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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| BCCIP | 56647 | BRCA2 and CDKN1A interacting protein | 10 | BCCIPalpha, TOK-1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24101097 | 2013 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 44 Stage : - | PCR , western blotting and immunohistochemistry | Down-regulation | - | BCCIP protein was chiefly reduced in ovarian cancer and RCC tissue samples. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] |
| Chromosome | 10 |
| Location | 10q26.2 |
| Start | 127512102 |
| End | 127542264 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 30163 |
| OMIM ID | 611883 |
| HGNC ID | HGNC:978 |
| Unigene ID | Hs.370292 |
| Ensembl ID | ENSG00000107949 |
| PharmGKB ID | PA25290 |
Protein Information
| Protein ID | NP_057651.1 |
|---|---|
| Protein Name | BRCA2 and CDKN1A interacting protein |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 314 |
| Uniprot ID | Q9BUX1 |
| Ensembl Protein ID | ENSP00000395466 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 42;- |
| S | Phosphorylation | 42;- |
| S | Phosphorylation | 42;- |
| S | Phosphorylation | 112;- |
| S | Phosphorylation | 115;- |
| S | Phosphorylation | 112;- |
| S | Phosphorylation | 115;- |
| S | Phosphorylation | 112;- |
| S | Phosphorylation | 115;- |
| S | Phosphorylation | 12 |
| S | Phosphorylation | 12 |
| S | Phosphorylation | 12 |
| T | Phosphorylation | 109 |
| T | Phosphorylation | 109 |
| T | Phosphorylation | 109 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 675 | BRCA2 | 2554 | NP_000050.2 | in vivo;yeast 2-hybrid | 11313963 |
| 1026 | CDKN1A | 298 | NP_510867.1 | in vitro;in vivo;yeast 2-hybrid | 1 087 800 614 726 710 |
| 5888 | RAD51 | 1557 | NP_597994.3 | in vivo | 15713648 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Ontology Information
| HPRD ID | 7637 |
|---|---|
| Molecular Class | Cell cycle control protein |
| Molecular Function | Cell adhesion molecule activity (GO:0005194) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
No matching records could be found.