Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ARNTL2 | 56938 | Aryl hydrocarbon receptor nuclear translocator-like 2 | 12 | CLIF; MOP9; BMAL2; PASD9; bHLHe6 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22198637 | 2012 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 50 Stage : - | - | Up-regulation | - | ARNTL2 and SERPINE1 are potential biomarkers for tumor aggressiveness in colorectal cancer. ARNTL2 and SERPINE1 expression in 50 colorectal cancer specimens and adjacent normal tissue and in colon cancer cell lines were evaluated. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Basic helix-loop-helix proteins |
| Description | This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (PER, ARNT, SIM) superfamily. The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature. This protein forms a transcriptionally active heterodimer with the circadian CLOCK protein, the structurally related MOP4, and hypoxia-inducible factors, such as HIF1alpha. Consistent with its role as a biologically relevant partner of circadian and hypoxia factors, this protein is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011] |
| Chromosome | 12 |
| Location | 12p12.2-p1 |
| Start | 27332854 |
| End | 27425813 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 92960 |
| OMIM ID | 614517 |
| HGNC ID | HGNC:18984 |
| Unigene ID | Hs.434269 |
| Ensembl ID | ENSG00000029153 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001248003.1 |
|---|---|
| Exon | join(1..283,35409..35559,47394..47551,52628..52707, 54375..54467,56326..56443,57243..57386,67681..67921, 68404..68510,68671..68821,69766..69824,70580..70688, 83016..83094,85235..85343,87543..92960) | mRNA Sequence | Download Select all |
| Length | 7300 |
CDS Information
| Location | join(220..283,35409..35559,37276..37377,43493..43534, 47394..47551,52628..52707,54375..54467,56326..56443, 57243..57386,67681..67921,68404..68510,68671..68821, 69766..69824,70580..70688,83016..83094,85235..85343, 87543..87679) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_001234931.1 |
|---|---|
| Protein Name | Aryl hydrocarbon receptor nuclear translocator-like 2 |
| Molecular Wt. (Da) | 69100 |
| Protein Sequence | Download Select all |
| Length | 622 |
| Uniprot ID | P09769 |
| Ensembl Protein ID | ENSP00000363115 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2034 | EPAS1 | 6787 | NP_001421.2 | in vitro;yeast 2-hybrid | 11018023 |
| 9575 | CLOCK | 3508 | NP_004889.1 | in vitro;in vivo | 1 086 497 711 018 020 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00130 | 370-468 | PAS |
| cl21578 | 370-468 | PAS superfamily |
| cd00083 | 109-161 | HLH |
| cl00081 | 109-161 | HLH superfamily |
| cd00130 | 192-287 | PAS |
| cl21578 | 192-287 | PAS superfamily |
| pfam00010 | 109-161 | HLH |
| smart00353 | 116-161 | HLH |
| smart00091 | 370-425 | PAS |
| smart00091 | 181-243 | PAS |
| pfam14598 | 370-472 | PAS_11 |
| pfam00989 | 181-287 | PAS |
| pfam08447 | 381-465 | PAS_3 |
| pfam00989 | 378-458 | PAS |
| COG2202 | 369-445 | PAS |
| TIGR00229 | 378-443 | sensory_box |
| pfam13426 | 378-445 | PAS_9 |
| TIGR00229 | 181-244 | sensory_box |
| pfam13426 | 200-287 | PAS_9 |
Ontology Information
| HPRD ID | 11794 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Isomerase activity (GO:0016853) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
No matching records could be found.