CoReCG

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
24318970	2014	Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 201 Stage : -	Immunohistochemistry	Up-regulation	-	matrilysin-2 expression was an independent prognostic factor for patients with colorectal cancer, which might be a high specific biomarker for colorectal cancer. matrilysin-2 expression level significantly elevated in colorectal cancer compared with adjacent normal specimens

Gene Details

Chromosome 11 - NC_000011.10 (4988194..4992429)
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Gene Type	protein coding
Gene Family
Description	Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein degrades type IV collagen, fibronectin, fibrinogen, casein, vitronectin, alpha 1-antitrypsin, alpha 2-macroglobulin, and insulin-like growth factor-binding protein 1, and activates MMP9 by cleavage. The protein differs from most MMP family members in that it lacks a conserved C-terminal protein domain.
Chromosome	11
Location	11p15
Start	4988194
End	4992429
Strand	+
Gene Sequence	>gi\|568815587:4988194-4992429 Homo sapiens chromosome 11, GRCh38.p2 Primary Assembly GACAAATGAGGGTTTGGCATGCAGCTCGTCATCTTAAGAGTTACTATCTTCTTGCCCTGGTGTTTCGCCG TTCCAGTGCCCCCTGCTGCAGACCATAAAGGATGGGACTTTGTTGAGGTAGGTGAACGACTCAGGACCAC ATTATTACATGGTGACCATTGTGGGCTCTTATTTCGTGTGTGTGTGTATGTGTGACTGCATGGTATAATG ATAAATACACACATTAATATTACACATGAAAACATTTTATTCTATCTATGTGTTCATTTTTCTCTTCTAA TTTTAAGAAAAAAATTAATTTTTTGTAGCCCCTAAAAGTGTTTTTGGGCCCTAGGCACTGTGCCTTCTGT GCCTAATTCAGCCCCATTGCTCATCTCTCACTTTCTTAGTCTTCTATATGGCATAGAGTGAACACTCCAG TATATAGGTCTCTGATCTATATACTGGAGTGAGAGATCAAGGGAAATCATTCAAATAAATTAATGGGACC TTCACATTGACTGAGTAATCTCCCAGTCGGTCTACCACACACTTTCAATTTCTAAAAAAATTATGAATTT GCTCCAAACTTTTAAGCATCCAAAATACCTAAAAAATGTTATAACTGGTTGCAGTCATGTATTTTGTAAT TGTATAGGAACCTAGTCAAATTTCCTGCTAATGTTTAGTCCAGAACAATACAATAAGTCATTTGCCTCTT AGTGCCCAGCTCAGCTGATAATAAAACAAAGGCATAAAAATGCAGTCATATAATTTAAAAAAAACAGTCA ATAGGTTTACGTCAAGTACTCATAAGAACTGTGGAATAATAGATCAAGCTGTATCAGACATGAGCATTGC CCTTAAAGTATTTTGAGTCCAGCTAGCATTCAAATACAGACAGAGAAAGCCTAATTACAATACAATGTGC TTTTTTTGTATTTAGAAGTTTACATTTAATACACTAGACTGGCAGAAAAATCAGTGGAGACAAGGAATAG GTAAACAACGGGCTCTTTAAAAGTAACTTAATGAAATGGAAGTAAATGCAAATGAAATGGGGAATGCAGA ACCAGCCAAATTTTATGTCCTGGAGTGATTGATTGTATCCTGATTAAGAAAACCTCCATCAGTCAGAAAG ACCAGAGGCCATCTTCCCCGGGGAATTCCCAGGTAATATCTTCCTGTCGTTTATACTTGGGTTTCTCCAT CCTAAAACTTGGAAGCTTTTTCTTTTAAAAAAATGTTATAGTTTATCCATGTTATTTTTATTCTGTCACT TCTCATTCATATCATTTCACTGTGGCATAAAGAATCAGGGATGGCTGCCATCATCTGACTGAGAACAGGA GACTTAGGAAGGCCAGACTAAGTACCGTCCTTCTGAGACCCTCAAAGAAGGCTATGCCCAGGGTAACTGA TATATGGGTCTTCCCTATTGACTCTTAGTACTCATCCTTCTTGATCTGATTCAGGGCTATTTCCATCAAT TTTTCCTGACCAAGAAGGAGTCGCCACTCCTTACCCAGGAGACACAAACACAGCTCCTGCAACAATTCCA TCGGAATGGGACAGACCTACTTGACATGCAGATGCATGCTCTGCTACACCAGCCCCACTGTGGGGTGCCT GATGGGTCCGACACCTCCATCTCGCCAGGAAGATGCAAGTGGAATAAGCACACTCTAACTTACAGGTGCT TGTTACTAAGGCCTAGAGGATAATGTGTGGGGTGATGACCTCAAAGGGCTTTCTACCAGGTCTCTCCTGG AGGTACCTCTACTCTCTTCTGCTTTCATTGGCAGCCCGCTCAAAGCCCAAAATCTCCCTCAGAGAAGGTA ATACTACCAGATCCTTTTCTAGCTTCCTCTAACCATCTCTTTAGAAAGTAGAGAGCATAACCACTATCCT TTCCCTTTGTTAAATCTTTTCTTTTTAATTTTAATGCGTGAGTGTGTGGATGGTTCTAAGGTACAATTTT GAAAACTTAATTTCTGCCTAGGTTACTCTTTCTGTTGGGGATTCTAAATATACTTGAGATATCTAAAGCA AGCAGTACTAAATTATGTAGAATGCTATACATTTTAATTTATGTAGAATGCTGTATATTTAATTTAATTT AATTTTGTTCACATTGTTTTATTTACTTATTTTTCCCCAACCACCAGATAGGACTGTCATTCTTAGACTT TAGCTGACCTAAGAATAATTTGGGATATTGTTAAAATTCTTAGAAATCTATATTTGCATGTTTAATTCCT TAAGTTTCTGATTTAATTAGTCTGAAATTAGCTCAACTTTATAAATAACCAAAATGAGTCCTAAAACTAT TAAATGATTCTCCCCAAAGTAGAATTATTCATGTTTAGAGCTAGGATAATTCCCATTCCTCTGAACTATT TCATTTAGAGATTGCTTTCCTCAGGATTATCAATTACCCACATGATATGAAGCCATCCGCAGTGAAAGAC AGTATATATAATGCAGTTTCCATCTGGAGCAATGTGACCCCTTTGATATTCCAGCAAGTGCAGAATGGAG ATGCAGACATCAAGGTTTCTTTCTGGCAGTGGGGTAAGAAATTGACATGGGAAGAAGGATATGTATATGC CCTGTGTAAAGGACAAAGGGTTTCCATCCTTAAACAAAAACCTAGCCCCCCTATTAAAGTTTCTGAGAAA AAAAGTCTGACAAAACCCTACTGCAAAGCAAATCCTGTAATAGGGAAGACATTTTTAGTAAAATGAAGCA ATAAATAAAGAAGAGGTGTTGGCTGCAGTGTGAATATGGTGGGGGTACTGCACATTTTCCTTCCAAAAAG ACGATGCATAGCTCCGAAATCTATTGAAATGCTATTCAAAGTTGAACCAACTTACTTATAAAAACTTTCT GAGTTTAAATTCTCTTTCCCTTTTCCCCTACCATTTTGAAAAGAGGTTATCATTATTATTGTTGTCTAAC TTGTAAGCTTTACTCAGTGTCTGCCATCTGTCTGTCTTTCTTTTTACCCTAGATAAGAGAGTAGGAAGAT TTTGGGCCCCACCTTATTTCTCTGCATAGATAATGCCTTAGCTCTCTCACATCCCCCAGTGGTAGACTGT TGCACAGTATCCTAAGTCTCTGAGGCTTACTTAAGACTATTCTGGCCTTTGTTTCTACCTCCACCCTCAT TGTGATCATAGCTTCTGTCGTCCACAGCCCATGAAGATGGTTGGCCCTTTGATGGGCCAGGTGGTATCTT AGGCCATGCCTTTTTACCAAATTCTGGAAATCCTGGAGTTGTCCATTTTGACAAGAATGAACACTGGTCA GCTTCAGACACTGGTAAATGCCTTGTTTGGTGGGATCGCTAGAACTCTCTGGGAACCTGGGGTTCAGTGT TGATGGTTTCCATTTAGGGATCCAGAGTGGTCAGGGTGAGGTGGAAGATTTGGCTGAGGAATCAGGTCTT CTTTATAAGTGAGGAGATGTGGGATCATTTCTGAACACAGATGATCCCATAATAAACACATTGTCAGATT GTGTTTTTTTCTCCTTATCTCTTTGCTTCTATTTGCCAGTCCCTCTTTCTTTCCATGTGTCTTTTTCACT TCAAGTTTATCTGTCCAAATATCTTGCCATTCTGTTTTCTACTTACTTTCTTTCCCTCCTTGCCTACCTT TTCCTTTACCCTGTAACATTTGCCCTTTCCTCGTTTTCTGTTCTCTCCTTTTTCTTTGTCCTATTTCACA CACTTTCAGCATTCCCTATGCATAGTTAATTTTATCTTTTTTTTTTCTATAATTTTTCAGGATATAATCT GTTCCTGGTTGCAACTCATGAGATTGGGCATTCTTTGGGCCTGCAGCACTCTGGGAATCAGAGCTCCATA ATGTACCCCACTTACTGGTATCACGACCCTAGAACCTTCCAGCTCAGTGCCGATGATATCCAAAGGATCC AGCATTTGTATGGTCTGTGCTGCTTAAGGAAGAGAAGGGAGATCTGGGCAGGAAAATTTCACCTGAAATT TACTGTTGTTTTTTTTTTCTGTTTCCATAGGAGAAAAATGTTCATCTGACATACCTTAATGTTAGCACAG AGGACTTATTCAACCTGTCCTTTCAGGGAGTTTATTGGAGGATCAAAGAACTGAAAGCACTAGAGCAGCC TTGGGGACTGCTAGGATGAAGCCCTAAAGAATGCAACCTAGTCAGGTTAGCTGAACCGACACTCAAAACG CTACTGAGTCACAATAAAGATTGTTTTAAAGAGTAA Download Select all
Length	4236
OMIM ID	605470
HGNC ID	HGNC:14249
Unigene ID	Hs.204732
Ensembl ID	ENSG00000167346
PharmGKB ID	-

mRNA Information

mRNA ID	NM_021801.3
Exon	join(1..117,1455..1675,2405..2553,3178..3303,3771..3932, 4021..4236)
mRNA Sequence	>56547 GACAAATGAGGGTTTGGCATGCAGCTCGTCATCTTAAGAGTTACTATCTTCTTGCCCTGGTGTT TCGCCGTTCCAGTGCCCCCTGCTGCAGACCATAAAGGATGGGACTTTGTTGAGGGCTATTTCCA TCAATTTTTCCTGACCAAGAAGGAGTCGCCACTCCTTACCCAGGAGACACAAACACAGCTCCTG CAACAATTCCATCGGAATGGGACAGACCTACTTGACATGCAGATGCATGCTCTGCTACACCAGC CCCACTGTGGGGTGCCTGATGGGTCCGACACCTCCATCTCGCCAGGAAGATGCAAGTGGAATAA GCACACTCTAACTTACAGGATTATCAATTACCCACATGATATGAAGCCATCCGCAGTGAAAGAC AGTATATATAATGCAGTTTCCATCTGGAGCAATGTGACCCCTTTGATATTCCAGCAAGTGCAGA ATGGAGATGCAGACATCAAGGTTTCTTTCTGGCAGTGGGCCCATGAAGATGGTTGGCCCTTTGA TGGGCCAGGTGGTATCTTAGGCCATGCCTTTTTACCAAATTCTGGAAATCCTGGAGTTGTCCAT TTTGACAAGAATGAACACTGGTCAGCTTCAGACACTGGATATAATCTGTTCCTGGTTGCAACTC ATGAGATTGGGCATTCTTTGGGCCTGCAGCACTCTGGGAATCAGAGCTCCATAATGTACCCCAC TTACTGGTATCACGACCCTAGAACCTTCCAGCTCAGTGCCGATGATATCCAAAGGATCCAGCAT TTGTATGGAGAAAAATGTTCATCTGACATACCTTAATGTTAGCACAGAGGACTTATTCAACCTG TCCTTTCAGGGAGTTTATTGGAGGATCAAAGAACTGAAAGCACTAGAGCAGCCTTGGGGACTGC TAGGATGAAGCCCTAAAGAATGCAACCTAGTCAGGTTAGCTGAACCGACACTCAAAACGCTACT GAGTCACAATAAAGATTGTTTTAAAGAGTAAAAAAAAA Download Select all
Length	998

CDS Information

Location	join(19..117,1455..1675,2405..2553,3178..3303,3771..3932, 4021..4049)
CDS Sequence	>lcl\|NM_021801.3_cds_NP_068573.2_1 [gene=MMP26] [protein=matrix metalloproteinase-26 preproprotein] [protein_id=NP_068573.2] [location=19..804] ATGCAGCTCGTCATCTTAAGAGTTACTATCTTCTTGCCCTGGTGTTTCGCCGTTCCAGTGCCCCCTGCTG CAGACCATAAAGGATGGGACTTTGTTGAGGGCTATTTCCATCAATTTTTCCTGACCAAGAAGGAGTCGCC ACTCCTTACCCAGGAGACACAAACACAGCTCCTGCAACAATTCCATCGGAATGGGACAGACCTACTTGAC ATGCAGATGCATGCTCTGCTACACCAGCCCCACTGTGGGGTGCCTGATGGGTCCGACACCTCCATCTCGC CAGGAAGATGCAAGTGGAATAAGCACACTCTAACTTACAGGATTATCAATTACCCACATGATATGAAGCC ATCCGCAGTGAAAGACAGTATATATAATGCAGTTTCCATCTGGAGCAATGTGACCCCTTTGATATTCCAG CAAGTGCAGAATGGAGATGCAGACATCAAGGTTTCTTTCTGGCAGTGGGCCCATGAAGATGGTTGGCCCT TTGATGGGCCAGGTGGTATCTTAGGCCATGCCTTTTTACCAAATTCTGGAAATCCTGGAGTTGTCCATTT TGACAAGAATGAACACTGGTCAGCTTCAGACACTGGATATAATCTGTTCCTGGTTGCAACTCATGAGATT GGGCATTCTTTGGGCCTGCAGCACTCTGGGAATCAGAGCTCCATAATGTACCCCACTTACTGGTATCACG ACCCTAGAACCTTCCAGCTCAGTGCCGATGATATCCAAAGGATCCAGCATTTGTATGGAGAAAAATGTTC ATCTGACATACCTTAA Download Select all
CCDS ID	CCDS7752.1

Protein Information

Protein ID	NP_068573.2
Protein Name	matrix metallopeptidase 26
Molecular Wt. (Da)	27676
Protein Sequence	>56547 MQLVILRVTIFLPWCFAVPVPPAADHKGWDFVEGYFHQFFLTKKESPLLTQETQTQLLQQFHRN GTDLLDMQMHALLHQPHCGVPDGSDTSISPGRCKWNKHTLTYRIINYPHDMKPSAVKDSIYNAV SIWSNVTPLIFQQVQNGDADIKVSFWQWAHEDGWPFDGPGGILGHAFLPNSGNPGVVHFDKNEH WSASDTGYNLFLVATHEIGHSLGLQHSGNQSSIMYPTYWYHDPRTFQLSADDIQRIQHLYGEKC SSDIP Download Select all
Length	261
Uniprot ID	P80188
Ensembl Protein ID	ENSP00000277480

Post-translational Modification Information (Source : HPRD)

No matching records could be found.

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
3484	IGFBP1	897	NP_000587.1	in vitro;in vivo	12119297
4318	MMP9	387	NP_004985.2	in vivo	12586837
5265	SERPINA1	2463	NP_000286.3	in vitro	12119297

Pathway Information

No matching records could be found.

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd04278	98-253	ZnMc_MMP
cl00064	98-253	ZnMc superfamily
cd04279	112-253	ZnMc_MMP_like_1
cd00203	103-252	ZnMc
cd04268	103-252	ZnMc_MMP_like
cd04277	121-253	ZnMc_serralysin_like
cd04267	121-229	ZnMc_ADAM_like
pfam05572	172-219	Peptidase_M43
cd04275	165-218	ZnMc_pappalysin_like
cd04273	192-229	ZnMc_ADAMTS_like
PRK13267	206-257	PRK13267
TIGR03935	205-248	fragilysin
cd04272	197-256	ZnMc_salivary_gland_MPs
COG1913	206-256	COG1913
cd04276	148-235	ZnMc_MMP_like_2
cd04269	165-256	ZnMc_adamalysin_II_like
cd11375	205-229	Peptidase_M54
pfam13582	126-219	Reprolysin_3
pfam00413	98-253	Peptidase_M10
smart00235	95-253	ZnMc

Ontology Information

HPRD ID	1025
Molecular Class	Metallo protease
Molecular Function	Catalytic activity (GO:0003824)
Biological Process	Metabolism (GO:0008152); Energy pathways (GO:0006091)

SNP Information

View SNP Geneview Report

CoReCG

Search results:

General Information

Evidence Information

Gene Details

mRNA Information

CDS Information

Protein Information

Post-translational Modification Information (Source : HPRD)

Enzyme Information

PPi Information

Pathway Information

Structure Information

Domain Information

Ontology Information

SNP Information

Drug Information

External Links

Important Information

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO