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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
STK31 56164 serine/threonine kinase 31  7TDRD8, SgK396 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22828137   2012Cell line : -

Source : US Biomax, Shenzhen Second People?s Hospital.

Sample Type : CRC tumor and normal tissue

No. of Sample : 110 colon cancer patients and 10 normal tissues

Stage : -

Tissue microarray, western blotting, flow cytometryUp-regulation-STK31 is able to control the differentiation state of colon cancer cells, which critically depends on its STK domain.

New therapeutic approach against cancer by targeting STK31 and cancer differentiation.


Gene Details



Chromosome 7 - NC_000007.14(23710167..23832513)

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Gene Type protein coding
Gene Family Tudor domain containing
Description This gene is similar to a mouse gene that encodes a putative protein kinase with a tudor domain, and shows testis-specific expression. Alternative splicing results in multiple transcript variants encoding different isoforms.  
Chromosome 7
Location 7p15.3
Start 23710167  
End 23832513  
Strand +  
Gene Sequence

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Length 122347  
OMIM ID 605790   
HGNC ID HGNC:11407   
Unigene ID Hs.309767   
Ensembl ID ENSG00000196335   
PharmGKB ID -   

mRNA Information


mRNA ID NM_031414.4
Exon join(1..169,1933..1979,2068..2120,7315..7413,17075..17149, 18925..19083,25372..25730,26738..26912,42551..42666, 44149..44308,52635..52757,58829..59008,59474..59590, 60839..60958,61981..62112,71253..71354,73417..73497, 75312..75437,76342..76467,76672..76758,77814..77963, 80658..80780,104978..105046,121970..122347)  
mRNA Sequence

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Length 3602  



CDS Information


   
Locationjoin(9..70,1933..1979,2068..2120,7315..7413,17075..17149, 18925..19083,25372..25730,26738..26912,42551..42666, 44149..44308,52635..52757,58829..59008,59474..59590, 60839..60958,61981..62112,71253..71354,73417..73497, 75312..75437,76342..76467,76672..76758,77814..77963, 80658..80780,81145..81156)
CDS Sequence

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CCDS ID -



Protein Information


      
Protein IDNP_001247433.1
Protein Nameserine/threonine kinase 31
Molecular Wt. (Da)113130
Protein Sequence

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Length 996  
Uniprot IDP06239
Ensembl Protein ID ENSP00000328213  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


   
EC2.7.11.1
Namenon-specific serine/threonine protein kinase
A-kinase
AP50 kinase
ATP-protein transphosphorylase
calcium-dependent protein kinase C
calcium/phospholipid-dependent protein kinase
cAMP-dependent protein kinase
cAMP-dependent protein kinase A
casein kinase
casein kinase (phosphorylating)
casein kinase 2
casein kinase I
casein kinase II
cGMP-dependent protein kinase
CK-2
CKI
CKII
cyclic AMP-dependent protein kinase
cyclic AMP-dependent protein kinase A
cyclic monophosphate-dependent protein kinase
cyclic nucleotide-dependent protein kinase
cyclin-dependent kinase
cytidine 3',5'-cyclic monophosphate-responsive protein kinase
dsk1
glycogen synthase a kinase
glycogen synthase kinase
HIPK2
Hpr kinase
hydroxyalkyl-protein kinase
hydroxyalkyl-protein kinase
M phase-specific cdc2 kinase
mitogen-activated S6 kinase
p82 kinase
phosphorylase b kinase kinase
PKA
protein glutamyl kinase
protein kinase (phosphorylating)
protein kinase A
protein kinase CK2
protein kinase p58
protein phosphokinase
protein serine kinase
protein serine-threonine kinase
protein-aspartyl kinase
protein-cysteine kinase
protein-serine kinase
Prp4 protein kinase
Raf kinase
Raf-1
ribosomal protein S6 kinase II
ribosomal S6 protein kinase
serine kinase
serine protein kinase
serine-specific protein kinase
serine(threonine) protein kinase
serine/threonine protein kinase
STK32
T-antigen kinase
threonine-specific protein kinase
twitchin kinase
type-2 casein kinase
betaIIPKC
epsilon PKC
Wee 1-like kinase
Wee-kinase
WEE1Hu
ClassTransferases; Transferring phosphorus-containing groups; Protein-serine/threonine kinases
SysnameATP:protein phosphotransferase (non-specific)  
SubstrateATP [CPD:C00002]; protein  
ProductADP [CPD:C00008]; phosphoprotein  
Reaction (IUBMB)



PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0450889-129  TUDOR
cl0257389-129  TUDOR superfamily
cd14014802-921  STKc_PknB_like
cl21453802-921  PKc_like superfamily
cd08220821-929  STKc_Nek8
cd13999795-920  STKc_MAP3K-like
cd05122797-919  PKc_STE
cd00180795-922  PKc
cd14066797-919  STKc_IRAK
smart0033389-134  TUDOR
cd08529821-934  STKc_FA2-like
cd14059795-920  STKc_MAP3K12_13
cd14155793-944  PKc_TESK
cd14062829-921  STKc_Raf
cd14010838-918  STKc_ULK4
cd08530825-918  STKc_CNK2-like
cd08221819-918  STKc_Nek9
cd08215821-918  STKc_Nek
cd14065795-918  PKc_LIMK_like
cd14150832-918  STKc_A-Raf
cd14154807-947  STKc_LIMK
cd14158825-919  STKc_IRAK4
cd14007806-968  STKc_Aurora
cd14117771-929  STKc_Aurora-B_like
cd14149830-921  STKc_C-Raf
cd14055806-899  STKc_TGFbR2_like
cd14151832-918  STKc_B-Raf
cd05123838-918  STKc_AGC
cd06606838-919  STKc_MAPKKK
cd05118833-919  STKc_CMGC
cd14039826-919  STKc_IKK_alpha
cd14191820-919  STKc_MLCK1
cd14045799-926  PK_GC_unk
cd08223776-918  STKc_Nek4
cd06621797-938  PKc_Pek1_like
cd14038791-917  STKc_IKK_beta
cd14189794-929  STKc_PLK3
cd13979825-920  STKc_Mos
cd14060838-920  STKc_MLTK
cd07848840-947  STKc_CDKL5
cd14188806-929  STKc_PLK2
cd14011838-918  PK_SCY1_like
cd08225838-931  STKc_Nek5
cd13975819-920  PKc_Dusty
cd13987805-918  STKc_SBK1
cd13989814-917  STKc_IKK
cd06614821-915  STKc_PAK
cd14201828-931  STKc_ULK2
cd07862830-941  STKc_CDK6
cd14145798-920  STKc_MLK1
cd13995825-919  STKc_MAP3K8
cd14112827-917  STKc_Unc-89_rpt2
cd05611806-918  STKc_Rim15_like
cd14006826-917  STKc_MLCK-like
cd05117826-968  STKc_CAMK
cd14664799-921  STK_BAK1_like
cd06657826-919  STKc_PAK4
cd14114826-917  STKc_Twitchin_like
cd07833799-918  STKc_CDKL
cd14012806-919  PK_eIF2AK_GCN2_rpt1
cd06628829-919  STKc_Byr2_like
cd14064795-920  PKc_TNNI3K
cd14002826-923  STKc_STK36
cd14221793-918  STKc_LIMK1
cd06655806-919  STKc_PAK2
cd14222820-918  STKc_LIMK2
cd08217832-918  STKc_Nek2
cd14187826-929  STKc_PLK1
cd06647806-917  STKc_PAK_I
cd05615838-1002  STKc_cPKC_alpha
cd06607825-898  STKc_TAO
cd14186825-929  STKc_PLK4
cd07864827-933  STKc_CDK12
cd14050840-919  PKc_Myt1
pfam0056731-147  TUDOR
pfam00069806-972  Pkinase
smart00220806-972  S_TKc
COG0515746-919  SPS1
TIGR03903787-919  TOMM_kin_cyc
PHA03212804-935  PHA03212
PLN00113798-931  PLN00113
PHA03207803-928  PHA03207
pfam02463280-656  SMC_N
PHA03390820-957  pk1


Ontology Information


   
HPRD ID2551
Molecular ClassSerine/threonine kinase
Molecular FunctionTransporter activity (GO:0005215)
Biological ProcessTransport (GO:0006810)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO