Search results:


General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
MAP2K1 5604 mitogen-activated protein kinase kinase 1  15MEK1, MAPKK1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
26185457   2015Cell line : -

Source : Twin Cities Metropolitan Area, a seven-county area of Utah, Kaiser Permanente Medical Care Program of Northern California (KPMCP).

Sample Type : Population-based case-control studies

No. of Sample : Colon 1555 , 1956 controls, rectal 754, 959 controls

Stage : -

MicroarrayHypomethylation-MAP2K1, MAPK3, MAPK11, and MAPK7 with promoter hypomethylation functioned via TGF-beta signaling pathway, neurotrophin signaling pathway, and chemokine signaling pathway.

23027623   2012Cell line : -

Source : Renji Hospital (Shanghai, Peoples Republic of China)

Sample Type : CRCTumor

No. of Sample : 2 CRC tumor and adjacent normal tissues

Stage : -

GenotypingPolymorhpism-Mitogen-activated protein kinase (MAPK) pathways regulate many cellular functions including cell proliferation, differentiation, migration and apoptosis.


Gene Details



NC_000015.9 (66679182..66783882)

View Larger Image
   
Gene Type protein coding
Gene Family Mitogen-activated protein kinase cascade / Kinase kinases
Description The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008]  
Chromosome 15
Location 15q22.1-q2
Start 66679182  
End 66783882  
Strand +  
Gene Sequence

   Download   Select all

Length 104701  
OMIM ID 176872   
HGNC ID HGNC:6840   
Unigene ID Hs.145442   
Ensembl ID ENSG00000169032   
PharmGKB ID PA30584   

mRNA Information


mRNA ID ?NM_002755.3
Exon join(1..555,48155..48365,49874..50020,56408..56485, 57784..57835,94883..95007,98118..98319,100356..100420, 102343..102404,102846..102891,103630..104672)  
mRNA Sequence

   Download   Select all

Length 2603  



CDS Information


   
Location 476..1657
CDS Sequence

   Download   Select all

CCDS ID CCDS10216.1



Protein Information


      
Protein IDNP_002746.1
Protein Namemitogen-activated protein kinase kinase 1
Molecular Wt. (Da)39187
Protein Sequence

   Download   Select all

Length 393  
Uniprot IDO76027
Ensembl Protein ID ENSP00000357943  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation304
TPhosphorylation292
SPhosphorylation218
SPhosphorylation222
SPhosphorylation298
TPhosphorylation286
SPhosphorylation218
SPhosphorylation222
SPhosphorylation222
SPhosphorylation218
TPhosphorylation286
TPhosphorylation292
TPhosphorylation386
SPhosphorylation218
SPhosphorylation222
SPhosphorylation385
SPhosphorylation231

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                       
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
842CASP93756NP_001220.2in vitro;in vivo12792650   
1432MAPK142619NP_001306.1in vitro;in vivo12697810   
2002ELK12407NP_005220.2in vitro1   071   698   310   997   880   
2033EP3004078NP_001420.2in vitro;in vivo11278389   
5584PRKCI2105NP_002731.4in vitro10848576   
5590PRKCZ1504NP_002735.3in vitro11535599   
7189TRAF63833NP_665802.1in vitro16313339   
8986RPS6KA44677NP_003933.1in vitro;in vivo10806207   
55742PARVA16283NP_060692.1in vivo15353548   


Pathway Information


                                                                                                                                                                                                                                                                                                                                                                                    
Pathway Name Pathway ID
Acute myeloid leukemia hsa05221
Alcoholism hsa05034
B cell receptor signaling pathway hsa04662
Bladder cancer hsa05219
cAMP signaling pathway hsa04024
Central carbon metabolism in cancer hsa05230
cGMP-PKG signaling pathway hsa04022
Chemokine signaling pathway hsa04062
Choline metabolism in cancer hsa05231
Cholinergic synapse hsa04725
Chronic myeloid leukemia hsa05220
Colorectal cancer hsa05210
Dorso-ventral axis formation hsa04320
Endometrial cancer hsa05213
ErbB signaling pathway hsa04012
Estrogen signaling pathway hsa04915
Fc epsilon RI signaling pathway hsa04664
Fc gamma R-mediated phagocytosis hsa04666
Focal adhesion hsa04510
FoxO signaling pathway hsa04068
Gap junction hsa04540
Glioma hsa05214
GnRH signaling pathway hsa04912
Hepatitis B hsa05161
HIF-1 signaling pathway hsa04066
Influenza A hsa05164
Insulin signaling pathway hsa04910
Long-term depression hsa04730
Long-term potentiation hsa04720
MAPK signaling pathway hsa04010
Melanogenesis hsa04916
Melanoma hsa05218
MicroRNAs in cancer hsa05206
Natural killer cell mediated cytotoxicity hsa04650
Neurotrophin signaling pathway hsa04722
Non-small cell lung cancer hsa05223
Oocyte meiosis hsa04114
Osteoclast differentiation hsa04380
Oxytocin signaling pathway hsa04921
Pancreatic cancer hsa05212
Pathways in cancer hsa05200
Phospholipase D signaling pathway hsa04072
PI3K-Akt signaling pathway hsa04151
Prion diseases hsa05020
Progesterone-mediated oocyte maturation hsa04914
Prolactin signaling pathway hsa04917
Prostate cancer hsa05215
Proteoglycans in cancer hsa05205
Rap1 signaling pathway hsa04015
Ras signaling pathway hsa04014
Regulation of actin cytoskeleton hsa04810
Renal cell carcinoma hsa05211
Serotonergic synapse hsa04726
Signaling pathways regulating pluripotency of stem cells hsa04550
Sphingolipid signaling pathway hsa04071
T cell receptor signaling pathway hsa04660
Thyroid cancer hsa05216
Thyroid hormone signaling pathway hsa04919
TNF signaling pathway hsa04668
Toll-like receptor signaling pathway hsa04620
Vascular smooth muscle contraction hsa04270
VEGF signaling pathway hsa04370


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0665062-380  PKc_MEK1
cl2145362-380  PKc_like superfamily
cd0661566-379  PKc_MEK
cd0664962-388  PKc_MEK2
cd0660566-365  PKc_MAPKK
cd0662062-374  PKc_Byr1_like
cd0662366-366  PKc_MAPKK_plant_like
cd0662266-375  PKc_PBS2_like
cd0662166-375  PKc_Pek1_like
cd0512267-361  PKc_STE
cd0661766-375  PKc_MKK3_6
cd0661967-376  PKc_MKK5
cd0661866-381  PKc_MKK7
cd0661666-377  PKc_MKK4
cd0661266-361  STKc_MST1_2
cd0660966-363  STKc_MST3_like
cd0661367-361  STKc_MAP4K3_like
cd0821567-361  STKc_Nek
cd1400767-362  STKc_Aurora
cd0660674-361  STKc_MAPKKK
cd0661466-362  STKc_PAK
cd0661066-361  STKc_OSR1_SPAK
cd1401468-362  STKc_PknB_like
cd0661166-365  STKc_SLK_like
cd0660863-361  STKc_myosinIII_N_like
cd0018074-256  PKc
cd0662773-361  STKc_Cdc7_like
cd0664465-363  STKc_STK10
cd0512374-360  STKc_AGC
cd0664068-361  STKc_MST4
cd0691768-362  STKc_NAK1_like
cd0664268-363  STKc_STK25
cd0664168-364  STKc_MST3
cd1400367-358  STKc_AMPK-like
cd0662574-361  STKc_MEKK3_like
cd0852967-262  STKc_FA2-like
cd0511767-358  STKc_CAMK
cd0664365-361  STKc_SLK
cd0662675-361  STKc_MEKK4
cd1400884-361  STKc_LKB1_CaMKK
cd0822467-363  STKc_Nek6_7
cd0853067-271  STKc_CNK2-like
cd1399974-262  STKc_MAP3K-like
cd0821767-361  STKc_Nek2
cd1399665-256  STKc_EIF2AK
cd0783368-360  STKc_CDKL
cd1400266-361  STKc_STK36
cd0663274-361  STKc_MEKK1_plant
cd0664667-361  STKc_MAP4K5
cd1401073-360  STKc_ULK4
cd0660768-363  STKc_TAO
cd0663668-361  STKc_MAP4K4_6_N
cd0664866-362  STKc_PAK_II
cd0557274-354  STKc_cGK
cd0663866-361  STKc_myosinIIIA_N
cd0663174-361  STKc_YSK4
cd0663074-359  STKc_MEKK1
cd0663966-362  STKc_myosinIIIB_N
cd0664566-363  STKc_MAP4K3
cd0663768-367  STKc_TNIK
cd0782968-361  STKc_CDK_like
cd0784766-360  STKc_CDKL1_4
cd0822867-363  STKc_Nek6
cd0662874-361  STKc_Byr2_like
cd0662465-361  STKc_ASK
cd1400974-262  STKc_ATG1_ULK_like
cd0558066-265  STKc_PKA_like
cd0511868-361  STKc_CMGC
cd1413777-360  STKc_GSK3
cd0557868-262  STKc_Yank1
cd0557980-362  STKc_MAST_like
cd0783267-256  STKc_CCRK
cd1409966-361  STKc_PLK
cd0557366-262  STKc_ROCK_NDR_like
cd1399767-358  PKc_Wee1_like
cd1411666-361  STKc_Aurora-A
cd0783568-360  STKc_CDK1_CdkB_like
cd0558166-271  STKc_PDK1
cd0665966-361  STKc_PAK6
cd0822274-256  STKc_Nek11
cd0664765-362  STKc_PAK_I
cd0822967-352  STKc_Nek7
cd0663364-363  STKc_TAO3
cd1398373-262  STKc_WNK
cd1411762-362  STKc_Aurora-B_like
cd0558674-367  STKc_Sck1_like
cd1405874-262  STKc_TAK1
cd0019273-355  PTKc
cd0784168-255  STKc_CDK7
cd0783968-360  STKc_CDK5
cd0665543-362  STKc_PAK2
cd0822067-257  STKc_Nek8
cd1409867-262  STKc_Rad53_Cds1
cd1420966-282  STKc_PKA
cd0561171-275  STKc_Rim15_like
cd0662974-361  STKc_Bck1_like
cd0821967-278  STKc_Nek3
cd0822568-278  STKc_Nek5
cd0786068-275  STKc_CDK2_3
cd0663559-369  STKc_TAO1
cd0665443-362  STKc_PAK1
cd0784668-360  STKc_CDKL2_3
cd0665643-362  STKc_PAK3
cd0787164-275  STKc_PCTAIRE3
cd1397874-282  STKc_RIP
cd0783068-360  STKc_MAK_like
cd06652114-274  STKc_MEKK2
cd0821868-273  STKc_Nek1
cd0560967-282  STKc_MAST
cd1404767-256  STKc_EIF2AK2_PKR
cd1421068-361  PKc_DYRK
cd0783868-360  STKc_CDK4_6_like
cd0562129-262  STKc_ROCK2
cd0559644-262  STKc_ROCK
cd0559866-262  STKc_LATS
cd1408174-271  STKc_BRSK1_2
cd0783668-260  STKc_Pho85
cd1410673-361  STKc_DRAK
cd0557466-262  STKc_phototropin_like
cd0559966-280  STKc_NDR_like
cd0784068-263  STKc_CDK9_like
cd0561266-265  STKc_PRKX_like
cd1412174-273  STKc_ULK3
cd0665866-362  STKc_PAK5
cd0560063-262  STKc_Sid2p_like
cd1406674-263  STKc_IRAK
cd1406574-281  PKc_LIMK_like
cd14162113-262  STKc_TSSK4-like
cd0787366-285  STKc_PCTAIRE1
cd1407368-271  STKc_NUAK
cd0787264-362  STKc_PCTAIRE2
cd1400674-273  STKc_MLCK-like
cd0786167-360  STKc_CDK1_euk
cd0663459-369  STKc_TAO2
cd1404667-256  STKc_EIF2AK4_GCN2_rpt2
cd0784866-278  STKc_CDKL5
cd0503865-349  PTKc_Jak_rpt2
cd0558274-274  STKc_RSK_N
cd06653114-274  STKc_MEKK3_like_u1
cd1466367-271  STKc_SnRK3
cd1405267-257  PTKc_Wee1_fungi
cd0557074-372  STKc_PKC
cd1399474-262  STKc_HAL4_like
cd0558474-369  STKc_p70S6K
cd1406967-262  STKc_Chk1
cd06651114-360  STKc_MEKK3
cd0665766-364  STKc_PAK4
cd0852867-355  STKc_Nek10
cd0562226-262  STKc_ROCK1
cd05592114-271  STKc_nPKC_theta_like
cd14080113-262  STKc_TSSK-like
cd1397973-262  STKc_Mos
cd0505762-271  PTKc_EGFR_like
cd0821672-362  PK_STRAD
cd1418874-270  STKc_PLK2
cd1466568-267  STKc_SnRK2-3
cd1409772-282  STKc_STK33
cd0504174-262  PTKc_Fes_like
cd1407268-271  STKc_MARK
cd1409465-365  STKc_CASK
cd1405068-257  PKc_Myt1
cd1405974-262  STKc_MAP3K12_13
cd1409574-273  STKc_DCKL
cd1418666-361  STKc_PLK4
cd1415674-267  PKc_LIMK_like_unk
cd1408274-262  STKc_PKD
cd0785268-373  STKc_MAPK15-like
cd1466268-267  STKc_SnRK2
cd1399174-262  STKc_NIK
cd1420267-275  STKc_ULK1
cd1404867-256  STKc_EIF2AK3_PERK
cd0559466-271  STKc_PKB_alpha
cd1418574-360  STKc_DCKL3
cd08221108-256  STKc_Nek9
cd1399368-270  STKc_Pat1_like
cd0558374-362  STKc_MSK_N
cd0559766-262  STKc_DMPK_like
cd0559574-271  STKc_PKB_beta
cd0505971-264  PTKc_Tec_like
cd1413368-361  PKc_DYRK_like
cd0559366-271  STKc_PKB_gamma
cd1414674-262  STKc_MLK4
cd0560166-262  STKc_CRIK
cd1415574-265  PKc_TESK
cd0561367-262  STKc_MSK1_N
cd1400568-358  STKc_PIM
cd14164111-262  STKc_TSSK6-like
cd0822367-261  STKc_Nek4
cd1420571-355  PTKc_Jak2_rpt2
cd13990112-360  STKc_TLK
cd0508473-266  PTKc_Fes
cd1398774-262  STKc_SBK1
cd1419274-283  STKc_MLCK3
cd1399594-262  STKc_MAP3K8
cd0562416-262  STKc_MRCK_beta
cd0561867-262  STKc_aPKC_iota
cd0783468-368  STKc_MAPK
cd1420165-275  STKc_ULK2
cd1415474-260  STKc_LIMK
cd1407974-262  STKc_AMPK_alpha
cd0561767-280  STKc_aPKC_zeta
cd0784965-265  STKc_ERK1_2_like
cd0508171-278  PTKc_Jak3_rpt2
cd1419873-361  STKc_DRAK2
cd1400174-256  PKc_TOPK
cd05620122-271  STKc_nPKC_delta
cd0562354-262  STKc_MRCK_alpha
cd0560765-269  STKc_GRK7
cd0784468-275  STKc_PCTAIRE_like
cd1398573-356  STKc_GAK_like
cd0783766-274  STKc_CdkB_plant
cd1403974-262  STKc_IKK_alpha
cd0787766-267  STKc_p38alpha
cd0558968-270  STKc_PKN
cd0558574-265  STKc_YPK1_like
cd0787071-272  STKc_PFTAIRE2
cd1404967-256  STKc_EIF2AK1_HRI
cd0784366-250  STKc_CDC2L1
cd1409374-262  STKc_PhKG
cd1416168-271  STKc_NUAK2
cd14165113-271  STKc_TSSK1_2-like
cd1410768-251  STKc_obscurin_rpt1
cd1419369-285  STKc_MLCK4
cd0785674-267  STKc_Sty1_Hog1
cd1398974-265  STKc_IKK
cd0786268-256  STKc_CDK6
cd1410374-250  STKc_MLCK
cd1414874-268  STKc_MLK2
cd0511266-262  PTKc_Itk
cd14119113-358  STKc_LKB1
cd1398874-265  STKc_TBK1
cd0557174-360  STKc_PKB
cd1414574-262  STKc_MLK1
cd1413167-360  PKc_Mps1
cd1412074-360  STKc_ULK1_2-like
cd0786964-264  STKc_PFTAIRE1
cd0557774-262  STKc_GRK
cd14118173-361  STKc_CAMKK
cd1403273-360  STKc_WNK2_like
cd0561962-271  STKc_nPKC_theta
cd1411365-262  STKc_Trio_C
cd0560374-275  STKc_SGK2
cd1409074-262  STKc_Mnk
cd0560264-265  STKc_SGK1
cd1402774-262  STKc_RIP1
cd1422274-279  STKc_LIMK2
cd0786368-256  STKc_CDK4
cd0510963-271  PTKc_HER2
cd1411466-251  STKc_Twitchin_like
cd1407767-262  STKc_Kin1_2
cd1418974-270  STKc_PLK3
cd0561467-262  STKc_MSK2_N
cd1415874-269  STKc_IRAK4
cd0562966-270  STKc_NDR_like_fungal
cd0559074-271  STKc_nPKC_eta
cd1419773-270  STKc_DRAK1
cd0560866-262  STKc_GRK1
cd1419658-251  STKc_DAPK2
cd1419465-361  STKc_DAPK1
cd1407168-262  STKc_SIK
cd1403874-265  STKc_IKK_beta
cd0506073-256  PTKc_Syk_like
cd0511573-262  PTKc_Zap-70
cd0503962-357  PTKc_Csk_like
cd14075113-262  STKc_NIM1
cd0510863-271  PTKc_EGFR
cd0561667-271  STKc_cPKC_beta
cd1408566-251  STKc_CaMKIV
cd0511363-262  PTKc_Btk_Bmx
cd14199173-361  STKc_CaMKK2
cd05588122-262  STKc_aPKC
cd1422174-281  STKc_LIMK1
cd0562668-273  STKc_LATS2
cd1418174-262  STKc_PhKG2
cd1410562-251  STKc_DAPK
cd0557574-360  STKc_SGK
cd1409167-262  STKc_RSK_C
cd1411173-272  STKc_SPEG_rpt2
cd1419074-251  STKc_MLCK2
cd0511673-313  PTKc_Syk
cd0508574-264  PTKc_Fer
cd14061106-262  STKc_MLK
cd1403396-262  STKc_WNK4
cd1406075-262  STKc_MLTK
cd0563068-262  STKc_GRK6
cd1407467-361  STKc_SNRK
cd1416767-283  STKc_CaMKI_alpha
cd0788066-260  STKc_p38gamma
cd0785165-260  STKc_p38
cd0560474-271  STKc_SGK3
cd0508374-271  PTKc_Chk
cd1416674-251  STKc_CaMKI_gamma
cd0503262-277  PTKc_InsR_like
cd0784567-364  STKc_CDK10
cd1408666-262  STKc_CaMKII
cd14084102-262  STKc_Chk2
cd1399875-257  STKc_TGFbR-like
cd0504073-256  PTKc_Ack_like
cd1409668-265  STKc_RCK1-like
cd14135107-361  STKc_PRP4
cd1419167-262  STKc_MLCK1
cd14064113-262  PKc_TNNI3K
cd14055166-283  STKc_TGFbR2_like
cd1422367-262  STKc_GRK2
cd1419562-362  STKc_DAPK3
cd1413459-259  PKc_CLK
cd1418774-270  STKc_PLK1
cd05606122-262  STKc_beta_ARK
cd0562568-262  STKc_LATS1
cd1403173-360  STKc_WNK3
cd1400467-262  STKc_PASK
cd0563168-262  STKc_GRK4
cd07850113-267  STKc_JNK
cd0563374-262  STKc_GRK3
cd0562766-262  STKc_NDR2
cd0785565-265  STKc_ERK5
cd0561066-369  STKc_MASTL
cd1400074-262  STKc_LRRK
cd1413266-262  STKc_CK2_alpha
cd0785768-263  STKc_MPK1
cd14147124-262  STKc_MLK3
cd0503474-264  PTKc_Src_like
cd1422659-259  PKc_DYRK1
cd14200173-361  STKc_CaMKK1
cd1417666-270  STKc_RSK2_C
cd0562866-344  STKc_NDR1
cd14163113-271  STKc_TSSK3-like
cd0822669-362  PK_STRAD_beta
cd1409274-270  STKc_MSK_C
cd1417866-270  STKc_RSK3_C
cd1466474-263  STK_BAK1_like
cd05591122-275  STKc_nPKC_epsilon
cd0561560-271  STKc_cPKC_alpha
cd0504573-265  PTKc_RET
cd0506862-264  PTKc_Frk_like
cd1408365-250  STKc_CaMKI
cd0784268-256  STKc_CDK8_like
cd0786660-275  STKc_BUR1
cd07878113-267  STKc_p38beta
cd1401966-262  STKc_Cdc7
cd14136125-261  STKc_SRPK
cd1402674-262  STKc_RIP2
cd0511471-262  PTKc_Tec_Rlk
cd0786565-263  STKc_CDK9
cd0507968-256  PTKc_Jak1_rpt2
cd1418274-262  STKc_PhKG1
cd05587124-271  STKc_cPKC
cd1421271-265  PKc_YAK1
cd1418456-251  STKc_DCKL2
cd0503373-262  PTKc_EphR
cd0785474-274  STKc_MAPK4_6
cd0506374-262  PTKc_EphR_A2
cd0507262-264  PTKc_Lyn
cd07853173-260  STKc_NLK
cd1410867-251  STKc_SPEG_rpt1
cd1408774-262  STKc_PSKH1
cd0563266-262  STKc_GRK5
cd1422568-361  PKc_DYRK4
cd0786461-274  STKc_CDK12
cd0508263-271  PTKc_Csk
cd14174108-262  STKc_Mnk1
cd0506762-264  PTKc_Lck_Blk
cd05044110-264  PTKc_c-ros
cd05605114-262  STKc_GRK4_like
cd1417970-262  STKc_MSK1_C
cd0506565-277  PTKc_EphR_B
cd0505062-256  PTKc_Musk
cd1403043-262  STKc_WNK1
cd1418352-251  STKc_DCKL1
cd05071112-264  PTKc_Src
cd1407673-361  STKc_Kin4
cd14203112-271  PTKc_Src_Fyn_like
cd1407873-262  STKc_MELK
cd0507058-271  PTKc_Fyn
cd1417574-270  STKc_RSK1_C
cd1411072-272  STKc_obscurin_rpt2
cd0509745-256  PTKc_DDR_like
cd0785970-274  STKc_TDY_MAPK
cd14040102-262  STKc_TLK1
cd14041102-262  STKc_TLK2
cd0511063-262  PTKc_HER4
cd0508068-274  PTKc_Tyk2_rpt2
cd07858173-265  STKc_TEY_MAPK
cd1416957-251  STKc_CaMKI_beta
cd14101159-362  STKc_PIM2
cd0783171-256  STKc_MOK
cd0505662-256  PTKc_FAK
cd0822787-363  PK_STRAD_alpha
cd1417266-361  STKc_MAPKAPK3
cd13992110-367  PK_GC
cd05073139-264  PTKc_Hck
cd14100159-262  STKc_PIM1
cd1417756-270  STKc_RSK4_C
cd0505574-269  PTKc_PDGFR
cd1408974-250  STKc_MAPKAPK
cd0511163-271  PTK_HER3
cd07879173-260  STKc_p38delta
cd14173101-262  STKc_Mnk2
cd1407072-262  STKc_HUNK
cd05066108-262  PTKc_EphR_A
cd0504962-262  PTKc_Trk
cd1418072-262  STKc_MSK2_C
cd14102186-262  STKc_PIM3
cd1401668-262  STKc_CK1
cd0787568-267  STKc_JNK1
cd1411574-262  STKc_Kalirin_C
cd14144143-257  STKc_BMPR1
cd1396874-210  PKc_like
cd14159106-263  STKc_IRAK1
cd0509273-262  PTKc_TrkA
cd14012113-360  PK_eIF2AK_GCN2_rpt1
cd1406798-263  STKc_LRRK1
cd14056174-257  STKc_TGFbR_I
cd1410967-251  PK_Unc-89_rpt1
cd0505183-256  PTKc_DDR
cd05098126-271  PTKc_FGFR1
cd0787468-361  STKc_JNK3
cd0514862-264  PTKc_Srm_Brk
cd0787668-259  STKc_JNK2
cd1417066-393  STKc_MAPKAPK2
cd05069112-264  PTKc_Yes
cd05100126-271  PTKc_FGFR3
cd1401768-280  STKc_TTBK
cd0504774-256  PTKc_Tie
cd0508964-256  PTKc_Tie1
cd1415071-262  STKc_A-Raf
cd14142126-257  STKc_ACVR1_ALK1
cd0505274-264  PTKc_Abl
cd1416866-283  STKc_CaMKI_delta
cd05101126-271  PTKc_FGFR2
cd1402574-244  STKc_RIP4_like
cd05106170-264  PTKc_CSF-1R
cd0509692-256  PTKc_DDR1
cd05053126-264  PTKc_FGFR
cd1421368-274  PKc_CLK1_4
cd05099126-271  PTKc_FGFR4
cd1422468-265  PKc_DYRK2_3
cd14053166-257  STKc_ACVR2
cd05043141-274  PTK_Ryk
cd1410473-250  STKc_Titin
cd14143126-257  STKc_TGFbR1_ACVR1b_ACVR1c
cd14054124-257  STKc_BMPR2_AMHR2
cd0509473-262  PTKc_TrkC
cd0509373-262  PTKc_TrkB
cd05104134-269  PTKc_Kit
cd05090109-256  PTKc_Ror1
cd14036111-269  STKc_GAK
cd0509551-255  PTKc_DDR2
cd1406874-259  STKc_LRRK2
cd05103170-264  PTKc_VEGFR2
cd1413867-264  PTKc_Wee1a
cd13977143-256  STKc_PDIK1L
cd1406274-262  STKc_Raf
cd1414962-262  STKc_C-Raf
cd0509162-256  PTKc_Ror2
cd05054170-264  PTKc_VEGFR
cd14207170-264  PTKc_VEGFR1
cd1405167-264  PTKc_Wee1
cd0504873-256  PTKc_Ror
cd1417174-262  STKc_MAPKAPK5
cd1422866-285  STKc_HIPK1
cd1403782-250  STKc_NAK_like
cd0786773-256  STKc_CDC2L6
cd14045109-358  PK_GC_unk
cd1421559-259  PKc_CLK2
cd1422766-342  STKc_HIPK2
cd1415162-262  STKc_B-Raf
cd05102170-264  PTKc_VEGFR3
cd0506269-257  PTKc_IGF-1R
cd0506169-257  PTKc_InsR
cd14220126-257  STKc_BMPR1a
cd1411266-250  STKc_Unc-89_rpt2
cd05064108-262  PTKc_EphR_A10
cd0508874-256  PTKc_Tie2
cd1421168-285  STKc_HIPK
cd0504671-256  PTK_CCK4
cd1398674-358  STKc_16
cd05107170-264  PTKc_PDGFR_beta
COG211273-209  COG2112
COG3642100-212  Bud32
smart0022068-361  S_TKc
pfam0006968-361  Pkinase
PLN000341-368  PLN00034
COG051567-371  SPS1
smart0021969-355  TyrKc
smart0022169-355  STYKc
PTZ0026357-262  PTZ00263
pfam0771468-256  Pkinase_Tyr
PTZ00267114-276  PTZ00267
PLN0000966-362  PLN00009
PTZ0026661-262  PTZ00266
PTZ0042646-281  PTZ00426
PHA0339048-273  pk1
PTZ0028374-282  PTZ00283
PTZ0003674-285  PTZ00036
PTZ0002474-260  PTZ00024
PHA03212100-260  PHA03212
PRK1318468-262  pknD
PHA0320951-262  PHA03209
PHA03207173-285  PHA03207
TIGR03903113-260  TOMM_kin_cyc
PHA03210154-256  PHA03210
PHA03211186-258  PHA03211
COG0661143-225  AarF
TIGR01982143-215  UbiB


Ontology Information


   
HPRD ID5567
Molecular ClassDual specificity kinase
Molecular FunctionEnzyme inhibitor activity (GO:0004857)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
Q02750DB05239CobimetinibSmallMoleculeDrug
Q02750DB06616BosutinibSmallMoleculeDrug
Q02750DB08911TrametinibSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO