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General Information
- Evidence
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- Enzyme
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- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21970873 | 2011 | Cell line : - Source : Helsinki University Central Hospital. Sample Type : Population based case control study No. of Sample : 643 Stage : DukeStage A-D | Immunohistochemistry | Up-regulation | - | High PROX1 expression is associated with a poor grade of tumour differentiation, and, in colon cancer patients, also with less favourable patient outcome. |
| 25242332 | 2014 | Cell line : SW620, SW480, DLD1 Source : ATCC Sample Type : - No. of Sample : - Stage : - | Immunohistochemistry | Up-regulation | - | PROX1 as a key regulator of the transcriptional network contributing to metastases outgrowth in colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Homeoboxes / PROS class |
| Description | The protein encoded by this gene is a member of the homeobox transcription factor family. Members of this family contain a homeobox domain that consists of a 60-amino acid helix-turn-helix structure that binds DNA and RNA. The protein encoded by this gene is conserved across vertebrates and may play an essential role during development. Altered levels of this protein have been reported in cancers of different organs, such as colon, brain, blood, breast, pancreas, liver and esophagus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012] |
| Chromosome | 1 |
| Location | 1q41 |
| Start | 214161278 |
| End | 214214853 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 53576 |
| OMIM ID | 601546 |
| HGNC ID | HGNC:9459 |
| Unigene ID | Hs.741808 |
| Ensembl ID | ENSG00000117707 |
| PharmGKB ID | PA33812 |
mRNA Information
| mRNA ID | ?NM_001270616.1 |
|---|---|
| Exon | join(1..98,13244..15035,21940..22047,28296..28490, 52421..58028) | mRNA Sequence | Download Select all |
| Length | 7801 |
Protein Information
| Protein ID | NP_001257545.1 |
|---|---|
| Protein Name | prospero homeobox 1 |
| Molecular Wt. (Da) | 19756 |
| Protein Sequence | Download Select all |
| Length | 737 |
| Uniprot ID | O15297 |
| Ensembl Protein ID | ENSP00000306682 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 179 |
| S | Phosphorylation | 511 |
| S | Phosphorylation | 514 |
| S | Phosphorylation | 79 |
| S | Phosphorylation | 199 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1387 | CREBBP | 2534 | NP_004371.2 | in vivo | 11943779 |
| 2494 | NR5A2 | 6830 | NP_995582.1 | in vitro;in vivo;yeast 2-hybrid | 15205472 |
| 2516 | NR5A1 | 1702 | NP_004950.2 | yeast 2-hybrid | 16488887 |
| 3172 | HNF4A | 2612 | CAA89989.1 | in vitro;in vivo;yeast 2-hybrid | 1 648 888 715 604 090 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam05044 | 578-734 | HPD |
| cl20287 | 578-734 | HPD superfamily |
| pfam09805 | 229-278 | Nop25 |
| cl23601 | 229-278 | Nop25 superfamily |
Ontology Information
| HPRD ID | 5529 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Structural molecule activity (GO:0005198) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
No matching records could be found.