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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
HACE1 57531 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1  6KIAA1320 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
18630515   2008Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : 32

Stage : -

methylation-specific PCR Methylation-HACE1 might act as a tumor suppressor in colorectal carcinomas and HACE1 methylation might present a malignant potential in colorectal cancer.


Gene Details



NC_000006.11 (105175968..105307794, complement)

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Gene Type protein coding
Gene Family Ankyrin repeat domain containing
Description This gene encodes a HECT domain and ankyrin repeat-containing ubiquitin ligase. The encoded protein is involved in specific tagging of target proteins, leading to their subcellular localization or proteasomal degradation. The protein is a potential tumor suppressor and is involved in the pathophysiology of several tumors, including Wilm's tumor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]  
Chromosome 6
Location 6q21
Start 105175968  
End 105307794  
Strand -  
Gene Sequence

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Length 131827  
OMIM ID 610876   
HGNC ID HGNC:21033   
Unigene ID Hs.434340   
Ensembl ID ENSG00000085382   
PharmGKB ID PA134983914   

mRNA Information


mRNA ID ?NM_020771.3
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS5050.1



Protein Information


      
Protein IDNP_065822.2
Protein NameHECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
Molecular Wt. (Da)0
Protein Sequence

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Length 909  
Uniprot IDQ9BX95
Ensembl Protein ID ENSP00000247225  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
5362PLXNA23033NP_079455.3yeast 2-hybrid12421765   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd00078554-903  HECTc
cl00077554-903  HECTc superfamily
cd0020492-217  ANK
cl0252992-217  ANK superfamily
pfam00632604-909  HECT
cd0020466-184  ANK
cd00204125-249  ANK
cd00204158-252  ANK
pfam0002398-129  Ank
pfam00023164-194  Ank
smart00248163-191  ANK
pfam0002366-95  Ank
cl0252966-95  ANK superfamily
smart0024898-126  ANK
pfam13606164-191  Ank_3
pfam1360698-126  Ank_3
smart0024866-93  ANK
smart00119579-902  HECTc
pfam1279669-161  Ank_2
pfam12796102-221  Ank_2
pfam13637199-249  Ank_4
COG5021555-899  HUL4
COG066683-220  ANKYR
PHA0310035-221  PHA03100
COG066633-187  ANKYR
pfam1279648-128  Ank_2
PHA0309577-201  PHA03095
PHA0310065-261  PHA03100
PHA0287536-251  PHA02875
PHA0309556-237  PHA03095
pfam12796168-253  Ank_2
PHA0287627-283  PHA02876
PHA0287683-233  PHA02876
PHA0287433-238  PHA02874
PLN031923-221  PLN03192
COG066646-159  ANKYR
PHA0309543-208  PHA03095
PHA0287846-204  PHA02878
COG0666161-253  ANKYR
pfam1363766-118  Ank_4
PHA0287576-249  PHA02875
PHA0287869-311  PHA02878
PTZ00322160-257  PTZ00322
pfam1385783-137  Ank_5
pfam13637166-217  Ank_4
pfam13637131-184  Ank_4
PTZ00322138-217  PTZ00322
PTZ0032268-153  PTZ00322
PHA0310045-159  PHA03100
pfam1385749-105  Ank_5
pfam13857150-204  Ank_5
PHA0294684-238  PHA02946
pfam13637100-151  Ank_4
PHA0279877-194  PHA02798
PTZ0032266-121  PTZ00322
pfam13857188-235  Ank_5
PHA0288464-135  PHA02884
PHA0271656-202  PHA02716
PHA0271684-201  PHA02716


Ontology Information


   
HPRD ID15649
Molecular ClassUbiquitin proteasome system protein
Molecular FunctionMolecular function unknown (GO:0005554)
Biological ProcessApoptosis (GO:0006915)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO