Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| OTUB1 | 55611 | OTU deubiquitinase, ubiquitin aldehyde binding 1 | 11 | FLJ20113, FLJ40710 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25431208 | 2014 | Cell line : SW620 ,SW480, DLD 1 Source : Sun Yat-sen University Cancer Center. Sample Type : Tissue from adenoma, carcinoma and ulcerative colitis. No. of Sample : 260 Stage : TNM Stage I-IV | Immunohistochemistry,migration and invasion assays | Up-regulation | - | OTUB1 promotes CRC metastasis by facilitating EMT and acts as a potential distant metastasis marker and prognostic factor in CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | OTU domain containing |
| Description | The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008] |
| Chromosome | 11 |
| Location | 11q13.1 |
| Start | 63753325 |
| End | 63765892 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 12568 |
| OMIM ID | 608337 |
| HGNC ID | HGNC:23077 |
| Unigene ID | Hs.473788 |
| Ensembl ID | - |
| PharmGKB ID | PA134988141 |
Protein Information
| Protein ID | NP_060140.2 |
|---|---|
| Protein Name | OTU deubiquitinase, ubiquitin aldehyde binding 1 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 271 |
| Uniprot ID | Q96PZ7 |
| Ensembl Protein ID |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 16 |
| K | Acetylation | 188 |
| S | Phosphorylation | 18 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 4093 | SMAD9 | 4484 | BAA21128.1 | yeast 2-hybrid | 15231748 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam10275 | 40-271 | Peptidase_C65 |
| cl19932 | 40-271 | OTU superfamily |
| pfam02338 | 158-266 | OTU |
| COG5539 | 50-270 | COG5539 |
Ontology Information
| HPRD ID | 11406 |
|---|---|
| Molecular Class | Ubiquitin proteasome system protein |
| Molecular Function | DNA binding (GO:0003677) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.