• Home
• Information
• HELP
• FAQ
• Contact

• Home
• Search
  • Keyword Search
    • Gene ID
    • Gene Symbol
    • Chromosome
  • Advanced Search
  • Sequence Search
  • Pubmed Search
• Browse
  • Biomarker/Drug Target
  • Gene Information
  • Gene Ontology
    • Molecular Class
    • Molecular Function
    • Biological Process
  • Mechanism
  • Pathways
  • Stage
• Tools
  • Blast
  • CoReCG GBrowse
• Database Statistics
• Submit Data
• Acknowledgement
• Team

Search results:

General Information

• Evidence
• Gene
• mRNA
• CDS
• Protein
• PTM
• Enzyme
• PPi
• Pathway
• Structural
• Domain
• Ontology
• SNP
• Drug
• External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
25847052	2015	Cell line : - Source : - Sample Type : - No. of Sample : - Stage : -	Flow cytometric analysis , lentivirus-based RNA interference,qRT-PCR,western blot analysis,MTT and colony formation assays.	Up-regulation	-	RTN4-C has an important role in colorectal cancer cell growth, which may provide a potential therapeutic approach for human colorectal cancer.

Gene Details

NC_000002.11 (55199325..55307770, complement)
View Larger Image   

Gene Type	protein coding
Gene Family	-
Description	This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Chromosome	2
Location	2p14-p13
Start	55199325
End	55307770
Strand	-
Gene Sequence	Download   Select all
Length	108446
OMIM ID	604475
HGNC ID	HGNC:14085
Unigene ID	Hs.637850
Ensembl ID	ENSG00000115310
PharmGKB ID	PA34883

mRNA Information

mRNA ID	?NM_007008.2
Exon
mRNA Sequence	Download   Select all
Length

CDS Information

   

Location
CDS Sequence	Download   Select all
CCDS ID	CCDS1851.1

Protein Information

      

Protein ID	NP_008939.1
Protein Name	reticulon 4
Molecular Wt. (Da)	0
Protein Sequence	Download   Select all
Length	1192
Uniprot ID	Q96NY9
Ensembl Protein ID	ENSP00000307853

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
S	Phosphorylation	860
S	Phosphorylation	863
S	Phosphorylation	654
S	Phosphorylation	657
S	Phosphorylation	184;-
T	Phosphorylation	188;-
S	Phosphorylation	184;-
T	Phosphorylation	188;-
S	Phosphorylation	181;-
S	Phosphorylation	181;-
S	Phosphorylation	196;-
S	Phosphorylation	196;-
S	Phosphorylation	107;-
S	Phosphorylation	107;-
S	Phosphorylation	107;-
S	Phosphorylation	11;-
S	Phosphorylation	7;-
S	Phosphorylation	11;-
S	Phosphorylation	7;-
S	Phosphorylation	11;-
S	Phosphorylation	7;-
S	Phosphorylation	15;-
S	Phosphorylation	15;-
S	Phosphorylation	15;-
S	Phosphorylation	13;-
S	Phosphorylation	13;-
S	Phosphorylation	13;-
S	Phosphorylation	182
S	Phosphorylation	182
S	Phosphorylation	12
S	Phosphorylation	12
S	Phosphorylation	12
S	Phosphorylation	515
S	Phosphorylation	525
Y	Phosphorylation	529
S	Phosphorylation	309
S	Phosphorylation	319
Y	Phosphorylation	323
S	Phosphorylation	943
S	Phosphorylation	737
K	Acetylation	1104
K	Acetylation	111
K	Acetylation	285
K	Acetylation	304
K	Acetylation	898
S	Phosphorylation	991
S	Phosphorylation	785
S	Phosphorylation	184

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING)      View   

                                                                                                                                                      

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
596	BCL2	1045	NP_000624.2	in vitro;in vivo;yeast 2-hybrid	11126360
598	BCL2L1	2497	NP_612815.1	in vivo;yeast 2-hybrid	11126360
4034	LRCH4	10062	NP_002310.2	yeast 2-hybrid	16189514
4155	MBP	1158	NP_001020272.1	in vivo	12377379
7277	TUBA4A	1851	NP_005991.1	in vivo	12377379
7384	UQCRC1	1875	NP_003356.2	in vivo;yeast 2-hybrid	12067236
7385	UQCRC2	1876	NP_003357.2	in vitro;in vivo;yeast 2-hybrid	12067236
8506	CNTNAP1	3825	NP_003623.1	in vitro;in vivo	14592966
51324	SPG21	10492	NP_057714.1	yeast 2-hybrid	16189514
79666	PLEKHF2	15147	NP_078889.1	yeast 2-hybrid	16189514

Pathway Information

No matching records could be found.

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
pfam02453	1005-1175	Reticulon
cl03599	1005-1175	Reticulon superfamily
pfam08377	751-952	MAP2_projctn

Ontology Information

   

HPRD ID	9860
Molecular Class	Integral membrane protein
Molecular Function	Molecular function unknown (GO:0005554)
Biological Process	Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)

SNP Information

View SNP Geneview Report   

Drug Information

No matching records could be found.

External Links

                                 

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO