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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| TMPRSS4 | 56649 | transmembrane protease, serine 4 | 11 | TMPRSS3, MT-SP2 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24072509 | 2013 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 122 CRC and 47 normal tissue Stage : - | Immunohistochemistry | Up-regulation | - | TMPRSS4 expression level may be used as a prognostic biomarker for CRC patients. Immunohistochemistry revealed high expression of TMPRSS4 in 69/122 CRC samples, compared with 14/47 in normal tissues (P < 0.01). |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Serine peptidases / Transmembrane |
| Description | This gene encodes a member of the serine protease family. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified as a gene overexpressed in pancreatic carcinoma. The encoded protein is membrane bound with a N-terminal anchor sequence and a glycosylated extracellular region containing the serine protease domain. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Chromosome | 11 |
| Location | 11q23.3 |
| Start | 118077012 |
| End | 118125505 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 48494 |
| OMIM ID | 606565 |
| HGNC ID | HGNC:11878 |
| Unigene ID | Hs.161985 |
| Ensembl ID | ENSG00000137648 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_019894.3 |
|---|---|
| Exon | join(1..294,17805..17844,21974..22087,26090..26242, 27680..27809,30763..30864,31845..31885,34730..34889, 36258..36424,37818..37916,38127..38269,40294..40443, 40891..42832) | mRNA Sequence | Download Select all |
| Length | 3534 |
CDS Information
| Location | join(292..294,17805..17844,21974..22087,26090..26242, 27680..27809,30763..30864,31845..31885,34730..34889, 36258..36424,37818..37916,38127..38269,40294..40443, 48284..48466) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_001077416.1 |
|---|---|
| Protein Name | transmembrane protease, serine 4 |
| Molecular Wt. (Da) | 47513 |
| Protein Sequence | Download Select all |
| Length | 432 |
| Uniprot ID | P00338 |
| Ensembl Protein ID | ENSP00000227157 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Influenza A | hsa05164 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00190 | 205-432 | Tryp_SPc |
| cl21584 | 205-432 | Tryp_SPc superfamily |
| cd00112 | 58-92 | LDLa |
| cl00104 | 58-92 | LDLa superfamily |
| pfam15494 | 108-199 | SRCR_2 |
| cl02509 | 108-199 | SRCR superfamily |
| smart00202 | 104-194 | SR |
| pfam00057 | 71-92 | Ldl_recept_a |
| pfam13365 | 232-403 | Trypsin_2 |
| smart00020 | 204-429 | Tryp_SPc |
| pfam00089 | 205-429 | Trypsin |
| COG5640 | 202-429 | COG5640 |
| pfam09342 | 216-312 | DUF1986 |
Ontology Information
| HPRD ID | 1026 |
|---|---|
| Molecular Class | Serine protease |
| Molecular Function | Catalytic activity (GO:0003824) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
No matching records could be found.