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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
PPP2R1B 5519 protein phosphatase 2, regulatory subunit A, beta  11PR65B, PP2A-Abeta 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
26247730   2015Cell line : RKO, HCT116, FET, GEO

Source : -

Sample Type : -

No. of Sample : -

Stage : -

Cell viability and apoptosis assays,Western blotting, RT-PCR,real-time RT-PCR,Luciferase assays,TUNEL assay Down-regulation-Inhibition of miR-587 or restoration of PPP2R1B expression may have significant therapeutic potential to overcome drug resistance in colorectal cancer patients


Gene Details



NC_000011.9 (111597632..111637169, complement)

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Gene Type protein coding
Gene Family Serine/threonine phosphatases / Protein phosphatase 2, regulatory subunits
Description This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]  
Chromosome 11
Location 11q23.1
Start 111597632  
End 111637169  
Strand -  
Gene Sequence

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Length 39538  
OMIM ID 603113   
HGNC ID HGNC:9303   
Unigene ID Hs.269128   
Ensembl ID ENSG00000137713   
PharmGKB ID PA33667   

mRNA Information


mRNA ID ?NM_001177562.1
Exon complement(join(<39529..42950,43690..43781,44506..44616, 45384..45547,45684..45968,46443..46671,54071..54235, 61307..61459,63023..63243,64871..64994,65436..65560))  
mRNA Sequence

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Length 5758  



CDS Information


   
Location174..2954
CDS Sequence

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CCDS ID CCDS53706.1



Protein Information


      
Protein IDNP_001171033.1
Protein Nameprotein phosphatase 2, regulatory subunit A, beta
Molecular Wt. (Da)51561
Protein Sequence

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Length 601  
Uniprot IDQ9UP38
Ensembl Protein ID ENSP00000287934  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation48
TPhosphorylation49
TPhosphorylation59
SPhosphorylation48
TPhosphorylation49
TPhosphorylation59
SPhosphorylation212
SPhosphorylation212

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                                                                                                        
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
308ANXA5568NP_001145.1in vivo17540176   
682BSG176NP_001719.2in vivo17540176   
983CDK1302NP_001777.1in vivo17540176   
1019CDK4447NP_000066.1in vivo17540176   
1080CFTR3883NP_000483.3in vivo;yeast 2-hybrid15936019   
1938EEF2561NP_001952.1in vivo17540176   
3065HDAC13143NP_004955.2in vivo17540176   
3329HSPD1318NP_002147.2in vivo17540176   
3717JAK2993NP_004963.1in vivo11440634   
4172MCM34072NP_002379.2in vivo17540176   
5052PRDX11458NP_002565.1in vivo17540176   
5515PPP2CA8912NP_002706.1in vivo1   754   017   618   715   870   
5527PPP2R5C3385NP_002710.2in vivo11929880   
5529PPP2R5E9040NP_006237.1in vivo17540176   
5970RELA1241NP_068810.3in vitro;in vivo11591705   
6418SET9023NP_001116293.1in vitro9353299   
6801STRN18124NP_003153.2in vivo17540176   
7001PRDX22763NP_005800.3in vivo17540176   
7879RAB7A3805NP_004628.4in vivo17540176   
8766RAB11A5715NP_004654.1in vivo17540176   
11116FGFR1OP10392NP_008976.1in vivo17540176   
11315PARK73961NP_009193.2in vivo17540176   
22931RAB183731NP_067075.1in vivo17540176   
29966STRN311613NP_001077362.1in vivo17540176   


Pathway Information


                                                                              
Pathway Name Pathway ID
Adrenergic signaling in cardiomyocytes hsa04261
AMPK signaling pathway hsa04152
Chagas disease (American trypanosomiasis) hsa05142
Dopaminergic synapse hsa04728
Hepatitis C hsa05160
Hippo signaling pathway hsa04390
Long-term depression hsa04730
mRNA surveillance pathway hsa03015
Oocyte meiosis hsa04114
PI3K-Akt signaling pathway hsa04151
Sphingolipid signaling pathway hsa04071
TGF-beta signaling pathway hsa04350
Tight junction hsa04530


Structure Information


No matching records could be found.

Domain Information




ID Location Description
pfam13513191-243  HEAT_EZ
cl22454191-243  ARM superfamily
PRK12428408-466  PRK12428
cl21454408-466  NADB_Rossmann superfamily
pfam13646217-315  HEAT_2
pfam13646501-596  HEAT_2
COG1413212-474  HEAT
COG1413177-434  HEAT
PRK13800187-322  PRK13800
COG1413102-315  HEAT
pfam13646185-272  HEAT_2


Ontology Information


   
HPRD ID4559
Molecular ClassSerine/threonine phosphatase
Molecular FunctionG-protein coupled receptor activity (GO:0004930)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO