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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| KDM3A | 55818 | lysine (K)-specific demethylase 3A | 2 | TSGA, KIAA0742, JHMD2A |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20823141 | 2010 | Cell line : - Source : Osaka University Hospital Sample Type : CRC tumor and normal tissue No. of Sample : 15 Hepatic metastatic CRC patients. Stage : TNM Stage IV | Immunohistochemistry, Western blotting, microarray,real time RT-PCR | Up-regulation | - | JMJD1A is a useful biomarker for hypoxic tumor cells and a prognostic marker that could be a promising therapeutic target against CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Chromatin-modifying enzymes / K-demethylases |
| Description | This gene encodes a zinc finger protein that contains a jumonji domain and may play a role in hormone-dependent transcriptional activation. Alternative splicing results in multiple transcript variants. |
| Chromosome | 2 |
| Location | 2p11.2 |
| Start | 86440647 |
| End | 86492716 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 52070 |
| OMIM ID | 611512 |
| HGNC ID | HGNC:20815 |
| Unigene ID | Hs.557425 |
| Ensembl ID | ENSG00000115548 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_011532985.1 |
|---|---|
| Exon | join(1..316,1372..1587,9161..9316,10457..10567, 14439..14541,15796..15920,16159..16231,16337..16425, 23407..23570,25726..26237,29558..29762,34130..34344, 37186..37383,37524..37619,37962..38089,39521..39716, 41284..41456,41812..42048,43341..43512,44296..44383, 45083..45213,48672..48791,48874..49013,50235..50411, 50495..50629,51393..52070) | mRNA Sequence | Download Select all |
| Length | 4638 |
CDS Information
| Location | join(1402..1587,9161..9316,10457..10567,14439..14541, 15796..15920,16159..16231,16337..16425,23407..23570, 25726..26237,29558..29762,34130..34344,37186..37383, 37524..37619,37962..38089,39521..39716,41284..41456, 41812..42048,43341..43512,44296..44383,45083..45213, 48672..48791,48874..49013,50235..50411,50495..50629, 51393..51473) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_001140160.1 |
|---|---|
| Protein Name | lysine (K)-specific demethylase 3A |
| Molecular Wt. (Da) | 147211 |
| Protein Sequence | Download Select all |
| Length | 1321 |
| Uniprot ID | P16949 |
| Ensembl Protein ID | ENSP00000350531 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 463 |
| T | Phosphorylation | 308 |
| K | Acetylation | 895 |
| S | Phosphorylation | 445 |
| S | Phosphorylation | 264 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam02373 | 1151-1264 | JmjC |
| cl22893 | 1151-1264 | JmjC superfamily |
| smart00558 | 1064-1134 | JmjC |
| cl22893 | 1064-1134 | JmjC superfamily |
Ontology Information
| HPRD ID | 4229 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Cytoskeletal protein binding (GO:0008092) |
| Biological Process | Signal transduction (GO:0007165); Regulation of signal transduction (GO:0009966); Cytoskeleton organization and biogenesis (GO:0007010) |
Drug Information
No matching records could be found.