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General Information
- Evidence
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 17290397 | 2007 | Cell line : - Source : Uppsala Falun region of Sweden Sample Type : CRC Tumor and adjecent normal tissue. No. of Sample : 99 Stage : Dukes stage A-D | real time RT-PCR,immunohistochemistry | Up-regulation | - | EP(1) and EP(2) subtype receptor protein was highly present in tumor cells, EP(3) occurred occasionally and EP(4) was not visible. |
| 18648368 | 2008 | Cell line : HT29,SW480, Caco 2 Source : - Sample Type : - No. of Sample : - Stage : - | RNA interference,Western blotting,real time RT-PCR,Immunofluorescent, immunohistochemistry | Up-regulation | - | - |
| 19055708 | 2008 | Cell line : Caco 2 Source : - Sample Type : - No. of Sample : - Stage : - | Transepithelial Electrical Resistance, Immunofluorescence Microscopy,Transmission electron microscopy | Up-regulation | - | Central role of Prostaglandin E2-EP1 and EP2 receptor signaling to mediate AJC disassembly through a mechanism that involves PKC and claudin-1 as important target for the TJ-related effects in human colorectal cancer cells (Caco-2). |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Prostaglandin (prostanoid) receptors |
| Description | The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, G-Q proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin. [provided by RefSeq, Jul 2008] |
| Chromosome | 19 |
| Location | 19p13.1 |
| Start | 14583278 |
| End | 14586174 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 2897 |
| OMIM ID | 176802 |
| HGNC ID | HGNC:9593 |
| Unigene ID | Hs.159360 |
| Ensembl ID | ENSG00000160951 |
| PharmGKB ID | PA286 |
Protein Information
| Protein ID | NP_000946.2 |
|---|---|
| Protein Name | prostaglandin E receptor 1 |
| Molecular Wt. (Da) | 39630 |
| Protein Sequence | Download Select all |
| Length | 402 |
| Uniprot ID | O14682 |
| Ensembl Protein ID | ENSP00000306356 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 9536 | PTGES | 5528 | NP_004869.1 | in vivo | 8253813 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Calcium signaling pathway | hsa04020 |
| Neuroactive ligand-receptor interaction | hsa04080 |
| Pathways in cancer | hsa05200 |
Structure Information
No matching records could be found.
Ontology Information
| HPRD ID | 16011 |
|---|---|
| Molecular Class | Not Available |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Cell cycle (GO:0007049) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P34995 | DB00297 | Bupivacaine | SmallMoleculeDrug |
| P34995 | DB00429 | Carboprost Tromethamine | SmallMoleculeDrug |
| P34995 | DB00770 | Alprostadil | SmallMoleculeDrug |
| P34995 | DB00905 | Bimatoprost | SmallMoleculeDrug |
| P34995 | DB00917 | Dinoprostone | SmallMoleculeDrug |
| P34995 | DB01088 | Iloprost | SmallMoleculeDrug |