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General Information
- Evidence
- Gene
- mRNA
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- Protein
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- Enzyme
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- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25477293 | 2015 | Cell line : Caco 2,HCT 116 Source : - Sample Type : - No. of Sample : - Stage : - | - | Up-regulation | - | SULF1 or SULF2 overexpression contributes to colorectal cancer cell proliferation, migration, and invasion. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).[supplied by OMIM, Mar 2008] |
| Chromosome | 20 |
| Location | 20q13.12-q |
| Start | 46286150 |
| End | 46415360 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 129211 |
| OMIM ID | 610013 |
| HGNC ID | HGNC:20392 |
| Unigene ID | Hs.162016 |
| Ensembl ID | ENSG00000196562 |
| PharmGKB ID | PA134902131 |
Protein Information
| Protein ID | NP_001155313.1 |
|---|---|
| Protein Name | sulfatase 2 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 870 |
| Uniprot ID | Q8TBC5 |
| Ensembl Protein ID | ENSP00000240727 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam12548 | 529-665 | DUF3740 |
| cl13923 | 529-665 | DUF3740 superfamily |
| pfam00884 | 44-375 | Sulfatase |
| cl21476 | 44-375 | alkPPc superfamily |
| PRK05434 | 341-388 | PRK05434 |
| COG0696 | 364-389 | GpmI |
| cl21476 | 364-389 | alkPPc superfamily |
| pfam01676 | 300-384 | Metalloenzyme |
| TIGR01307 | 341-387 | pgm_bpd_ind |
| pfam02995 | 290-398 | DUF229 |
| COG3119 | 43-395 | AslA |
| PRK13759 | 43-412 | PRK13759 |
| TIGR03417 | 43-390 | chol_sulfatase |
| COG1368 | 291-443 | MdoB |
| COG3083 | 249-370 | YejM |
Ontology Information
| HPRD ID | 14387 |
|---|---|
| Molecular Class | Enzyme: Sulphatase |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Biological_process unknown (GO:0000004) |
Drug Information
No matching records could be found.