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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
MTUS1 57509 microtubule associated tumor suppressor 1  8MTSG1, KIAA1288, DKFZp586D1519, FLJ14295, ATIP1, MP44, ATBP, ICIS 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
24693684   2013Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

Laser Microdissection ,oligo microarrays,CGH,real time RT-PCRDown-regulation-Decreased expression and genomic deletion of MTUS1 were observed in lymph node positive cases (p = 0.0195) in another subset of 172 cases of CRC.

19956880   2010Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : 172

Stage : -

Western blotting, RT-PCRUnknown-MTUS1 could be involved in the loss of proliferative control in human colon cancer.


Gene Details



NC_000008.10 (17501303..17658729, complement)

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Gene Type protein coding
Gene Family -
Description This gene encodes a protein which contains a C-terminal domain able to interact with the angiotension II (AT2) receptor and a large coiled-coil region allowing dimerization. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the transcript variants has been shown to encode a mitochondrial protein that acts as a tumor suppressor and partcipates in AT2 signaling pathways. Other variants may encode nuclear or transmembrane proteins but it has not been determined whether they also participate in AT2 signaling pathways. [provided by RefSeq, Jul 2008]  
Chromosome 8
Location 8p22
Start 17501303  
End 17658729  
Strand -  
Gene Sequence

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Length 157427  
OMIM ID 609589   
HGNC ID HGNC:29789   
Unigene ID Hs.7946   
Ensembl ID ENSG00000129422   
PharmGKB ID PA134968054   

mRNA Information


mRNA ID ?NM_001001924.2
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS43716.1



Protein Information


      
Protein IDNP_001001924.1
Protein Namemicrotubule associated tumor suppressor 1
Molecular Wt. (Da)0
Protein Sequence

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Length 1270  
Uniprot IDQ6ZMT4
Ensembl Protein ID ENSP00000380692  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation443
SPhosphorylation443
SPhosphorylation443
SPhosphorylation1264;-
SPhosphorylation1268;-
SPhosphorylation1210;-
SPhosphorylation1214;-
SPhosphorylation515;-
SPhosphorylation511;-
SPhosphorylation434;-
SPhosphorylation430;-
SPhosphorylation528
SPhosphorylation528
SPhosphorylation528
SPhosphorylation399
SPhosphorylation399
SPhosphorylation399
SPhosphorylation1266
SPhosphorylation1212
SPhosphorylation513
SPhosphorylation432
TPhosphorylation483
TPhosphorylation483
TPhosphorylation483
SPhosphorylation1203
SPhosphorylation1149
SPhosphorylation450
SPhosphorylation369
TPhosphorylation1204
TPhosphorylation1150
TPhosphorylation451
TPhosphorylation370
SPhosphorylation1224
SPhosphorylation1170
SPhosphorylation471
SPhosphorylation390

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
186AGTR22071NP_000677.2in vitro;in vivo;yeast 2-hybrid15123706   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
pfam033571085-1234  Snf7
cl215881085-1234  Snf7 superfamily
pfam127181078-1193  Tropomyosin_1
cl228571078-1193  Tropomyosin_1 superfamily
pfam124741055-1193  PKK
cl224311055-1193  PKK superfamily
pfam097441013-1163  Jnk-SapK_ap_N
cl180421013-1163  RILP-like superfamily
cd00176944-1156  SPEC
cl02488944-1156  SPEC superfamily
pfam055651083-1179  Sipho_Gp157
cl052391083-1179  Sipho_Gp157 superfamily
PRK141601080-1194  PRK14160
cl030751080-1194  GrpE superfamily
cd00187971-1117  TOP4c
cl19084971-1117  TOP4c superfamily
pfam097271019-1181  CortBP2
cl216051019-1181  CortBP2 superfamily
pfam130941088-1215  CENP-Q
cl224381088-1215  TMF_TATA_bd superfamily
pfam146441008-1142  DUF4456
cl206071008-1142  DUF4456 superfamily
pfam103681071-1221  YkyA
cl215091071-1221  ApoLp-III_like superfamily
pfam014861081-1191  K-box
cl032341081-1191  K-box superfamily
COG1340940-1233  COG1340
TIGR02168919-1215  SMC_prok_B
COG0419900-1231  SbcC
COG1196904-1224  Smc
COG1196940-1244  Smc
COG1196940-1224  Smc
TIGR02168943-1218  SMC_prok_B
TIGR02168936-1218  SMC_prok_B
TIGR02168947-1239  SMC_prok_B
TIGR02169976-1230  SMC_prok_A
COG0419932-1230  SbcC
COG1196937-1230  Smc
TIGR02169899-1231  SMC_prok_A
TIGR02169940-1206  SMC_prok_A
COG1196945-1228  Smc
TIGR02168895-1215  SMC_prok_B
COG0419904-1190  SbcC
COG1196900-1195  Smc
TIGR00618976-1235  sbcc
TIGR02169943-1230  SMC_prok_A
COG0419933-1234  SbcC
pfam02463900-1222  SMC_N
COG0419976-1223  SbcC
TIGR02168930-1159  SMC_prok_B
COG15791038-1237  COG1579
TIGR04523900-1236  Mplasa_alph_rch
pfam02463979-1235  SMC_N
PRK03918865-1187  PRK03918
PRK03918931-1236  PRK03918
TIGR00618921-1205  sbcc
TIGR02168958-1230  SMC_prok_B
PRK03918940-1235  PRK03918
pfam09731978-1148  Mitofilin
pfam13868976-1229  Trichoplein
PRK03918932-1215  PRK03918
pfam05483903-1185  SCP-1
COG4477944-1213  EzrA
TIGR04523941-1231  Mplasa_alph_rch
pfam01576977-1230  Myosin_tail_1
pfam07888976-1226  CALCOCO1
COG4372964-1210  COG4372
pfam05483902-1231  SCP-1
PRK03918940-1224  PRK03918
pfam01576944-1234  Myosin_tail_1
pfam01576933-1236  Myosin_tail_1
pfam09728921-1223  Taxilin
pfam05557868-1230  MAD
pfam13514976-1248  AAA_27
TIGR00618939-1188  sbcc
PRK090391034-1184  PRK09039
pfam13514943-1148  AAA_27
TIGR02169904-1124  SMC_prok_A
pfam01576991-1218  Myosin_tail_1
COG4487967-1157  COG4487
pfam05483999-1255  SCP-1
TIGR04523940-1181  Mplasa_alph_rch
COG49421002-1216  EnvC
smart007871012-1150  Spc7
TIGR02169976-1234  SMC_prok_A
pfam05622905-1231  HOOK
TIGR04523939-1230  Mplasa_alph_rch
pfam05557957-1223  MAD
pfam01576943-1230  Myosin_tail_1
TIGR03007976-1219  pepcterm_ChnLen
pfam13868958-1229  Trichoplein
TIGR00618949-1228  sbcc
COG4372935-1189  COG4372
pfam10174941-1239  Cast
pfam01576932-1230  Myosin_tail_1
TIGR021681019-1231  SMC_prok_B
pfam06160904-1195  EzrA
PRK127041013-1207  PRK12704
pfam02463920-1166  SMC_N
PRK039181059-1234  PRK03918
pfam05557997-1231  MAD
pfam068181058-1233  Fez1
pfam138511005-1156  GAS
PRK04778944-1230  PRK04778
PTZ00121976-1207  PTZ00121
pfam02463942-1164  SMC_N
COG1340930-1124  COG1340
TIGR033461078-1165  chaperone_ClpB
pfam00038978-1202  Filament
PRK02224930-1205  PRK02224
COG11961051-1230  Smc
COG2433929-1200  COG2433
COG1293934-1168  YloA
pfam048491033-1236  HAP1_N
PTZ00121979-1222  PTZ00121
COG13401069-1222  COG1340
pfam041111059-1193  APG6
PRK127041079-1218  PRK12704
COG3096940-1223  MukB
pfam024631023-1236  SMC_N
PRK02224946-1217  PRK02224
pfam153971090-1221  DUF4618
TIGR042111057-1216  SH3_and_anchor
PRK057711033-1230  PRK05771
TIGR01069999-1167  mutS2
pfam015761023-1193  Myosin_tail_1
pfam050101048-1234  TACC
PRK00409999-1119  PRK00409
pfam12128910-1216  DUF3584
PRK02224978-1216  PRK02224
PRK04778904-1195  PRK04778
pfam149151046-1216  CCDC144C
TIGR02169940-1121  SMC_prok_A
PRK066691006-1149  fliH
pfam06160944-1216  EzrA
PRK004091023-1166  PRK00409
pfam13514948-1219  AAA_27
TIGR00634943-1143  recN
pfam00038932-1148  Filament
PTZ00121944-1216  PTZ00121
TIGR03185940-1193  DNA_S_dndD
pfam097311034-1220  Mitofilin
PRK04863944-1230  mukB
pfam09755945-1215  DUF2046
PTZ00121976-1223  PTZ00121
COG5022977-1230  COG5022
pfam152941048-1170  Leu_zip
COG5281939-1228  COG5281
COG1196904-1127  Smc
PTZ00440955-1229  PTZ00440
COG11961068-1235  Smc
COG13401002-1251  COG1340
pfam09738940-1157  DUF2051
pfam07111947-1243  HCR
COG0497913-1150  RecN
pfam13166946-1191  AAA_13
TIGR00618916-1242  sbcc
pfam12128982-1230  DUF3584
PRK01156904-1187  PRK01156
pfam07926976-1115  TPR_MLP1_2
pfam10174931-1218  Cast
TIGR033191016-1194  RNase_Y
COG43721036-1230  COG4372
pfam024631016-1236  SMC_N
TIGR01612978-1228  235kDa-fam
pfam07111946-1218  HCR
COG49421063-1231  EnvC
TIGR016121062-1203  235kDa-fam
COG24331041-1236  COG2433
pfam04012940-1145  PspA_IM30
pfam121281024-1237  DUF3584
PRK01156958-1230  PRK01156
pfam052621061-1229  Borrelia_P83
COG5185974-1188  HEC1
smart007871057-1171  Spc7
COG04431016-1123  DnaK
pfam04156982-1125  IncA
pfam101861081-1213  Atg14
pfam041111007-1144  APG6
pfam149881008-1215  DUF4515
pfam10174936-1226  Cast
pfam083171002-1121  Spc7
pfam09726727-1198  Macoilin
pfam05911976-1230  DUF869
COG40261069-1154  COG4026
COG4477983-1230  EzrA
PRK04863976-1154  mukB
PRK05771900-1106  PRK05771
pfam15619976-1125  Lebercilin
PRK011561023-1229  PRK01156
pfam05262946-1122  Borrelia_P83
COG04661012-1144  Lon
pfam05483934-1230  SCP-1
TIGR02168904-1126  SMC_prok_B
TIGR042111149-1236  SH3_and_anchor
PRK107871013-1144  PRK10787
COG07111023-1163  AtpF
pfam14915952-1189  CCDC144C


Ontology Information


   
HPRD ID10226
Molecular ClassGrowth inhibitory factor
Molecular FunctionLipid phosphatase activity (GO:0042577)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO