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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ADI1 | 55256 | Acireductone dioxygenase 1 | 2 | ARD; APL1; SIPL; mtnD; Fe-ARD; MTCBP1; Ni-ARD; HMFT1638 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22968445 | 2012 | Cell line : - Source : Department of Pathology of Wrocaw Medical University. Sample Type : CRC tumor and normal tissue No. of Sample : 8 Stage : - | Laser capture microdissection,FFPE-FASP,SAX fractionation,LC-MSMS,Label-free quantitation. | Up-regulation | 6 | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes an enzyme that belongs to the aci-reductone dioxygenase family of metal-binding enzymes, which are involved in methionine salvage. This enzyme may regulate mRNA processing in the nucleus, and may carry out different functions depending on its localization. Related pseudogenes have been defined on chromosomes 8 and 20. [provided by RefSeq, May 2010] |
| Chromosome | 2 |
| Location | 2p25.3 |
| Start | 3497919 |
| End | 3519579 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 21661 |
| OMIM ID | 613400 |
| HGNC ID | HGNC:30576 |
| Unigene ID | Hs.502773 |
| Ensembl ID | ENSG00000182551 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_018269.3 |
|---|---|
| Exon | join(1..212,5604..5723,18587..18766,20498..21661) | mRNA Sequence | Download Select all |
| Length | 1685 |
CDS Information
| Location | join(93..212,5604..5723,18587..18766,20498..20617) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS1653.1 |
Protein Information
| Protein ID | NP_060739.2 |
|---|---|
| Protein Name | Acireductone dioxygenase 1 |
| Molecular Wt. (Da) | 21367 |
| Protein Sequence | Download Select all |
| Length | 179 |
| Uniprot ID | P11362 |
| Ensembl Protein ID | ENSP00000327229 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
| EC | 1.13.11.53 |
|---|---|
| Name | acireductone dioxygenase (Ni2+-requiring) ARD 2-hydroxy-3-keto-5-thiomethylpent-1-ene dioxygenase (ambiguous) acireductone dioxygenase (ambiguous) E-2 |
| Class | Oxidoreductases; Acting on single donors with O2 as oxidant and incorporation of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2; With incorporation of two atoms of oxygen |
| Sysname | 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one:oxygen oxidoreductase (formate- and CO-forming) |
| Substrate | 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one [CPD:C15606]; O2 |
| Product | 3-(methylthio)propanoate; formate [CPD:C00058]; CO |
| Reaction (IUBMB) |  |
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cysteine and methionine metabolism | hsa00270 |
| Metabolic pathways | hsa01100 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam03079 | 3-157 | ARD |
| cl21464 | 3-157 | cupin_like superfamily |
| COG1791 | 51-177 | Adi1 |
| pfam07883 | 86-135 | Cupin_2 |
| COG0662 | 88-135 | ManC |
| pfam02311 | 85-157 | AraC_binding |
| COG3435 | 87-133 | COG3435 |
Ontology Information
| HPRD ID | 625 |
|---|---|
| Molecular Class | Growth inhibitory factor |
| Molecular Function | Transmembrane receptor protein tyrosine kinase activity (GO:0004714) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| Q9BV57 | DB02325 | Isopropyl Alcohol | SmallMoleculeDrug |