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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| C8orf4 | 56892 | chromosome 8 open reading frame 4 | 8 | TC-1, hTC-1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 15185345 | 2004 | Cell line : Vaco Source : - Sample Type : - No. of Sample : - Stage : - | DNA microarray,Northern blotting and real-timeRT- PCR | Down-regulation | - | C8orf4 is a gene regulated by TGF beta signaling and loss in advanced colon cancer suggests C8orf4 may play a role in colon cell differentiation or growth regulation. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies. [provided by RefSeq, Nov 2011] |
| Chromosome | 8 |
| Location | 8p11.2 |
| Start | 40010987 |
| End | 40012827 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 1841 |
| OMIM ID | 607702 |
| HGNC ID | HGNC:1357 |
| Unigene ID | Hs.591849 |
| Ensembl ID | ENSG00000176907 |
| PharmGKB ID | PA25962 |
Protein Information
| Protein ID | NP_064515.1 |
|---|---|
| Protein Name | chromosome 8 open reading frame 4 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 106 |
| Uniprot ID | Q96JQ2 |
| Ensembl Protein ID | ENSP00000298912 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
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Structure Information
No matching records could be found.
Ontology Information
| HPRD ID | 6397 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.