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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| MRGBP | 55257 | Chromosome 20 open reading frame 20 | 20 | Eaf7; URCC4; MRG15BP; C20orf20 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 18829976 | 2009 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 34 non-progressed colorectal adenomas, 41 progressed adenomas and 33 adenocarcinomas Stage : - | Ccomparative genomic hybridisation,Microarray analysis, immunohistochemistry on tissue microarrays. | Amplification | - | C20orf24, AURKA, RNPC1, TH1L, ADRM1, C20orf20 and TCFL5 genes to be important in chromosomal instability-related adenoma to carcinoma progression. These genes therefore may serve as highly specific biomarkers for colorectal cancer with potential clinical applications. C20orf24, AURKA, RNPC1, TH1L, ADRM1, C20orf20 and TCFL5, mapping at 20q, were significantly overexpressed in carcinomas compared with adenomas as a consequence of copy number gain of 20q.. |
| 21535316 | 2011 | Cell line : HCT 116, HCT 15, SW 480, SW 620, DLD 1, Caco 2, LS 174T, and HT 29 Source : Institute of Medical Science, The University of Tokyo, Tokyo, Japan, ATCC. Sample Type : CRC tumor and normal tissue No. of Sample : 22 adenomas and 47 carcinomas Stage : - | Immunohistochemistryy,PCR and gene amplification analysis, | Amplification | - | MRGBP contributes to colorectal carcinogenesis through rendering advantages in cell proliferation and/or division of cancer cells and might be a useful specific biomarker for colorectal cancer and the development of diagnostic and/or therapeutic approaches. 22 adenomas and 47 carcinomas in the colon and rectum showed that high levels of MRGBP expression were observed more frequently in carcinomas (45%) than adenomas (5%), linking its role to malignant properties of colorectal tumors. Copy number analysis revealed that gene amplification is involved in the elevated expression. |
| 0 | 0 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | PCR, immunohistochemistry | Up-regulation | - | Results suggest that MRGBP has an important function in proliferation of cancer cells through the regulation of BRD8 and that MRGBP should be a novel therapeutic target for colorectal cancer. |
| 20051959 | 2010 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 11 Stage : - | real time RT-PCR, Immunohistochemistry, Yeast two-hybrid and Immunoprecipitation analysis | Up-regulation | - | MRGBP has an important function in proliferation of cancer cells through the regulation of BRD8 and that MRGBP should be a novel therapeutic target for colorectal cancer. The elevated expression of MRGBP was observed in colorectal cancer tissues. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | - |
| Chromosome | 20 |
| Location | 20q13.33 |
| Start | 62796453 |
| End | 62800593 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 4141 |
| OMIM ID | 611157 |
| HGNC ID | HGNC:15866 |
| Unigene ID | Hs.590870 |
| Ensembl ID | ENSG00000101189 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_018270.4 |
|---|---|
| Exon | join(1..219,658..779,2135..2216,2523..2597,3004..4141) | mRNA Sequence | Download Select all |
| Length | 1659 |
CDS Information
| Location | join(72..219,658..779,2135..2216,2523..2597,3004..3191) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS13503.1 |
Protein Information
| Protein ID | NP_060740.1 |
|---|---|
| Protein Name | Chromosome 20 open reading frame 20 |
| Molecular Wt. (Da) | 22286 |
| Protein Sequence | Download Select all |
| Length | 204 |
| Uniprot ID | P22607 |
| Ensembl Protein ID | ENSP00000260795 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 191 |
| S | Phosphorylation | 195 |
| S | Phosphorylation | 194 |
| S | Phosphorylation | 197 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 60 | ACTB | 32 | NP_001092.1 | in vitro | 12963728 |
| 86 | ACTL6A | 5389 | NP_004292.1 | in vitro | 12963728 |
| 3621 | ING1 | 3337 | NP_005528.3 | in vitro | 12963728 |
| 8089 | YEATS4 | 3666 | NP_006521.1 | in vitro | 12963728 |
| 8295 | TRRAP | 4310 | NP_003487.1 | in vitro | 12963728 |
| 8607 | RUVBL1 | 9143 | NP_003698.1 | in vitro | 12963728 |
| 9643 | MORF4L2 | 2326 | NP_036418.1 | in vitro | 1 296 372 816 230 350 |
| 10902 | BRD8 | 4166 | NP_631938.1 | in vitro | 12963728 |
| 10933 | MORF4L1 | 9532 | NP_996670.1 | in vitro | 12963728 |
| 55929 | DMAP1 | 5465 | NP_061973.1 | in vitro | 12963728 |
| 64769 | MEAF6 | 13347 | NP_073593.2 | in vitro | 1 296 372 816 230 350 |
| 203068 | TUBB | 1852 | NP_001060.1 | in vitro | 12963728 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Ontology Information
| HPRD ID | 1288 |
|---|---|
| Molecular Class | Unknown |
| Molecular Function | Protein-tyrosine kinase activity (GO:0004713) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.