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General Information
- Evidence
- Gene
- mRNA
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- Protein
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- Enzyme
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- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23839493 | 2013 | Cell line : - Source : University Hospital of Verona (Italy) Sample Type : CRC tumor, normal tissue and blood plasma No. of Sample : 67 Stage : - | Methylation-specific PCR | Methylation | - | The PCDH10 promoter methylation was detected in 63 out of 67 (94.0%) surgically resected colorectal tumours and in 42 out of 67 (62.7%) plasma samples. There was a significant correlation between PCDH10 methylation in cfDNA and tumour tissue in patients with early CRC (P<0.0001) |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Cadherins / Protocadherins : Non-clustered |
| Description | This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. This family member contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of the classical cadherins. The encoded protein is a cadherin-related neuronal receptor thought to function in the establishment of specific cell-cell connections in the brain. This gene plays a role in inhibiting cancer cell motility and cell migration. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| Chromosome | 4 |
| Location | 4q28.3 |
| Start | 133149290 |
| End | 133208606 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 59317 |
| OMIM ID | 608286 |
| HGNC ID | HGNC:13404 |
| Unigene ID | Hs.192859 |
| Ensembl ID | ENSG00000138650 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_011532150.1 |
|---|---|
| Exon | join(1..3482,5018..5076,5628..5734,13688..13993, 58787..59317) | mRNA Sequence | Download Select all |
| Length | 4621 |
CDS Information
| Location | join(852..3482,5018..5076,5628..5734,13688..13993, 58787..58857) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_065866.1 |
|---|---|
| Protein Name | protocadherin 10 |
| Molecular Wt. (Da) | 94938 |
| Protein Sequence | Download Select all |
| Length | 896 |
| Uniprot ID | P41159 |
| Ensembl Protein ID | ENSP00000312652 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd11304 | 254-354 | Cadherin_repeat |
| cl15786 | 254-354 | CA_like superfamily |
| cd11304 | 590-680 | Cadherin_repeat |
| cl15786 | 590-680 | CA_like superfamily |
| cd11304 | 367-459 | Cadherin_repeat |
| cl15786 | 367-459 | CA_like superfamily |
| cd11304 | 467-570 | Cadherin_repeat |
| cl15786 | 467-570 | CA_like superfamily |
| cd11304 | 128-246 | Cadherin_repeat |
| cl15786 | 128-246 | CA_like superfamily |
| cd11304 | 21-118 | Cadherin_repeat |
| cl15786 | 21-118 | CA_like superfamily |
| pfam08266 | 19-101 | Cadherin_2 |
| smart00112 | 273-356 | CA |
| pfam00028 | 255-349 | Cadherin |
| pfam00028 | 590-678 | Cadherin |
| smart00112 | 381-461 | CA |
| smart00112 | 486-572 | CA |
| smart00112 | 605-680 | CA |
| pfam00028 | 367-453 | Cadherin |
| pfam00028 | 468-564 | Cadherin |
| smart00112 | 145-248 | CA |
| cd00031 | 22-118 | CA_like |
| pfam00028 | 128-241 | Cadherin |
| smart00112 | 56-120 | CA |
Ontology Information
| HPRD ID | 3001 |
|---|---|
| Molecular Class | Adhesion molecule |
| Molecular Function | Receptor activity (GO:0004872) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.