTTGCCTGTTCCAGAAGT GTCACACCTAGAACGAATATGAAGAATCAGTGGGATCATGCAATCTCTGCCCTTTTGTGTCTGGCTTCTC TCACTGAGCATCATGTTTTCCGGGTTCATCCGTGTTGTAGCATTTTCAGTGCTTCACCCCTTTTTATGGC TGAATCATATCCTATTGTATGGCTAGACCACTGTGTTTATCCACTCATCTGTGGCTGGACACTTGTCTGT TTCCAGAGGAATGAGAGTTCTTAAGAAGCTGCGGGTAATTCTTAGGATTGAGGTGTCTGGGGAAAGCTGG ATGTGGGCGACGCCGTGTCACTCCTCATTCCCTGTCTGAGCCGCACAGTGGGGGCTTCAGGTCCTGTTTA TGGCTGCAGCCCAGGTGCTCAGCCCAGGGGATAGCTGACAGTGAACCAAGAGTTGATAGACTGAAGAATG GGCAAGAGAATTTTCGAGAACAAAAAGGGGAGGCTATTATCAAAACCTAGAAAGAAGCTATAGTATTAAG TCTGGATGTTCCTAGTACAGAGAGAGGAACTGAATCAAAGACACCTCAAGACTTACTGATACATCCAAGA AAACATGTCACAGAGGTGGCATCTCATGGATGGGTGGGAAGGGACCTGGCTTTTCCCAGTGAGGCCCCTA AGGAGCCAGCTCAGGGAGGGTGGGGCTGTCTCCACGCAGAGGAGCCTCAGGCTCAGCACAGGGTCCCATG CTGGACTCCAGGTGAACCGGAGGCCCAGCCCCGCCTGAGGGATGAGCTTGAAGCCTCCGACAGAAGCCCA GGTGCTTCTAGTGGTTTCCTGGCTGTAACAGAGCCACCTTCTCCCCTAGTTTCACGAAGACGTGAAGGAC GCTCAGGAGCTGCTGCGCAAGGTGGACTCGGACCTGAACCAGAAGTATGGCCCTGACTTCAAGGACCGGT ACCAGATTGAGCTGCTGCTGCGGGAGCTGGATGTGAGCGATGGCCCAGGACCCCTGCTGGCCCGGGGGGC GGGGGACCCCTCTACACCATGCCTGCCCTCAGCCCTGTACAGGCCCCTCCACAGCACCCCACCTGCTGAA TCCAGCCCCTGCTCTGCGTCCTCCCACCAGGGGGAAGGCTGTTGGTCTCACCTGGGCCCCTGACCCCGTT CTCTCCAGGACCAGGAGAAGGTGCTGGACAAGTATGAGGACGTGGTGCAGGGGCTGCAGAAGCGAGGCCA GCAGGTGGTGCCCCTCAAGTACCGCCGGGAGACTCCGCTCAAGCCCATCCCCGTGGAGGCACTCTGTGAC TTTGAGGGGGAGCAGGTGCGTGGGGCCAGCTCCTCTGTTCACATCACTACAAAGTTTTTGGGGTAACATG GTTGGATCCCGGGCCTCAGGCGCCGTTCTCAGGAGCCTGTGCCTGTCTCCGTGGTTGGTGTCACTCTGCC AACCCTTCCCCTGGTGCAGGCCAACTGGCACCCCTATGCCGCCCCCACCTCGGCTGCCCTGGCCTTGTGT TCCACCAGCTTAGCAACCCCAGTCCCTCCTCAGAAGTCCCAGGCCAGGTTCTCATTGGCTCACTGTGAGT CACGTGTCCATCCTACACCAATCACTGTGGCCAGGGAATGCCAGGGTCCACCCTATACCAATGACTGTGG CTGGCGAATGCCAGTCATTGGCCAGGTCCAAGTCACATGTCCATCTGGAGCTTGGGAATGGAGAAGGAGA GACCACAGGGACTGGGAATTGGGAGGGAAGGTTCCCCAAAGGGAAATGGAGGTGGGTTGCTGGGCCGGCA GCCTCAACACATGTGCTTCTCCTGCATGCCCCTCCCCACTCTACGGGGAGGGTCCAAGTGATGAGCCGGG GCTCCCCAGGTCCAAGAGTCGGGGGCTGAGATGGCAACCGGGCTCCCAGGCCCTCAGGCCCTGCCGGGAT CCTGACTGTCCAGCCTGCCCCCGCCAGGGCCTGATCTCGCGGGGCTACAGCTACACCCTGCAGAAGAACA ACGGGGAGAGCTGGGAGCTCATGGACAGCGCTGGGAACAAGCTGATTGCTCCGGCCGTGTGTTTTGTGAT CCCCCCCACAGACCCTGAGGCCCTGGCTCTGGCTGACAGGTACAAGGGCAAAGGCGGGAGTCTGCATGGA CCAGTCCCACCCCCAGGGCTTCTCAGGCCCCATTCATAGCCCCGGGGATTTGGACTCAGCCTGTGGGGAG CGCGGGGTCGCTGACACTCTCCATCTGCACCCCCTTGGAAGTTCATGCAGGAGAGGGGCAGATTGTGGGC CAGCTGACTTGCTAAACATGAATGTCTAGCTCTGGGCTTCGTCCTGGCCCCCTCACGAGTTTCTAAGCAG TTTCTAAGGGCCCCTGACTCCCGCACGCACTGCTCCCTGTACTTGCAGACCCCAGCCCCTTGGCTGGAGG ACTCAGCTGGGATAAGGGCTGCCTCCTCTTTGCTCCCAGGCACCTTCTTCCACTGCACGCACCGCTTTTT ATTAAGTGACTAGCGTATGCGTCAGTCTCATTGGGCCTGGGCTCCTTGAATTTCCTCTCTCCAGGGCCTA GTTAAGTACCTGGTACAAAGTAGGTGCCCAGGAACTCCTTGCTGAATGAGTGGATCATTCAAGGAATGCC TTCATTTATTAAGTATTTATTGAGCACCTACTGTGTATGCTCCCTCAGAAGTAACATCTTGGTGGTGATT ATTGGACAGACAATTTTAGGTAGTGAGACTTCCTACGAAAGAGGAGGGAAGGAGGGAGAAGAGCTCTGAG CCCAGGAGCACAGAAAGGCCAGTGCCACAGTGAGCACTTGCTGTCCGCATCTAAGGAGCTGTCAGGCTCC TCTGGGGTGTCTGCCCAGCCAGAGTCCGCAGTCCCGCCTCTGTGGGTGCAGGGGGTGGTGGGCTGCCCAG GTTCCCAGCTCATTTCTGTCCTCACAGCCTGGGCAGCCAGTACCGGAGCGTGCGGCAGAAGGCAGCTGGG AGCAAACGCACGCTGCAGCAGCGGTATGAGGTGCTGAAGACCGAGAATCCCGGAGGTGGGTGCCAGGGCC ACTCGCCTGAGGCTCTGGGGGTACCGGGGAGGAGGGGCTGGACCAGGGTCTGTGCTGTGGATGAGACGGC GGGGGGCTGGCTGCCTAGGTCCATCCCTGGGCCTCACACCCCTGGCCCGTTGTCACACCTGCCTGTGTCC TCCCTCCCTCCACAGATGCCTCTGACCTACAGGGGCGGCAGCTGCTGGCTGGCTTGGACAAGGTGGCCAG CGACCTGGACCGGCAGGAGAAGGCCATCACAGGGATCCTGCGGCCACCACTGGAGCAAGGCCGGGCTGTG CAGGACAGTGCCGAGCGGGCCAAGGACCTCAAGGTACCTGCGGGTCAGGAGCACAGGTGGGGCCGGGGGA GCCCTGCACTGGCCCCCTGGGGCCCCTATTTGAGGTCTTTTCCCCATGGAGTCTTGGGATATTCACTGCA GCTGTCTGTCAGGGACAGCCTGCTGCATGTAAAAGGGTCCCAAGTCATGGAGGTGGCAGGGCTGCTGTCA TTACCTCCCCAGGAGAAAGAGCTGGCAGGACTTGCATTGTTCCTGCACGGCTTGTCGATCTGACGCCTGG CATGGCACATGGGCTGTGGAATTCCGCAGGACTGGGTCACCGGCTGGCTTGACTGCAAACACGTTAGCGT TTGTATTTATAAACTCCAGGCCTCAGTGTCTTCAGTAGGATGGGTTGGCCCTGCTCACAGGGCAGTGGCG AGGACAGGGTGAGCTGATGCCAGGGGGGACGTGGAGGGGCCACCTCCCCCCACCTCCTTTCCTATACAAA GTCTCCCACATCCTCAAGGCAGCCCTCTGAGGCAGTGAGTAGCACTCCAATTTTACAGAAGAGGATCTGG GATTGGAGAAGTGCCATAGCCCCTGATGGGGCCTCAGAGTGAGAGCCAAGTCAGGGCGAGAGGATGCCGG TCTCGGGTGTAGCCTGACCCCACAAGTCCCTTCCTAAGCTGCTGGGAGTCGTCACACCCCCACCCGTGAC TGGGTGGAGTCGTAGTACTCACCTCCCGGGGTTGCCGCAAAGATTAAACAGAAGCGTCCGCGTGCAGTGC TGAGGACAGCACAGGCCCGGCAGCTGCCTGGGTGCTTCTGGTGTCACTAGTCCATTCCACCTCAGCGGTT CCCTGGGATGCTCGTGAAAAATACAGCCCTCAGGCTGGGGTCCAGATGCCGGGTCAGAGCCCCAGAATGT GCCAGGCCTCTCCAGCTGCTTCCACTGTGCCTGATGTGGGAATCTGTGCTCACCCTGGGCACATCCTCAG GGGAAGGGGCTGCCTGGCTGTGTCCAAAACTGAGGGGCCCTGGTTCCCACAGAACATCACCAACGAGCTA CTGCGGATTGAACCTGAGAAGACGCGGAGCACGGCTGAGGGCGAAGCCTTCATCCAGGCCCTCCCAGGCA GTGGCACCACACCCCTGCTGAGGACCCGGGTGGAGGACACCAACCGGAAATACGAGCACCTCCTGCAGCT GCTGGACTTGGCCCAGGAGAAGTGGGTGGCAGACAGGCAGCATGGAGGTTGGGGTGGGGTCAGGGGGCCA GGTGGGCATCCCCCGACGCCTGATTGGTGCTCTCAGGGTTGATGTGGCCAACCGCCTGGAGAAGAGCCTG CAGCAGAGCTGGGAGTTGCTGGCCACACACGAGAACCATCTGAATCAGGATGACACAGTGCCTGAGAGCA GCCGTGTCCTGGACAGCAAGGGGCAGGAGCTGGCGGTGAGTCTAGGGCCCAAGTCCTGGGAGTCCTTCTC TGAGCAGGTGAGAGCATCTGGCACATCCACCCGCCCGTCTGGATAGATGAGGACACCAGCATCCAGTCTC CCCAGGTTTGGAATGCCCAAATTGGGAACTGCAAATGGAGGCCCACAGCACAAATCCAAGCTATTCACGG GATCTGTGTGACTTACGGGATTTCGGGTGCCAGCATTTTAAGATCAAATATCTGCAATAGCCAGTGTAGT GGCACATGCCTGTAACACCAGCCATTCAGGAGGCTGGGGCAGGATTGCTTGAGCCTTGGAGTTTAAGTCC AGCCGCCTGGACAACGTTGCAAGACCCTATCTCTTAAAAAAAAAAAAAAAAAAAAAAAAGCATAAAGCAC ATAACAATCCATGTTCCCAGTATCTCTTGCTGAGCAGAGCTGGCATCCTGGGCTGCAGCTCAGAGGGCAA GTCAGTGGGCAGAGGAGCAGCTGCCTTCTCGGCCTGCTTACCTCGCAGTTGCCACGGGCCCCCTTCCCAC ACTGCCTGAGCACAGGAAACATTCAAGTCTGTGACCTGAGGCCCCTTATTCACACTCCCATCTCACGACT TGCTTTTGCCACAGCCTCATGACCAGACAGTGGCAGGCTGTTCTCGCGCAGGGCACGAGCTGCCTGCTGC AGGGTTTTTAGAAGTTAGCTTTTCAGGGCTTTGTTCATTGTTAAAAAACAGAAGATGGCAGAAGTGACCC AGGTTTGGGATGTACAGAGCAAGGCTCCGGTCCTTCCTACCTGTGGCCTTGCCCACCCTCCTACAGTCAG TGGCCCAGGGGCTTCAGTGGGTGTCATCGCCTGGCTCTGGGAGCTCTGGCCGTAGCACCGCCGTCTCCTC CTCTGCCCCGCCAGGCCATGGCCTGTGAGTTACAGGCCCAGAAGTCCCTCCTGGGTGAGGTGGAGCAGAA CTTGCAGGCGGCCAAGCAGTGCTCGAGCACACTGGCCAGCCGCTTCCAGGAGCACTGTCCGGACCTGGAG CGCCAGGAGGCCGAGGTGCACAAGCTGGGCCAGCGTTTCAACAACCTGCGCCAGCAGGTGGAACGCAGGT GAGGGTGCGGTGGGTGGTGGCCATTTTTGTTTTCTGAGAATGCGATCTAATTCCCTCTAAGCAATGCTTT AGCCGTGTCCCACAGATTTTGCTGTTTTTCTTTTTGGTGAGTTCGTCAGATTCTCTGACGGCCCTGTGGT CTCTCTTTTGAGTCATGCTTACCTGGGTCCTGTAATCCACAATGGGCATCTCTGCAAGTCAATGTATATG GACCCACCTGGTTCTCCACAGTCCAACCTGACGTTCCCTAATGACCACCCACCCTGTGTGGGAGATACTT GGGGTATTTCTGGTTGTTACATTTGGTTGTTTCCCACTTTAAAAAAAAAAATGAGGGCTCGGTGAGGCAT CTGTTTGCTGTGGCTGAGGCCTGAACGCTTTGCCTTGACAGGGCGCAGAGCCTACAGAGCGCCAAGGCAG CCTACGAGCACTTCCACCGCGGCCATGACCACGTGCTGCAGTTCCTAGTCAGCATCCCCAGTTACGAGCC CCAGGAGACAGACAGCCTCAGCCAGATGGAGACCAAGCTGAAGAACCAGAAGGTGAGATGGCCGTTTCCG CAGCCCCAGGCACACACTGGCAAGGGAGGGTCAGAGGTCAACAAGCCCCTTTCTGGGGAGCCAAGCCTTT GGGAGGTGGAGCAGGGCAGAGGCCTGCCACAGCTGTGTCCTCCCTGGGCCTCAGCTCAAGCTCCCAACAC CCAACCCTCTGAGAACAAGAACCGAGTGTGTCGCTCACCTCTCCCAGCTCAGTGCCCCGCACAGGGCCTG GTGCAGAATGGACACTTGGCGTGGGTTGGCTATGTGAGTGAACAGCTACAGAATGAGGAGCCGCCTTTGT GGGGGAAATCCCATTTTCAAAGTTGGGACTCCTGCCTCCCCCATGCCCAACGCAGTGCCTTGGGGTGAGG GAGGAACACGGGAAGCCAATGGCTGAGATGCAAATCCCGGGTCCACCCCATCAGCCACATCCCCACCTCA GAAGCTTTCCTCACTCATAAGCTGGAGGTCACGATGCTTACCTCCTGGCATCGTTTGAAGATTAAATGAG ATAATCTAAGTCAGACAGCAGAACAGTGTCTGGTGGTCCAAATCATCAGTAAACATTTGTTTCCTAGCAG AGATAATGATCTTGGCCCTTCTTCACAGAGCCTTAGAACTGCCTTTTGTGGCTGGGCGCGGTGGCTCACA CCTGTAATCCCGGCATTTTGGGAGGCTGAGGCAGGAGGATCACAAGTTCAGGAGTTCAAGACCAGCCTGG CCAACATAATGAAACCAAATCTCTACTAAAAATACAAAAAAAAATTAGCTGGGTATGGTGGCAGGAGCCT GTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATTGCTTGAACCCAGGAGGCTAAGGCTGCAGTGAG CTGAGATCGCGCCACTGTACTCCAGCCTGGGCGATGCAGTGAGACTGTCTCAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAACAACAACAACAAAAAAACTGCCTTTTGCAATGAATAAAAATGTATACAAGGGAGCC ATTCATCATACTTTGTGCTAGAGAAGAATAAATTCAGATTCTGAGATTTCCAGCTACTGCATCCATGGTT GCTTTTTTAAATTTTTTTTCTGGTTAGTTTTGATTTTTAAACTCTGTCTTACAGAACCTGCTAGATGAGA TAGCAAGTAGGGAGCAGGAAGTACAGAAGATCTGTGCCAATTCCCAGCAGTACCAGCAAGCTGTAAAGGT GAGCCGGGAAACTTCCGCCCAAAGCACAAACAGCAGGGGTCTTATTCCACCGTGCCCTGGTCAGAGAAGC AGCAAGCACCGGCCCTGGCACATGGGGGTGGAGCTGGCCATCCGAGGCACTGCCGGCTGCTGTGCAAACT GGCACAGGCTTTTGGGAAAACAGCATGGTACTAGACATGGAATGCTGTAAAAGGGTTTTATACTCTGAAG CAGTAAACACTTTGGGGGAATTTATCCTTAAGGAAAAAGTACAAAAAAAAAAATGCAGGATAAACAACAT TGTTGCAACAGCACTATTTACAATAGCAAAACTAGTACGCTGGAAAGGACTGGTGTCCAGTGGAAGGGGA AAGCTGCGTGAATCAGCACACATCCACCTGATGGATTATAAAGTCAGCAAGCTGGTAAACATGAGAAGAG GTGGTGGCAAGGTGAGACAGGGTTATGGTACGATGTTAAAAGCAGCAGCAGAATGTGAAAATCTCTAGGC ATGTAGAAAGGCTGGGAGGGGAATTCAGGGGGCACTTCTTGTCTCATATGTTACTGAGTGATGGAGCTAT GTACTGCTGAGATATCAGTAATTCTCAAAACCTCCTGGAAATCACTGCAGGGTGCAGCTGTGAGGAAGAC CCACGCAGATTATAAAACCAGCACATGGCACAGGGCAGGTCTGGGTCAGCCTGAAGGGGTACAGGAACAT GTCTGTCTCTTCTCAGCTGTTTTAATCTCCCCTCTGCCATGTCTCTCCCTCATGCAGGACTATGAGTTAG AAGCAGAAAAACTAAGGTCTCTTCTCGACTTGGAGAATGGAAGGAGAAGCCACGTGAGCAAGAGAGCCAG GCTCCAATCTCCTGCCACCAAAGTGAAGGAAGAGGTGAGTTCCATGGGCCAGGCGGCCTCGGGACTGAGG TGGAGGCCAAGCTGCCCTGCTCCCCAGGGAGCATGGTGTCACACGCTGGCCTCAGAGATGCACACACAAC AGGGAAGCCACTGAGAGCCCTCCTGCATGCAAACAGGTTTGGTAAGAGATGAGGAACTTGTTCTAGGGCA GTGACATCAATATGCCTAGAAAGACAGCAAGGCCGGGCGCAGTGGCTCACACCTGTAATCCTAGCACTTT GGGAGGCCGAGGTGGGAGAACTGCTTGAGCCCAGGGGTTGGAGACCAGCCTGGGCAACAAAGCAGGACCC CATATCTACAAAAATATTAGCCAGGCGTGGTGGTGCAAACCTGTAGTCCCAGCTACTTGGGAGGTTGAGG AGGGAGGATCACTTGGGCCCAGGAGTTCAAGGCTGCAGTGAGCTACAATCACACCATGGCACTTCAGTCT GAGTGAAAGAGATTCTGTCTTTAAGAAATAAAAATTTTTGAAAATGCAGCTGAACAGAAGTGTCAGGGTC AGAACCATGGATCTGGGAAGTTCCTGTTTTGCTCACCTCAGTAAGTACAGTGGAGGGCTGATATTAGTCT CCTGTACACACAAGAGAGAACACTGGTGCTCTAAGAGGCAGAAAGACTTGCTCAAAGTCAGTGTGGCCAA GACCCTGGCCTGGATCTTCTGCCTCGAGATCCATTTTTCTCTCCACCGGTGAGGCTACAGTCTAACTCCA GGCAGGAGTGGGCAAGAGCTATGCCTCTACCCCCAAATTCCACACTTCTCAAGAACCACGTCCACGCTGT CTAGCTCTCTGTTGCTTACCCTGTTGACACCTGTTTGTTGACCGCTCTCCTAATCCTCTTCTCTGCAGGA AGCAGCACTTGCCGCCAAGTTCACTGAAGTTTATGCCATCAACAGACAGAGGCTGCAGAATCTGGAGTTT GCTCTGAATCTCCTCAGACAGGTAACTGATCTTAGTAAGAAATTCTACTTCAGGCTGTTCTAACAGGTGA CAAATACAGACTCTGTCTTAGAGAAATGGTTTGTGAATTGATGGAAGTGTCCCCTTGCTAACGTTTCTGG GCAGGGCCAATGCAAAGACTGGCCCGAGCCAATGCTTCTACTGACATGAGAACTTATTCAACTCAGTAAA CATCTGCTGAAAGTGAATGCTATTTTCAGCTGGGCATGGTGGCTCACGCTTGTAATCCCAGCACTTTGGG AGGCCGAGGCAGGCGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTAAAACTCCGT CTCTACTAAAAATACAAAAATTAGCTGGGCGTCGTGGCGCATGCTTGTAATCCCAGCTACTCAGGAGACT GAGGCAGGAGAATTGCTTGAACCCAGGAGGTGGAGGTTGCAGGGAGCTGAGACTGTGCCACTGCACTCCA GCCTGGGCAACAGAGCGAGACTCTGTCTCAGAAAAAAAGAAAGAAACAAAAGAAAGTGAATGTTATTTTC TGAAGTCCATGATGTTGATGACAGCATTGTTTTTTAATAGCAAGACACTGGAAGCAGTTCACTCTTCATC AGCAATGGGCTAAACTGCGGTCTGTCCAGAGAGCGGAAACAATGCTGCTGGTAAATCCTGAAGCAGCACT CTCTGTGCTGAGCTGGAATGAGCTCTGTAAGTGCAGTGAGCAGCAGGAATACCATTTGTGCAGGAGAGAT AAACACATGGTACATACTACAGACAGATATTCTTGTGTGAGCACAGATAGCATCTGCAAGGCTGACAGAC ACGCCCTAGGACGGGGACCAGAGGTGGGAGACCGTGGTTTCATTTTAAACTCTTCCACAGCTCAAAAATG TTTTACCTGATTAAAAAAAACCCCAAACTAGTTGTTTGATCCTTTTTGAAAGTAACCCTAGAACTCTACA ACTAACATGAACTGGCACTGAGGGAGTCCCTTGGGGACCACAGGACAGCCACTCTGACCAGGTGGGGACA GGCCCTACATGTGCTGCCAGAGCCTGGCTTTAACCTTGTCTTGTCTTCTCCATCACAGCAGCCGGAAGTA GAAGTGACCCATGAGACCCTGCAAAGGAATAGGCCGGACTCTGGAGTGGAGGAGGCGTGGAAGATCAGGA AGGAACTGGATGAGGAGACTGAGCGGAGGCGGCAGCTGGAGAACGAGGTCAAGAGCACCCAGGAAGAAAT CTGGACCTTGAGGAATCAGGGGCCTCAGGAATCGGTGGTGAGGAAGGAGGTGCTCAAGAAGGTGCCGGAT CCCGTGCTGGAGGAGAGCTTCCAGCAGCTGCAGCGGACGCTGGCAGAGGAGCAGCACAAGAACCAGCTGC TGCAGGAGGAGCTGGAGGCACTGCAGCTGCAGCTGCGTGCCCTGGAGCAGGAGACCAGAGACGGGGGGCA GGAGTACGTGGTCAAGGAGGTCCTGCGCATCGAGCCTGACAGGGCCCAGGCGGATGAGGTCTTGCAGCTG CGGGAGGAGCTGGAGGCACTGAGGCGGCAGAAGGGCGCCCGGGAGGCAGAGGTGCTCCTCCTGCAGCAGC GTGTGGCCGCCCTGGCTGAAGAGAAGAGCCGGGCGCAGGAGAAGGTCACAGAGAAAGAGGTGGTGAAACT GCAGAATGACCCCCAGCTGGAGGCAGAGTACCAGCAGCTGCAGGAGGACCACCAGCGCCAGGACCAGCTC AGGGAGAAGCAGGAGGAGGAGCTGAGCTTCCTCCAGGACAAGCTCAAGAGGCTAGAGAAGGAGCGGGCCA TGGCCGAGGGCAAGATCACCGTCAAGGAGGTGCTCAAGGTGGAGAAGGACGCGGCCACCGAGAGGGAGGT CAGCGATCTCACCCGCCAATATGAGGACGAGGCTGCCAAGGCTCGCGCTAGCCAGAGGGAGAAGACGGAG CTGCTCCGAAAGATATGGGCCTTGGAGGAGGAGAACGCCAAAGTGGTGGTGCAGGAGAAGGTGCGGGAGA TCGTGCGGCCAGACCCCAAGGCGGAAAGTGAAGTGGCGAACCTCCGCCTGGAGCTTGTGGAGCAGGAGCG AAAGTACCGGGGTGCCGAGGAGCAGCTCCGGAGCTACCAGAGTGAGCTGGAGGCCCTCAGGAGGCGAGGC CCCCAGGTGGAAGTCAAAGAGGTGACTAAGGAAGTCATTAAGTACAAGACTGACCCTGAGATGGAGAAGG AGCTTCAGCGGCTCAGGGAGGAGATCGTGGACAAGACCAGACTGATCGAAAGGTGTGATTTAGAGATCTA CCAGCTGAAAAAGGAAATCCAGGCCCTGAAAGACACCAAACCCCAGGTCCAGACCAAAGAGGTGGTCCAG GAGATCCTCCAATTCCAAGAAGACCCTCAAACCAAGGAGGAGGTGGCGTCTCTGAGGGCAAAGCTCTCAG AGGAGCAGAAGAAACAAGTGGATCTGGAGAGGGAAAGAGCTTCCCAGGAAGAGCAGATCGCCCGGAAAGA GGAGGAGCTCTCGCGGGTGAAGGAAAGGGTGGTGCAGCAGGAGGTGGTCAGGTATGAGGAGGAGCCAGGC CTGCGGGCCGAGGCGAGCGCCTTTGCCGAGAGCATCGATGTGGAGCTGCGGCAGATTGACAAGCTGCGGG CAGAGCTGCGGCGGCTGCAGCGCCGGCGCACCGAGCTTGAGCGGCAGCTGGAGGAGCTAGAGCGCGAGCG GCAGGCCCGCAGGGAGGCCGAGCGCGAGGTACAGCGGTTGCAGCAGCGGCTGGCAGCGCTGGAGCAGGAA GAAGCTGAGGCCCGTGAGAAGGTAACCCATACGCAGAAGGTGGTGCTGCAGCAGGACCCGCAGCAGGCGC GAGAGCATGCCCTGCTCCGACTCCAGCTGGAAGAAGAGCAGCACCGGCGGCAGCTCCTGGAGGGGGAGCT CGAGACCCTCCGGAGGAAACTGGCTGCACTGGAGAAGGCGGAGGTCAAGGAGAAGGTGGTGCTCTCCGAG AGTGTCCAGGTGGAGAAGGGCGACACCGAGCAAGAGATCCAGAGGCTCAAGAGCAGCCTGGAGGAGGAGA GCCGCAGCAAGCGCGAGCTGGACGTCGAGGTGAGCCGGCTGGAAGCCAGGCTTTCGGAGCTGGAATTCCA TAACTCCAAGTCATCCAAGGAACTAGACTTTCTGAGGGAAGAGAACCACAAATTACAGCTGGAGAGGCAA AACCTGCAGCTGGAGACCCGAAGGCTCCAATCGGAAATCAACATGGCAGCGACGGAAACACGAGACCTGC GGAACATGACCGTGGCGGACTCTGGGACCAACCATGACTCCAGACTGTGGTCCCTGGAGAGGGAACTGGA TGACCTCAAGAGGCTCTCCAAGGACAAAGACCTCGAGATCGACGAGCTGCAGAAGCGCCTGGGCTCCGTG GCCGTCAAGCGGGAGCAGCGGGAGAACCACCTGCGGCGCTCCATCGTAGTCATCCACCCTGACACAGGCC GCGAGCTGTCCCCGGAGGAAGCCCACCGTGCCGGGCTCATTGACTGGAACATGTTCGTGAAACTCAGAAG CCAGGAGTGCGACTGGGAGGAGATCTCAGTGAAGGGTCCCAATGGGGAGTCCTCAGTGATACACGACAGG AAGTCTGGCAAGAAGTTCTCCATCGAAGAGGCCCTGCAGAGTGGCAGGCTGACCCCTGCTCAGTATGACC GCTATGTCAACAAGGATATGTCCATCCAGGAGCTGGCGGTCTTGGTATCTGGGCAGAAGTAGGCACAGCT CTTGCAACTCTTCGTAACGGCAGACGCTGGCCCTCTCCTACGACGCAGTGACCTCCTTGGTGTCGTCCTC TCCCTTGCCCTGGTGCAGGCCAAGCATTTTATACATACCCTCGCTGCCAGGCTGCTCAGAGTCCCGCCCA CATATGAGACAGGCACTGGCTGAAGACAGGCAACTCTCGTCCCAACCATCATTCACCCTGAGTGACGTAC TTCATCCTCCAATGACTGGACAACTGCGATGCCTTTTCCTCCCTTTTCCTGTACACTCCCAGCAACAAAC TCCTCATGATAACTGCACACAATCTGAAAACCACTGAAGGACAAGCCAACCACAGCAGCCAAGCCCACTC CTTGCAGCATGGGTACTGGTGGCACACCAGACAGTGACACTGCCCCACAAAGGCCTGGGCCCGTGGGGGC TGCTGCCTGGCATGACATCTCTCCAGATTTCTGGCTTAAAACCAACTTTCCATCCGAGAAGCCTCCTCAG TAGTTACTCTGCTCATGAGACAGATCTGGGCTCCAAGCCAGGAAAGGTGAACAGAAACCACAAGTGTCCA GCCCTCGGTGCTGGAGTGGACGTTAATTGTCAGCCACCAGACTGTCCCGGCACCTACAGAGAATGTTTCA CAGTTCTGGCATTTAAATCCTTTGATAGTGGATTGTGCTGCTGTTAGCCTTAGTTTCAGTGCTTTACAAG TCTCGCTTATTATCTCACTGGTATTTAGGTATACAAAACAGTTGATTATTCACCACGCCAATATCTGGGT CTCTGTATCTCATGTAGAACATAAGAAAATGGGAACTAATAGGGAAATTTATTTATAGCATGAAAATAAA CCTGGTGGCTGGAGTCTGCTTGTACGGTC Download Select all
Length	54629
OMIM ID	602871
HGNC ID	HGNC:9273
Unigene ID	Hs.192233
Ensembl ID	ENSG00000118898
PharmGKB ID	-

mRNA Information

mRNA ID	NM_002705.4
Exon	join(1..152,26187..26286,33096..33250,34610..34730, 36047..36172,36265..36306,37752..37913,38016..38123, 39366..39461,41420..41542,41729..41875,42518..42669, 43498..43595,43766..43923,44923..45101,45187..45325, 46215..46408,46802..46952,48075..48158,48918..49034, 49909..50001,51089..54629)
mRNA Sequence	>5493 CGCGCCGCCGCTCGCTCACCTGCGCTCCCGCCCGCCCCTCGGTGCGCGCCCGGCCCGCCAGCCG CCGCCGCCCGCACCCCGAGCGCCACCATGAACTCGCTCTTCAGGAAGAGAAACAAAGGCAAATA CAGCCCCACTGTGCAGACCCGGAGCATCTCTAACAAGGAGCTCTCGGAGCTGATCGAGCAGCTG CAGAAGAATGCCGACCAGGTGGAGAAGAACATCGTGGACACAGAGGCCAAGATGCAGAGTGACC TGGCTCGGCTGCAGGAGGGTCGGCAGCCTGAGCACCGGGACGTGACCCTGCAGAAGGTGTTGGA CTCTGAGAAGCTGCTCTATGTGCTAGAGGCGGATGCGGCCATTGCCAAGCACATGAAGCACCCA CAGGGGGACATGATCGCCGAGGATATCCGCCAGCTGAAGGAGCGTGTGACCAACCTGCGCGGGA AACACAAGCAGATCTACAGGCTGGCGGTGAAGGAAGTGGATCCACAGGTCAACTGGGCGGCACT GGTGGAGGAGAAGCTGGACAAGCTGAACAACCAGAGCTTTGGGACTGACCTGCCGCTGGTGGAC CACCAAGTGGAGGAGCATAACATCTTCCACAATGAGGTCAAGGCCATCGGGCCCCACCTGGCCA AGGACGGGGACAAGGAGCAGAACAGCGAACTCCGGGCCAAGTACCAGAAACTGCTGGCAGCATC ACAGGCCCGGCAGCAGCACCTGAGTTCGCTGCAGGACTACATGCAGCGCTGCACCAATGAGCTG TACTGGCTGGACCAGCAGGCCAAGGGCCGCATGCAGTACGACTGGAGTGACCGCAACCTCGACT ACCCCAGCCGCCGGCGCCAGTATGAGAATTTCATCAACCGGAACCTGGAGGCCAAAGAGGAGAG AATCAACAAACTGCACAGCGAGGGCGACCAGCTGCTGGCGGCCGAGCACCCCGGGAGGAACTCC ATTGAGGCGCACATGGAGGCTGTGCACGCAGACTGGAAGGAGTACCTGAACCTGCTCATCTGCG AGGAGAGCCACCTCAAGTACATGGAGGACTACCACCAGTTTCACGAAGACGTGAAGGACGCTCA GGAGCTGCTGCGCAAGGTGGACTCGGACCTGAACCAGAAGTATGGCCCTGACTTCAAGGACCGG TACCAGATTGAGCTGCTGCTGCGGGAGCTGGATGACCAGGAGAAGGTGCTGGACAAGTATGAGG ACGTGGTGCAGGGGCTGCAGAAGCGAGGCCAGCAGGTGGTGCCCCTCAAGTACCGCCGGGAGAC TCCGCTCAAGCCCATCCCCGTGGAGGCACTCTGTGACTTTGAGGGGGAGCAGGGCCTGATCTCG CGGGGCTACAGCTACACCCTGCAGAAGAACAACGGGGAGAGCTGGGAGCTCATGGACAGCGCTG GGAACAAGCTGATTGCTCCGGCCGTGTGTTTTGTGATCCCCCCCACAGACCCTGAGGCCCTGGC TCTGGCTGACAGCCTGGGCAGCCAGTACCGGAGCGTGCGGCAGAAGGCAGCTGGGAGCAAACGC ACGCTGCAGCAGCGGTATGAGGTGCTGAAGACCGAGAATCCCGGAGATGCCTCTGACCTACAGG GGCGGCAGCTGCTGGCTGGCTTGGACAAGGTGGCCAGCGACCTGGACCGGCAGGAGAAGGCCAT CACAGGGATCCTGCGGCCACCACTGGAGCAAGGCCGGGCTGTGCAGGACAGTGCCGAGCGGGCC AAGGACCTCAAGAACATCACCAACGAGCTACTGCGGATTGAACCTGAGAAGACGCGGAGCACGG CTGAGGGCGAAGCCTTCATCCAGGCCCTCCCAGGCAGTGGCACCACACCCCTGCTGAGGACCCG GGTGGAGGACACCAACCGGAAATACGAGCACCTCCTGCAGCTGCTGGACTTGGCCCAGGAGAAG GTTGATGTGGCCAACCGCCTGGAGAAGAGCCTGCAGCAGAGCTGGGAGTTGCTGGCCACACACG AGAACCATCTGAATCAGGATGACACAGTGCCTGAGAGCAGCCGTGTCCTGGACAGCAAGGGGCA GGAGCTGGCGGCCATGGCCTGTGAGTTACAGGCCCAGAAGTCCCTCCTGGGTGAGGTGGAGCAG AACTTGCAGGCGGCCAAGCAGTGCTCGAGCACACTGGCCAGCCGCTTCCAGGAGCACTGTCCGG ACCTGGAGCGCCAGGAGGCCGAGGTGCACAAGCTGGGCCAGCGTTTCAACAACCTGCGCCAGCA GGTGGAACGCAGGGCGCAGAGCCTACAGAGCGCCAAGGCAGCCTACGAGCACTTCCACCGCGGC CATGACCACGTGCTGCAGTTCCTAGTCAGCATCCCCAGTTACGAGCCCCAGGAGACAGACAGCC TCAGCCAGATGGAGACCAAGCTGAAGAACCAGAAGAACCTGCTAGATGAGATAGCAAGTAGGGA GCAGGAAGTACAGAAGATCTGTGCCAATTCCCAGCAGTACCAGCAAGCTGTAAAGGACTATGAG TTAGAAGCAGAAAAACTAAGGTCTCTTCTCGACTTGGAGAATGGAAGGAGCAGCCACGTGAGCA AGAGAGCCAGGCTCCAATCTCCTGCCACCAAAGTGAAGGAAGAGGAAGCAGCACTTGCCGCCAA GTTCACTGAAGTTTATGCCATCAACAGACAGAGGCTGCAGAATCTGGAGTTTGCTCTGAATCTC CTCAGACAGCAGCCGGAAGTAGAAGTGACCCATGAGACCCTGCAAAGGAATAGGCCGGACTCTG GAGTGGAGGAGGCGTGGAAGATCAGGAAGGAACTGGATGAGGAGACTGAGCGGAGGCGGCAGCT GGAGAACGAGGTCAAGAGCACCCAGGAAGAAATCTGGACCTTGAGGAATCAGGGGCCTCAGGAA TCGGTGGTGAGGAAGGAGGTGCTCAAGAAGGTGCCGGATCCCGTGCTGGAGGAGAGCTTCCAGC AGCTGCAGCGGACGCTGGCAGAGGAGCAGCACAAGAACCAGCTGCTGCAGGAGGAGCTGGAGGC ACTGCAGCTGCAGCTGCGTGCCCTGGAGCAGGAGACCAGAGACGGGGGGCAGGAGTACGTGGTC AAGGAGGTCCTGCGCATCGAGCCTGACAGGGCCCAGGCGGATGAGGTCTTGCAGCTGCGGGAGG AGCTGGAGGCACTGAGGCGGCAGAAGGGCGCCCGGGAGGCAGAGGTGCTCCTCCTGCAGCAGCG TGTGGCCGCCCTGGCTGAAGAGAAGAGCCGGGCGCAGGAGAAGGTCACAGAGAAAGAGGTGGTG AAACTGCAGAATGACCCCCAGCTGGAGGCAGAGTACCAGCAGCTGCAGGAGGACCACCAGCGCC AGGACCAGCTCAGGGAGAAGCAGGAGGAGGAGCTGAGCTTCCTCCAGGACAAGCTCAAGAGGCT AGAGAAGGAGCGGGCCATGGCCGAGGGCAAGATCACCGTCAAGGAGGTGCTCAAGGTGGAGAAG GACGCGGCCACCGAGAGGGAGGTCAGCGATCTCACCCGCCAATATGAGGACGAGGCTGCCAAGG CTCGCGCTAGCCAGAGGGAGAAGACGGAGCTGCTCCGAAAGATATGGGCCTTGGAGGAGGAGAA CGCCAAAGTGGTGGTGCAGGAGAAGGTGCGGGAGATCGTGCGGCCAGACCCCAAGGCGGAAAGT GAAGTGGCGAACCTCCGCCTGGAGCTTGTGGAGCAGGAGCGAAAGTACCGGGGTGCCGAGGAGC AGCTCCGGAGCTACCAGAGTGAGCTGGAGGCCCTCAGGAGGCGAGGCCCCCAGGTGGAAGTCAA AGAGGTGACTAAGGAAGTCATTAAGTACAAGACTGACCCTGAGATGGAGAAGGAGCTTCAGCGG CTCAGGGAGGAGATCGTGGACAAGACCAGACTGATCGAAAGGTGTGATTTAGAGATCTACCAGC TGAAAAAGGAAATCCAGGCCCTGAAAGACACCAAACCCCAGGTCCAGACCAAAGAGGTGGTCCA GGAGATCCTCCAATTCCAAGAAGACCCTCAAACCAAGGAGGAGGTGGCGTCTCTGAGGGCAAAG CTCTCAGAGGAGCAGAAGAAACAAGTGGATCTGGAGAGGGAAAGAGCTTCCCAGGAAGAGCAGA TCGCCCGGAAAGAGGAGGAGCTCTCGCGGGTGAAGGAAAGGGTGGTGCAGCAGGAGGTGGTCAG GTATGAGGAGGAGCCAGGCCTGCGGGCCGAGGCGAGCGCCTTTGCCGAGAGCATCGATGTGGAG CTGCGGCAGATTGACAAGCTGCGGGCAGAGCTGCGGCGGCTGCAGCGCCGGCGCACCGAGCTTG AGCGGCAGCTGGAGGAGCTAGAGCGCGAGCGGCAGGCCCGCAGGGAGGCCGAGCGCGAGGTACA GCGGTTGCAGCAGCGGCTGGCAGCGCTGGAGCAGGAAGAAGCTGAGGCCCGTGAGAAGGTAACC CATACGCAGAAGGTGGTGCTGCAGCAGGACCCGCAGCAGGCGCGAGAGCATGCCCTGCTCCGAC TCCAGCTGGAAGAAGAGCAGCACCGGCGGCAGCTCCTGGAGGGGGAGCTCGAGACCCTCCGGAG GAAACTGGCTGCACTGGAGAAGGCGGAGGTCAAGGAGAAGGTGGTGCTCTCCGAGAGTGTCCAG GTGGAGAAGGGCGACACCGAGCAAGAGATCCAGAGGCTCAAGAGCAGCCTGGAGGAGGAGAGCC GCAGCAAGCGCGAGCTGGACGTCGAGGTGAGCCGGCTGGAAGCCAGGCTTTCGGAGCTGGAATT CCATAACTCCAAGTCATCCAAGGAACTAGACTTTCTGAGGGAAGAGAACCACAAATTACAGCTG GAGAGGCAAAACCTGCAGCTGGAGACCCGAAGGCTCCAATCGGAAATCAACATGGCAGCGACGG AAACACGAGACCTGCGGAACATGACCGTGGCGGACTCTGGGACCAACCATGACTCCAGACTGTG GTCCCTGGAGAGGGAACTGGATGACCTCAAGAGGCTCTCCAAGGACAAAGACCTCGAGATCGAC GAGCTGCAGAAGCGCCTGGGCTCCGTGGCCGTCAAGCGGGAGCAGCGGGAGAACCACCTGCGGC GCTCCATCGTAGTCATCCACCCTGACACAGGCCGCGAGCTGTCCCCGGAGGAAGCCCACCGTGC CGGGCTCATTGACTGGAACATGTTCGTGAAACTCAGAAGCCAGGAGTGCGACTGGGAGGAGATC TCAGTGAAGGGTCCCAATGGGGAGTCCTCAGTGATACACGACAGGAAGTCTGGCAAGAAGTTCT CCATCGAAGAGGCCCTGCAGAGTGGCAGGCTGACCCCTGCTCAGTATGACCGCTATGTCAACAA GGATATGTCCATCCAGGAGCTGGCGGTCTTGGTATCTGGGCAGAAGTAGGCACAGCTCTTGCAA CTCTTCGTAACGGCAGACGCTGGCCCTCTCCTACGACGCAGTGACCTCCTTGGTGTCGTCCTCT CCCTAGCCCTGGTGCAGGCCAAGCATTTTATACATACCCTCGCTGCCAGGCTGCTCAGAGTCCC GCCCACATATGAGACAGGCACTGGCTGAAGACAGGCAACTCTCGTCCCAACCATCATTCACCCT GAGTGACGTACTTCATCCTCCAATGACTGGACAACTGCGATGCCTTTTCCTCCCTTTTCCTGTA CACTCCCAGCAACAAACTCCTCATGATAACTGCACACAATCTGAAAACCACTGAAGGACAAGCC AACCACAGCAGCCAAGCCCACTCCTTGCAGCATGGGTACTGGTGGCACACCAGACAGTGACACT GCCCCACAAAGGCCTGGGCCCGTGGGGGCTGCTGCCTGGCATGACATCTCTCCAGATTTCTGGC TTAAAACCAACTTTCCATCCGAGAAGCCTCCTCAGTAGTTACTCTGCTCATGAGACAGATCTGG GCTCCAAGCCAGGAAAGGTGAACAGAAACCACAAGTGTCCAGCCCTCGGTGCTGGAGTGGACGT TAATTGTCAGCCACCAGACTGTCCCGGCACCTACAGAGAATGTTTCACAGTTCTGGCATTTAAA TCCTTTGATAGTGGATTGTGCTGCTGTTAGCCTTAGTTTCAGTGCTTTACAAGTCTCGCTTATT ATCTCACTGGTATTTAGGTATACAAAACAGTTGATTATTCACCACGCCAATATCTGGGTCTCTG TATCTCATGTAGAACATAAGAAAATGGGAACTAATAGGGAAATTTATTTATAGCATGAAAATAA ACCTGGTGGCTGGAGTCTGCTTGTACGGTCAAAAAAAAAAAAAAAAAA Download Select all
Length	6256

CDS Information

Location	join(91..152,26187..26286,33096..33250,34610..34730, 36047..36172,36265..36306,37752..37913,38016..38123, 39366..39461,41420..41542,41729..41875,42518..42669, 43498..43595,43766..43923,44923..45101,45187..45325, 46215..46408,46802..46952,48075..48158,48918..49034, 49909..50001,51089..53752)
CDS Sequence	>gi\|118572594:91-5361 Homo sapiens periplakin (PPL), mRNA ATGAACTCGCTCTTCAGGAAGAGAAACAAAGGCAAATACAGCCCCACTGTGCAGACCCGGAGCATCTCTA ACAAGGAGCTCTCGGAGCTGATCGAGCAGCTGCAGAAGAATGCCGACCAGGTGGAGAAGAACATCGTGGA CACAGAGGCCAAGATGCAGAGTGACCTGGCTCGGCTGCAGGAGGGTCGGCAGCCTGAGCACCGGGACGTG ACCCTGCAGAAGGTGTTGGACTCTGAGAAGCTGCTCTATGTGCTAGAGGCGGATGCGGCCATTGCCAAGC ACATGAAGCACCCACAGGGGGACATGATCGCCGAGGATATCCGCCAGCTGAAGGAGCGTGTGACCAACCT GCGCGGGAAACACAAGCAGATCTACAGGCTGGCGGTGAAGGAAGTGGATCCACAGGTCAACTGGGCGGCA CTGGTGGAGGAGAAGCTGGACAAGCTGAACAACCAGAGCTTTGGGACTGACCTGCCGCTGGTGGACCACC AAGTGGAGGAGCATAACATCTTCCACAATGAGGTCAAGGCCATCGGGCCCCACCTGGCCAAGGACGGGGA CAAGGAGCAGAACAGCGAACTCCGGGCCAAGTACCAGAAACTGCTGGCAGCATCACAGGCCCGGCAGCAG CACCTGAGTTCGCTGCAGGACTACATGCAGCGCTGCACCAATGAGCTGTACTGGCTGGACCAGCAGGCCA AGGGCCGCATGCAGTACGACTGGAGTGACCGCAACCTCGACTACCCCAGCCGCCGGCGCCAGTATGAGAA TTTCATCAACCGGAACCTGGAGGCCAAAGAGGAGAGAATCAACAAACTGCACAGCGAGGGCGACCAGCTG CTGGCGGCCGAGCACCCCGGGAGGAACTCCATTGAGGCGCACATGGAGGCTGTGCACGCAGACTGGAAGG AGTACCTGAACCTGCTCATCTGCGAGGAGAGCCACCTCAAGTACATGGAGGACTACCACCAGTTTCACGA AGACGTGAAGGACGCTCAGGAGCTGCTGCGCAAGGTGGACTCGGACCTGAACCAGAAGTATGGCCCTGAC TTCAAGGACCGGTACCAGATTGAGCTGCTGCTGCGGGAGCTGGATGACCAGGAGAAGGTGCTGGACAAGT ATGAGGACGTGGTGCAGGGGCTGCAGAAGCGAGGCCAGCAGGTGGTGCCCCTCAAGTACCGCCGGGAGAC TCCGCTCAAGCCCATCCCCGTGGAGGCACTCTGTGACTTTGAGGGGGAGCAGGGCCTGATCTCGCGGGGC TACAGCTACACCCTGCAGAAGAACAACGGGGAGAGCTGGGAGCTCATGGACAGCGCTGGGAACAAGCTGA TTGCTCCGGCCGTGTGTTTTGTGATCCCCCCCACAGACCCTGAGGCCCTGGCTCTGGCTGACAGCCTGGG CAGCCAGTACCGGAGCGTGCGGCAGAAGGCAGCTGGGAGCAAACGCACGCTGCAGCAGCGGTATGAGGTG CTGAAGACCGAGAATCCCGGAGATGCCTCTGACCTACAGGGGCGGCAGCTGCTGGCTGGCTTGGACAAGG TGGCCAGCGACCTGGACCGGCAGGAGAAGGCCATCACAGGGATCCTGCGGCCACCACTGGAGCAAGGCCG GGCTGTGCAGGACAGTGCCGAGCGGGCCAAGGACCTCAAGAACATCACCAACGAGCTACTGCGGATTGAA CCTGAGAAGACGCGGAGCACGGCTGAGGGCGAAGCCTTCATCCAGGCCCTCCCAGGCAGTGGCACCACAC CCCTGCTGAGGACCCGGGTGGAGGACACCAACCGGAAATACGAGCACCTCCTGCAGCTGCTGGACTTGGC CCAGGAGAAGGTTGATGTGGCCAACCGCCTGGAGAAGAGCCTGCAGCAGAGCTGGGAGTTGCTGGCCACA CACGAGAACCATCTGAATCAGGATGACACAGTGCCTGAGAGCAGCCGTGTCCTGGACAGCAAGGGGCAGG AGCTGGCGGCCATGGCCTGTGAGTTACAGGCCCAGAAGTCCCTCCTGGGTGAGGTGGAGCAGAACTTGCA GGCGGCCAAGCAGTGCTCGAGCACACTGGCCAGCCGCTTCCAGGAGCACTGTCCGGACCTGGAGCGCCAG GAGGCCGAGGTGCACAAGCTGGGCCAGCGTTTCAACAACCTGCGCCAGCAGGTGGAACGCAGGGCGCAGA GCCTACAGAGCGCCAAGGCAGCCTACGAGCACTTCCACCGCGGCCATGACCACGTGCTGCAGTTCCTAGT CAGCATCCCCAGTTACGAGCCCCAGGAGACAGACAGCCTCAGCCAGATGGAGACCAAGCTGAAGAACCAG AAGAACCTGCTAGATGAGATAGCAAGTAGGGAGCAGGAAGTACAGAAGATCTGTGCCAATTCCCAGCAGT ACCAGCAAGCTGTAAAGGACTATGAGTTAGAAGCAGAAAAACTAAGGTCTCTTCTCGACTTGGAGAATGG AAGGAGCAGCCACGTGAGCAAGAGAGCCAGGCTCCAATCTCCTGCCACCAAAGTGAAGGAAGAGGAAGCA GCACTTGCCGCCAAGTTCACTGAAGTTTATGCCATCAACAGACAGAGGCTGCAGAATCTGGAGTTTGCTC TGAATCTCCTCAGACAGCAGCCGGAAGTAGAAGTGACCCATGAGACCCTGCAAAGGAATAGGCCGGACTC TGGAGTGGAGGAGGCGTGGAAGATCAGGAAGGAACTGGATGAGGAGACTGAGCGGAGGCGGCAGCTGGAG AACGAGGTCAAGAGCACCCAGGAAGAAATCTGGACCTTGAGGAATCAGGGGCCTCAGGAATCGGTGGTGA GGAAGGAGGTGCTCAAGAAGGTGCCGGATCCCGTGCTGGAGGAGAGCTTCCAGCAGCTGCAGCGGACGCT GGCAGAGGAGCAGCACAAGAACCAGCTGCTGCAGGAGGAGCTGGAGGCACTGCAGCTGCAGCTGCGTGCC CTGGAGCAGGAGACCAGAGACGGGGGGCAGGAGTACGTGGTCAAGGAGGTCCTGCGCATCGAGCCTGACA GGGCCCAGGCGGATGAGGTCTTGCAGCTGCGGGAGGAGCTGGAGGCACTGAGGCGGCAGAAGGGCGCCCG GGAGGCAGAGGTGCTCCTCCTGCAGCAGCGTGTGGCCGCCCTGGCTGAAGAGAAGAGCCGGGCGCAGGAG AAGGTCACAGAGAAAGAGGTGGTGAAACTGCAGAATGACCCCCAGCTGGAGGCAGAGTACCAGCAGCTGC AGGAGGACCACCAGCGCCAGGACCAGCTCAGGGAGAAGCAGGAGGAGGAGCTGAGCTTCCTCCAGGACAA GCTCAAGAGGCTAGAGAAGGAGCGGGCCATGGCCGAGGGCAAGATCACCGTCAAGGAGGTGCTCAAGGTG GAGAAGGACGCGGCCACCGAGAGGGAGGTCAGCGATCTCACCCGCCAATATGAGGACGAGGCTGCCAAGG CTCGCGCTAGCCAGAGGGAGAAGACGGAGCTGCTCCGAAAGATATGGGCCTTGGAGGAGGAGAACGCCAA AGTGGTGGTGCAGGAGAAGGTGCGGGAGATCGTGCGGCCAGACCCCAAGGCGGAAAGTGAAGTGGCGAAC CTCCGCCTGGAGCTTGTGGAGCAGGAGCGAAAGTACCGGGGTGCCGAGGAGCAGCTCCGGAGCTACCAGA GTGAGCTGGAGGCCCTCAGGAGGCGAGGCCCCCAGGTGGAAGTCAAAGAGGTGACTAAGGAAGTCATTAA GTACAAGACTGACCCTGAGATGGAGAAGGAGCTTCAGCGGCTCAGGGAGGAGATCGTGGACAAGACCAGA CTGATCGAAAGGTGTGATTTAGAGATCTACCAGCTGAAAAAGGAAATCCAGGCCCTGAAAGACACCAAAC CCCAGGTCCAGACCAAAGAGGTGGTCCAGGAGATCCTCCAATTCCAAGAAGACCCTCAAACCAAGGAGGA GGTGGCGTCTCTGAGGGCAAAGCTCTCAGAGGAGCAGAAGAAACAAGTGGATCTGGAGAGGGAAAGAGCT TCCCAGGAAGAGCAGATCGCCCGGAAAGAGGAGGAGCTCTCGCGGGTGAAGGAAAGGGTGGTGCAGCAGG AGGTGGTCAGGTATGAGGAGGAGCCAGGCCTGCGGGCCGAGGCGAGCGCCTTTGCCGAGAGCATCGATGT GGAGCTGCGGCAGATTGACAAGCTGCGGGCAGAGCTGCGGCGGCTGCAGCGCCGGCGCACCGAGCTTGAG CGGCAGCTGGAGGAGCTAGAGCGCGAGCGGCAGGCCCGCAGGGAGGCCGAGCGCGAGGTACAGCGGTTGC AGCAGCGGCTGGCAGCGCTGGAGCAGGAAGAAGCTGAGGCCCGTGAGAAGGTAACCCATACGCAGAAGGT GGTGCTGCAGCAGGACCCGCAGCAGGCGCGAGAGCATGCCCTGCTCCGACTCCAGCTGGAAGAAGAGCAG CACCGGCGGCAGCTCCTGGAGGGGGAGCTCGAGACCCTCCGGAGGAAACTGGCTGCACTGGAGAAGGCGG AGGTCAAGGAGAAGGTGGTGCTCTCCGAGAGTGTCCAGGTGGAGAAGGGCGACACCGAGCAAGAGATCCA GAGGCTCAAGAGCAGCCTGGAGGAGGAGAGCCGCAGCAAGCGCGAGCTGGACGTCGAGGTGAGCCGGCTG GAAGCCAGGCTTTCGGAGCTGGAATTCCATAACTCCAAGTCATCCAAGGAACTAGACTTTCTGAGGGAAG AGAACCACAAATTACAGCTGGAGAGGCAAAACCTGCAGCTGGAGACCCGAAGGCTCCAATCGGAAATCAA CATGGCAGCGACGGAAACACGAGACCTGCGGAACATGACCGTGGCGGACTCTGGGACCAACCATGACTCC AGACTGTGGTCCCTGGAGAGGGAACTGGATGACCTCAAGAGGCTCTCCAAGGACAAAGACCTCGAGATCG ACGAGCTGCAGAAGCGCCTGGGCTCCGTGGCCGTCAAGCGGGAGCAGCGGGAGAACCACCTGCGGCGCTC CATCGTAGTCATCCACCCTGACACAGGCCGCGAGCTGTCCCCGGAGGAAGCCCACCGTGCCGGGCTCATT GACTGGAACATGTTCGTGAAACTCAGAAGCCAGGAGTGCGACTGGGAGGAGATCTCAGTGAAGGGTCCCA ATGGGGAGTCCTCAGTGATACACGACAGGAAGTCTGGCAAGAAGTTCTCCATCGAAGAGGCCCTGCAGAG TGGCAGGCTGACCCCTGCTCAGTATGACCGCTATGTCAACAAGGATATGTCCATCCAGGAGCTGGCGGTC TTGGTATCTGGGCAGAAGTAG Download Select all
CCDS ID	CCDS10526.1

Protein Information

Protein ID	NP_002696.3
Protein Name	Periplakin
Molecular Wt. (Da)	204547
Protein Sequence	>5493 MNSLFRKRNKGKYSPTVQTRSISNKELSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQEGRQ PEHRDVTLQKVLDSEKLLYVLEADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRGKHKQIYRLA VKEVDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNEVKAIGPHLAKDGDKEQNS ELRAKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLDQQAKGRMQYDWSDRNLDYPSRRRQYE NFINRNLEAKEERINKLHSEGDQLLAAEHPGRNSIEAHMEAVHADWKEYLNLLICEESHLKYME DYHQFHEDVKDAQELLRKVDSDLNQKYGPDFKDRYQIELLLRELDDQEKVLDKYEDVVQGLQKR GQQVVPLKYRRETPLKPIPVEALCDFEGEQGLISRGYSYTLQKNNGESWELMDSAGNKLIAPAV CFVIPPTDPEALALADSLGSQYRSVRQKAAGSKRTLQQRYEVLKTENPGDASDLQGRQLLAGLD KVASDLDRQEKAITGILRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQA LPGSGTTPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDDT VPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQEAEV HKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLK NQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLENGRSSHVSKRARLQSPA TKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIR KELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQRTLAEE QHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQADEVLQLREELEALRRQK GAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQE EELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAKARASQREKT ELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSEL EALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALK DTKPQVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELS RVKERVVQQEVVRYEEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELER ERQARREAEREVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHR RQLLEGELETLRRKLAALEKAEVKEKVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVE VSRLEARLSELEFHNSKSSKELDFLREENHKLQLERQNLQLETRRLQSEINMAATETRDLRNMT VADSGTNHDSRLWSLERELDDLKRLSKDKDLEIDELQKRLGSVAVKREQRENHLRRSIVVIHPD TGRELSPEEAHRAGLIDWNMFVKLRSQECDWEEISVKGPNGESSVIHDRKSGKKFSIEEALQSG RLTPAQYDRYVNKDMSIQELAVLVSGQK Download Select all
Length	1756
Uniprot ID	P29762
Ensembl Protein ID	ENSP00000299529

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
S	Phosphorylation	1331
D	Proteolytic Cleavage	1603
T	Phosphorylation	1579
S	Phosphorylation	779
S	Phosphorylation	14
S	Phosphorylation	1657

Enzyme Information

EC	3.1.1.3
Name	triacylglycerol lipase lipase (ambiguous) butyrinase tributyrinase Tween hydrolase steapsin triacetinase tributyrin esterase Tweenase amno N-AP Takedo 1969-4-9 Meito MY 30 Tweenesterase GA 56 capalase L triglyceride hydrolase triolein hydrolase tween-hydrolyzing esterase amano CE cacordase triglyceridase triacylglycerol ester hydrolase amano P amano AP PPL glycerol-ester hydrolase GEH meito Sangyo OF lipase hepatic lipase lipazin post-heparin plasma protamine-resistant lipase salt-resistant post-heparin lipase heparin releasable hepatic lipase amano CES amano B tributyrase triglyceride lipase liver lipase hepatic monoacylglycerol acyltransferase
Class	Hydrolases; Acting on ester bonds; Carboxylic-ester hydrolases
Sysname	triacylglycerol acylhydrolase
Substrate	triacylglycerol [CPD:C00422]; H2O
Product	diacylglycerol [CPD:C00165]; carboxylate
Reaction (IUBMB)

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
207	AKT1	1261	NP_005154.2	in vitro;in vivo	12176997
1308	COL17A1	223	NP_000485.3	yeast 2-hybrid	9521878
2125	EVPL	3352	NP_001979.2	in vitro;in vivo	94 124 761 106 225 900 000 000
7431	VIM	1899	NP_003371.2	yeast 2-hybrid	12366696
7874	USP7	3950	NP_003461.2	yeast 2-hybrid	16713569

Pathway Information

No matching records could be found.

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd00176	215-389	SPEC
cl02488	215-389	SPEC superfamily
smart00250	1657-1685	PLEC
cl23349	1657-1685	PLEC superfamily
pfam05483	789-1546	SCP-1
COG1196	796-1587	Smc
PTZ00121	818-1537	PTZ00121
TIGR02168	946-1640	SMC_prok_B
COG1196	946-1655	Smc
TIGR02169	761-1592	SMC_prok_A
COG1196	946-1651	Smc
TIGR02168	758-1592	SMC_prok_B
COG1196	967-1651	Smc
TIGR02169	943-1656	SMC_prok_A
TIGR02168	696-1493	SMC_prok_B
PRK03918	987-1577	PRK03918
COG1196	654-1426	Smc
COG1196	866-1223	Smc
COG1196	1145-1582	Smc
TIGR02169	1243-1652	SMC_prok_A
TIGR02169	1004-1342	SMC_prok_A
TIGR02168	586-1279	SMC_prok_B
TIGR02169	1037-1659	SMC_prok_A
COG1196	1005-1396	Smc
TIGR02168	533-1221	SMC_prok_B
COG1196	1135-1513	Smc
TIGR00618	946-1588	sbcc
pfam02463	791-1588	SMC_N
COG0419	967-1548	SbcC
PRK03918	904-1424	PRK03918
COG0419	767-1394	SbcC
pfam02463	955-1653	SMC_N
TIGR00618	637-1349	sbcc
COG1196	771-1122	Smc
PRK03918	1080-1652	PRK03918
COG4942	894-1147	EnvC
PRK02224	1078-1569	PRK02224
TIGR03185	950-1273	DNA_S_dndD
TIGR02168	1378-1656	SMC_prok_B
pfam12128	945-1597	DUF3584
TIGR02169	743-1106	SMC_prok_A
COG4372	896-1142	COG4372
COG0419	1150-1658	SbcC
COG4717	805-1490	YhaN
PRK04863	954-1350	mukB
pfam02463	585-1391	SMC_N
PRK03918	1128-1651	PRK03918
pfam04111	971-1103	APG6
pfam13166	1038-1397	AAA_13
pfam12128	627-1346	DUF3584
PRK04863	643-1492	mukB
TIGR04523	1089-1638	Mplasa_alph_rch
TIGR00606	706-1485	rad50
COG1269	1009-1282	NtpI
pfam01496	977-1256	V_ATPase_I
TIGR00606	897-1624	rad50
pfam13514	696-1397	AAA_27
pfam12128	895-1587	DUF3584
COG0419	534-1059	SbcC
TIGR03319	1008-1152	RNase_Y
COG1269	898-1139	NtpI
pfam07111	887-1425	HCR
COG3206	932-1220	GumC
COG4372	1005-1208	COG4372
PRK02224	889-1361	PRK02224
TIGR04523	894-1349	Mplasa_alph_rch
pfam04111	1464-1601	APG6
PRK03918	666-1255	PRK03918
pfam04111	1065-1221	APG6
COG4942	1243-1522	EnvC
PLN03229	951-1360	PLN03229
pfam01576	906-1548	Myosin_tail_1
pfam04012	1164-1352	PspA_IM30
TIGR03794	930-1113	NHLM_micro_HlyD
PRK12704	1008-1151	PRK12704
pfam13514	948-1622	AAA_27
pfam10174	945-1656	Cast
TIGR04523	894-1325	Mplasa_alph_rch
PRK09510	1023-1167	tolA
COG4372	1272-1522	COG4372
pfam04286	899-1101	DUF445
TIGR04523	1088-1586	Mplasa_alph_rch
COG5022	889-1348	COG5022
PRK11448	1002-1092	hsdR
COG0419	1246-1651	SbcC
COG4942	1303-1548	EnvC
PRK09510	1071-1187	tolA
TIGR04211	944-1047	SH3_and_anchor
PRK04778	894-1264	PRK04778
PRK04863	854-1128	mukB
COG4942	1123-1354	EnvC
PRK05771	994-1270	PRK05771
pfam05557	1034-1627	MAD
pfam06160	894-1222	EzrA
PRK09510	924-1146	tolA
pfam13514	1268-1598	AAA_27
COG2433	1217-1368	COG2433
PRK09039	968-1135	PRK09039
COG4477	948-1275	EzrA
PRK12704	1023-1176	PRK12704
pfam01576	783-1486	Myosin_tail_1
pfam05622	1200-1618	HOOK
COG4942	952-1176	EnvC
COG1579	1244-1389	COG1579
COG3096	954-1352	MukB
PTZ00108	904-1165	PTZ00108
pfam07111	751-1355	HCR
COG3064	1028-1189	TolA
pfam13514	1058-1656	AAA_27
PRK09510	1035-1187	tolA
pfam02463	1320-1655	SMC_N
COG4372	1465-1656	COG4372
pfam09726	1160-1352	Macoilin
pfam05557	585-1120	MAD
pfam04111	1501-1656	APG6
pfam07888	1147-1469	CALCOCO1
pfam06637	997-1269	PV-1
COG1269	1243-1523	NtpI

Ontology Information

HPRD ID	3596
Molecular Class	Cytoskeletal protein
Molecular Function	Receptor signaling complex scaffold activity (GO:0030159)
Biological Process	Cell communication (GO:0007154); Signal transduction (GO:0007165)

SNP Information

View SNP Geneview Report

Drug Information

No matching records could be found.

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO