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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22859396 | 2012 | Cell line : - Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : 408 Stage : - | Tissue microarray, immunohistochemistry | Down-regulation | - | Absence of B2M protein expression identifies MMR-deficient cancers with a favourable clinical course and absence of metastatic disease. Validation of B2M protein expression for sub-classification of MMR-deficient CRC is recommended for future clinical trials. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Immunoglobulin superfamily / C1-set domain containing |
| Description | This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia. |
| Chromosome | 15 |
| Location | 15q21-q22. |
| Start | 44711487 |
| End | 44718159 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 6673 |
| OMIM ID | 109700 |
| HGNC ID | HGNC:914 |
| Unigene ID | Hs.534255 |
| Ensembl ID | ENSG00000166710 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_004048.2 |
|---|---|
| Exon | join(1..127,3937..4215,4843..4870,6121..6673) | mRNA Sequence | Download Select all |
| Length | 987 |
CDS Information
| Location | join(61..127,3937..4215,4843..4856) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS10113.1 |
Protein Information
| Protein ID | XP_005254606.1 |
|---|---|
| Protein Name | beta-2-microglobulin |
| Molecular Wt. (Da) | 13841 |
| Protein Sequence | Download Select all |
| Length | 122 |
| Uniprot ID | P23378 |
| Ensembl Protein ID | ENSP00000370737 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2 | A2M | 72 | NP_000005.2 | in vitro | 10731476 |
| 811 | CALR | 169 | NP_004334.1 | in vivo | 8769474 |
| 925 | CD8A | 1737 | NP_001759.3 | in vitro | 11914379 |
| 7917 | BAT3 | 808 | NP_004630.3 | yeast 2-hybrid | 16169070 |
| 11098 | PRSS23 | 7149 | NP_009104.1 | yeast 2-hybrid | 16169070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Antigen processing and presentation | hsa04612 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd05770 | 24-116 | IgC_beta2m |
| cl11960 | 24-116 | Ig superfamily |
| pfam07654 | 31-112 | C1-set |
| smart00407 | 40-110 | IGc1 |
| cd05767 | 24-116 | IgC_MHC_II_alpha |
| cd00098 | 27-116 | IgC |
| cd05766 | 25-116 | IgC_MHC_II_beta |
| cd07698 | 25-116 | IgC_MHC_I_alpha3 |
| cd07699 | 25-111 | IgC_L |
| cd05768 | 43-107 | IgC_CH4 |
| cd05772 | 25-110 | IgC_SIRP |
| cd05847 | 43-104 | IgC_CH2_IgE |
| cd05771 | 43-110 | IgC_Tapasin_R |
| PLN02236 | 24-68 | PLN02236 |
Ontology Information
| HPRD ID | 677 |
|---|---|
| Molecular Class | MHC complex protein |
| Molecular Function | G-protein coupled receptor activity (GO:0004930) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P61769 | DB00254 | Doxycycline | SmallMoleculeDrug |