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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| AKR1B10 | 57016 | aldo-keto reductase family 1, member B10 (aldose reductase) | 7 | AKR1B12, ARL-1, HIS, ARL1, HSI, ALDRLn |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20586184 | 2010 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : - | RT-PCR and PCR. | Down-regulation | - | The significant decrease of AKR1B10 mRNA in most samples of colorectal cancer could be considered as potential diagnostic marker of this type of cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Aldo-keto reductases |
| Description | This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis. [provided by RefSeq, Jul 2008] |
| Chromosome | 7 |
| Location | 7q33 |
| Start | 134212344 |
| End | 134226166 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 13823 |
| OMIM ID | 604707 |
| HGNC ID | HGNC:382 |
| Unigene ID | Hs.116724 |
| Ensembl ID | ENSG00000198074 |
| PharmGKB ID | PA24676 |
Protein Information
| Protein ID | NP_064695.3 |
|---|---|
| Protein Name | aldo-keto reductase family 1, member B10 (aldose reductase) |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 316 |
| Uniprot ID | Q969K3 |
| Ensembl Protein ID | ENSP00000355137 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| K | Acetylation | 263 |
| K | Acetylation | 95 |
| K | Acetylation | 69 |
| K | Acetylation | 125 |
| K | Acetylation | 27 |
| K | Acetylation | 179 |
| S | Phosphorylation | 23 |
| T | Phosphorylation | 288 |
| S | Phosphorylation | 291 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Fructose and mannose metabolism | hsa00051 |
| Galactose metabolism | hsa00052 |
| Glycerolipid metabolism | hsa00561 |
| Metabolic pathways | hsa01100 |
| Pentose and glucuronate interconversions | hsa00040 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd06660 | 8-289 | Aldo_ket_red |
| cl00470 | 8-289 | Aldo_ket_red superfamily |
| COG0656 | 1-297 | ARA1 |
| PRK11565 | 3-289 | dkgA |
| pfam00248 | 16-289 | Aldo_ket_red |
| PRK11172 | 12-297 | dkgB |
| COG4989 | 18-214 | YdhF |
| PRK10376 | 13-289 | PRK10376 |
| PRK10625 | 35-214 | tas |
| PRK09912 | 12-289 | PRK09912 |
| COG0667 | 16-289 | Tas |
| COG1453 | 9-289 | COG1453 |
| TIGR01293 | 16-213 | Kv_beta |
Ontology Information
| HPRD ID | 8570 |
|---|---|
| Molecular Class | Enzyme: Reductase |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Transcription (GO:0006350) |
Drug Information
No matching records could be found.