CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
PRNP	5621	Prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia)	20	CJD; GSS; PrP; ASCR; KURU; PRIP; PrPc; CD230; AltPrP; p27-30; PrP27-30; PrP33-35C

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
22972305	2012	Cell line : - Source : - Sample Type : - No. of Sample : - Stage : TNM Stage IV	-	Up-regulation	-	Characterize a novel molecular mechanism that links PrPc expression to the regulation of CRC metastasis. Targeting PrPc will, therefore, be a promising strategy to overcome the metastatic advantage in colorectal tumors.

Gene Details

Chromosome: 20; NC_000020.10 (4666797..4682234)
View Larger Image

Gene Type	protein coding
Gene Family	CD molecules
Description	The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
Chromosome	20
Location	20p13
Start	4686151
End	4701588
Strand	+
Gene Sequence	>gi\|568815578:4686151-4701588 Homo sapiens chromosome 20, GRCh38.p2 Primary Assembly ATTAAAGATGATTTTTACAGTCAATGAGCCACGTCAGGGAGCGATGGCACCCGCAGGCGGTATCAACTGA TGCAAGTGTTCAAGCGAATCTCAACTCGTTTTTTCCGGTGACTCATTCCCGGCCCTGCTTGGCAGCGCTG CACCCTTTAACTTAAACCTCGGCCGGCCGCCCGCCGGGGGCACAGAGTGTGCGCCGGGCCGCGCGGCAAT TGGTCCCCGCGCCGACCTCCGCCCGCGAGCGCCGCCGCTTCCCTTCCCCGCCCCGCGTCCCTCCCCCTCG GCCCCGCGCGTCGCCTGTCCTCCGAGCCAGTCGCTGACAGCCGCGGCGCCGCGAGCTTCTCCTCTCCTCA CGACCGAGGCAGGTAAACGCCCGGGGTGGGAGGAACGCGGGCGGGGGCAGGGGAGCCGCGGGGGCCGAGT GAGGACCCCGGGCCTCGGGTCCCAGGCGCAAGGGTGCCCGGCCGGGCGGGGTCGGGACCCCAGTGAGGAG GGGCCGGGGGCTGCCCCGCGGGCGCGTGACGCGTCTCGGGCCTGCCCGGCTGCGCTGGTCTCCGCTCGGG TGAGGCGGCTTGGCTTCGCTTTTCAGGTTAGGAAAGCTCCCTTTACTGCGCGTTGGGGGGCTGGGGGAGC TGGCGGAGCCCCGTTAGGGAGGTCGGTGGCGCCGGGGTGTCTCAGCGCCCCCTGCACCCCGCGCGGGTCC GGCCCAGCGGGCGATCGCTGGCGCCCAGGGAACTCCGGGAGGGCCGCCAGCGGGCTCCGCAGGGCGCGGG GCGGGGAGGGGCGCCTGGGGGCCGCGGGGCTCGCGCTCCCCGCCCGTTGGCCGCCCCTCGGAGGCCGAGA TCGGGGCCCAGAACGCCCCTTGGCAAGGCCTGGCGCTTCCGCGATGCCCAGAGGGTGCTTGGGGGGATGG AGAGAGGGGCGCCCGCCGGGGGAGTTCCGGGAGCCTCGGTGCCTCCCGCCGCAGCTGCAGCGTTCCTCCC GGGAGGCGGCCCAGCCCTTCATCCTCGCCGCCTGAGCTTCTCCGAGGGGGGCTGCAGCCTTGCGGCCGTT GCCACCGCCTGGAGAAGCGGCCCACGCGGACTGACGGGCGGGGGCGGGGCCTCGGGCCTCGGCGGGGGCG GGGTCCGGGGAGGCCCCACCCTCTGTTCTCCAGGGGCGGGGAGAGAGGAGCTGCAGGTCTGCGGCCTGGC CCCAGGTGCGATGGCGGACCCCAGCTTGGCCAGTCACATTCCTCCCAGTCCCCCTGGAGGGAGAACGCTG GCCATGGGGGGCTCCAAGGAACAACCAGCCTCGGATGACGACCCTTGGGTCACCGGTCTCCCCACCTGTG CGGCAGGCGCCTTCACGTTTCATTATTAAACAATGGGGAGAAATCCATGTTTACTGTCCTTTTTAAGGAA TTTTTTGCTCTTCTCTTTGAGGTGGCTGTAGGAAATAGATTTTTTTTTTAACCTCGCAATTCCACCACGG TCACATCCATCCTCGCCATCGCAGAGCCACAGCTCTCCGTTTTTGTTTCCTAGCCTCCAGATTCTCACAC AACACAGTGCAGTTTCACTGCTGTAATGATGAGGATCTTCATGGCCGCGTTATTTTCTTGTTCTGAGAGC ATCACGGTTTAATTAGCAGTTCCCCATATGATTTGAAGTGTTTCCCGTTTCCTTAGGGAAAACTCCTGGT AGAATAGGATTAAGGATTTTTACAAATATAATTATCAAAAACATAGGAACAGGGAATTGGATAAATATGT TAAACTTCTGGAAAAATCAACAACGCTCTTAGATTTGTAGAAGAAAGGAAAAAATCACCAGTGGAAAGGA GCAATTTTACTTACACAAACACAGAGAAGGTCTTACAGTGAAAAAAAGCTAACCAGTAAGGGGAAAAGCA GGCAGAGGGGTAGGATGTGATTTGTATGTTATTTATATCTAACACAAGTCTTCCACACCGAAAGGAAAAT ATTAAGATTATAATAGATAAATGGCAAAATGATGAGTCATTTACACAATAAAATGCAAATTAGAGCATGT TTGGGTTATCATTTTACATCTATTAAAATAACCAAAATAATTAATAGTAACAGCAACCCTTGCTGGAAGG TTGCCCAAAACTTGGCATTTTCAAGTGTCTGGGGAGGTGGCAGGGCTTTGGGGTCACAAAGATGGTTCTG CAGTCAATTTTGTGACCTTGGACAGGCTACCTAATTTCCTGATCCTCCTTTTGTCCATTCATAGAATGGA GGAAATGATAGCTACTTTCTGCGTCTGTATGTATGAGTTATTGGGGGCATTTCGAACCAGTGACAAACAT TTTGTTAAGCAATCTGGTGATGCATTAAGAAGCTGGAAGCTGTGACCCAGAAACCCCACTCCTGAGAACT TACCTGCAATGGAAGAAACAAACAAACAAAAACAGGCATGTATTCCTAGCAGAATGATCTAAAATTAGAA CACCTGGAAAAGAGCCTAAATGTATAACACCAGGGCAGTAGCTAAGAAAATTATGACACATTAACTGAAA TGAACATTATGTAACCACTAAAAATCATGATTTTGGAGCCTGTGATATGTGGGGAAAAACTGACAAGTAA AAAAGTGGGTTATTAACTGCACCTGCTTACTCTAACGTGAACGCATATGTGAAAAATCTGAAAGGAAAAG CACAGAAAATGGACGTTTTCATTGAAATTGTCGGTGATCTTAATTTTCCTTTGGTGAATATATTGCTCTC ACTAAGGGCGTTTAAAAAATAGTTCACAGGTTTTAATTTTTTAGATGAAATGGACCCACAGTTTTCTGTA AGAGAAAGGAGAGATTGTTATATTTGCTACTTAGAATAAAAGATTTTTAGCCAACGTTGTTTCCTTTTTC AAATATTTTTCCATTTTTTTAGTTGATTAATGATTTAGTAATTTGTGTATTGGGTTTTTTTAAGAATCAG TTCTTAGATTCATTTATCAATTCTAGTTTTTTGTTGTTGTTTTTAAGGACTCCTGAATATTTTTCAAAAC TGAACAATTTCAGCCATGTCTGAGCTTTCCGTCTTCCTGGAGGCACAAATCTAGTTTAGCTGAACCACAA CAGATTGTACATATCCTGCAGAACCTCTGTGGTCTTAGGAAGGTTGAAAGTCACCAAATGTCACAGAAAA TGAGGGTCAGGAAAGGCTGTGATCACAAGCTCTTGATCCAGAGGCCACTCGGGTGCATCTGTGTGACTGA CACCTCATTGCATCATCATTTCTTGTAAAATCAGCTTAATTTTGCAGAGAAATGGCCACAGATTTTTAGA ATTATGCTGAATTATGTAAGGGAGCAGCCATTTTAAAAATAATGTAATCAAATAACAATAATAACATAAC AGAAGTTTCTGCACCACACTGACACTGAACATGGCTGTCAACCAACTAGCCAAACCAAGGTGAAAGATTC TCTGAACTTCAGTTTTAACTTACTTCGTCCATTCTCCCTTTTCAGATCTTATTTCTTCTTCCAAGGCAAC TATATCCACTGTGAACTGCTGCATATTAAACATTCAAAACATGTCTGTATCTAACCCAGTGATGGCTACA GCATTATAAAATAACTCCTAAGTGAATAGTGTGTGCAGCAATTCTCACAGCTAGGAGAATTTTTTTTGTC GATGTGTTAACCATTCCTTTTTCTCCAACTGCATTCTACTTAAACTGTTACAGTATTGTGTGATCACTTT AAGGGAGGTAATCCTTCAGTGAAAAGCATTATAAATGTTGAAGATTAGACCCCTGAGGACCTAGCACTGA AGCCTGATCACGGGTGCCAATTCCCTGAGAAGCTTTTATAGATTCCCAAATCCCATCGCTAGGCACTCTC TGACTGGCTTGTGATGGGTTCCAGCAATGTTGTTTTTTAAAAGCTCCTCAGGTAATTCTGATCATGGACC AGGTTGGGGACCCTTTGCTCTGTTCAGTTTGTGGTTTCTAGGTGCCAGTGAGAAACCCCTACCCCCAATT TTTGTGCAAAATTTTTTTCAGCTTACATCAAGTTCTTTATGAACCTCAGAAAATTAAAATATAACAAGGG AATTTACTTAGCTCAGAAGAGACAAGGGACATTATGGGGTGAAGGTCGGGGGTTGTTTGACATTTGCCCC TTCCCGATGTAACTAATTAAGCTTCAAGTTGTAATGTGTTTTATGGGCTAGAAGGCTTTAGTGCCTATAT TTGGATCTCAGCTCCAACACCTTGGACTCTTACAACCTTGGGATAAGTTCTTACTAGCTCTGACTCTCAC TCCCCATCTATAAATGGGAATAAGATGAACGGGGTAATTTATAGATTTTTTAGTACCCTCTCTCTAGTTC CGCTGTTTTGCCATTCTGCTCATGCACCAATGCCATGTGATCTTATTGTAGCTTTGCACTCTGACACCTG GCAGGTCAAGTGCACCCTTGATTATCTTCTCATTAAAAATTTTCTTCAGTCTTTTAAGTTTTGAGTATAA TTTCATAATGTCTTTTAAAATCTCTTTTGAATTCTTTTTCAAATTTATTTATTTTTTCTTTGACAGATAA GATTATATGTATTGTGTACAAAATTAGAAAGAGATCTTTTCCTCTAAGATCTGAAACAAGACAAGAATGC TCACACGCACTAGTTCTATTCAACATATGGTACTGCAAGTCCTAGCCAGGACAGTTAGACAAGAGAAAGA AATAAAAAGCATCCAAATTTGAAAGGAAAAAGTTAAATTGTTCCTATTTGGAGACGACATGATTTTACAC TTATAAAACCCTAAAGACTCCACCAGAAAACCATTAGAACTAATAAATTCAGTAAAGTTGCAGGATACAA AATTAACATACAAAAATCAGTAGTGTTTCTATATGCCAACAGTGAACTATCAGGAAAGAAATAAAAAGAA AGTGCCATTTACAATAGCTACAAAATAAATATTTCAGAATAAATTTAGCCAAGAAGGTGAAAGATCTCTA CACTGAAAACTATAAAACACTGATGAAAGAAATTCAAGGAGACACAAATAGAAAGATAGCCTGTGCTCAT GGGGGGATAATTAATGTTGTTAAAATGTCCATACTACCCAAAGTGACCTACAGATTCCATAGAATCCCTA TCAAAATACCAATGACATTCTTCACAGAAATAGAAAAAACAATCCTAAAATTGGGTGAAGGTGGCATCTT TGTCTCGTTTCAGATCTAAGAGGAAAAGCTCTCAATTTTTCACCATTAAGTATGATGTTAGCTGTGACCT TGTCATATGTGGCCTTTATTGTGTTGAGGTACAATGCTTCTACACCTAATTCATTGAGAGTTTTTATCAT GAAAGAATGTTGAATTTTGTCAAACGCTTTTTCTGCATCTATTGAAATGATCGTATGGTTATTGTCTCAC TCTGTTACTGTGATGTATCACACTTATTGATTTGTGTATGTTGAACCATCCTTGCAGCCCTGGGATGAAT CCCACTGTATCATAGTAAATGATCTTTTTAATGAGCTGTTGAATTTGCTTCGCTAGAATTTTGTTAAGAA TTTTTGCACCTATGTTCATCAGGGATATTGGCCTATACTGCCATTTTCTTGTGTGTTTTTGTGGGACTTT GACATCAGGATAATGCTGGTTTCTCCTGTTATTAATTTCTAGTTTTATACCATCATGCTTAGAAAAAAAA CTTGATACGATTTCAGTCTAATTAAGTTTGTTAAGACTTGTTTTATGGCCTAACATATGATCTGTCTTGG AGCATGCTCCATGTGCTGTTGAGAAGAATGTGTATTCTGCAGCTGTTGGATGGAATGTCCTGTATTTGTC TGTTTGGATCCATTTGGTCTAAGTGAAGTGTAAGTCTGATGCCTCCTTATTTATTTTCTTTCTAAATCTC CCGTCCAAAAATCTAAGAGATCCAAAGCAAACAGGGGGTTATAAAATTACCTTTGAATTCTGACTGAAAT TGTGTTTACTTTGTAGATTATTTGCTGGTGACTTGGTATCTTTCAATATTGGTTTCCCAAACAAAAAACA TTGTATGTCTTTCTCTTTTTCCAGTCTTCTTTTATGTCTCAGTAAAATTTTGTAGCTTGCCTACTACTTA TTTTCAGGTTAAATCCTAGATATTTTCAATTCTTACTGCCATTATGAATGAATGTTTTTCCCCATGAAAT GTTTAACTACAGCTGATTTAGGGACTCACTGAGTTTTGATTTGTTGATTTGAAAAACTACCACCCTGTTG AGCTCATGTATTTATTCTAAGACATTTTTTGAGATTTTCCAGGTAAAAAAATTATACCTAGATGAATTTA TAGAACAACCTAATAGCATAAAAGCAATAGATTATTGTTCACCACATTAATGGGAATGCCTTTCCTCTTA AAATTATGATATCTTGGGCTTTGTGTTTGTGACAGCATTTCTTTATGATGGAAAGAGACTATCCTTCCAG TTCTATAGAAACGTTTTAAAAATAGCTTACATTTTTAAAAATTTAGGAATGATATTGATTTTCATTGAAA ACTTTTCAACATCTGAAGAAAATCTTTTCTTCCTAACCTATTAATAGAGCTCCTGATTTTCAACCATTCT TGTATTCCTAAAATAATCCATATTGGTCATAATGTATTCTTCTTTTACTAAACTGTTAAAATAAGTTGGG TGCTGTTTTTTTAGATTTTGGCACCTGTGTGAGAGGAGGGTGCCATGGCAGGGTGGCTAAGTGTGCCCAC CTGTGTACTAGCATTGAATTTTGACCCTTTATCCCATTGGCTCTAAACACTACATCTCAGGTGAAGACGC CCAAATGTTTATCTCTACTGAGTTACAGATTCCTATAACAATTGCTTAAATTGATACTCCCACTTGAATG TCTCATAGGTGTGGCAAAGTTTACATGTCTATACTGAAACTCTTGGTTTTCTCTCCCAGGCATGACCCTC CACCAGTTTGTCCTATTTCAGTAGATGGCATCACCGCCATCTCCCTGGTTATGGAAGTCCCAGACCCGGG CAACTCTCACTCCTCCATCCACTCAACCAGCAGGTCTTATTGGCTCTTTCTGTAAAATATGTCTCATTTA TTCACAGCCTGCTAGCTGCATGGACTCCATCCCAGGCCACGCCACCATCTTCCTGCAGCAGTTTCTTAAC TGGCCTCTCCATTCCCTTTCTTGTCCCACTAAATTTTCTTCTATTTAAGAAAAAATGTTTTGTAGACATG GGGTTTCACCATGTTGCCCAGGCTGGTCTCAAACTCCTGGGCTCAAGCAATCCTCCTGCCTGAGCTTCCC AAAGTGCTGGGATTATAGGCTTGAGCTGAGCTTTTGAAAAAACATTCTATGATGTTACTGTCCTACTAAG ACCCTTTAATGGCTCCCCACTGCTTTCAGAGGAAAATAGAAATTTCTCTCTGTGGACCATGAGGCCCTCA TGATCTGACCCTCACCACCTCCCTAGTCTTAGCAGTCCACCTGCCACTGTCTCATGGGGCTCCACAGATT TGATCTCCTTTTTGGTCCTTAAGCCCACCAAGCTAAGTATCTTATTCAAAACTGTGTCCTCAGCCCCTAG CACAATTCTTGACCCTTAGAATTCTGACACTTGAAATGTGTGTTAAGCTAATCAATAAATTATTGTGCCA GGCTTGGTGGCACAATAATGTGTTGTGGGTCACCTATATATAGCTGTGGCTCACACCTATAATCCCAGCA CTTTGGGAGGCTGAGGCCTGCAGATTGGTTGAGCCCAGGAATTTGAGACCAGCCTGGGCAACATGGCAAG ACCCCATCACTATTAAAAATACAAAAAAAAAAAAAACCAGGCGTGGTGTTGCATACCTGTGGTCCCAGCT ACTCAGGAGGATCACTTGAGCCCACTGGGTGGAGGTTGCAGAGAGCTGAGATCATGCCACTACACTTTGG CCTGGGTAAGACCCTGTCTCAAGAAAAAAAAAAAAAGGTTATGGTACTGTAAATATTATATTACAGTGTA TAATTTTTGACAGCTTTTTTTCTCCATTTCTTCTATGGTTATTGGTCAGTTCTAGCCTTCTATTTTTTTT TTTAAGCTGACACATACTGGCTGGGCATGGTGGCTCACACCTGTAATCTCAGCACTTTGGGAGGCCAAGA CAGGAAGATCTCTTGAGCCCAGAAGTTTGAGGCGAGCCTGGGCAACATAGCAAGACCCCATCTCTACCAG AAAAGAAACAACAACAAAAAGAAACTGGCACATACTAGTTATTCCATAAATATTTCTTAAATGAATTAAT TCTAAAGTTGATTTTTATAATTTACATCTTAATAGAAAGACAATCCATCTCAGAGATATTTTTATTCATT AAGGAAAGTTGCATAAAGTAATTTATTAACCTTTTAAAGCATTCTCTAAGCCTATTTCCCCTTATAGAGA TATGTTTTCTAGTGATGTGTGTATGTTACATTTTCAAATAACTCTTAATTTTATTTAGAAATTCCACATT TTTGTGGGTTTTATTTATTAAATTCGATTTTCATCTCTATTATTAATTTATGACAGTTTATTTTGAAGTT TTCTGTTTTCTTCCTTTTGAGTTGAATAATCATTTACTTTATTTTACTTCTTCTATTCAGTTGTATTATC CATGTTCCTCTGATAGCCATGCAGGTTCCAAATCCTCACATTTTTCAACTTCTTTAAAAGATTTTTTTTG TGCTATCCTGATAAGCGTTAAGTGTTATATCATTTTTTTTCATTTTTATTATATTCTTAATGATTTTGAT TCTCTTTTTCTATCCTTTTGGTTTTCTTTCTTAGGTAAATGATCAGTTATATCTTTTGGCCATTTTTTTC TGTTGGAATTACTGTCTCTTACTGCTCTGTAAGAATTCCTTGCAAGTTCTAGAAATGAATCCTCTGTTGA TTTTAAGTACTAAAGTCCCCTTTACCATTGTGTACTCTTTCTATTAACTTTGTCCAGAGTCAGCTTTATC GTGCTGAACAAGAATCTTTACATTTTAATTTTTTTTTTTAATTTTTAAGTTCAAGGGTACAAGTGCAGGT TTGTTCCATAGGTAAACTCGTGTCATGGGGGTTTGTCATACAGATTATTTCATCACTCAGGTACTAAGCC TAGTACCCATTAGTTATTTTTCCTGATCCTCTCCCTCCCTTAGCCCTCCGATAGGCCCTAGTATGTGTTG TTCCTCTGCATGCGTCCATGTGTTCTTATCATTTAGGTCCCACTTATAAATGAGAACATGTAGAATTGGG TTTTCTGTTCCTGTGTCAGTTTGCATATCCCTGCAAAGAACATGATCTCGTTCTTTTCTGGGGCTGCATA GTATTCGATAGCATATATGTACCACACTTTCATTATCCCAGCTATCACTGATGGGCATTTAGGTTGATTC CATGTCTTTGCTATTGTGGATAGTTTTGCAATGAACATACACGTGCATGTGTCTTTGTAATAGGATGATT TATATTCCTTTGGGTATATACCTAGTAATGGGATTGCTGAGTCGAATGATATTTCCGTCTTTAGGTTTTT GAGGATGTAATCAAATTCATCAATTATTTGCCTTATGGTTTGTGCTTTTTGTTTAAAAAGTTCTTCCCCC ATTCCTCCTCCAGGTCACAAAGACATTTCCCAATATTTTCCTCTTCTAGCGCCAAACTTGTACCTTTCAC ATGTAAGTCTTGGATCCATCTAGAGTTCACTTTTGTATGTAGTTAGGGATCTAGTTTTCTTTTTCTTGTT TCCCAGAAGCATGAAACCTTCCTCCTTTATTGGTTCGTGGTGCCCATGTCAGCACACATCAAGTCCCTGT TAAAGTGTATCTACGTGGGTTTCTCTCTCAACTTGCTTTTCTGTTTCCTTTGGTCTCTCCGTCTATTCCT GAGCTTTACCGTCCAGTCTTCGTCACTGTGGTTTTGTAGTGATTTCATGTCTGCTTTGGCAGATTCCCTC CTCTTTACACTTTTTTTTTAAGGTTGACCTTATTATTCATGGACATTTTCTTCCCCATAGAAGTTTACTG AACTTCTCAAAAAATTGAGATTACCTGGAATTTTAACTGGCATTTTATTGCAACTACCAGTTCATTTAGG ATAATGGACATCTTTATAATACTGAGTTATCGCCATCAAGACCATGGAATGCCTCTCCATTTTTTTCAGA CCATCTTCTGTGTTCTCTGTATAATGTGTCACCCATCAGAAGTCTTTTCTTAGTTAAGTCAATTCCTAGA CGCTTTACAGTTTGGTTGTTACTTTGAATATCTGTATTTTCTTCTGGTCAGTTATTGCTACTGTAGAGGA ATGCCGTTGGTTTTCGTAGGCTGACCTTCAGTCCCACAACCTTGCACTCTAGCGTTGGTTCTCATGTTAT CCCTGTTATTCTGTTGGATTTTCTATGTGCATGATCACACTAATTGCAAATAGTGTCAGCTAGAGCACTT TCCTTGCCATTCTTACACCTGTTACTTCTTTGCATATGGCCTTGGACAGCACCTTGAGTCCCATGACAAT GGATGTCCCTGTTGTATTTCTGAGTGTATTCTTAGCATTCTTCTTAGTAATAAACAGGTATTGACCATTA CCATATACTTAATAGGATATCTTGAAATATGCCAGAGGACTAGGCCACTACTTGACTGGTGACAGAGAGT ATCTTAGATGTATAGGCCCCCAGACATGCCAGTGTCCTCTCTCACCACCCATCTCCACTCCAAAGTTGTC TGGCCTCACCCACCTTCTGTGCCTGGTTCTTCTCCTCTGTGCTTCTCTCACTATGCCATGTCCTCGCCTG TTCAGGTGTCTCTAAGAGCTCATAGATCCTTAACTCTTACAGCTTTAAATGAGGCACATTCAAAGCCCGA CTCAGTGTCATTCCCTGCAGTCTCCTCTTCCTCCCATCTTACCCATTTCAGGTAATATCTCCAGCCAGCC AGAGTCTACTGCAGTAGCTGGCACATGAAATAAATGTTTATTTAACTGAATTGAAAATGTTAGCTGGCCA TTGTCAAAAATACTATTTTGTAAATTTATAAATATGGTTCTCTTTGTATATCCATTATAAATATTTAGTA TTTAGTTTGATTATTCCTTATGCTTTATAACATGTGTTTTCCCATTCATTCATTTATCCAGCATTTATTT TGCATGTCTATGGGTCAAGCGCTCTGTCTAGGAACACTGCTGTGAACAAAACCAAACTCCCGCCCTAAAG GAGCCTGCACTCCCGTGGAGAACATGAATAATAAGCACAGAGGAAATAACATAATATCTCAAGTAGCTGT AACTGCTCCAGAGAATAATGAAGCCAGGAAAGGGGGTGGGCTAGGGGGTGCTGTTTTAGGTAGAGTGATG GGAACAGCCCCACTGAGCAAACTTTAGCCACATGAGTAGCTGGAAGAAAAGCCTTCTAGGACCAGGGAAC AGCAAGTGCAACAGCCCTGAGACAGGATGGGCTTGTCAGTTTGAGGAGCAGTGGGAGGCCTGAACCAGGT TACATGGGGCCCAGCCAGTATGGCCACGACTTTGTGTTTTATCCAGAGTACAAAGGAGCCTCACTGAGGG ACAAGGGAAGTGGCATGATGTGACCCGCATATTAAGAGGAGAGCGCTCAATGGCAGCCAGGGGAGGAGCA GGGAGGCTGGTTGGGAGGCTGTTGAAGAAATCAGGTGAGAAGTGATGGAAGCACCGAATAAGATGGTCAT GTTGGAAAAATTGAGAAGCTGAGGTGCTTAGCATTGATTTTCAAGGTAGAGCTACTGAGATTTGCTGATA GATCCAATGTATGCTGGGAGAGAAAATTCAGTCACTCTAGAGCATTGGCTGGATTTGTCACCCATTGCAG CGAATGGAGAAGGTGCTGACATAAAAGCCCTTTAGACTGAAAGCTACTGACTGAGGGGATGGTGCCCTAG TTTGATTTCCTGGGGTGTATGAGTAGCAGGGAGGCCAAGAGCTGGGCCTCACGAGATTGTGGGGACTACA TCAGGGAAGCAGGCCTGCAAAGAACCTGCACCACAGACCCCCACCTAAAAGAGCCTCCAAAAACCCTAAC TGGCATGACCTGAGTACTTTAACTCTGCTTGTAACTTTCAAATATATTTTGATTTGCTTATGACCACCAA GGCAAAACTTCCCATTTCAATAATGTTAGTAGAAACATAAACAGGATGTTAATTTATTTATTTGGTAATT CTTTTTATGAATATTATCCAGTTTAATCATTAGCTCTGAAGGAGATGAAAAATAATTTTCTAATTTTTAG AAAAATTTGCAGCTAATTGGGTGATAAAGGTAAGGGGTTTCTGAGTTCACAAAAATGTTCTAAAATTGGC AACAGTTTCGGTTGCACGTTTCATTAAATGTACTAAAAACCATTGAACTGTACATGGTATATGGTGAATT ATATGGTATGTGAATTATATCTCAACAAGCTGGGTATTGTTTTTTTAAAAAATAAAAATAAAAAAGGAGA AAGAGAGAGAGAAAAACAATTGCAGATCATCCCAGCACTGAGGACAAGACTAACTTCAGTGTTCCAGTAT ATGCCATTATAGGTTTTACGGCACACAGTGATGATTTGGAGCCTATGATTTGACCTAGGGTACAGCAGGT ACTGTTTAGCAATCATTTTACTATTGTCATAGGTCTCTGCTCTTGGAGCTAAGTGCCCAGGGTAAATGAG ATCTTTAATTTGAAAAGAGATTTTTGATTTGATGAATGTACATTCTCCAAAGGGTCATAAATTGTCATTC TGGATGTTTGATCTGTTTGTTGTTTTGGTACAAAAATTAGAAGAAAATAATTCACTCATAAAATGTTAAA TAATGAACTAAAAGTCATTCATCAAGTCCATAACTTAGGGTCACATTTGTCCTTGGAGCAGGAGAAAGAG TTGTGTTCACCCTTTTCTTACTTTTGCTTTTGTCCTAAGTGCTTCAGAGAAGTACAGGGTGGCAACAGTG TTTCTACTGAGCAGCTGATACCATTGCTATGCACTCATTCATTATGCAGGAAACATTTAGTAATTTCAAC ATAAATATGGGACTCTGACGTTCTCCTCTTCATTTTGCAGAGCAGTCATTATGGCGAACCTTGGCTGCTG GATGCTGGTTCTCTTTGTGGCCACATGGAGTGACCTGGGCCTCTGCAAGAAGCGCCCGAAGCCTGGAGGA TGGAACACTGGGGGCAGCCGATACCCGGGGCAGGGCAGCCCTGGAGGCAACCGCTACCCACCTCAGGGCG GTGGTGGCTGGGGGCAGCCTCATGGTGGTGGCTGGGGGCAGCCTCATGGTGGTGGCTGGGGGCAGCCCCA TGGTGGTGGCTGGGGACAGCCTCATGGTGGTGGCTGGGGTCAAGGAGGTGGCACCCACAGTCAGTGGAAC AAGCCGAGTAAGCCAAAAACCAACATGAAGCACATGGCTGGTGCTGCAGCAGCTGGGGCAGTGGTGGGGG GCCTTGGCGGCTACATGCTGGGAAGTGCCATGAGCAGGCCCATCATACATTTCGGCAGTGACTATGAGGA CCGTTACTATCGTGAAAACATGCACCGTTACCCCAACCAAGTGTACTACAGGCCCATGGATGAGTACAGC AACCAGAACAACTTTGTGCACGACTGCGTCAATATCACAATCAAGCAGCACACGGTCACCACAACCACCA AGGGGGAGAACTTCACCGAGACCGACGTTAAGATGATGGAGCGCGTGGTTGAGCAGATGTGTATCACCCA GTACGAGAGGGAATCTCAGGCCTATTACCAGAGAGGATCGAGCATGGTCCTCTTCTCCTCTCCACCTGTG ATCCTCCTGATCTCTTTCCTCATCTTCCTGATAGTGGGATGAGGAAGGTCTTCCTGTTTTCACCATCTTT CTAATCTTTTTCCAGCTTGAGGGAGGCGGTATCCACCTGCAGCCCTTTTAGTGGTGGTGTCTCACTCTTT CTTCTCTCTTTGTCCCGGATAGGCTAATCAATACCCTTGGCACTGATGGGCACTGGAAAACATAGAGTAG ACCTGAGATGCTGGTCAAGCCCCCTTTGATTGAGTTCATCATGAGCCGTTGCTAATGCCAGGCCAGTAAA AGTATAACAGCAAATAACCATTGGTTAATCTGGACTTATTTTTGGACTTAGTGCAACAGGTTGAGGCTAA AACAAATCTCAGAACAGTCTGAAATACCTTTGCCTGGATACCTCTGGCTCCTTCAGCAGCTAGAGCTCAG TATACTAATGCCCTATCTTAGTAGAGATTTCATAGCTATTTAGAGATATTTTCCATTTTAAGAAAACCCG ACAACATTTCTGCCAGGTTTGTTAGGAGGCCACATGATACTTATTCAAAAAAATCCTAGAGATTCTTAGC TCTTGGGATGCAGGCTCAGCCCGCTGGAGCATGAGCTCTGTGTGTACCGAGAACTGGGGTGATGTTTTAC TTTTCACAGTATGGGCTACACAGCAGCTGTTCAACAAGAGTAAATATTGTCACAACACTGAACCTCTGGC TAGAGGACATATTCACAGTGAACATAACTGTAACATATATGAAAGGCTTCTGGGACTTGAAATCAAATGT TTGGGAATGGTGCCCTTGGAGGCAACCTCCCATTTTAGATGTTTAAAGGACCCTATATGTGGCATTCCTT TCTTTAAACTATAGGTAATTAAGGCAGCTGAAAAGTAAATTGCCTTCTAGACACTGAAGGCAAATCTCCT TTGTCCATTTACCTGGAAACCAGAATGATTTTGACATACAGGAGAGCTGCAGTTGTGAAAGCACCATCAT CATAGAGGATGATGTAATTAAAAAATGGTCAGTGTGCAAAGAAAAGAACTGCTTGCATTTCTTTATTTCT GTCTCATAATTGTCAAAAACCAGAATTAGGTCAAGTTCATAGTTTCTGTAATTGGCTTTTGAATCAAAGA ATAGGGAGACAATCTAAAAAATATCTTAGGTTGGAGATGACAGAAATATGATTGATTTGAAGTGGAAAAA GAAATTCTGTTAATGTTAATTAAAGTAAAATTATTCCCTGAATTGTTTGATATTGTCACCTAGCAGATAT GTATTACTTTTCTGCAATGTTATTATTGGCTTGCACTTTGTGAGTATTCTATGTAAAAATATATATGTAT ATAAAATATATATTGCATAGGACAGACTTAGGAGTTTTGTTTAGAGCAGTTAACATCTGAAGTGTCTAAT GCATTAACTTTTGTAAGGTACTGAATACTTAATATGTGGGAAACCCTTTTGCGTGGTCCTTAGGCTTACA ATGTGCACTGAATCGTTTCATGTAAGAATCCAAAGTGGACACCATTAACAGGTCTTTGAAATATGCATGT ACTTTATATTTTCTATATTTGTAACTTTGCATGTTCTTGTTTTGTTATATAAAAAAATTGTAAATGTTTA ATATCTGACTGAAATTAAACGAGCGAAGATGAGCACCA Download Select all
Length	15438
OMIM ID	176640
HGNC ID	HGNC:9449
Unigene ID	Hs.472010
Ensembl ID	ENSG00000171867
PharmGKB ID	PA33796

mRNA Information

mRNA ID	NM_000311.3
Exon	join(1..362,13061..15438)
mRNA Sequence	>5621 ATTAAAGATGATTTTTACAGTCAATGAGCCACGTCAGGGAGCGATGGCACCCGCAGGCGGTATC AACTGATGCAAGTGTTCAAGCGAATCTCAACTCGTTTTTTCCGGTGACTCATTCCCGGCCCTGC TTGGCAGCGCTGCACCCTTTAACTTAAACCTCGGCCGGCCGCCCGCCGGGGGCACAGAGTGTGC GCCGGGCCGCGCGGCAATTGGTCCCCGCGCCGACCTCCGCCCGCGAGCGCCGCCGCTTCCCTTC CCCGCCCCGCGTCCCTCCCCCTCGGCCCCGCGCGTCGCCTGTCCTCCGAGCCAGTCGCTGACAG CCGCGGCGCCGCGAGCTTCTCCTCTCCTCACGACCGAGGCAGAGCAGTCATTATGGCGAACCTT GGCTGCTGGATGCTGGTTCTCTTTGTGGCCACATGGAGTGACCTGGGCCTCTGCAAGAAGCGCC CGAAGCCTGGAGGATGGAACACTGGGGGCAGCCGATACCCGGGGCAGGGCAGCCCTGGAGGCAA CCGCTACCCACCTCAGGGCGGTGGTGGCTGGGGGCAGCCTCATGGTGGTGGCTGGGGGCAGCCT CATGGTGGTGGCTGGGGGCAGCCCCATGGTGGTGGCTGGGGACAGCCTCATGGTGGTGGCTGGG GTCAAGGAGGTGGCACCCACAGTCAGTGGAACAAGCCGAGTAAGCCAAAAACCAACATGAAGCA CATGGCTGGTGCTGCAGCAGCTGGGGCAGTGGTGGGGGGCCTTGGCGGCTACATGCTGGGAAGT GCCATGAGCAGGCCCATCATACATTTCGGCAGTGACTATGAGGACCGTTACTATCGTGAAAACA TGCACCGTTACCCCAACCAAGTGTACTACAGGCCCATGGATGAGTACAGCAACCAGAACAACTT TGTGCACGACTGCGTCAATATCACAATCAAGCAGCACACGGTCACCACAACCACCAAGGGGGAG AACTTCACCGAGACCGACGTTAAGATGATGGAGCGCGTGGTTGAGCAGATGTGTATCACCCAGT ACGAGAGGGAATCTCAGGCCTATTACCAGAGAGGATCGAGCATGGTCCTCTTCTCCTCTCCACC TGTGATCCTCCTGATCTCTTTCCTCATCTTCCTGATAGTGGGATGAGGAAGGTCTTCCTGTTTT CACCATCTTTCTAATCTTTTTCCAGCTTGAGGGAGGCGGTATCCACCTGCAGCCCTTTTAGTGG TGGTGTCTCACTCTTTCTTCTCTCTTTGTCCCGGATAGGCTAATCAATACCCTTGGCACTGATG GGCACTGGAAAACATAGAGTAGACCTGAGATGCTGGTCAAGCCCCCTTTGATTGAGTTCATCAT GAGCCGTTGCTAATGCCAGGCCAGTAAAAGTATAACAGCAAATAACCATTGGTTAATCTGGACT TATTTTTGGACTTAGTGCAACAGGTTGAGGCTAAAACAAATCTCAGAACAGTCTGAAATACCTT TGCCTGGATACCTCTGGCTCCTTCAGCAGCTAGAGCTCAGTATACTAATGCCCTATCTTAGTAG AGATTTCATAGCTATTTAGAGATATTTTCCATTTTAAGAAAACCCGACAACATTTCTGCCAGGT TTGTTAGGAGGCCACATGATACTTATTCAAAAAAATCCTAGAGATTCTTAGCTCTTGGGATGCA GGCTCAGCCCGCTGGAGCATGAGCTCTGTGTGTACCGAGAACTGGGGTGATGTTTTACTTTTCA CAGTATGGGCTACACAGCAGCTGTTCAACAAGAGTAAATATTGTCACAACACTGAACCTCTGGC TAGAGGACATATTCACAGTGAACATAACTGTAACATATATGAAAGGCTTCTGGGACTTGAAATC AAATGTTTGGGAATGGTGCCCTTGGAGGCAACCTCCCATTTTAGATGTTTAAAGGACCCTATAT GTGGCATTCCTTTCTTTAAACTATAGGTAATTAAGGCAGCTGAAAAGTAAATTGCCTTCTAGAC ACTGAAGGCAAATCTCCTTTGTCCATTTACCTGGAAACCAGAATGATTTTGACATACAGGAGAG CTGCAGTTGTGAAAGCACCATCATCATAGAGGATGATGTAATTAAAAAATGGTCAGTGTGCAAA GAAAAGAACTGCTTGCATTTCTTTATTTCTGTCTCATAATTGTCAAAAACCAGAATTAGGTCAA GTTCATAGTTTCTGTAATTGGCTTTTGAATCAAAGAATAGGGAGACAATCTAAAAAATATCTTA GGTTGGAGATGACAGAAATATGATTGATTTGAAGTGGAAAAAGAAATTCTGTTAATGTTAATTA AAGTAAAATTATTCCCTGAATTGTTTGATATTGTCACCTAGCAGATATGTATTACTTTTCTGCA ATGTTATTATTGGCTTGCACTTTGTGAGTATTCTATGTAAAAATATATATGTATATAAAATATA TATTGCATAGGACAGACTTAGGAGTTTTGTTTAGAGCAGTTAACATCTGAAGTGTCTAATGCAT TAACTTTTGTAAGGTACTGAATACTTAATATGTGGGAAACCCTTTTGCGTGGTCCTTAGGCTTA CAATGTGCACTGAATCGTTTCATGTAAGAATCCAAAGTGGACACCATTAACAGGTCTTTGAAAT ATGCATGTACTTTATATTTTCTATATTTGTAACTTTGCATGTTCTTGTTTTGTTATATAAAAAA ATTGTAAATGTTTAATATCTGACTGAAATTAAACGAGCGAAGATGAGCACCAAAAAAAAAAAAA AAA Download Select all
Length	2755

CDS Information

Location	13071..13832
CDS Sequence	>gi\|122056620:373-1134 Homo sapiens prion protein (PRNP), transcript variant 1, mRNA ATGGCGAACCTTGGCTGCTGGATGCTGGTTCTCTTTGTGGCCACATGGAGTGACCTGGGCCTCTGCAAGA AGCGCCCGAAGCCTGGAGGATGGAACACTGGGGGCAGCCGATACCCGGGGCAGGGCAGCCCTGGAGGCAA CCGCTACCCACCTCAGGGCGGTGGTGGCTGGGGGCAGCCTCATGGTGGTGGCTGGGGGCAGCCTCATGGT GGTGGCTGGGGGCAGCCCCATGGTGGTGGCTGGGGACAGCCTCATGGTGGTGGCTGGGGTCAAGGAGGTG GCACCCACAGTCAGTGGAACAAGCCGAGTAAGCCAAAAACCAACATGAAGCACATGGCTGGTGCTGCAGC AGCTGGGGCAGTGGTGGGGGGCCTTGGCGGCTACATGCTGGGAAGTGCCATGAGCAGGCCCATCATACAT TTCGGCAGTGACTATGAGGACCGTTACTATCGTGAAAACATGCACCGTTACCCCAACCAAGTGTACTACA GGCCCATGGATGAGTACAGCAACCAGAACAACTTTGTGCACGACTGCGTCAATATCACAATCAAGCAGCA CACGGTCACCACAACCACCAAGGGGGAGAACTTCACCGAGACCGACGTTAAGATGATGGAGCGCGTGGTT GAGCAGATGTGTATCACCCAGTACGAGAGGGAATCTCAGGCCTATTACCAGAGAGGATCGAGCATGGTCC TCTTCTCCTCTCCACCTGTGATCCTCCTGATCTCTTTCCTCATCTTCCTGATAGTGGGATGA Download Select all
CCDS ID	CCDS13080.1

Protein Information

Protein ID	NP_000302.1
Protein Name	Prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal fam
Molecular Wt. (Da)	25235
Protein Sequence	>5621 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGG WGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGY MLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTT TKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG Download Select all
Length	253
Uniprot ID	P02511
Ensembl Protein ID	ENSP00000227251

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
H	Proteolytic Cleavage	111
C	Disulfide Bridge	179;214
N	Glycosylation	181
N	Glycosylation	197
S	Glycosyl phosphatidyl inositol GPI	230
P	Hydroxylation	44
H	Proteolytic Cleavage	96
H	Proteolytic Cleavage	111
C	Disulfide Bridge	179;214
N	Glycosylation	181
N	Glycosylation	197
S	Glycosyl phosphatidyl inositol GPI	230
P	Hydroxylation	44
H	Proteolytic Cleavage	96
N	Glycosylation	196
N	Glycosylation	196
N	Glycosylation	196
N	Glycosylation	196
N	Glycosylation	196

Enzyme Information

No matching records could be found.

PPi Information

No STRING Network could be found.

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
333	APLP1	102	NP_001019978.1	in vivo	15146195
334	APLP2	103	NP_001633.1	in vivo	15146195
348	APOE	135	NP_000032.1	in vivo	15146195
1804	DPP6	525	NP_570629.2	in vivo	15146195
2885	GRB2	150	NP_002077.1	in vitro;in vivo;yeast 2-hybrid	11571277
3309	HSPA5	682	NP_005338.1	in vivo	15146195
3329	HSPD1	318	NP_002147.2	in vitro;in vivo	8676499
4099	MAG	1160	NP_002352.1	in vivo	15146195
4684	NCAM1	301	NP_851996.2	in vivo	15146195
5340	PLG	1417	NP_000292.1	in vivo	11100730
5684	PSMA3	1463	NP_002779.1	yeast 2-hybrid	16713569
7917	BAT3	808	NP_004630.3	yeast 2-hybrid	16169070
81628	TSC22D4	18231	NP_112197.1	yeast 2-hybrid	16713569

Pathway Information

Pathway Name	Pathway ID
Prion diseases	hsa05020

Structure Information

PDB ID	1E1G
Resolution	-
Method	SOLUTION NMR
Chains	A
Molecule	PRION PROTEIN
Model	View

Domain Information

ID	Location	Description
smart00157	23-240	PRP
cl02493	23-240	Prion superfamily
pfam00377	134-252	Prion
pfam11587	28-Jan	Prion_bPrPp
cl13097	28-Jan	Prion_bPrPp superfamily

Ontology Information

HPRD ID	1269
Molecular Class	Membrane bound ligand
Molecular Function	Transmembrane receptor protein tyrosine kinase activity (GO:0004714)
Biological Process	Cell communication (GO:0007154); Signal transduction (GO:0007165)

SNP Information

View SNP Geneview Report

Drug Information

Uniprot ID DrugBank ID Name Type
P04156 DB00759 Tetracycline SmallMoleculeDrug

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO