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General Information
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26013439 | 2015 | Cell line : - Source : Databases from China, U.S. and Sweden of CRC Sample Type : Population based case control study No. of Sample : - Stage : TNM Stage I-IV | Immunohistochemistry,Functional analysis | Up-regulation | - | The PRL, RBM3, Wrap53, p53 and DNA status are potential prognostic biomarkers for the young CRC patients. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes the anterior pituitary hormone prolactin. This secreted hormone is a growth regulator for many tissues, including cells of the immune system. It may also play a role in cell survival by suppressing apoptosis, and it is essential for lactation. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011] |
| Chromosome | 6 |
| Location | 6p22.3 |
| Start | 22287473 |
| End | 22303082 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 15610 |
| OMIM ID | 176760 |
| HGNC ID | HGNC:9445 |
| Unigene ID | Hs.1905 |
| Ensembl ID | ENSG00000172179 |
| PharmGKB ID | PA33790 |
mRNA Information
| mRNA ID | ?NM_000948.5 |
|---|---|
| Exon | join(31..124,5805..5929,8300..8475,10239..10346, 12531..12710,15291..15640) | mRNA Sequence | Download Select all |
| Length | 1043 |
Protein Information
| Protein ID | NP_000939.1 |
|---|---|
| Protein Name | prolactin |
| Molecular Wt. (Da) | 83201 |
| Protein Sequence | Download Select all |
| Length | 227 |
| Uniprot ID | Q13616 |
| Ensembl Protein ID | ENSP00000326804 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 5479 | PPIB | 458 | NP_000933.1 | in vitro;in vivo;yeast 2-hybrid | 10935542 |
| 5618 | PRLR | 1457 | NP_000940.1 | in vitro;in vivo | 9 626 554 109 666 540 000 000 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cytokine-cytokine receptor interaction | hsa04060 |
| Jak-STAT signaling pathway | hsa04630 |
| Neuroactive ligand-receptor interaction | hsa04080 |
| PI3K-Akt signaling pathway | hsa04151 |
| Prolactin signaling pathway | hsa04917 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd10288 | 29-227 | prolactin_like |
| cl07831 | 29-227 | growth_hormone_like superfamily |
| pfam00103 | 30-227 | Hormone_1 |
| cd10284 | 46-225 | growth_hormone_like |
| cd10287 | 43-227 | prolactin_2 |
| cd10286 | 35-227 | somatolactin |
| cd10285 | 46-227 | somatotropin_like |
Ontology Information
| HPRD ID | 5831 |
|---|---|
| Molecular Class | Peptide hormone |
| Molecular Function | Receptor signaling complex scaffold activity (GO:0030159) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.