Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| SLC12A5 | 57468 | solute carrier family 12 (potassium/chloride transporter), member 5 | 20 | KIAA1176, KCC2 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24699064 | 2014 | Cell line : - Source : Peking University Cancer Hospital. Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : - | Genotyping | Mutation | - | Functional characterization of mutant SLC12A5 revealed its potential oncogenic effect in colon cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Solute carriers |
| Description | K-Cl cotransporters are proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The protein encoded by this gene is an integral membrane K-Cl cotransporter that can function in either a net efflux or influx pathway, depending on the chemical concentration gradients of potassium and chloride. The encoded protein can act as a homomultimer, or as a heteromultimer with other K-Cl cotransporters, to maintain chloride homeostasis in neurons. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Sep 2008] |
| Chromosome | 20 |
| Location | 20q13.12 |
| Start | 44650329 |
| End | 44688789 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 38461 |
| OMIM ID | 606726 |
| HGNC ID | HGNC:13818 |
| Unigene ID | Hs.21413 |
| Ensembl ID | ENSG00000124140 |
| PharmGKB ID | PA37814 |
Protein Information
| Protein ID | NP_001128243.1 |
|---|---|
| Protein Name | solute carrier family 12 (potassium/chloride transporter), member 5 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 1139 |
| Uniprot ID | Q9GZT5 |
| Ensembl Protein ID | ENSP00000258411 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| GABAergic synapse | hsa04727 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| TIGR00930 | 44-1139 | 2a30 |
| pfam00324 | 125-699 | AA_permease |
| COG0531 | 120-658 | PotE |
| pfam13520 | 417-647 | AA_permease_2 |
| TIGR00909 | 428-652 | 2A0306 |
| TIGR00911 | 445-646 | 2A0308 |
| TIGR03810 | 424-665 | arg_ornith_anti |
| TIGR00913 | 444-598 | 2A0310 |
| TIGR00905 | 451-647 | 2A0302 |
| PRK11021 | 428-653 | PRK11021 |
| pfam10146 | 906-997 | zf-C4H2 |
Ontology Information
| HPRD ID | 18997 |
|---|---|
| Molecular Class | Membrane transport protein |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Biological_process unknown (GO:0000004) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| Q9H2X9 | DB00761 | Potassium Chloride | SmallMoleculeDrug |
| Q9H2X9 | DB00887 | Bumetanide | SmallMoleculeDrug |
| Q9H2X9 | DB00761 | Potassium Chloride | SmallMoleculeDrug |